|FDA OKs new drug for advanced prostate cancer||The Food and Drug Administration said Friday it approved the pill Xtandi for men with advanced prostate cancer that has returned or spread despite major medical intervention.|
|Selecting Nutritional Supplements||Nutritional supplements can help compliment a diet that could be missing some necessary nutrients. But Nutritional supplements are only as good as the ones you select, and how you combine your Nutritional supplements with healthy food so that none of the nutrients are cancelled out.|
An estimated 50 percent of American adults use Nutritional supplements regularly. But some doctors suggest that half of these adults aren't using these Nutritional supplements correctly.
So, how exactly is it possible to use Nutritional supplements incorrectly? Well, incorrect nutritional supplement use starts with a lack of understanding of these types of supplements. Too many people make the mistake of looking for bargain prices when they look for Nutritional supplements. The cheapest is rarely the best when it comes to Nutritional supplements.
People looking to add Nutritional supplements to their already fairly healthy diets should take the time and do some background research. Don't buy low-quality Nutritional supplements with little or no research behind them. And, unfortunately, a large percentage of the useless Nutritional supplements are those that put all their money into advertising instead of quality ingredients. These are the types of Nutritional supplements that are promoted as "popular" and often seem to be forever on sale.
When choosing a nutritional supplement, it's always better to choose a caplet over a tablet. The simple reason for this is that your body usually can't effectively dissolve a tablet nutritional supplement. And if your body can't dissolve this type of nutritional supplement, then it won't be able to breakdown the ingredients and feed the nutrients to different parts of your body. Plus, the super low-quality Nutritional supplements rarely dissolve at all. Studies of these types of Nutritional supplements show that the entire whole form of the tablet can sit in your stomach like a tiny stone for many, many hours. So always select a capsule nutritional supplement. It's much nicer to your digestive system and much better for you body.
Avoid single-nutrient Nutritional supplements. Single-nutrient foods don't exist, so why would you feed your body single-nutrient Nutritional supplements? Eating these types of Nutritional supplements will only succeed in ruining the balance of your body's chemicals.
And don't try a "piecemeal" approach to nutritional supplement use. A piecemeal approach is when you select a variety of single- or multiple-nutrient Nutritional supplements, and mix-and-match them to try and make up for where you think your diet lacks. Few people have the skills to do this type of nutritional supplement maneuvering.
When selecting Nutritional supplements look for ones that say they are "laboratory tested." Laboratory tested Nutritional supplements means that they've been created by responsible manufacturers who choose to follow the FDA regulations, even though they're not required to do so.
Pick Nutritional supplements that are "quality guaranteed." Quality guaranteed Nutritional supplements are ones that use pharmaceutical-grade products.
Be wary of Nutritional supplements that claim to be 100 percent natural. A 100 percent natural nutritional supplement, just like 100 percent cobra venom, is probably not good for you. And always make sure every nutritional supplement container you buy has an expiry date. Nothing stays good forever, not even Nutritional supplements.
|Supplements And Nutrition||A well-balanced diet and affinity for all food groups ensure right amounts of much-needed nutrients. However, not all people are blessed with a liking for vegetables or tolerance for milk. There are also people with allergies to nuts and poultry which are excellent sources of protein and good fat. What if you are one of them? How can you be sure that you get proper nutrition without force-feeding yourself brocollis? This is why Supplements and Nutrition should work together.|
Before taking supplements, it would be wise to seek your doctor's advice. After all, you want to be sure to have the proper Supplements and Nutrition. The wide variety of supplements include multivitamins, protein supplements, minerals, and specialized supplements. Multivitamins are the most prescribed supplements. Regulated and concentrated amounts of essential vitamins are packed in a tablet or gels. Protein supplements are commonly used by people who want to build more muscle such as athletes. Mineral supplements include calcium for bone growth. Dietary supplements and memory enhancers are commonly classified as specialized supplements.
Supplements and Nutrition must be complementary. For example, a person who consumes large amounts of carrots and squash need not take a supplement of Vitamin A. This is because too much of Vitamin A can cause a yellow or orange tinge to the skin. Other overdoses on minerals and vitamins can even disrupt normal hormonal function. After all, even too much of a good thing can be hazardous to health.
Hence, a proper Supplements and Nutrition scheme must be discussed with the doctor in order to prevent overdoses or taking unnecessary supplements. The US FDA in recognition of the growing market and need for supplements has taken steps to regulate the production, dosage, and sanitation of supplements. This was done to ensure good-quality products. This move is also partly due to rising number of unprescribed supplement use among consumers. The agency also stressed the importance of informed use among supplement users. It is not enough to know the name of your supplements. You should know what deficiency it corrects and how it works. Studies show that many use different supplements whereas tests done to them indicate only a minimal lack which can be corrected by a single kind. Also, despite the supplement rage, doctors and health experts still stand by natural correction of deficiencies by means of a proper diet. They suggest eating alternative sources of nutrients found in allergy-inducing foods. Hey, real food tastes better than capsules anyway.
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|ê°ê¸°ì½ ë´ì±ì¼ë¡ ê³ì ë°ë³µ! ë©´ìì¦ê°ì¼ë¡ ê°ê¸°ì¡¸ì|
ë ì´íë¡ ì´ë¦°ì´ì§ì ë¤ëë©´ì ìë¡ ì£¼ê³ ë°ë(?) ë°ì´ë¬ì¤ íê²½ì ë ¸ì¶ì´ ëë©´ì,
ì½ë¡ì½ë¡ ê°ê¸°ë¥¼ ë¬ê³ ì´ë ì ìì¤ì¸ë°ì.
ê·¸ë¬ë¤ê° ìë ì¸ 2015ë 1ì 1ì¼ íë ´ì í ë² ê±¸ë¦¬ë©´ì,
ê·¸ ì´íë¡ë íìì ë³µì©ì ë°ë³µì´ììµëë¤. ì© ã ã
ìë¬´ë¦¬ ì ê²½ì ì°ê³ ë ì¨ë,
ë§¤ë² ì´ì ëë°í ì½ê°ê¸°ì í ë² ê±¸ë¦¬ë©´ ê¼ íìì ë¡ ëëë¤ ë³´ë,
ì´ë¬ì§ë ì ë¬ì§ë ëª»í´ì ìµê·¼ê¹ì§ë ëë¬´ ë§ìì´ ìì¢ììµëë¤.
(ì¬ì¤ ì´ ê¸ì ì°ê¸° ì§ì ê¹ì§ë ì ìì¤ë ê°ê¸°ì½ì ë³µì©íìµëë¤. ã ã )
ìë§ë¡ì¨ ì ë§ í° ê´ì¬ì ê°ê³ ,
íìì ìì´ í¤ì¸ ì ìë ë°©ë²ì ì°¾ê¸° ìí´ ì¤ê°ì¸ê° ì¤ë«ë§ì ê³µë¶ë¥¼ íìµëë¤.
ì¸ ìì´ì ìë²ì§ì´ì,
16ë ê° 15,000ëª ì´ìì ìì ìì ë©´ì ì¦ê°ì ìí ê·¼ë³¸ì¹ë£ë¥¼ í
ì±ëª¨ìì´íììì ê¹ì±ì² íìì¬ëì´ ì°ì ì± ì ë§ëê² ëë©´ì ìì´ ê±´ê°ì ëí ê³ ë¯¼ì´ ë§ì ë¶ë¶ìì ëìì´ ëììµëë¤.
ê·¸ëì ì´ ìë§, ì ìë§, ê·¸ë¦¬ê³ ì¸í°ë·ìì ì£¼ìë¤ìë ì´ì¼ê¸°ë¤ì ì´ì ë¦¬í ëëì´ë¼ê³ í ê¹ì?
ê°ê¸°ìë ì¹ë£ì½ì´ ìì§ ìë¤ë¼ë ë§ì ì ìì´ ë¤ì´ë´¤ëë°,
ìì´ìê² ë¨¹ì´ë ì½ì´ ì íí ì´ë¤ ìí ì íê³ ìëì§ ë§ì ì ë³´ë¥¼ ì»ê² ëììµëë¤.
ì± ìì ê³ì ê°ì¡°íë ë´ì©ì,
ì°ë¦¬ ìì´ê° ë¨¹ê³ ìë ê°ê¸°ì½ê³¼ íìì ë,
ìì´ê° ê²ªê³ ìë ì¦ìì ë°ë¥¸ ë¶í¸í¨ì ë³´ë¤ í¸íê² ëìì£¼ë ííì½íì¼ ë¿,
ìì´ì ë©´ìë ¥ ì¸¡ë©´ìì ë´¤ìëë ê·¼ë³¸ì ì¸ ì¹ë£ê° ìëë¿ë§ ìëë¼,
ë©´ìë ¥ì´ ì ëë¡ ë°íë ê¸°íê° ìì´ ì¤íë ¤ ê°ê¸°ë¥¼ ì´ê²¨ë´ë íì´ ê¸¸ë¬ì§ì§ ìê² ëë¤ë ë ¼ë¦¬ì ëë¤.
ìì ìë¤ìê² ê°ì¥ ííê² ë°ë³ëë,
ì´ê°ê¸°, ì½ê°ê¸°, ì¶ëì¦ì ì¤ê°ì¸ë êµì¥í ì§ì¤í´ì ì ë ì íìµëë¤.
êµì¥í ì¸ìì ì´ìê³ ,
ìë§ë¡ì¨ ì ë¿ìë ë´ì©ì,
ìë ìì´ ë°ë³µëë ê°ê¸°ì ì¸ì°ëë¼ ì±ì¥ì íìí ìëì§ë¥¼ ìë¹íë ë°ëì,
ì´ë¬í ìë³ì¹ë¡ì ë©´ìë ¥ì ê°ìë ìì´ê° ì±ì¥íëë° êµì¥í í° íê²©ì ì¤ë¤ë ê²ì ëë¤.
ì´ê±´ ì ë§ ì¤ì ìì´ë¥¼ í¤ì°ë ìë§ë¡ì¨ ìë¿ë ë´ì©ì´ê³ ,
ì¤ì ë¡ ì¤ê°ì¸ì ë§ìì í¬ê² ìì§ììµëë¤.
ê°ê¸°ê° ë°ë³ëë ìì¸ì êµì¥í ë¤ìíì§ë§,
ì²´ì§ì ë°ë¼ ì¹ë£íë ë°©ë² ëí ë¤ìí©ëë¤.
ëª¨ë ì¬ëìê² íì¼, ëë¼ì§ê° ì¢ìê²ì´ ìëë¼ë ë´ì©ë ëì¬ê²¨ ë´ì¼í ë¶ë¶ì ëë¤.
ì¤ê°ì¸ì²ë¼ ëª¸ì´ ì°¬í¸ì¸ ì¬ëìê²ë íì¤í ëìì´ ëì§ë§,
ì´ì´ ë§ì ì°ë¦¬ ìë¤ìê²ë ë§ì§ ìì ì ìë¤ë ê²ì´ì£ .
íì§ë§ ì´ë°ë¶ë¶ë¤ì ìë§í¼ì íë¨íê¸°ë íë¤ê³ ,
ì ë¬¸ íìì¬ìê² ì§ë£ë¥¼ ë°ìì¼ í©ëë¤.
ë, ê¹ì§ ëëë§í ê°ê¸°ì ëí ì ë³´ë ì± ìì íì¸í ì ìììµëë¤.
ì°ë¦¬ê° ê°ê¸°ë¼ê³ ìê°íë ì ì ê°ê¸°ìë,
ìíë¶ëì¼ ê°ë¥ì±ì´ ììë ìììµëë¤.
ì¦, ì¤íì ëë°íì§ ìë ë°ì´ì¼ ë ì§ìì ìê¸ì¡°ì¹ë¡,
ì¼ë¨ ìë°ì ë° ì£¼ê³ , ê³µë³µì ì·¨íë ê²ì´ ì¢ë¤ê³ í©ëë¤.
í´ì´ì ìì ë¬´ì¡°ê±´ ë¯¸ì´ëë¶í° ë¨¹ì´ë ê²ì´ ìëë¼,
(ì¸ê· ê³¼ ë©´ìì¸í¬ê° ì¸ì°ë íëì´ë¯ë¡ ë°ë¡ í´ì´ì ë¥¼ ë¨¹ì´ë ê²ì ì³ì§ ìë¤ë¼ê³ í©ëë¤.)
ìµëí ííì±ë¶ì ìì½ì ë³µì©íì§ ìì ì ìëë¡ ì¡°ì¹ë¥¼ ì·¨í´ë³¸ í,
ê·¸ëë ê³ ì´ë¡ ì¸í´ ê³ íµì¤ë¬ìí ë í´ì´ì§íµì ë¥¼ ìë ë³µì©íë ë°©ìì¼ë¡ì.
ì¦, ííì±ë¶ì ìì½ì ìµëí ì ì¤í í¬ì¬í´ì¼íë¤ë ê²ì ëë¤.
í¹í, ì± ìì ì¶©ê²©ì ì¸ ë°ì´í°ë¥¼ ë´¤ëë°ì.
ì¸êµê³¼ íêµì ìì ìì ëí ì½ì²ë°©ì ëí ì°¨ì´ë¥¼ íì¸í ì ììµëë¤.
ë¯¸êµ FDA ìë¬¸ììíë 2007ë ë§ 2ì ë¯¸ë§ ìì ìë¤ì ëí OTCê°ê¸°ì½ ì¬ì©ì¤ë¨ì ê¶ê³ íìê³ ,
ìêµ/ìºëë¤/í¸ì£¼/ë´ì§ëëììë ë§ 6ì¸ ë¯¸ë§ ìììê² OTC ê°ê¸°ì½ì íë§¤ë¥¼ ì ííë ì¡°ì¹ë¥¼ ìííë¤ê³ í©ëë¤.
ì¬ê¸°ì OTCë 'over the counter'ì ì½ìë¡ ìì¬ì ì²ë°© ìì´ ì´ ì ìë ìì½íì ìë¯¸í©ëë¤. ì¦, ì½êµìì ì½ê² êµ¬ì í ììë ì¼ë° ìì½íê³¼ ì ì¬í ê°ë ì´ì£ .
ì± ì ì²ìë¶í° ê±°ì íë°ë¶ê¹ì§ ì½ì ìíì¸ë°ì.
ìì´ìê² ì ì¤í ì½ì í¬ì¬í´ì¼í¨ì ë¬¼ë¡ ,
ë©´ìë ¥ì ì¬ë ¤ ì¤ì¤ë¡ ì´ê²¨ë¼ ì ìë íì ê¸¸ë¬ì¤ì¼ í¨ì ì ì ì¼ë¡ ëìë¥¼ íê² ëììµëë¤.
ì± ì ì½ê¸° ì ê¹ì§ë ê·¸ë¥ ê·¸ë ë¤ëë°... ê·¸ëì¼ íë¤ëë°.. ì ëë¡ ë§ì°íìëë°,
êµ¬ì²´ì ì´ê³ íì¸ë ë°ì´í°ë¥¼ ë³´ë©° ê³µë¶í´ë³´ë,
ì°ë¦¬ ìë¤ìê² ì ë§ íìí ë³´ì´íì´ ì´ë¤ ê²ì¸ì§ ìê² ëììµëë¤.
ë¬´ë¶ë³íê² ì½ì í¬ì¬í ê²ì´ ìëë¼,
ìë¤ì ì²´ì§ì ë§ê² ê·¼ë³¸ì ì¸ ì¹ë£ë¥¼ ëê³ , ë©´ìë ¥ì í¤ìì¤ì¼ ê² ë¤ë¼ë ìê°ì´ ê°íê² ë¤ëë¼ê³ ì.
ë³ì ëí ë¶ëª ì¶ì ìì´ì ìì´ìë ìë ê¸°ê´ì´ê³ ,
ì¤ì ëìì ë§ì´ ë°ìììµëë¤ë§,
íì¬ ìë ì´íë¡ ì ê° ë´ë ë©´ìë ¥ì´ ëë¬´ ë¨ì´ì§ ìë¤ì ìí´,
ì§ê¸ë¶í°ë¼ë ë©´ìì¦ê°ì ë ì§ì¤í´ì¼ê² ë¤ê³ êµ³ê² ë¤ì§í´ë´¤ìµëë¤.
ìì´ë¥¼ í¤ì°ë ìë ë¶ë¤ì´ë¼ë©´,
ì¤ê°ì¸ê° ì½ì "ê°ê¸°ì¡¸ì "ì´ë¼ë ì´ ì± ì ì ê·¹ ì¶ì²í©ëë¤.
ë¤ìí ë¯¼ê°ìë²ì ëí ì ë³´ë ìê³ ,
ííì½íì ëí ì ë³´ë ìê³ ê³ìë©´ ìë§ë¤ì ì íì í° ë³íê° ìì ê²ì´ë¼ ìê°ë©ëë¤.
ì ë§ ë§ì ë¶ë¶ìì ëìì´ ëììµëë¤.
ì¤ì ë¡ ì¤ê°ì¸ë ì´ ì± ì ì½ê³ ,
ë§ì ë¶ë¶ìì ì§ì¬ì¼ë¡ ê³µê°ì íê² ëì´,
ë¤ë¥¸ íììì´ì§ë§ ì¤ë«ëì ì¤ê°ì¸ê° ëìì ë°ìì¨ íììì ì²ì ìë¤ì ë°ë¦¬ê³ ê°ì ì¸ì¬íê² ì§ì°°ì ë°ê³ ììµëë¤.
ì¬í´ë¶í°ë ì°ë¦¬ ìë¤ë ëª¸ ìììë¶í° ê±´ê°ì´ ì°ë¬ëì¤ë ìë¤ì´ ëëë¡ ìì² í ì¢ ì¸ ê±°ëëë¤.
ì¤ëë ê°ëì¸ ì¸ì ì¤ê°ì¸ììµëë¤.
ê±´ê°íê³ íë³µí íë£¨ ëì¸ì~ ^^
|Top 5 reasons to love your SCOBY|
One kind of post title that people appear to like promises a list of reasons for something. I've been meaning to write a post about the joys of the fermentation community for a while, and the original title of this post was "It takes a village to grow a SCOBY". But I'm going to use the list format, instead. Tell me whether you like it and I should do more of them, or you think it is just gimmicky.
Just to remind you, a SCOBY is a Symbiotic Colony Of Bacteria and Yeast. The acronym usually refers to the culture used in making kombucha, but milk kefir and water kefir grains are also SCOBYs. Yoghurt cultures are not.
5. While there isn't much scientific proof of the benefits of fermented drinks such as kombucha and kefir, there is plenty of anecdotal evidence that people with gut issues who drink kombucha seem to feel better. That is certainly true in my case. There was a scare a few years ago in which the FDA linked deaths to kombucha, but there doesn't seem to have been any conclusive evidence there. I've never felt ill after drinking my home-brew. It's also a great source of B vitamins. Of course it is important to make sure everything is clean, etc. - well, duh. They haven't warned people off Pepsi yet, because, you know, it doesn't do anything bad to you.
4. Even if you, like me, can't drink cultured milk directly, you can still make wonderful dairy products with it. I made the most amazing cultured butter from local organic milk I had fermented with milk kefir grains. It tasted just as good as the store-bought butter brought in from Quebec, and was considerably cheaper, which you can't always say for home-made stuff. Just as an aside, if I were able to access raw milk in Manitoba it is entirely possible that I would be able to drink the milk kefir. Again, there hasn't been much scientific research but I've heard many anecdotal reports of people who were supposedly intolerant of dairy doing just fine with the unpasteurised version. Again, you need to make sure everything is clean and safe. Well, duh.
3. There is something very magical about watching the slow transformation of sweet tea into something resembling cider. You plop your little alien-looking colony into the tea, cover the jar and put it in a warm place. After about a week you will have a new baby SCOBY to share with your friends, and a yummy drink to put into bottles for a second fermentation with fruit or herbs. I usually use blueberries, strawberries or ginger. It's incredibly delicious. Even if it didn't have a single health benefit, it just tastes so nice, especially first thing in the morning. Move over, grapefruit juice.
2. It does take patience, whether you are making kefir or kombucha. You can't hurry it up, although you can slow it down by keeping it in a temperature that is too low. I usually put my jar in the oven with just the light on (and a BIG sign on the door to prevent me from cooking my ferments!). Having to wait on nature is good for the soul in these frenzied times. It can be quite zen.
1. Best of all, you get to interact with an amazing community of fellow enthusiasts. You can't buy a SCOBY in the supermarket. There are websites out there which will sell one to you, but it is much more fun to get one from a local person. I was fortunate to be put in touch with a lovely lady named Andrea, who gave me my first kombucha SCOBY. I am so grateful to her, and to Sarah who gave me milk kefir grains. I was fortunate to be able to pass on some of my baby SCOBYs to others interested in travelling a similar route. You can't buy that kind of experience, either.
So, those are my top reasons for loving my SCOBYs. I'm sure I could come up with more, but I don't want the blog post to be too long. What do you think?
|Support the CREATES Act, S. 974 and H.R. 2212|
On behalf of FreedomWorksâ activist community, I urge you to contact your representative and ask him or her to support the Creating and Restoring Equal Access To Equivalent Samples (CREATES) Act, S. 974 and H.R. 2212. This bill would lower prescription drug prices by crushing illegal, anti-competitive, and monopolistic practices by the biggest pharmaceutical companies.
Prescription drug prices have soared above general inflation rates for years, a telltale sign of lacking producer competition. Large moneyed pharmaceutical companies abuse a loophole in the FDA Amendments Act of 2007 that allows them to bar potential competitors from entering the market. They do this by refusing to provide drug samples and safety information that new producers need for medical research required in the FDA approval process of generic drugs.
Without these samples and safety procedures, new producers never earn FDA approval. Meanwhile, existing producers establish monopolies and hike prices.
This especially harms the emerging market for âbiosimilars,â innovative remakes of biologic drugs. Biosimilars are often much cheaper to produce than name-brand biologics, reducing costs for millions of Americans.
The CREATES Act would grant relief in court for generic and biosimilar competitors seeking FDA approval. This would clear the pathway for new drugs to enter the market, drastically reducing prices through increased competition. The cost savings stemming from this legislation could reach between 15 percent and 50 percent of current prices for impacted drugs.
Such legislation would reduce both the federal deficit and national debt. Decreasing prescription drug costs would lessen the financial burden on Medicare, saving taxpayers up to $5 billion annually.
As you know, FreedomWorks fights for free markets and smaller government. The CREATES Act would lead to a freer market, less cronyism, and cheaper medication. For these reasons, I urge you to contact your representative and ask him or her to support the CREATES, S. 974 and H.R. 2212.
Adam Brandon, President, FreedomWorks
|Congress Should Lower Ridiculous Drug Prices by Passing CREATES Act|
Perpetually increasing prescription drug prices ravage everyday Americans. Specifically, name-brand prices outpace inflation by about 50%, largely due to government-protected market power. A beacon of hope for reducing drug prices are the generic and biosimilar drug industries, which produces existing brand drugs and biologics drugs through distinctly cheaper methods. But big Pharma doesnât want competition, so it does everything it can to block generic and biosimilar innovation. The CREATES Act, H.R. 2212, solves a loophole commonly abused by big pharmaceutical companies for unlawful market advantages in the emerging generics and biosimilars markets.
Existing drug companies exploit the Food and Drug Administrationâs (FDAâs) Abbreviated New Drug Application (ANDA) requirements for FDA approval of competitive generic and biosimilar products. This is an unlawful tactic to increase market-power. Biosimilars are a type of biologic drug â drugs manufactured from living cells â that mimic both the composition and the function of an existing biologic drug but employ cheaper production processes. Tragically, established producers prevent aspiring competitors from completing ANDA.
To complete a generic or biosimilar approval process, applicants must acquire sample drugs from existing producers. This allows medical researchers to demonstrate that the functions and properties of the original brand drug and the new generic or biosimilar are, in fact, equivalent. Sadly, many brand companies refuse to provide samples to potential competitors, preventing them from gaining approval. Thus, innovative generics and biosimilars hit the market less frequently, trapping consumers with fewer options and higher prices. While this practice of abusing distribution networks is illegal, there are no enforcement mechanisms preventing it.
Remember the damnable pharmaceutical executive Martin Shkreli, who raised the price of a biologic AIDS drug Daraprim by over 5000% in one night? One of his profit-protection methods was to deny competitor applicants the samples they need to earn FDA approval. Competing with losers like Shkreli would be easy it if werenât for this loophole. High school chemistry students reproduced Daraprim for less than $2 a pill compared to Shkreliâs $750.
A similar monopolistic scam employed by entrenched pharmaceutical companies involves exploiting shared Risk Evaluation and Mitigation Strategy (REMS) procedures. Producers of existing brand drugs are sometimes required by the FDA to establish safety protocols that protect consumers from safety risks. The FDA encourages companies to share, or streamline, their REMS procedures for maximum safety and congruency among user experiences. If a person taking biologic drug X switches to biosimilar drug X, the shared procedure is supposed to ensure that there are no major differences in how this person safely consumes the drug. In a similar fashion to denying samples, big pharma often refuses to share REMS procedures. When a REMS program has previously been required, FDA cannot approve a generic or biosimilar until a shared REMS has been negotiated or the agency has been given sufficient evidence to waive the requirement. This imposes redundant and costly burdens on biosimilar producers, and ultimately delays market entry for far less expensive but equally safe drugs.
Both of these tactics, refusal to share samples and failure to fairly negotiate shared REMS programs, establish de facto monopolies for original drug producers, but theyâre easily fixed by the CREATES Act. Under the CREATES Act, generics and biosimilar manufacturers will be able to seek injunctive relief in court against companies that withhold samples or REMS information. This will improve competition with new generics and biosimilars, reducing prescription drug costs possibly as much as 40%. It will also help sustain Medicare Part D, the national deficit, and debt, by reducing government drug expenses by up to $5 billion per year.
Congress should end illegal monopolies and help Americans afford their medications by passing the CREATES Act, all without increasing the size of government.
|Capitol Hill Update: July 24, 2017|
The House and Senate are in session this week.
There are five (5) legislative days remaining for the House before the August recess and 53 legislative days remaining in the year. The Senate will supposedly work through the first two weeks of the August recess.
The FY 2018 budget resolution, dubbed "Building a Better America," was marked up and approved by the Budget Committee on Thursday in a party-line vote. The budget would reduce the budget deficit by $6.5 trillion over the ten-year budget window and eventually come into balance in FY 2027, creating a $9 billion surplus.
Perhaps one of the most important components of the budget is that it begins the reconciliation process for fundamental tax reform. There are also reconciliation instructions for 11 House committees to find roughly $200 billion savings or reforms in mandatory spending.
The FY 2018 budget resolution isn't on the calendar for the week. It's unclear if House Republican leaders will bring it to the floor.
Additionally, the 21st Century Aviation Innovation, Reform, and Reauthorization (AIRR) Act, H.R. 2997, introduced by Transportation and Infrastructure Committee Chairman Bill Shuster (R-Pa.) could come to the floor for a vote this week. The bill reauthorizes the Federal Aviation Administration (FAA) and reforms the United States' out of date air traffic control (ATC) system. FreedomWorks has released a key vote in support of the 21st AIRR Act.
On Monday, the House will consider 17 bills on the suspension calendar. Most of the bills on the suspension calendar related to veterans or active military issues. There are three bills on the suspension calendar that relate to small businesses and investment. The House will also consider the Intelligence Authorization Act, H.R. 3180, sponsored by Intelligence Committee Chairman Devin Nunes (R-Calif.) on suspension.
There are three bills on the suspension calendar for Tuesday, including the Medicare Part B Improvement Act, H.R. 3178, sponsored by Ways and Means Chairman Kevin Brady (R-Texas), and a yet-to-be-numbered resolution that will impose sanctions on Russia, Iran, and North Korea.
The House will also consider H.J.Res. 111, a resolution of disapproval under the Congressional Review Act, to cancel the Consumer Financial Protection Bureau's (CFPB) giveaway to trial lawyers. The rule put restrictions on the use of arbitration to settle disputes over consumer products. This would lead to more class-action lawsuits, benefiting trial lawyers and hurting consumers. FreedomWorks has signed a coalition letter in support of H.J.Res. 111 and will likely include the vote on our 2017 Congressional Scorecard.
For the balance of the week, the House will consider at least four more bills on the suspension calendar. The Make America Secure Appropriations Act, H.R. 3219, will also come to the floor. This is the consolidated appropriations bill, or "minibus," for the Department of Defense, the Legislative Branch, Military Construction and Veterans Affairs, and Energy and Water. Like virtually every other bill to come to the floor this year under "regular order," the Make America Secure Appropriations Act is subject to a rule to limit or prevent amendments from the floor.
On Thursday at 10:00 am, the Judiciary Committee will hold a hearing entitled "The Need for the Balanced Budget Amendment." The witness list for the hearing has not yet been announced. Twelve constitutional amendments have been introduced in the House that would require a balanced budget. Chairman Bob Goodlatte (R-Va.) is the sponsor of two of them, H.J.Res. 1 and H.J.Res. 2. Rep. Justin Amash (R-Mich.), the primary sponsor of H.J.Res. 15, is among the House conservatives who have introduced a balanced budget amendment.
The committee and subcommittee schedule for the week can be found here.
Presumably, the Senate will vote this week on the motion to proceed to the House-passed version of H.R. 1628. It's still unclear on what happens next. A vote to proceed to the House-passed version has always been the first step. The next step will be for an amendment to the bill that will substitute the language of either the Better Care Reconciliation Act or language similar to the 2015 ObamaCare repeal bill, now called the ObamaCare Repeal Reconciliation Act. FreedomWorks' key vote on the motion to proceed applies only if the base text that will be substituted is similar to the 2015 ObamaCare repeal bill.
At least a few Senate Republicans have backed away from their votes for the 2015 ObamaCare repeal bill, which was passed in December 2015 with the support of all but two Republicans, including Sen. Susan Collins. Moderate Republicans who refuse to vote for the 2015 ObamaCare repeal bill have demanded $200 billion in Medicaid funding offered by Majority Leader Mitch McConnell (R-Ky.) to get them to support the Better Care Reconciliation Act.
Some parts of the Better Care Reconciliation Act are in limbo, however, as the Senate parliamentarian has apparently ruled that provisions limiting funding for Planned Parenthood and tax credits for plans that cover abortion will require 60 votes. Other provisions that may require 60 votes include the State Innovation Waivers. Many of these provisions can be altered to make them withstand a Byrd rule challenge, as was done in 2015.
The Senate still has several nominees to consider and, on the legislative front, the FDA Reauthorization Act, S. 934; the National Defense Reauthorization Act; and the debt ceiling are among the items awaiting action.
Separately, Senate Democrats are rolling out their "better deal" economic agenda today, which is a rehashing and repackaging of virtually every leftist policy proposal in recent years. The agenda is Democrats' attempt to find a message after a string of special election losses around the country.
The full committee schedule for the week can be found here.
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Karnataka 1st Year D.Ed.(Diploma in Education) Exams Question Papers-June/July-2015
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|Celltrion/Teva and Amgen/Allergan Announce FDA Submissions for Proposed Biosimilars of HerceptinÂ®||
|FDA Reauthorization Act of 2017 passes the House||
|Merck Receives Tentative FDA Approval for Lantus Follow-on||
|TermografÃa para la detecciÃ³n de CÃ¡ncer de Seno.|
TermografÃa para la detecciÃ³n de CÃ¡ncer de Seno.
Esta tambiÃ©n llamada âtermografÃa de pecho', Ã³ termomastografÃa tiene la habilidad de descubrir las primeras seÃ±ales que indiquen que un cÃ¡ncer puede estarse formando, incluso 10 aÃ±os antes de que cualquier otro procedimiento pueda detectarlo.
Desde 2006 el Centro de Estudios y PrevenciÃ³n del CÃ¡ncer A.C. (CEPREC), estÃ¡ evaluando esta novedosa e innovadora prueba. Este hecho, lo convierte en el Ãºnico centro con Ã©sta tecnologÃa en el paÃs: una cÃ¡mara de rayos infrarrojos que al captar el calor de la mama permite detectar alteraciones tempranas.
Su ventaja es que no produce radiaciones, no es dolorosa y su sensibilidad para detectar el cÃ¡ncer de mama es hasta el 94%.
"Este estudio, en combinaciÃ³n con la mastografÃa convencional de rayos X y la mastografÃa digital nos ayudarÃ¡ a diagnosticar el cÃ¡ncer de mama en etapas mÃ¡s tempranas, aumentar la supervivencia y reducir la mortalidad por este tumor", asegurÃ³ a rotativo de QuerÃ©taro el Dr. Francisco GutiÃ©rrez Delgado, director del CEPREC en JuchitÃ¡n, Oaxaca.
El Dr. JosÃ© G. VÃ¡zquez Luna, profesor investigador de la BUAP empleÃ³ la tecnologÃa militar e hizo transferencia a la medicina, diseÃ±ando un sistema capaz de registrar ondas que registran calor.
El antecedente de Ã©sta tecnologÃa estÃ¡ en la investigaciÃ³n militar, durante la vigilancia nocturna de tropas. El calor de los cuerpos de los soldados enemigos, delata su posiciÃ³n a kilÃ³metros de distancia. Con Ã©ste sistema se detecta, registra y produce imÃ¡genes de la superficie de la piel de los senos y es posible correlacionar los puntos de calor detectados con el tamaÃ±o del tumor. "El cÃ¡ncer exige al cuerpo que lo alimente, existe un proceso de angiogÃ©nesis cuando se inicia el cÃ¡ncer, es decir, se crean nuevos vasos sanguÃneos que llevan alimento al tumor.
Este fenÃ³meno de formaciÃ³n de nuevos vasos sanguÃneos resulta revelador porque incrementa localmente la temperatura. Con la termografÃa se pueden detectar estos pequeÃ±os incrementos locales de temperatura.
La imagen tÃ©rmica se convierte en un inmejorable coadyuvante, que el mÃ©dico con otro grupo de pruebas determinarÃ¡ si es o no cÃ¡ncer". "Es una prueba fisiolÃ³gica que puede detectar cambios mÃnimos de temperatura, la termografÃa puede usarse como pesquisa o prueba discriminatoria, es decir, si una mujer pasa primero por esta prueba y no se localiza ningÃºn riesgo no tendrÃa caso exponerla a la masto grafÃa, y si se encuentra alguna anormalidad entonces con apoyo de la masto grafÃa y/o ultrasonido se lograra un certero diagnÃ³stico" revelÃ³ el doctor en fÃsica.
El Investigador de la Escuela FÃsico MatemÃ¡ticas de la BUAP, expuso que el principio fÃsico es sencillo: La energÃa tÃ©rmica Ã³ infrarroja, por su longitud de onda, no es visible por el ojo humano, pero la termografÃa, por medio de una cÃ¡mara, "ve" y "mide" la energÃa infrarroja que estÃ¡ siendo emitida por un objeto.
La capacidad de emisiÃ³n de la piel humana es muy alta, por lo tanto, la radiaciÃ³n infrarroja emitida puede ser convertida a valores de temperatura. JosÃ© G. VÃ¡zquez Luna, en entrevista para este medio, tambiÃ©n explicÃ³ que existen mÃ¡s de 1200 estudios, incluidos en el Index Medicus que han evaluado su rol en la detecciÃ³n temprana del cÃ¡ncer de mama. "En 1982, la FDA aprobÃ³ la termografÃa de pecho como un procedimiento vÃ¡lido para la detecciÃ³n de cÃ¡ncer de mama, sin embargo, la termografÃa de pecho ha sido profusamente investigada desde 1950.
En mÃ¡s de 30 aÃ±os de investigaciÃ³n se han reunido mas de 800 estudios en el Ã¡rea y se encuentran en la literatura mÃ©dica. En esta base de datos, mÃ¡s de 300,000 mujeres se han incluido como participantes del estudio, algunos estudios han seguido a los pacientes a lo largo mÃ¡s de 12 aÃ±os y se sabe que se han establecido estrictos protocolos de interpretaciÃ³n estandarizados durante mas de 15 aÃ±os.
La termografÃa de pecho tiene una media sensibilidad y especificidad de 90%" argumenta VÃ¡zquez Luna. La literatura mÃ©dica reporta que un termograma anormal es 10 veces mÃ¡s significativo, como un indicador de riesgo futuro de cÃ¡ncer de mama, que un antecedente familiar de primer orden.
Un termograma anormal persistente incrementa 22 veces el riesgo de desarrollar en el futuro un cÃ¡ncer de mama. Una imagen infrarroja anormal es por sÃ sola, el marcador mas importante de riesgo de desarrollar cÃ¡ncer del pecho.
CÃ¡ncer de mama, un asunto nuestro: fÃsico y oncÃ³logo
El fÃsico JosÃ© G. VÃ¡zquez Luna y el oncÃ³logo Francisco GutiÃ©rrez Delgado comparten la certeza: Diariamente se diagnostican 26 casos nuevos de cÃ¡ncer de mama. Y es que el cÃ¡ncer de mama ocupa el segundo lugar como causa de muerte por tumores en el sexo femenino.
Esta situaciÃ³n es agravada por el insuficiente personal de salud entrenado para educar a la poblaciÃ³n femenina y el escaso equipo radiolÃ³gico especializado (mastÃ³grafos), el cual se concentra solamente en las grandes ciudades del paÃs, el resultado es que 8 de 10 mujeres con cÃ¡ncer de mama se diagnostican en etapa avanzada, prÃ¡cticamente cuando cualquier tipo de tratamiento es ineficaz y 11 mujeres mueren diariamente por esta enfermedad.
"Evaluamos el rol de la termomastografÃa de nueva generaciÃ³n en la detecciÃ³n temprana del cÃ¡ncer de mama en poblaciÃ³n abierta del Istmo de Tehuantepec. Este estudio tiene una sensibilidad y especificidad alta para el diagnÃ³stico de patologÃa de la mama (85%) asegurÃ³ su director, el Dr. Francisco GutiÃ©rrez Delgado, especialista OncologÃa y Doctor en Ciencias MÃ©dicas.
"Cuando se utiliza con otros mÃ©todos AutoexploraciÃ³n, Ultrasonido y mastografÃa, se puede detectar hasta el 95% del cÃ¡ncer.
Diversas investigaciones ha mostrado que la termografÃa de pecho aumenta significativamente la tasa de supervivencia de las mujeres hasta en un 61%".
ExplicÃ³ tambiÃ©n que las ventajas del termÃ³grafo, es su elevada productividad ya que se pueden realizar mas de 10 termomastografÃas por hora con cada termÃ³grafo, y como es un equipo ligero, puede ser desplazado a comunidades alejadas y municipios de todo el paÃs, donde los servicios mÃ©dicos no existen o son precarios.
El Dr. GutiÃ©rrez Delgado es Fellow del American Collage of Physicians (FACP), miembro de la American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), y American Society for Blood and Marrow Transplantation (ASBMT) y sostiene que el objetivo del Centro, es educar a la poblaciÃ³n mexicana en una nueva cultura que incrementa el interÃ©s por la salud y que prioriza la prevenciÃ³n sobre la curaciÃ³n.
Is Breast Thermography Safe?
Breast thermography is very safe. There is no exposure to radiation or any compression of the breast tissue.
Es la TermografÃa segura?
La termografÃa de seno es muy segura. No hay exposiciÃ³n a radiaciones Ã³ ningÃºn tipo de compresiÃ³n del tejido mamario.
How is Breast Thermography different from a Mammogram?
Both tests are looking for completely different signs of breast cancer. Thermography looks for changes that occur as a growing cancer alters the blood supply of the breast and changes the physiology and chemical environment of the tissue of the breast. Mammograms look for changes to the density of the breast that indicates the presence of a tumor. Mammography identifies the physical. The medical literature views both procedures as complimentary to each other.
Conf Proc IEEE Eng Med Biol Soc. 2007;2007:3312-4.
GonzÃ¡lez FJ.Infrared imager requirements for breast cancer detection.
Ann Acad Med Stetin. 2006;52(1):35-9; discussion 39-40.
Mikulska D.Contemporary applications of infrared imaging in medical diagnostics
Surg Technol Int. 2005;14:51-6.Agnese DM.Advances in breast imaging.
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|Rihanna : La nuditÃ© et la provocation sont Ã la mode...|
Je veux aussi que les femmes, vÃªtues d'une maniÃ¨re dÃ©cente, avec pudeur et modestie, ne se parent ni de tresses, ni d'or, ni de perles, ni d'habits somptueux, mais qu'elles se parent de bonnes Åuvres, comme il convient Ã des femmes qui font profession de servir Dieu. (1 TimothÃ©e 2:9-10)Des filles possÃ©dÃ©es comme Rihanna travaillent avec des hordes de dÃ©mons pour dÃ©truire l'archÃ©type fÃ©minin. Il faut arrÃªter de se bercer d'illusions, nous sommes dans un conflit primordial qui oppose les forces des tÃ©nÃ¨bres aux forces de la lumiÃ¨re, Rihanna a choisit le camp des tÃ©nÃ¨bres contre la gloire Ã©phÃ©mÃ¨re de ce monde. Elle est donc aujourd'hui un outil des tÃ©nÃ¨bres pour la destruction des bonnes valeurs morales d'autrefois. Ces cÃ©lÃ©britÃ©s travaillent tellement bien que les gens vous diront : "Bof! Ecoute, tu es un rÃ©trograde, le monde Ã©volue." Rihanna, comme beaucoup d'autres cÃ©lÃ©britÃ©s, Ã©chouent au test du Seigneur, lorsqu'il demande de ne pas inciter les hommes Ã la convoitise sexuelle:
Vous avez appris qu'il a Ã©tÃ© dit: Tu ne commettras point d'adultÃ¨re. Mais moi, je vous dis que quiconque regarde une femme pour la convoiter a dÃ©jÃ commis un adultÃ¨re avec elle dans son cÅur. (Matthieu 5:27-28)Ces stars passent le temps Ã exhiber leurs corps nus, sous le regard Ã©moustillÃ© des gens. Les gens qui regardent ce genre de pourritures sont autant coupables que les stars eux-mÃªmes. Les photos de Rihanna que je vais vous montrer sont choquantes, mais il faut que vous voyez ces gens dont se nourrissent vos enfants Ã la tÃ©lÃ©vision. Il faut que vous les voyez sous leur rÃ©elle apparence afin de prendre une dÃ©cision dans vos vies. J'ai mis ces photos dans ce lien-ci, Ã¢mes sensibles, abstenez-vous, ici nous prÃ©sentons l'oeuvre des esprits qui pilotent Rihanna pour la perte de l'humanitÃ©.
Il ne suffit pas de savoir que Rihanna et compagnie sont des illuminati et consort, ce qui est le plus important c'est de prendre position par rapport Ã ce fait, il faut mettre des limites quelque part, je ne peux pas dire que j'ai la Foi en Dieu mais je continue Ã Ã©couter les musiques d'une femme qui de maniÃ¨re Ã©vidente travaille pour la perte de l'humanitÃ©, il faut choisir son camp tout de suite, c'est une question de vie ou de mort Ã©ternelle. Pour que nous soyons Ã l'image de notre CrÃ©ateur, nous devons lui ressembler, pour lui ressembler, il faut connaitre sa parole et la mettre en pratique, sa parole qui est contenue dans la Sainte Bible. Nous devons donc l'imiter Ã©galement lorsqu'il dit:
"Je ne mettrai rien de mauvais devant mes yeux; je hais la conduite des pÃ©cheurs; elle ne s'attachera point Ã moi." (Psaumes 101.3)Il vous faut vous repentir!
|Rebuttal: Botched Executions||Rebuttal: Botched Executions |
To: Professors and Staff, Georgetown Law School
and Georgetown Law Journal
RE: Rebuttal: Facing the Firing Squad, ANDREW JENSEN KERR, 104 Geo L.J. Online 74 (2016)
Note: This rebuttal applies to any of the related writings by Austin Sarat
From: Dudley Sharp
I hope this helps Kerr and the Law Journal to vet a little better.
It appears that lethal injection executions are "botched" about 1% of the time, not 7%.
The vast majority of the "botched" executions are no such thing.
The majority of the false "botched" claims are attributed to multiple needle pricks and/or problems with the murderer's veins.
Everyone familiar with lethal injections and other IV procedures knows that multiple needle pricks are a responsible and necessary function to avoid "botched" executions or botched medical IV use.
Multiple needle pricks are 1) not "botched" executions, but represent a common, normal safety practice with all IV procedures, daily and worldwide, 2) preparation for the execution, not the execution, and 3) often required to have secure needle insertion and retention.
It would be negligent not to go through that procedure, the opposite of "botched".
The entire process of looking for good veins is to prevent "botched" executions. Once good usable , secure veins were found, the executions proceeded.
It is the opposite of "botched".
Other, wrongly, identified "botched" executions are when the murderer is gasping for breath, coughing, etc., which are the expected, known outcomes of respiratory distress, common effects with these drugs, whose effects are well known to include . . . . respiratory distress, (1) with very few of those incidents having any evidence to show consciousness or pain.
Other false claims of "botched" executions are cases where the murderer is making noise, jerking, having spasms, etc., well known in cases of drug overdoses, which is, precisely, what we are dealing with (1) - drug overdoses are what lethal injections are - with zero evidence of consciousness or pain.
These are the well known side effects of the drugs used, not "botched" executions.
In addition, many of the sources for alleged "botched" are media, which, completely, blew the reality of the Arizona execution of Wood and the Ohio execution of McGuire cases, two infamous "botched" executions (2).
These were not botched executions, but just took a long time to die, as expected, with no evidence of any consciousness or pain (2).
What happens when an author doesn't fact check their sources and their sources are media that don't fact check? Will anyone rely on those sources or the conclusions drawn from them?
"(Wood's execution) doesnât actually sound like a botched execution. This actually sounds like a typical scenario if you used that drug combination,â said Karen Sibert, an anesthesiologist and associate professor at Cedars-Sinai Medical Center. Sibert was speaking on behalf of the California Society of Anesthesiologists." (2).
Both of those executions are included in "botched" execution claims, only because folks depended upon inaccurate media reporting and did not fact check them.
Kerr writes: " The desiccated market for this anesthetic has forced U.S. wardens to shop for off- brand pharmaceuticals in places like India or U.S. state regulated âcompoundingâ pharmacies, where standards of quality control might be lacking."
"Might" is irrelevant. Facts are relevant. Quality control might not be lacking.
Denno brings up, constantly, the 2012 meningitis outbreak at a compounding pharmacy, as if that is representative of compounding pharmacies.
Has there been one case of improperly compounded drugs used in an execution? No.
Somehow, that was left out of the article.
Has Kerr or Denno considered how many innocent people have died and or been injured, in the US, since 1973, because of errors by non-compounding pharmacies and because of the FDA and the drug companies approving drugs that were, later, found to be deadly or injurious?
My educated guess is that it is way over 100,000 innocents dead, with countless injured (2). Why don't they check out "medical misadventures" (3), finding up to 400,000 innocent patients dying, every year in the US, due to such "misadventure" (3).
I am speaking of innocent patients, not guilty murderers.
Has it been shown that compounding pharmacies are a less reliable source for execution drugs than other sources? Not that I am aware of.
Did Kerr review the medical literature on the overdosing properties of all the drugs being used for executions? It appears not.
Does Kerr understand that those properties are the same, whether in an execution setting, or not?
The properties of the drugs don't, all of a sudden, magically, change, when they are used in lethal injection.
This, below, indicates that Kerr is unaware.
Kerr writes: " . . . in the post Baze world of midazolam and other off brand substitutes the trigger anesthetic might fail to sedate the executed."
"Might" is not a fact. Factually, all the cases Kerr is speaking of were sedated.
Kerr writes: " . . . the anti epileptic drug pentobarbital has even been repurposed to replace sodium thiopental. The deleterious consequences of these kinds of substitute compounds are exacerbated by the tranquilizing effect of pancurium (the second drug of the traditional three part cocktail)." ""The feint here is that in the botched injection this muscle relaxant can mimic a look of serenity on the face of the executed, when they are in fact experiencing the visceral terror of their âwhole body burning. It is the orcaâs false smile of Blackfish." "the terrific pain of the botched lethal injection remains masked". "The executed personâs musculature is too incapacitated to reflect the existential pain of cardiac arrest. Instead, the mask of the executed is inflected as a performance of dignified passing for the execution audience. "
Such fiction. Such drama. Kerr has no evidence to support his claims.
Texas uses a one drug protocol, pentobarbital and has had no problems.
What evidence does Kerr have that those states, which use pentobarbital, first, and pancuriun, second, have had any problems with that protocol? None.
Is Kerr aware that those two drugs, used together, may increase the potency or effects of both?
Kerr fails to tell us why and how the first drug, which causes unconsciousness just, all of a sudden, decides, on its own, to stop being effective, and thus, somehow allows the murderer to become conscious, even though such is not possible, with the drugs known characteristics, at the dosages given.
Kerr could not have botched this more.
Kerr, also, botched the physician's "do no harm" oath.
"(D)o no harm" is not part of the Hippocratic Oath (5) and is, only, specified with regard to patients (5), in another document. Death row inmates are not patients.
The Hippocratic Oath bans physician participation in both euthanasia and abortions (5), practices which countless physicians participate in, millions of times per year, without any complaints from the AMA or any concern for the Hippocratic Oath.
There is no death penalty ban in that oath.
The AMA seems to only follow the Hypocrisy Oath.
Alternate Executions Options
All states need to seek an exception for lethal injection drugs, from both DEA and FDA control, so the states can used whatever they find to be the best alternative.
The single drug, lethal injection protocol with penatobarbitol seems to work very well.
Fentanyl maybe the best alternative.
"The researchers asked the respondents to describe what happened during a suspected fentanyl overdose. The most common characteristic, described in 20 percent of the cases, was that the person's lips immediately turned blue, followed by gurgling sounds with breathing (16 percent of the cases), stiffening of the body or seizure-like activity (13 percent), foaming at the mouth (6 percent) and confusion or strange behavior before the person became unresponsive (6 percent), according to the report." (6)
Sound familiar? Sounds and body movement.
The alternate method for execution in Oklahoma and Alabama is nitrogen gas, by far the most foolproof method, when looking at 1) the fewest things that can go wrong, 2) the total lack of pain for the executed murderer and 3) it cannot be withheld or restricted (3). All organs are useful in the very off chance the murderer wishes to donate viable organs or their body to science. I agree that the firing squad is a responsible option.
1) There are a lot of medical writings on these issues. Here are just two.
Opioid Drug Use and MyoclonusPosted in Physical Health
Opiates and Sleep-Disordered Breathingby Barry Krakow, Sleep Dynamic Therapy | Nov 12, 2015
2) No "Botched" Execution - Arizona (or Ohio)
3) see Do MORE Harm: The Anti Death Penalty Solution
within The Death Penalty & Medical Ethics Revisited
4) Nitrogen Gas; Flawless, peaceful, unrestricted method of execution
5) see THE ETHICS OF LYING - The Hippocratic Oath
within The Death Penalty & Medical Ethics Revisited
6) Here's What Happens During a Fentanyl Overdose, Sara G. Miller, LIVESCIENCE, April 13, 2017
|FDA approves world's first GMO fish: fast-growing Atlantic Salmon||
In a landmark decision more than two decades in the making, the US Food and Drug Administration announced its approval of a genetically modified Atlantic Salmon variant on Thursday. The AquAdvantage salmon, which was initially developed back in 1989 and submitted for approval in 1995, grows far faster than its conventionally bred brethren. The FDA has deemed it safe for human consumption, equally nutritious as other salmon varieties and not dangerous to the environment. And since the GMO salmon is considered nutritionally equivalent to regular salmon supermarkets will be able to carry the fish without having to label them being GMO.
Source: US FDA
|FDA Walks a Fine Line on E-Cigs|
WASHINGTON --Â The U.S. Food and Drug Administration (FDA) appears to be performing a complicated balancing act with electronic cigarettes, at once easing rules by delaying deadlines for manufacturers to apply for new-product approval while also tightening its grip by announcing a new education campaign designed to deter youth from vaping.
The FDA announced Aug. 8 that it would pursue what it called âa strategic, new public-health education campaign aimed at discouraging the use of e-cigarettes and other electronic nicotine delivery systems (or ENDS) by kids.â
In a press release, the agency said it plans this fall to expand its âThe Real Costâ public-education campaign to include messaging to teens about the dangers of using these products, while developing a full-scale campaign to launch in 2018. It is the first time the FDA will be using public-health education to specifically target youth use of e-cigarettes or other ENDS.
The announcement comes about a week after the FDA saidÂ it would delay the August 2018 deadline for manufacturers of ENDS products to submit FDA-approval applications, pushing the date back to August 2022. Itâs a move that many in the tobacco industry saw as positive.
âWhile we pursue a policy that focuses on addressing the role that nicotine plays in keeping smokers addicted to combustible cigarettes, and to help move those who cannot quit nicotine altogether onto less harmful products, we will also continue to work vigorously to keep all tobacco products out of the hands of kids,â said Dr. Scott Gottlieb, commissioner of the FDA.
Addressing the schedule it announced in July, the agency said it will put nicotine and the issue of addiction at the center of its efforts.
âThis policy aims to strike a careful balance between the regulation of all tobacco products and the opportunity to encourage development of innovative tobacco products that may be less dangerous than combustible cigarettes,â the agency said in a statement. âBut, importantly, the approach also continues to focus on the need to reduce the access and appeal of all tobacco products to youth, including e-cigarettes and other ENDS, and maintains all of the existing regulations that currently apply to these products.â
Catheter Research, Inc. (dba Thomas Medical, Inc.) Honored as One of the 2012 Indiana Companies to Watch
Twenty-five companies from
Companies to Watch is an awards program that celebrates Indianaâs privately held second-stage companies, typically those businesses that are past the startup phase, are considered to be established, and face issues of growth, not survival.
Companies honored range in industries and have headquarters based in 13 counties throughout the state. Among the 25 honored companies in 2012 is Catheter Research, Inc.
About Catheter Research, Inc.
Located in Indianapolis, Indiana, Catheter Research, Inc. (CRI) is a market leader in medical device manufacturing, contract development, and product life cycle management. CRI specializes in catheter design /assembly, medical tubing /extrusion, and OBGYN Disposables. CRI provides excellence in project management, lean manufacturing techniques, supply chain controls, and regulatory compliance. CRIâs quality system has been designed to tailor processes to meet the diverse requirements of customers, in an ever changing regulatory and economic environment. CRI is an ISO 13485 certified manufacturer and FDA Registered.
CRI is the parent company of Thomas Medical, a distributor of OBGYN Products and Surgical Instruments. CRI/Thomas Medical is 100% owned by a workforce of 120+ employees who participate in the employee stock ownership plan (ESOP).
About Indiana Companies to Watch
Companies to Watch firms must employ between six and 150 full-time equivalent employees, have between $750,000 and $100 million in annual revenue or working capital in place, and demonstrate the intent and capacity to grow based on employee or sales growth, exceptional entrepreneurial leadership, sustainable competitive advantage or other notable strengths.
This year the program attracted more than 160 nominees and applicants. From that pool, 63 finalists were selected, and 25 companies emerged to become the 2012 class of Indiana Companies to Watch.
This awards program is unique because of its focus on second-stage companies. The impact of these companies on
Looking at the contributions of these companies from a different perspective, from 2007-2009 only 9.2 percent of
This program would not be possible without the generous support of Barnes & Thornburg LLP as well as Premier Capital Corporation, Katz, Sapper & Miller, KeyBank, Miles Printing and
About the program presenters:
The state of
The Indiana Small Business Development Center Network offers free and low-cost strategic assistance for growth oriented entrepreneurs and businesses with less than 500 employees. Funded in part by the federal and state government, the ISBDC is focused on growing the economy through small businesses.
The Edward Lowe Foundation inspired the creation of the Companies to Watch program to celebrate second-stage entrepreneurs and their companies. Established in 1985, the Edward Lowe Foundation is a Michigan-based nonprofit organization that supports entrepreneurship through recognition, education and research with a focus on second-stage companiesâthose that have moved beyond the startup phase and seek significant, steady growth. The foundation also encourages economic gardening, an entrepreneur-centered strategy providing balance to the traditional approach of business recruitment.
CATHETER RESEARCH INC.
Catheter Research Inc. (CRI) specializes in catheters and tubing, and has expanded as a developer and manufacturer of medical devices. Our goal is to provide the most cost-effective product development combined with quality OEM medical device manufacturing. ISO 13485:2003.
With complete solutions for design, development, and manufacturing processes within the medical devices industry, CRI is a leading medical product developer and manufacturer of medical devices. CRI provides its customers with unbeatable service, excellent quality control and regulatory compliance. Located in Indianapolis, Indiana, CRI is a top Midwest medical device manufacturer and employs 100+ people. In 2008, CRI began the process to become an employee-owned business with a 30% ESOP acquisition. In December 2010, CRI became 100% employee owned company.
CRI has a dedicated staff focused on being the internal advocates for all of our customers to ensure a high level of satisfaction. The customer service staff follows up on all customer requests for timely action and responses. All customer feedback and questions are entered into a tracking database within hours of receipt. The system includes a follow up loop and closure after the feedback is addressed. The feedback is categorized and trended for improvements and preventive measures to be put in place if needed. CRI has an annual goal of 98% on time delivery, and has met this goal consistently.
CRI has an excellent track record with project management. Each new customer is assigned a dedicated project manager, to ensure effective and timely communication. This includes operating to a plan and schedule, with reporting on deliverables and budget attainment. Project Management is used for new design, design changes and manufacturing transfer programs.
Quality Tools and Regulatory Excellence
CRI has developed and implemented a state of the art Quality Management System, combining both simplicity and regulatory compliance. This system includes a Quality Manual consisting of only 3 pages, which is the road map for all of our employees to follow, to stay on track within the system. You will find this roadmap hanging in all areas, as a quick reference to procedural guidance. The document numbering system is designed to allow for quick retrieval and reference to quality procedures, manufacturing and inspection procedures, work instructions and forms. All new hires at all levels receive FDA QSR (GMP) and ISO13485:2003 training within their first week, ensuring critical requirements are understood. This training is repeated quarterly to re-emphasize critical objectives.
CRIâs engineering department offers an extensive and diverse background in all phases of engineering design and development. We specialize in medical device disposables, from concept stage through final Medical Packaging and distribution, with 80% of our business being contract manufacturing of Medical Disposables and other devices. We focus on design for manufacturability, with emphasis on creating repeatable, controlled processes and high functioning devices for our customers. Our internal areas of expertise include:
CRI's supply chain management is designed to manage and control the most difficult piece for anyone's business. Controlling quality, delivery and responsiveness at the supplier level is not only critical, but is becoming the primary focus for all regulatory bodies, including FDA and ISO13485:2003. Our innovative process provides for excellence to meet not only the regulatory requirements, but to ensure customer's needs are met consistently. This includes a comprehensive feedback system for suppliers and partnering with suppliers for combined excellence and rewards.
Fulfilment and Distribution
CRI has implemented an extrusion and tubing line for flexible PVC, single lumen, medical Tubing; with a focus on quality and short lead-times.
CRI is committed to the highest quality medical tubing and strong customer service. We have invested in state-of-the-art extrusion and tubing manufacturing equipment to insure a ârobustâ extrusion process and we have a highly skilled and dedicated extrusion team.
Let CRI assist you with the production of plastic tubing and extrusion that will meet your exact requirements and exceed your expectations.
Our capabilities include:
Manufacturing and Transfers
CRI takes a team approach to transferring manufacturing lines into our facility. We assign a dedicated Program Manager at the start, to ensure all deliverables are documented and tracked. We focus on improving process and product during the transfer, resulting in lower costs and improved quality. CRI also minimizes the effort for our customers, making transfers seamless and smooth.
|FDA panel favors Pfizer's new arthritis drug||Federal health advisers said Wednesday that a first-of-a-kind drug from Pfizer appears to be safe and effective for patients with rheumatoid arthritis, though they recommended follow-up studies to gauge the pill's long-term side effects.|
|I wish every Trump voter would read this article ... by gimleteye|
Lots of Trump voters had become disaffected by the dysfunction of Washington DC and believed a "disrupter" had a better chance at positive reform as any conservative GOP candidate. We tried to warn you.
Trump turns out to be exactly the president that extremists wanted; one who would tear apart the functions of executive authority and radically realign regulatory matters in the hands of the states.
As Michael Lewis points out for Vanity Fair, there are many critical functions of the federal government that are necessary to the health and security of all the American people, and that these functions rely on capable, qualified civil servants.
Lewis points out the tragedy unfolding as a result of the Trump presidency; only halfway through his first year. Trump's indifference and incompetence has crushed the personnel ranks of the Energy Department, now headed by the most clueless appointee in the agency's history, former TX Gov. Rick Perry. (Ukrainian pranksters recently engaged Perry in a half hour discussion broadcast to the world. He thought they were representatives of the Ukrainian prime minister. Oh well.)
The same disintegration of talent and expertise is happening in other federal entities: from the State Department to the US EPA and Department of Interior, from the FDA to the USDA. Trump said he would "drain the swamp". Nothing could be further from the truth.
He has created a viper's nest of influences in the White House, all competing for his attention from one second to the next. Meanwhile, the functions of the federal government are crumbling. The GOP Congress is not lifting a finger.
It is a dangerous world, Trump supporters have made it much, much more dangerous.
|The Future of AI: Redefining How We Imagine|
To commemorate the silver jubilee of FICOâs use of artificial intelligence and machine learning, we asked FICO employees a question: What does the future of AI look like? The post below is one of the thought-provoking responses, from Sadat Nazrul, an analytic scientist at FICO, working in San Diego.
Looking at the next 20 years, I see us moving well beyond the productivity enhancements AI has brought about so far. With the advent of AI, we will be seeing a renaissance in our own personal lives as well as society as a whole.
Today, our gadgets have the ability to monitor the number of steps we take, the rate of our heart beat, as well as the contents of our sweat. All this rich information allows a team of doctors, engineers and analysts to monitor our well-being and to maintain our peak performance. Similarly, with innovations in genomic sequencing and neural mapping passing FDA trials, we will soon be seeing huge leaps in the field of personalized medicine. AI will help us understand individual physiological needs in order to come up with customized prescriptions and improve our overall health standards.
People are keen to improve cognition. Who wouldnât want to remember names and faces better, to be able more quickly to grasp difficult abstract ideas, and to be able to âsee connectionsâ better? Who would seriously object to being able to appreciate music at a deeper level?
The value of optimal cognitive functioning is so obvious that to elaborate the point may be unnecessary. Today we express ourselves through art, movies, music, blogs, and a wide range of social media applications. In the field of image recognition, AI can already âseeâ better than we can by observing far more than the RGB. Virtual Reality allows us to feel as though we have teleported to another world. New idioms of data visualization and Dimensionality Reduction algorithms are always being produced for us to better experience the world around us.
We are constantly trying to enhance our 5 senses to go beyond our human limits. 10 years from now, these innovations, coupled with IoT gadgets, will act as extensions of who we are and help us experience our surroundings more profoundly.
Just as we enhance our 5 cognitive senses, so too do we enhance our ability to express ourselves and to understand those around us.
Many times, we donât even know what we want. We strive to connect with those around us in a specific way or consume a particular product, just so we could feel a very unique emotion that we fail to describe. We feel much more than just happiness, sadness, anger, anxiety or fear. Our emotions are a complex combinations of all of the above.
With the innovations in neural mapping, we will better understand who we are as human beings and better understand the myriad emotional states that we can attain. Our complex emotional modes will be better understood as we perform unsupervised learning on brain waves and help find innovative ways to improve our emotional intelligence. This would include both understanding our own emotions and being more sensitive towards those around us.
Perhaps we can unlock new emotions that we have never experienced before. In the right hands, AI can act as our extensions to help us form meaningful bonds with the people we value in our lives.
Experience and Imagination
The effect of AI on our experience and imagination would result from an aggregate of better cognitive abilities and emotional intelligence. The latest innovations in AI may help us unlock new cognitive experiences and emotional states.
Letâs imagine that the modes of experience we have today is represented in space X. 10 years from now, letâs say that the modes of experience are represented in space Y. The space Y will be significantly bigger than space X. This futuristic space of Y may have access to new types of emotions other than our conventional happy, sad and mad. This new space of Y can even allow us to comprehend abstract thoughts that reflect what we wish to express more accurately.
This new space of Y can actually unlock a new world of possibilities that lies beyond our current imagination. The people of the future will think, feel and experience the world at a much richer degree than we can today.
10 years ago, most of our communication were restricted to phones and emails. Today, we have access to video conferences, Virtual Reality and a wide array of applications on social media. As we enhance our cognitive abilities and emotional intelligence, we can express ourselves through idioms of far greater resolution and lower levels of abstractions.
We already have students from the University of Florida achieving control of drones using nothing but the mind. We even have access to vibrating gaming consoles that take advantage of our sense of touch for making that Mario Kart game that much more realistic. 10 years from now, the way we communicate with each other will be much deeper and more expressive than today. If we are hopeful enough, we might even catch a glimpse of the holograms of Star Wars and telepathic communications of X-Men.
Virtual Realities of today only limit us to our vision and sense of hearing. In the future, Virtual Realities might actually allow us to smell, taste and touch our virtual environment. Along with access to our 5 senses, our emotional reaction to certain situations might be fine-tuned and optimized with the power of AI. This might mean sharing the fear of our main characters on Paranormal Activity, feeling the heartbreak of Emma or being excited about the adventures of Pokemon. All this can be possible as we explore the theatrical arts of smart Virtual Reality consoles.
AI allow us to unearth more unstructured data at higher velocity to generate valuable insight. However, the risk of those very sensitive data falling into the wrong hands will also escalate.
Today, cybersecurity is a major concern on everyoneâs mind. In fact, 2017 is the year the fingerprint got hacked. With the help of AI, information technology will get more sophisticated in order to protect the things we value in our lives.
It is human nature to want to go beyond our limits and become something much more. Everyone wants to live longer healthy lives, experience more vividly and feel more deeply. Technology is simply a means to achieve that end.
See other FICO posts on artificial intelligence.
|FDA Approves the First Dose-Stretching Vaccine For H5N1 Bird Flu||To prepare for a potential pandemic of avian influenza caused by H5N1, the Food and Drug Administration approved the first vaccine boosted so its doses can provide stronger immune responses against the flu virus. Most bird flu viruses do not harm people, but the H5N1 strain may be fatal in up to half of those infected. It likely originated in poultry, and does not transmit effectively from person to person, but if the virus mutates and becomes more infectious, it could spread easily among unprotected populations. In 2007, the FDA started stockpiling the first vaccine against H5N1, to prepare for a possible pandemic. The latest vaccine will be a second vaccine option, and could be helpful if inventory of the immunizations starts to run low, since this version can provide enhanced immunity with a smaller dose. âThis vaccine could be used in the event that the H5N1 avian influenza virus develops the capability to spread efficiently from human to human, resulting in the rapid spread of disease across the globe,â said Dr. Karen Midthun, the director of the FDAâs Center for Biologics Evaluation and Research in a statement. âVaccines are critical to protecting public health by helping to counter the transmission of influenza disease during a pandemic.â The vaccine, made by GlaxoSmithKline, is not available for commercial sale or purchase. FDA reviewed studies involving 3,400 people who were vaccinated with the new shot, and compared their responses to another 1,100 who were inoculated with a placebo. [FDA]|
|Source : Handbook of Strategy and Management|
Strategic Change Issues Associated with Life Cycle Dynamics
The genesis of life cycle dynamics in the strategy literature may be traced to early work in technology studies. Two counter-forces shape the development and diffusion of technological systems. One is a ‘law of progress’ (Adams, 1931) that points to an exponential growth in the development of a technological system after a relatively slower start. A second force is the ‘law of limits’ that represents the physical limits one invariably confronts with the performance of a technological system. Together, these two forces combine to prescribe an ‘S’ shaped curve in the development and diffusion of a technological system (Foster, 1986).
Life cycle dynamics implicit in the ‘S’ shaped curve were productively employed in other disciplines as well. In the marketing literature, for instance, these dynamics are manifest in product life cycle issues (Kotler, 1994; Mahajan et al, 1990). In the economics literature, life cycle dynamics are apparent in the works of economists such as Vernon (1966). In the organizational field, life cycle dynamics can be found in conceptualizations of organizations progressing from one crisis to another as it grew in scale and scope (Greiner, 1972). They are also implicit in the contagion models that have been employed in diffusion studies and the creation of bandwagons in the development of fads and fashions (Abrahamson, 1991; Rogers, 1983). Clearly this is not an inclusive but an indicative list of those who have contributed to this way of thinking. However, as is apparent from even this short survey, life cycles unfold at various levels.
Several issues confront practitioners associated with processes exhibiting life cycle dynamics. First, there is a need to determine the stage in the life cycle of the organizational entity that is undergoing change. Monitoring internal and external contexts is an approach that has been advocated for this purpose. Although monitoring might appear to be a routine task, cognitive biases may create many difficulties in accomplishing this task (Kahneman et al., 1982; Kiesler and Sproull, 1982; Dutton and Jackson, 1987). Despite these difficulties, some tell-tale signs that have been employed to determine what stage an industry might be in its development are product price, the level of commoditization, the number of new entrants and exits.
In addition to correctly recognizing the stage of development of the entity being examined, another managerial challenge is determining the appropriate mode of operation in each stage of a life cycle. For instance, Utterback (1994) suggests that strategy implies competition based on functionalities during a ‘fluid’ stage of technology development whereas it implies competition based on reliability, quality and price during a ‘specific’ stage of development. Similar considerations have led others to suggest that a firm should be organized to ‘explore’ during early growth stages and organized to ‘exploit’ during later stages (March, 1991).
The most difficult challenge in managing processes driven by life cycle dynamics is to make transitions in between stages. Transitions are difficult as they imply changing one set of competencies well suited for one stage of operation to a different set of competencies required for a different stage of operation. Indeed, appropriate forms of behavior at one stage of operation may be the very forces that prevent organizations from transiting to the next stage. In other words, transitions become difficult as competencies at one point become traps (Levitt and March, 1988; Leonard-Barton, 1992).
While life cycle models are seductively simple to understand, they are easy for managers to misread. For instance, in the development of cochlear implants (a bio-medical prosthetic device), proponents of the single-channel device that gained early FDA approvals concluded to their peril that industry dynamics had switched to a growth and maturity stage (Garud and Van de Ven, 1992). This belief turned out to be misplaced when other firms continued developing their cochlear implants under the assumption that the industry was still at an introductory stage.
In a similar vein, Henderson (1997) illustrates how beliefs about the limits of a technology based on its internal structure can be misleading. Using the development of optical photolithography as an example, Henderson shows how the ‘natural’ or ‘physical’ limits of the technology were relaxed by unanticipated progress on three fronts: significant changes in the needs and capabilities of users, advances in the performance of component technologies (lenses), and unexpected development in the performance of complementary technologies. These observations lead Henderson to caution against using a life cycle model to predict the limits of a technology. Such predictions must be tempered by a recognition that many other factors (beyond the immediate grasp of those forecasting) may play a role in extending the life of a technology.
Life cycle dynamics are at play in a key field that drives change in contemporary times -semiconductors. For about three decades, Moore's law described progress that has been made with semiconductor chips - a doubling of the number of chips that might fit into a silicon chip every 18 months. Announcements by scientists at Intel suggest that the silicon substrate may be reaching its limit (Markoff, 1999). In Grove's terminology, these limits may represent the onset of a strategic inflexion point with the potential to create a ‘10X change’ (Grove, 1996). As this limit is reached, semiconductor firms will have to decide whether to continue with silicon chips, shift to a new architecture or to a new substrate. To ensure that Intel makes appropriate decision as it encounters this and other such inflexion points, Grove and his colleagues have put in place ‘dialectical processes’ that shape decision making at Intel. We explore issues associated with dialectical processes as they pertain to strategic change in the next sub-section.
|Emergent files application to expand production of BioThrax|
Emergent BioSolutions has filed a supplemental Biologics License Application with the U.S. Food and Drug Administration to scale up production of its anthrax vaccine BioThrax.
BioThrax is the only FDA-approved anthrax vaccine for humans. It's primarily produced for and purchased by the U.S. military, and has been in distribution since the 1970s.
Emergent's most recent application concerning BioThrax said production of the vaccine would begin in its large-scale production facility known as "Building 55."
âEmergent is pleased to have reached this significant milestone in our BioThrax comparability program," Biodefense Division President and Executive Vice President Adam Havey said. "We believe that our submission conveys the robustness of our large-scale manufacturing process, the comparable product attributes, and the efficacy and consistency of the product from our new facility, supported by a variety of developmental and pivotal nonclinical studies. This milestone reflects many years of steadfast dedication from our project team and their effective collaboration with the U.S. government.â
Havey said the company expect the FDA to complete its review of Emergent's recent application by the fall.
|House oversight subcommittee reports on safety of bioresearch labs|
The House Energy and Commerce Subcommittee on Oversight and Investigations has released a report on its investigation of allegations that a bioresearch lab in Maryland mishandled vials of smallpox.
The issue was expected to be discussed Wednesday during a hearing with U.S. Food and Drug Administration (FDA) and National Institutes of Health (NIH) officials on Capitol Hill.
The subcommittee's report calls for further investigation into each agency's handling of potentially dangerous biological agents, including antibiotic-resistant anthrax and antibiotic-resistant plague. According to the memo, research facilities have failed to conduct regular inventories of hazardous materials, account for the whereabouts of vials of hazardous materials and restrict access to the hazardous materials.
âThereâs a problem when the government somehow loses track of smallpox and other deadly agents, only to have them turn up in a soggy cardboard box,â Energy and Commerce Committee Chairman Fred Upton (R-MI) and Oversight and Investigations Subcommittee Chairman Tim Murphy said in a joint statement. âWhatâs worse, the urgency that should accompany such a discovery has failed to spur absolutely necessary changes. Today serves as an important opportunity to ask some of the agencies in question about their next steps to ensure safety for those working in the labs, as well as the general public.â
The Government Accountability Office also raised the issue in its own report.
The subcommittee is expected to call for a full internal investigation by both the FDA and NIH.
|FDA gives clearance for Great Basin E.coli test|
The U.S. Food and Drug Administration (FDA) recently gave the clearance for Great Basin Scientific Inc. to conduct its Shiga Toxin Direct Test.
The FDA gave them 510(k) clearance for the test, which is intended as a molecular test to detect E.coli that produces Shiga toxins. The test will most likely be tested on the Great Basin Analyzer, which also performs tests for Clostridium difficile and Group B Streptococcus.
The Great Basin Shiga Toxin Direct Test will allow lab techs to get immediate results from samples. It will require under one minute of hands-on contact. It will detect stx1 and stx2, while providing results quickly
âWe are pleased to receive 501(k) clearance for our Shiga Toxin Direct Test, and are excited about the opportunity to drive new site placements with this unique test,â Ryan Ashton, co-founder and CEO of Great Basin Scientific, said. âBy offering the only direct-from-patient specimen test, and identifying the O157 strain and quickly detecting stx1 and stx2 genes, we are providing clinicians a powerful tool to provide a better outcome for their patients. The clearance of this test is particularly timely given the growing number of multi-state outbreaks for Shiga toxin-producing Escherichia coli O157 (STEC O157) infections.â
|FDA approves new inhalational anthrax treatment|
Officials with the U.S. Food and Drug Administration (FDA) recently approved the Anthim (obiltoxaximab) injection, to be used with specific antibacterial drugs to treat people who have had inhalational anthrax.
Anthim has also been approved for preventing inhalational anthrax if other alternative therapies are unavailable or inappropriate.
Inhalational anthrax, a rare illness, happens when people are exposed to animals or animal products that are either contaminated or infected with the disease. Sometimes people are exposed to the disease when anthrax spores are intentionally released.
When anthrax spores are released, people inhale the bacterium Bacillus anthracis spores. Then the bacteria spreads through the body, generating toxins that cause irreversible and massive tissue injuries that lead to death.
Anthim, a monoclonal antibody, eliminates the toxins that anthrax generates. The FDA has approved Anthim as part of its Animal Rule, enabling researchers to conduct efficiency studies within well-controlled, adequate animal studies. Scientists hope to see Anthim progress to human studies in the near future.
In the past, anthrax has been used as a bioterrorism threat. The spores resist destruction and easily spread through the air, making them a bioweapon of choice.
âAs preparedness is a cornerstone of any bioterrorism response, we are pleased to see continued efforts to develop treatments for anthrax,â Edward Cox, director of the Office of Antimicrobial Products in the FDA Center for Drug Evaluation and Research, said.
|New Device-Based Therapy Reduces Severe Asthma Attacks|| Bronchial thermoplasty (BT), is a new device-based therapy approved by the FDA in 2010 and uses a series of three radio-frequency treatments to open the|
|FDA Approved a Device Meant to Treat Cluster Headaches|| The FDA has approved the first noninvasive vagus nerve stimulation device, gammaCore, for the acute treatment of pain from episodic cluster headache in|
|A Femaleâs Guide: How to Optimize Your Sex Life|
The topic of female sexuality has progressively become more accepted in modern society, but there are many regions throughout the world where it remains heavily stigmatized. The sexual revolution of the Western world has primarily focused on female reproductive health and rights, but the topics of female sexual desire and pleasure have also steadily gained acknowledgement. Within the past decade, the feminist movement has gained strength in numbers and media exposure, leading to a surge in female sexual empowerment and increased opportunities for women to explore their sexual identity. Needless to say, there is still a great deal of work to be done in the female sexual empowerment movement. This is to be expected, as humans have primarily focused on the sexual urges and desires of men since the dawn of mankind. Mankind. The status of female sexuality and sexual health can be largely attributed to the uneven power dynamics between men and women.1 The female sexual revolution is a laborious process with challenging, long-term goals. However, there are numerous measures that you can take to increase your personal and sexual satisfaction. By living a happy and sexually fulfilling lifestyle, you can in turn educate your peers about the importance of awareness, knowledge and resources available in your community. This guide serves as a tool to help navigate females through the intricate and overlooked topics regarding their sexuality. Individuals like yourself can take part in the female sexual revolution by becoming educated and comfortable with your body, portraying your confidence and insight to the people that surround you and living a happy and healthy physical, mental and sexual lifestyle.
Step 1: Education
Education is the first step to improving the sexual health and rights of females because without an accurate understanding of their needs and desires, there cannot be progress. Educating yourself on the various methods and health practices that promote mental and physical health will not only help you to feel happier and more confident on a daily basis, but this positivity will also carry over into your sexual lifestyle. Female sexual health is often only discussed when it relates to sexual disease, dysfunction and child-rearing basis. Although these are highly important topics, this approach fails to consider a femaleâs romantic needs, sexual pleasure and mental health.Â Ask your doctor about what resources are available for women in your community and engage in discussion with your peers. Asking questions about your sexual health and seeking help for any problems you may experience will allow you to gain knowledge, confidence, and an understanding of your body. This can also open the door for conversations with your doctor, family, friends and partners in the future.
Once you have educated yourself on how to improve your physical, mental, and sexual health, the next step is to make this process more personal to you. If you feel unfamiliar or uncomfortable with your anatomy, take a few minutes out of each day to explore your body. Become familiar with every part of your body and how it feels to touch different areas. Be curious! Donât hesitate to use a small hand mirror to look at yourself. Or just close your eyes and explore the various erogenous zones of your body with your hands. This can help you to relax and become familiar with what areas are most sensitive and enjoyable to touch.
For women who experience negative body image, the education and self-exploration steps may be difficult. The media portrays the female (and male) body in extremely unrealistic ways, which can create impossible standards to live up to. If it is difficult for you to find pride in the way that Â you look, try to find self-confidence through what you do and who you are. Whether you are great at your job, a fantastic mother, a reliable friend, or an attentive partner, recognize the aspects of your life where you succeed and give yourself some credit! It does not matter how much you weigh, how flat your stomach is or what size clothes you wear. The more you like yourself, the more others will want to be around you and enjoy your company. The more comfortable you feel in your own skin, the more you can relax and enjoy sex, whether itâs during masturbation or with your partner. You do not have to fit societyâs standards to be and feel physically beautiful. Feeling good, beautiful and confident inside and outside is important. Everyone is beautiful. Make an effort to find the parts of your body that you love.
Step 2: Adopt a Healthy and Happy Lifestyle
An active lifestyle can contribute to a healthy weight, a reduced risk for cardiovascular disease, and improved mental health and mood. It can also lead to more pleasurable sexual experiences.2 Exercise increases blood flow to the sex organs, in addition to boosting mood through the release of exercise-induced chemicals called endorphins, also known as the âfeel-good chemicals.â3 Additionally, testosterone levels are heightened during the hour following exercise, which can lead to an increased sex drive.3 Daily exercise is incredibly important, but establishing a realistic and sustainable routine is even more crucial. Setting goals for yourself and working alongside your partner can be excellent motivators for sustaining your healthy diet and lifestyle. A healthy and balanced lifestyle can lead to increased fitness and confidence, in addition to helping you feel more sexy, playful and open to trying new things inside and outside of the bedroom with your partner.
Sex Enriching Foods: There are many foods that can increase libido by increasing blood circulation to the sexual organs:
Stress has a profound effect on the functioning of the human body. When the body is under high levels of stress, this leads to a release of the hormone cortisol, which is known to suppress the sexual response cycle and cause low libido.3 Maintaining low levels of stress is important for cardiovascular, mental, and sexual health. Finding a balance between work, family, hobbies, your partner and your personal time can be difficult, but it is a key element for a healthy lifestyle.
Step 3: Communication
Maintaining strong, open communication is crucial in sustaining a gratifying personal relationship and sexual experience with your partner. Making assumptions about what your partner is thinking or feeling based on their body language alone is not a reliable way of communicating. Discussing any concerns or problems that you may have before engaging in sex is the best way to avoid unwanted situations and discomfort so your experience is not filled with worry or apprehension. Keeping the dialogue open throughout sex can also ensure that you have your partnerâs consent and that you are both enjoying the experience. Sexy talk is a form of communication in which individuals discuss intimate scenarios together and this can be a great way to maintain communication during sex. Engaging in sexy talk before, during, or after sexual intercourse can heighten the excitement and connection between you and your partner by keeping you both in the moment, and allowing you to introduce specific sexual positions or scenarios that you would like to try. Sexy talk can also help reaffirm that you are both enjoying yourselves and make you both feel confident and empowered.Â
If you feel uncomfortable discussing your sexual desires with your partner or find that it is difficult to bring up the subject in a conversation, try writing a letter or email to your partner. Writing down your thoughts, desires, or concerns is a great way to express yourself because you can take time to formulate your ideas and ensure that you address the subject in its entirety.
If you have suffered trauma in your past, this can put a strain on a relationship if you have refrained from sharing it with your partner, your partner has problems coping with it, or if your partner does not know how to provide you with all the support that you need. Although it may be a difficult subject to discuss, confiding in your partner can bring you closer together and provide you with an additional personal resource to help you navigate through the healing process. If your partner feels uncomfortable or unable to advise you on the trauma on their own, group or coupleâs counseling is an excellent option to help move the dialogue forward in a useful way. Seeking help for any personal or relationship problems can allow you to let go of previous trauma, establish stronger relationships with individuals that you can confide in the future, and allow you to move forward with your life and pursue the things that make you the most happy.
Step 4: Address Any Sexual Difficulties Â
It can be difficult to talk about sexual difficulties with your partner or your doctor, but sexual dysfunction is common (43 percent of women and 31 percent of men report some degree of difficulty during their lifetime).5 These problems can occur at any stage of a male of femaleâs life and it is not something that you need to be ashamed of. There are many resources on SexInfo to help navigate you through this process and educate you on the possible causes and treatments.
Insufficient lubrication can be caused by a number of factors including inadequate amounts of foreplay, poor body image or self-confidence issues, improper diet or exercise, menopause, anxiety and stress, lack of partner communication, or prescription medications.6 In addition, some female bodies just do not produce enough lubrication for a pleasurable sexual experience, even if they do not possess any underlying medical issues and they are sufficiently aroused.
A femaleâs body experiences a multitude of changes throughout the lifecycle. Vaginal dryness is typical during menopause due to changes in estrogen levels. This reduction in vaginal lubrication can lead to painful intercourse and a decreased libido. Fortunately, there are multiple over the counter remedies available for women experiencing vaginal dryness. Vitamins B, A and beta carotene are high in essential fatty acids and may be taken as supplements to increase vaginal lubrication.7 Vitamins E and A suppositories can also be inserted in the vagina to provide relief for vaginal dryness.7 Drinking plenty of water, decreasing alcohol and caffeine intake, and refraining from douching or harsh chemical soaps that interfere with the vaginal pH levels can all lead to an increase in vaginal lubrication.6Personal lubricants (also known as âlubeâ) can also be utilized during sexual intercourse to help reduce friction and irritation, thereby increasing sexual pleasure.
Estrogen is an important hormone that is responsible for keeping a femaleâs vaginal tissues healthy. This hormone helps to maintain the vaginaâs normal lubrication, acidity levels, and elasticity.7 When estrogen levels decline, the lining of the vagina becomes thinner and less elastic, leading to a decreased production of vaginal lubrication. Estrogen levels drop during and after menopause, during pregnancy, and during periods of breastfeeding.7 Estrogen can also decrease in females who smoke cigarettes, who have had their ovaries removed, who have been previously treated for cancer, or who have certain immune disorders. Estrogen cream can help relieve vaginal dryness, but they are also notorious for causing a variety of other unpleasant symptoms.7 Talk to your doctor if you are experiencing vaginal dryness and discuss the best options pertaining to your medical history.
Low sexual desire can have large variety of causes including age, menopause, negative sexual experiences, depression, anxiety and stress, habituation to oneâs partner, or relationship problems to name a few.7 Researchers are avidly searching for the âfemale Viagra,â but many drugs are still in the testing phase and include adverse side effects. If you are experiencing a lack of sexual desire, talk to your doctor about what might be causing this and whether there are any supplements or prescriptions that could benefit you:
Supplements and prescription drugs should be used as a last resort, if lifestyle changes are not leading to any noticeable changes in your sex life. Sexual desire is dependent not only on socio-cultural, psychological, and interpersonal influences, but also on each personâs biology. Because so many factors are involved, it can be difficult to pinpoint the source of the problem. Prescription drugs can also lead to adverse side effects that could possibly interfere with your sexual lifestyle more than it benefits it.
Step 5: Novelty
Partaking in a fun, new and exciting activity can lead to an increase in the brain chemical dopamine, which helps fuel sex drive.3 Adding some novelty to your sex life can increase pleasure and add excitement to the scenario:
Adding some novelty to your sex life can help rejuvenate a connection between you and your partner.Â Check out the Spice Up Your Sex Life section on our website to learn more about Sexpert approved techniques.
Step 6: Masturbation
Masturbation can help you learn more about your body and determine what pleasures you the most. Masturbation is all about you. This practice can allow you to experiment with touch and determine what speed, pressure, intensity, or technique makes you feel the best. Many women enjoy incorporating a vibrator or dildo into their masturbation technique, because it can target the sensitive clitoris or g-spot. Check out the female masturbation article to learn more about different methods.Â
Step 7: Intentions
When life becomes stressful, it can be difficult to find time for sex and intimacy, or even just a moment for oneself. Taking a moment to set an intention for the day or set an intention before engaging in intercourse with your partner can help to bring you back into the moment and gain more pleasure from the experience.Â Whether your intention is to not think about work, to spend the evening with your partner without distractions, to be more mindful of your relationship with your partner, or to tell yourself that you are beautiful and you are doing the very best you can do, try to let go of unnecessary worries and live in the moment. A few moments of relaxation, deep breathing, meditation, or self-reflection each day can help you find some peace and clarity even on the busiest of days. Setting an intention before sex and resolving any conflicts with your partner beforehand can allow you to focus more on the experience and heighten the pleasurable sensations even further.
Female sexuality is incredibly complex and there is a lot that scientists still do not understand. Being confident in yourself and your sexuality as a female is an excellent way to not only live a happy and fulfilling life, but also to open up the conversation about the female populationâs specific needs and rights as a whole.
Last Updated: 11 February 2017.Â
|Re: Off topic topic|
Oh yeah that's just great next thing you know they're gonna announce a Grand Army of the U.S. which will be cloned from uh........hey that's a good question if the U.S. made a clone Army who would they clone it from? Be reasonable don't say something retarded like "Me" or "michael Jackson" ok well anyways I nominate the following people:
1. Arnold Scwarzennegar ( how da F&*K do u spell his last name??), because he used to be really strong, so maybe that would help his clones.
2. uh.............that's all I can think of for now but there's a few other people that could be the template, I assure you.
draco fett wrote:
What's a "therapy bunny"?
|Re: Off topic topic|
New off topic note the FDA just announced that cloned meat is safe to eat.
Yes a special label will be on the cloned meat.
|LexaMed Presenting at BioOhio FDA Regulatory 101 Series: Medical Device Testing, Emerging Trends and Regulatory Expectations||August 18, 2016/in Events /by computol Come and join us at the BioOhio Meeting on Wednesday, September 28, 2016. LexaMed President, Bob Reich will be speaking Join us to learn more about FDA requirements for reprocessing reusable medical devices (cleaning/disinfection/sterilization), AET, Environmental Isolates and Quality Management. For more information, click here Where: Ascend Innovations […]|
|FDA Continuing to Issue 483âs to Compounding Pharmacies||FDA continues to issue 483s to compounding pharmacies for a lack evidence and cGMP framework in preventing/mitigating beta-lactam cross-contamination Warning Letters and significant FDA 483 observations continue to plague the compounding pharmacy industry with over 40% of compounders inspected receiving Warning Letters and nearly 100% receiving critical observations. One of the more common observations cited […]|
|Unsupervised Learning: No. 82|
This week’s topics: Live from London, Gamestop hacked, PowerPoint malware, Chinese Apple Hack, XSS, WWDC summary, FDA approves cancer drug, heroin $51B, ideas, discovery, recommendation, aphorism, and moreâ¦ This is Episode No. 82 of Unsupervised Learning—a weekly show where I curate 3-5 hours of reading in infosec, technology, and humans into a 15 to 30 minute summary. The...
|Drug Safety Associate - Merck - West Point, PA||A Bachelor's degree, preferably in a biological science, nursing, or pharmacy. West Point, PA. FDA regulations, the prompt or periodic classification of each... $80,000 a year|
From Indeed - Tue, 01 Aug 2017 11:14:53 GMT - View all West Point, PA jobs
|VGI Medical Announces FDA Clearance of the VerteLPÂ® Lateral Lumbar Cage System|| |
First lateral lumbar cage with integrated plating featuring bi-cortical fixation
(PRWeb January 19, 2016)
Read the full story at http://www.prweb.com/releases/2016/01/prweb13170416.htm
|Why Did The FDA Approve 57 Percent Fewer New Medicines Last Year Than 2015?||The Food and Drug Administration has reported it approved only 19 innovative new medicines last year, versus 51 in 2015. To be sure, 2015 was a high-water mark. Nevertheless, such a dramatic drop signals a problem for patients eager for new treatments. These new drugs, though few, represent advances in the treatment of ovarian cancer, […]|
|Capitol Hill Update: July 17, 2017|
The House and Senate are in session this week.
There are nine (9) legislative days remaining for the House before the August recess and 57 legislative days remaining in the year. The Senate will work through the first two weeks of the August recess.
After the passage of the nearly $700 billion National Defense Authorization Act on Friday, it'll be a relatively slower week in the House, at least on the floor of the chamber. Committees and subcommittees will be very active this week.
Today, the House will take up three pieces of legislation on the suspension calendar, two of which relate to mass transit the District of Columbia, Maryland, and Virginia. One resolution, H.J. Res. 92, allows the D.C., Maryland, and Virginia to amend Washington Area Transit Regulation Compact, which regulates transit D.C. and its suburbs. The other resolution, H.J.Res. 76, allows D.C., Maryland, and Virginia to create the Washington Metrorail Safety Commission. After all, what Metro needs is another layer of bureaucracy. (Yes, that was sarcasm.)
Three more bills will be considered on the suspension calendar on Tuesday. The Ozone Standards Implementation Act, H.R. 806, sponsored by Rep. Pete Olson (R-Texas), will also be considered, though likely under a rule to limit or prevent amendments, much like virtually every other bill the House has brought the floor under "regular order" this year.
On Wednesday, the House will take up the Promoting Interagency Coordination for Review of Natural Gas Pipelines Act, H.R. 2910, introduced by Rep. Bill Flores (R-Texas), and the Promoting Cross-Border Energy Infrastructure Act, H.R. 2883, introduced by Rep. Markwayne Mullin (R-Okla.). Both bills will likely be brought to the floor under a rule.
Finally, on Thursday, the only bill currently scheduled to hit the floor is the King Cove Road Land Exchange Act, H.R. 218, sponsored by Rep. Don Young (R-Alaska). The bill will likely to come to the floor under a rule.
Though it's not currently on the calendar, the 21st Century Aviation Innovation, Reform, and Reauthorization (AIRR) Act, H.R. 2997, introduced by Transportation and Infrastructure Committee Chairman Bill Shuster (R-Pa.) could come to the floor for a vote this week. The bill reauthorizes the Federal Aviation Administration (FAA) and reforms the United States' out of date air traffic control (ATC) system. FreedomWorks has released a key vote in support of the 21st AIRR Act.
Outside normal legislative business, there is increasing chatter about the FY 2018 budget. The House Majority Whip's office hosted a briefing on the budget on Friday. As of now, it's unclear what to expect from the budget.
The House Appropriations Committee will complete its work on the 12 appropriations bills this week. The Whip team will be talking to House Republicans today about lumping all 12 appropriations bill into yet another omnibus. Of course, this is because the last one went over so well with conservatives. (Yes, that's more sarcasm.)
The committee schedule for the week can be found here.
The Senate was supposed to bring the Better Care Reconciliation Act (BCRA), H.R. 1628, to the floor this week for a procedural vote. Leader Mitch McConnell (R-Ky.) has delayed legislative action because Sen. John McCain (R-Ariz.) is set to have eye surgery, giving Leader McConnell one less vote that he will almost certainly need to advance the bill. Additionally, the Congressional Budget Office's score of the bill has been delayed by at least a day. The score was supposed to come out today.
The latest iteration of the BCRA was rolled out on Thursday. FreedomWorks explained some of the major changes to the bill. Our friends at the Texas Public Policy Foundation have a solid overview of the latest version compared to previous versions. Though there are questions that need to be answered, the bill appears to be a slight improvement over existing law.
The biggest question that needs to be answered is whether the Consumer Freedom Option will work in single risk pools, as mandated by the BCRA. The Consumer Freedom Option, which was included thanks to the efforts of Sens. Ted Cruz (R-Texas) and Mike Lee (R-Utah), would work best with bifurcated risk pools, where health insurance companies could price a traditional risk pool differently, with lower premiums, than the ObamaCare exchanges, which would effectively function as a high-risk pool, with access to more than $180 billion in subsidies.
It's unclear whether there are enough Republican votes to get past the initial motion to proceed. Sens. Susan Collins (R-Maine) and Rand Paul (R-Ky.) have gone on record as no votes. Sen. Dean Heller (R-Nev.) is facing pressure back home, as Republican Gov. Brian Sandoval opposes the bill. Similarly, Republican Gov. John Kasich, who also opposes the bill, could influence Sen. Rob Portman (R-Ohio) to vote against it.
FreedomWorks believes the bill may be a mild improvement over existing law, but there are serious concerns over how the Consumer Freedom Option will work, or if insurers will even bother to offer such plans because of the single risk pool mandate. The mindset right now is protecting what gains conservatives have made. Once the Senate gets past the motion to proceed, if it does, FreedomWorks expects to key vote against amendments that will undermine the Medicaid modernization, HSA reforms, and other positive reforms.
If a 2015-style repeal amendment is offered by a conservative senator, FreedomWorks will key vote in support of it, triple-weighted.
In addition to a backlog of nominations, the Senate still has several pieces of legislation awaiting floor action, including Coast Guard Authorization Act, S. 1129; the FDA Reauthorization Act, S. 934; the National Defense Reauthorization Act. The debt ceiling is rumored to be a top item either before the August recess or while the Senate works through the first two weeks of the recess.
In committees this week, the Commerce, Science, and Transportation Committee will hold a hearing on the reappointment of Federal Communications Commission (FCC) Chairman Ajit Pai on Wednesday. Chairman Pai unveiled the FCC's plans to roll back Title II regulation of the Internet at a FreedomWorks' event in April. The reappointment of FCC Commissioner Jessica Rosenworcel, a Democrat, and nomination Brendan Carr, a Republican, to serve on the commission.
The Judiciary Committee will also take up the nomination of Christopher Wray to serve as the next director of the Federal Bureau of Investigation (FBI). The hearing is scheduled for Thursday.
The full committee schedule for the week can be found here.
|Herbal Supplements - A New Study|
Download: herbal supplements.mp3
In a recent commentary I argued that we should be skeptical about alternative medicine because, contrary to conventional medicine, its claims are not confirmed by science and it is unregulated by the FDA (Food and Drug Admistration). New evidence has now surfaced about herbal supplements, a staple in alternative medicine, which underscores the need for such skepticism.Â The evidence appears in an important research study in Canada which was published last month in the journal BMC Medicine (1) and reported this month in The New York Times (2).
The study was led by Steven G. Newmaster of the Biodiversity Institute of Ontario at the University of Guelph.Â He and his colleagues genetically tested forty-four bottles of popular herbal supplements sold by twelve companies in Canada and the United States.Â Here is what they found:
And what was the reaction to the study?Â On the one hand, a senior nutritionist at the Center for Science in the Public Interest - David Schardt - concluded that the study shows such a serious lack of quality control that people who recommend herbal supplements should stop doing so. On the other hand, spokespersons for the supplement industry - Stefan Gafner of the American Botanical Council and Duffy McKay of the Council for Responsible Nutrition - insisted that the study exaggerated the problem and that the herbal supplement industry can improve quality control without government interference. (9)
Meanwhile, in the wake of the study, three things seem clear:
So, to buyers of herbal supplements, I invoke a Latin warning from the 1500s: Caveat emptor!Â - "Let the buyer beware!"
|USDA Warning: Gluten-Free Diets Cause Cancer||WASHINGTON, D.C. –Â A joint statement released today from the USDA and the FDA discusses new information, based on several years of research, that provesÂ that a gluten-free diet, done solely on a pretentious, bandwagon-style mentality, will give you cancer. Researchers and medical staff at the Wyatt Institute in Clearwater, Michigan say that they have been...|
|KOMPOSISI JASON WINTERS TEA|
JASON WINTERS TEA
RAMUAN HERBAL AJAIB 3 BENUA
Merupakan kombinasi dari 3 macam ramuan herbal (Red Clover, Herbalene dan Chapparal ) dari 3 benua (eropa, amerika & asia) yang berfungsi memurnikan darah dan memberikan nutrisi sehingga kekebalan tubuh meningkat. ramuan ini ditemukan dan digunakan oleh sir Jason Winter ketika putus asa dalam usahanya menghadapi vonis kematian 90 hari dari penyakit kankerstadium akhir. 3 minggu setelah mengkonsumsi ramuan, di luar dugaan hasilnya sungguh menakjubkan: beliau berhasil mengalahkan dan membunuh kanker yang dideritanya! dan dalam waktu 9 mingguSir Jason sudah dapat bekerja secara normal (baca buku membunuh kanker/Killing Cancer-gramedia).
1. Red Clover berasal dari benua Eropa adalah tumbuhan padang rumput yg memiliki bunga berwarna merah muda, dan populer sebelum masehi digunakan untuk memurnikan darah. Tahun 1884 mulai digunakan sebagai terapi untuk penyakit kanker payudara dan pasiennya sembuh (New York Tribune) di dapati Sir Jason Winters dari referensi buku karangan Jethro Kloss yaitu âGospel of Essenceâ tanaman ini bermanfaat untuk:
Â· -Memurnikan darah,sebagai antibiotic dan antiseptik
Â· -Meningkatkan kekebalan tubuh
Â· -Membantu mengatasi masalah ginjal,liver dan saluran pernafasan atas
Â· -Menanggulangi keadaan yg tidak menyenangkan akibat rendahnya kadar estrogen
2. Chaparralberasal dari benua Amerika, sejenis tanaman kaktus, satu-satunya tumbuhan yang mampu bertahan di tempat percobaan Nuklir Ground Zero dan daerah kelembaban tinggi (Death Valley). Tahun 1968-1969 diselidiki oleh FDA di Universitas Utah Medical Centre memiliki senyawa aktif SOD (Super Oxide Dismutase) yaitu Nordihydroguaiaretic Acid (NDGA) yg berfungsi sebagai antioksidant dan menjadikan Chaparral sebagai Tumbuhan Terkuat didunia (Sa Semana Medica 2:123,1955)Dr Smart & Hogle dari Universitas Utah Medical Centre menulis artikel kesehatan yang menampilkan Ernest Farr, usia 86 th yang sembuh dari penyakit Kanker dengan Chaparral.
Manfaat chaparral :
Â· -Penghancur radikal bebas
Â· -Menghambat pertumbuhan tumor dan kanker
Â· -Berfungsi sebagai analgesic dan antiseptic
Â· -Membantu menurunkan tekanan darah
Â· -Memerangi efek dari radiasi dan pembakaran akibat sinar matahari
Â· -Baik untuk masalah-masalah kulit
3. Herbalenedari benua Asia adalah tumbuhan yang banyak terdapat di China, Tibet dan India sering dipakai dalam pengobatan Chinese medication (Fu Zheng) atau sering disebut tanaman Huang Qi & 2500 tahun yang lalu Sang Budha merekomendasikan untuk untuk penyembuhan Tumor, saat ini dikembangkan dalam pengobatan penyakit kanker dan stimulus mental. dalam pengobatan modern Fu Zheng diyakini dapat memulihkan kembali kekebalan tubuh yang hilang akibat dari terapi penyinaran (radiation) dan chemotherapy.
|Breast Implant Revision - The Difference Between Silicone and Normal Saline Breast Implants|
ï»¿No "perfect" breast implant exits. All breast implants have their advantages and disadvantages. There are essentially two breast implants used today: saline-filled breast implants and silicone-filled breast implants. Both breast implants have an outer pliable envelope, or shell, which is made of silicone. The contents of the shell are either saline (saltwater) or silicone gel. For saline breast implants, the silicone shell is filled with saline at the time of surgery. Saline breast implants have been used for decades: they are safe and effective. The silicone breast implants come pre-filled. Both come in similar sizes and shapes.
The advantages of saline breast implants are:
The disadvantages of saline breast implants:
Silicone breast implants have evolved into a safer product as a result of two major improvements. Todayâs silicone breast implants have a much thicker outer shell and they contain a much more cohesive gel than earlier versions. The latter means that the silicone contents are more solid or viscous, as opposed to the more liquid versions of their predecessors. For example, if a modern silicone breast implant is cut with a pair of scissors and squeezed, the silicone material will go out and then retract back inward into the silicone shell.
The advantages of silicone breast implants are:
The disadvantages of silicone breast implants are:
Dr Miguel Delgado is a breast revision specialist. He has performed hundreds of these surgeries and has a dedicated breast implant revision website. Also view the many before and after photos of Dr. Delgado's patients and the breast revision videos.
Dr. Miguel Delgado has offices located in San Francisco Bay Area and Marin County-Novato. Also serving Sonoma and Napa County since 1988.
Call today 415898-4161 or email for a consultation.
|PIP Breast Implant Scare|
|With Latest Announcement, FDA Inches Closer to Tobacco Harm Reduction||On Friday, July 28 the Food and Drug Administration (FDA) announced changes in their regulation of tobacco products, including electronic nicotine delivery systems (ENDS). FDA ascribed their Center for Tobacco…|
|Building My Work Shop #21: Cryo or PM Turning Tools???||
I am shopping for a 1/4” bowl gouge and am trying to choose between a “cryogenic” or a “Powdered Metallurgy” gouge. They are in the same price range and both say they last “up to 3 times longer than HSS”. Do any of you have any experience using the two of them? Is one really any better than the other?
Oh & I am sure there is some sort of crazy controversial issue surrounding these materials and can’t wait to read about it. So please feel free to Rant away about how cryogenic is really alien material or PM is a FDA conspiracy. I love that kind of stuff!!!
|In The Beginning #7: Food Safe Finishes||
The Below is informational only. It in no way any reflection on anyones political beliefs. It is for those that would like to do their own research into the subject. This is NOT a political forum so please refrain from posting your political beliefs regarding the FDA or any portion of any Government Entity. We each have our own religious and political beliefs and this topic is not the place for them to be expressed. I fully respect everyones right to have their own thoughts, beliefs and ideas. However, they are not welcome here. Please feel free to start your own thread and discuss your political or religious thoughts and beliefs to your hearts content.
Anyone who posts any responses that could be construde as a politically based opinion will be blocked. There are quite literally thousands of websites devoted to politics, government, etc. This is however, a forum on Woodworking, please keep your replies on the topic of woodworking.
I recently I came across a great little pamphlet of finishing âBob Flexnerâs Finishing Factsâ. I must say as a very novice finisher it did quite a bit to educate and clarify. Best of all it removed quite a bit of mythâs and replaced them with facts.
For me the most informative is the section on Food Safe Finishes. In that Section he cites Title 21, Part 175 of the Code of Federal Regulations, so you can check it out for yourself!!!!
In the article Mr Flexner states the following
âIn fact, all ingredients used in common finishes, including metallic driers, are approved by the Federal Drug Administration (FDA) for food contact as long as the finish is made so it cures properly. Lead and Mercury are, of course, not on this list. But, neither Lead nor Mercury is used in common finishes anymoreâ
He then goes on to say the following:
âIn spite of the fact that no health problems have ever been reported, woodworkers and ,especially woodturners, continue to worry themselves about the food safety of finishes. This has resulted in many wooden objects receiving inferior, non curing mineral or vegetable oil finishes.â
Please make up your own minds about what you feel is safe. Believe me I really don’t care what you decide is best for your own personal use.
Again, this IS NOT a forum for your own personal Political Views!!!! If you have a problem with the FDA or if You Love the FDA please feel free to write your own blog and tackle that topic. But as far as this thread goes leave the politics out. I am only sharing information from a a source I found and am in no way advocating for or against the FDA or any other Government Entity. If you respect this I will respect You!
|Garcinia Cambogia Review: Are There Any Hydroxycitric Acid Side Effects?|
Los Angeles, CA -- (SBWIRE) -- 04/08/2014 -- This Garcinia Cambogia Review is about a secret ingredient that this popular product contains, known as hydroxycitric acid (HCA) and its effectiveness in weight loss. Many people have concerns about eventual hydroxycitric acid side effects, so this review answers all their questions and worries regarding the safety of this product.
There are multiple researches and tests made with the pure Garcinia Cambogia extract derived from the fruit, which contains 60% HCA. All of them confirm that HCA has two positive effects in people: it suppresses their appetite and burns excess fat, preventing more fat accumulation. This secret ingredient is secreting the fat through the urine. All clinical researches made confirm that there are absolutely no hydroxycitric acid side effects, if the product is taken in its 100% pure form.
100% pure Garcinia Cambogia Extract contains a proper percentage of at least 60% HCA. The supplement should be taken two or three times per day. The product must not contain preservatives, additives, fillers, GMO, gluten or binders. These type of fillers that some of the manufacturers add into the supplement, makes the product ineffective and can cause harmful negative effects. Customers, who would like to avoid any risk and to get really effective Garcinia Cambogia, should opt for its pure form. They need to select a product that is produced in a FDA registered cGMP facility.
The active ingredient HCA blocks the special enzyme, which is responsible for conversion of sugar into fat. It is an effective natural appetite suppressant that increases the level of serotonin. Some additional benefits of Garcinia Cambogia are control of cortisol levels, mood enhancement, bad cholesterol reduction, lowering of high blood pressure and other effects associated with overweight and obesity, such as easy maintenance of the reached results.
It is a completely safe and all natural weight loss product that requires no special diet or exercises to lose weight. A lot of diet specialists and doctors recommend this product to their overweight patients. Garcinia Cambogia is known as one of the most powerful fat blockers and fat burners that is clinically proven to be all natural and completely safe. It is an effective remedy for emotional eaters as well, because of its effect of serotonin level increase, so it can improve customers' sleeping patterns and mood. People report to have increase of energy and no food cravings after regular intake of this amazing supplement.
These multiple benefits make Garcinia Cambogia a more and more popular weight loss supplement today without any hydroxycitric acid side effects known.
People, who like to to know more about this doctor-recommended weight loss supplement, can look here for more information.
About Better Shape
For more information on this press release visit: http://www.sbwire.com/press-releases/hydroxycitric-acid-side-effect/release-490262.htm
Media Relations Contact
|Pure Garcinia Cambogia Extract: The Popular Diet Pills That Work Are Offered at a Discounted Price Now|
BetterShape.Org now offers pure Garcinia Cambogia extract at a discounted price. Garcinia Cambogia is a weight loss supplement that owes its double positive effect to the amazing hydroxycitric acid. The product works by burning body fat and curbing appetite, promoting a slim and attractive body. The Pure Garcinia Cambogia Extract offered by Better Shape is 100% natural, which means there are no preservatives, additives, GMO, blinders, fillers, or gluten.
St. Petersburg, FL -- (SBWIRE) -- 03/18/2014 -- These diet pills that work efficiently do not allow the body to accumulate fat rather than secreting it in the urine. The product includes 80mg of potassium and 80mg of calcium per serving, so regular diet pill intake will bring people many more additional benefits, such as the ones described below. Garcinia Cambogia is said to:
- Increase the levels of serotonin and control the enzyme called citrate lyase that is responsible for converting excess sugar into fat.
- It is recommended by doctors and is made in the US by a FDA registered company.
Garcinia Cambogia Extract Pure is derived from a small exotic fruit called Garcinia Cambogia that grows in Indonesia, India, Africa, and southeast parts of Asia. It has been used in traditional local dishes for centuries, as its beneficial qualities have been known from a long time. The soup of Garcinia eaten before other meals helps locals feel full faster because HCA (hydroxycitric acid) curbs their appetite.
Studies show that people who take this extract regularly in the recommended dosage lose approximately four pounds per month. If appropriate exercising and dieting is included, it will be even more. The product is connected with other beneficial effects on people's health, such as reduction of cortisol (the primary stress hormone), reduction of bad cholesterol and triglycerides, and increase of good cholesterol.
Another study has shown the great results of this supplement when combined with a calorie restricted diet of 1,200 kcal a day. Obese people who followed this diet and took Garcinia cambogia for a period of two months were able to lose 14 pounds and reported reduced appetite.
The recommended dose of Garcinia Cambogia Extract Pure is between 800 and 1,600 mg before each meal, but the total intake per day should not exceed 3,000 mg. Since this diet pill is a strong appetite blocker, it is recommended to start with one pill, taking it about a half an hour to two hours before each meal, while drinking a lot of water throughout the day to help the body faster adjust to the changes. After a week or so, people can increase their servings to two capsules (1,600 mg) in order to boost the weight loss effect.
All who are interested in finding more information on this effective diet supplement can visit www.bettershape.org and http://www.amazon.com/Garcinia-Cambogia-Extract-Pure-Caps/dp/B00HS3IB8A.
Media Relations Contact
For more information on this press release visit: http://www.sbwire.com/press-releases/garciniacambogiaextract/release-477860.htm
Media Relations Contact
|Past Vogue CFDA winners doing well||In advance of announcing the winner of the 2006 CFDA/Vogue Fashion Fund Award ($200,000), Vogue Editor in Chief Anna Wintour gave a run-down of whatâs become of winners past. She also spoke very highly of the awardâs career-boosting effects. âIn only the third year of the competition, we know that to win a first or runner-up prize is to receive a substantial professional boost. The inaugural|
|Kime Daha Ãok YakÄ±ÅmÄ±Å: Adriana Lima vs. Shay Mitchell|
KoÄuÅ kalk, gÄ±ybet var!
AslÄ±nda birazdan bahsedeceÄim kÄ±yafet piÅti sayÄ±lmaz, aynÄ± Åey deÄiller ama aynÄ± renk ve aynÄ± konsept olunca uydurayÄ±m dedim. Ay iÃ§imden Ã§an Ã§an konuÅmak geldi, kÄ±lÄ±fÄ±na uyduruverdim iÅte.
Adriana Lima ile baÅlÄ±yoruz. GeÃ§en ayÄ±n baÅÄ±nda CFDA Fashion Awards'a giderken bu Urban Zen beyaz tulumu giydiÄinde dikkatimi Ã§ekmiÅti aslÄ±nda. Teoride tiril tiril, tam yazlÄ±k, aÅÄ±rÄ± ÅÄ±k olmasÄ± gerekirken bi eÄretilik var ama Ã§Ã¶zemiyorum. Halbuki o katanalÄ±ÄÄ± gitmiÅ, majyajÄ± abartmamÄ±Å, saÃ§Ä± desen cool, narin bi Ã§iÃ§ek gibi Adriana ama o efil tulumda bi sorun var.
Åimdi gelelim ikinci beyaz efil tulumlu falso ismimize.
TarzÄ±na bayÄ±ldÄ±ÄÄ±mÄ±z Shay Mitchell ise Much Music Awards pembe halÄ±sÄ±nda bu Åeffaf tulumla karÅÄ±lÄ±yor bizi. Yine teoride her Åey harika. Ä°Ã§ gÃ¶steren kumaÅ, beyaz ÅÄ±k bi mayo, harika bi hatun. Ama canlanÄ±nca hiÃ§ de iÃ§ aÃ§Ä±cÄ± bi gÃ¶rÃ¼ntÃ¼ yok ortada. Hele o kafasÄ±nÄ± defalarca highlight kutusuna batÄ±rÄ±p Ã§Ä±karmÄ±Å gibi gÃ¶rÃ¼nen makyajÄ±nÄ±n hali nedir? Saten Ã§antasÄ±, ucu dekolteli ayakkabÄ±larÄ±yla cesur bi sÃ¼nnet annesinden farksÄ±z geldi gÃ¶zÃ¼me.
Ä°kisine de yakÄ±ÅmamÄ±Å ama ben Åimdi herkese yakÄ±Åacak bi kaÃ§ beyaz kÄ±yafet Ã¶nereceÄim. AyrÄ±ca gÃ¼nlÃ¼k giyilebilecek aÅÄ±rÄ± rahat bi beyaz pantolon arÄ±yorum, gÃ¶ren duyan sÃ¶ylesin.
Omzu aÃ§Ä±k mini romantik tulum (tam tatil akÅamÄ±lÄ±kkkk)
Uzun beyaz ÅÄ±k tulum (al dÃ¼ÄÃ¼ne giy gelin Ã§Ä±ldÄ±rsÄ±n)
Beyaz uzun kollu gÃ¶mlek elbise (Valla bunu Ã§ok ucuz ve ÅÄ±k diye koydum ve %90 alÄ±cam da, Ã¼zerimde gÃ¶rÃ¼rseniz aha linki)
KÄ±rmÄ±zÄ± kareli minnoÅ tulum (Ay bu da konudan baÄÄ±msÄ±z ama aÅÄ±rÄ± beÄendim, yazlÄ±Äa gidecek olan alsÄ±n)
Hadi bi de adettendir kime daha Ã§ok yakÄ±ÅmÄ±Å anketi yapalÄ±m.
Beyaz pantol Ã¶nerilerinizi, nadide yorumlarÄ±nÄ±zÄ± ve yazÄ± isteklerinizi bekliyorum. Danimarka'dan dÃ¶ndÃ¼ÄÃ¼mde sÃ¶z bu yazÄ±ya gelen isteklerden birini yazÄ±cam!
|Creation Technologies Launches FDA UDI Compliance Program in Global Manufacturing and Design Operations|| |
Electronic product design and contract manufacturing leader demonstrates commitment to medical OEMs in all ten of its manufacturing locations
(PRWeb October 27, 2016)
Read the full story at http://www.prweb.com/releases/2016/10/prweb13801283.htm
|Creation Technologies Receives FDA Registration for California Manufacturing Facility|| |
Medical OEMs Gain Additional Option for Risk Mitigation through Leading Contract Manufacturer
(PRWeb June 17, 2014)
Read the full story at http://www.prweb.com/releases/creation-technologies/fda-registration/prweb11948953.htm
|Creation Technologies Receives FDA Registration in USA|| |
Leading Electronics Manufacturer Demonstrates Quality Expertise
(PRWeb November 04, 2013)
Read the full story at http://www.prweb.com/releases/2013/11/prweb11289689.htm
|Creation Technologies Receives FDA Registration|| |
Award-winning electronics manufacturer demonstrates commitment to Medical Devices industry.
(PRWeb May 30, 2013)
Read the full story at http://www.prweb.com/releases/2013/5/prweb10773946.htm
|Regulatory and Risk Manager||Overview: We are currently working with a ground breaking medical device manufacturing company, who are in a state of growth and therefore looking to recruit a Regulatory and Risk Manager to their team based near Warwick. Your purpose in this role will be to develop a regulatory strategy to support all target markets, and to maintain regulatory compliance as required. You will be responsible to the Director of Quality and Regulatory Affairs. Essential Candidate Experience: Â· Experience as a Regulatory Manager with ideally some team leading or management experience. Â· 510K and FDA submission experience Key Responsibilities To drive the company to deliver sufficient depth of evidence to demonstrate regulatory compliance. To drive the vigilance processes (PMS feedback, regulatory changes, adverse events, competitor information, literature searches) required in Europe, US and other relevant markets. To deliver PMS report, Vigilance Report and clinical evaluation report in line with the relevant plans. To define the appropriate regulatory pathways for entry into global markets and support other members of the company in understanding the regulatory pathways. To provide advice on possible approaches to de-risking and accelerating project completion. To provide advice on approaches taken by other companies for comparable products in satisfying regulatory requirements. To provide risk assurance support into the design and development process, to assure risk consideration and acceptability as ALAP throughout the product development lifecycle. To provide managerial leadership for RA team members, ensuring that there is a common agreement on strategy, priorities and deadlines, and to maintain a strong understanding of delivery against plans and targets. Requirements/Qualifications Strong understanding of regulatory standards and their implementation in a Medical Device framework i.e. Medical Device Directive (93/42EEC), ISO 13485, ISO 14971, IEC 60601, IEC 62366, IEC 62304, 21 CFR 820,21CFR 807, 21 CFR 11. Experience in working with PEMS (Programmable Electrical Medical Systems) or equivalent high-integrity software-intensive systems i.e. complex devices requiring multidisciplinary development effort (mechanical engineering, software, electronics, system integration, pneumatics, fluid mechanics, etc.). Experience of working with risk management, regulatory requirements, document management systems, issue management systems. Trained in application of IS014971. Ability to work with external bodies. Good team player and effective communicator. Flexible approach to hours. Ability to operate at strategic and operational levels. Ability to identify strategic and operational issues and develop plans to address. Ability to lead; demonstrating assertiveness, team building and management skills. Attention to detail. Effective communicator. Articulate, persuasive personality. Extensive experience working in product development & delivery. Sound technical knowledge of product base and application. Degree or equivalent experience in appropriate subjects.|
|Senior Microbiologist Validation Specialist||Senior Microbiologist Validation Specialist - Northampton Opportunity : Are you currently working within the pharmaceutical industry managing a microbiology lab? Does your experience include IQ, OQ, PQ of instruments cleaning validation? Want to work for a growing company? Yes then this is the role for you. Your role as a Senior Microbiologist Validation Specialist based in Northampton will involve managing the site microbiology. Duties and responsibilities include: Responsible for the instrument procurement and supplier assessment. SOP preparation and review. IQ, OQ, PQ of instruments cleaning validation. Preparing protocols and reports for cleaning validation, water system, calibration, IQ, OQ, PQ of instruments. Validation of microbial limit test. Microbiological analysis. Writing and reviewing Microbial validation protocols and reports. Aseptic area qualification by environmental monitoring of new manufacturing facility. Preparation of COA for microbial analysis. This is a full time permanent job opportunity paying between Â£28,000 - Â£30,000 per annum and great benefits. There is a lot of career development as the company has set up a brand new production site so it is a great time to join a growing business and be able to play a key role in the success of the company and become a pivotal team member for the future. Skills: To apply for the Senior Microbiologist Validation Specialist role you will have the following: Degree or equivalent qualification in a scientific subject. 8-9 years experience in Microbiology. Experience of GMP, GDP and FDA CFRs. How to Apply: To apply for this one off opportunity, please send a word copy of your CV to me now by clicking on the Apply button or call me for a confidential chat. If this sounds like the role for you or a colleague then please donât hesitate to contact us. If we manage to successfully fill a permanent placement from your recommendation then we will send you a cheque of Â£300. We also have many incentive schemes for referring contractors/temp staff so please contact us with the referral and we can provide you with more information. For a list of our current vacancies, please visit www.qualitystart.co.uk If you do not hear from Quality Start within 2 weeks your CV has not been short listed for this role. Quality Start are acting as a specialist recruitment consultancy for this role.|
|fat children and your teenager||Children and obesity|
Someone once said, "Health is wealth." This statement is true given that there are more teens obese today than it was 20 years ago which could lead to various problems in the future such as diabetes and heart disease.
The best way to lose those extra pounds is by working out and going on a diet. Unfortunately, a lot of teens find it difficult to balance the time, which is why many have turned to weight loss pills.
Weight loss pills are designed to make a person lose weight by suppressing one's appetite. The only drug approved by the FDA for use on teens between the ages of 12 and 16 is Xenical, which was once only used by overweight women.
When teens decide to eat food, the main ingredient, Orlistat blocks the absorbing of fat and releases this out through the intestine as waste. In a comparative study done between those who took the drug and those on a placebo diet, results prove that the people here lost an average of seven to eight pounds, which is much higher than the other group.
Since the body needs fat, teens are advised to compensate for the losses by having this replenished during the three regular meals of the day.
The test group did not just take Xenical to get the results. These people also had to follow a strict diet plan and exercise to maintain the weight that was lost. One of the things to also watch out for are the side effects such as gas pains, nausea and wet stools that will prompt the person to frequently go to the toilet.
Xenical is a prescription drug. This means that the parents of the teenager or that person cannot just buy this off the counter. It is only after a thorough medical examination has been conducted that the doctor will allow the patient to use this kind of medication.
Will someone who takes this get the same results like those in the test study? The answer is no. This figure could be higher or lower which really depends on the patient's metabolism.
Patients are advised to discontinue the use of Xenical if there are no signs of improvement after six months. Doctors may have to try something stronger such as the next one called Meridia.
Meridia is a diet pill that sends a signal to the brain making the person think that the body is already full after eating only a few servings. The ingredient that makes this happen is called Sibutramine. It works much differently than Xenical with the same objective of losing the excess weight.
There are two other diet pills that the patient may take. These are namely Bontril and Didrex. These ingredients of these two drugs are different and the doctor may increase the dosage if there are no signs of improvement.
Unlike Xenical and Meridia, both of these pills have certain ingredients that are quite addictive so this can only be used for a short period of time. A gradual decrease in the dosage is also done to prevent withdrawal symptoms.
Diet pill such as those mentioned are only used for teens that are obese. Those who are overweight will have to go on a diet and exercise given that people at this young age can still engage in strenuous activity unlike people two or three times that age.
Visit the Free Tips Online website to learn about swimming tips and work out tips.
childhoodobesitystatistics: childrens obesity
childhoodobesitystatistics: childrens obesity
Article Source: www.articlesnatch.com
Peter Abbott has helped thousands of families tackle the distressing issue of children and obesity. His website at http://www.children-and-obesity.com will provide parents with a guaranteed solution to the "single greatest tragedy facing our society today" (Former President Bill Clinton)
|Why You Shouldn't Trust Calorie Counts|
Yes, itâs possible to lose weight eating only Twinkies, provided that your calories in are less than your calories out. And itâs that logic that leads many people to conclude that calories are simple math. Even astrophysicist Neil deGrasse Tyson tweeted, "A weight-loss book by physicists would be one sentence long: 'Consume calories at a lower rate than your body burns them.'" Trouble is, things are not that straightforward.
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>Calorie counts are everywhere these days, from <a href="http://www.nytimes.com/2014/11/25/us/fda-to-announce-sweeping-calorie-ru... rel="">fast food menus</a> to fitness trackers. You might even be able to rattle off the calories in a cup of spinach. But what exactly is a calorie?</p><p>In short, it’s a measurement of energy; the “calories” seen on nutrition labels describes the <a href="http://www.scientificamerican.com/article/how-do-food-manufacturers/" rel="nofollow">amount of energy</a> needed to heat up a gram of water by one degree Celsius. But the energy in the cranberry <a href="http://greatist.com/eat/healthy-muffin-recipes" rel="nofollow">muffin</a> you just ate doesn’t go to heating up water; instead, it provides fuel for a number of processes in the body, including staying alive and breathing. So figuring out how many calories are in that muffin is a bit more complicated.</p></body></html> To determine the total energy content of a food, scientists use a fancy-pants piece of scientific equipment known as a bomb calorimeter. Into this device goes our muffin, which gets completely incinerated. During that muffin-burning process, the bomb calorimeter measures the heat produced. This number represents the total amount of energyâor what is known as the âgross energyââof the muffin. But gross energy isnât very helpful in indicating how much energy humans can actually get out of foods, because human digestion isnât as efficient as a bomb calorimeter. Our digestive systems produce waste products and canât completely break down all foods, which means that not all of the gross energy in food goes to fueling our bodies. When youâre looking at the calorie count on muffinâs nutritional label, youâre not seeing the gross energy. What youâre seeing is the amount of energy thatâs up for grabs by your digestive system, or metabolizable energy (ME). Since this is tricky to measure, we have to rely on estimates, which have been approved by the FDA as accepted ways that food manufacturers can calculate the calories posted on food labels. One way to estimate ME involves taking the gross energy and adjusting that number downward to account for waste and digestive inefficiency. Foods containing fats and simple sugars, (like doughnuts) are fairly easy for your body to digest, so their metabolizable energy is pretty darn close to their gross energy. However, other foods with complex carbs and fiber (think a whole-grain bran muffin) take a bit more digestive power to break down, hence their ME is much less than their gross energy. The most common method used for calculating ME is known as the Atwater System. This method uses a series of factors derived from 19th century experiments to give an approximation of the energy per gram of protein, fat, carbohydrate, and alcohol. To calculate total calories in a muffin, food manufacturers count up the number of grams of fat, protein, carbohydrate, and alcohol; multiply each by its respective factor (nine calories per gram of fat, four calories per gram of protein, four calories per gram of carbohydrate, and seven calories per gram of alcohol); and add up the totals. <!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>Though the original system remains in widespread use more scientific research ">www.ncbi.nlm.nih.gov%2Fpubmed%2F22760558%22+rel%3D%22%22%3EDiscrepancy+B... has been done since Atwater’s original experiments to come up with “specific factors” for particular food groups such as dairy products.</p><p>Scientists are learning that calories calculated from the Atwater factors are <a href="http://greatist.com/health/calorie-counts-misleading-research-022113" rel="nofollow">more accurate</a> for certain diets and certain foods than others. One study found that the Atwater general factors overestimated the energy content of a low-fat, high-fiber diet by 11 percent .</p><p>More">www.ncbi.nlm.nih.gov%2Fpubmed%2F18065582%22+rel%3D%22%22%3EAccuracy+of+t... recently, USDA researchers discovered that Atwater factors overestimate the calories in a serving of raw almonds. Food labels typically list a calorie count of 160 to 170 calories per ounce of the nut, but this study showed that our bodies only absorb about 129 calories .</p><p>But">www.ncbi.nlm.nih.gov%2Fpubmed%2F22760558%22+rel%3D%22%22%3EDiscrepancy+B... this may not apply to almond butter since less-processed foods give up their energy less readily. Whereas nut butter is already ground and therefore kind of “pre-digested,” our digestive systems have to work a lot harder to break down whole almonds. Same goes for cooked foods: Raw foods, ounce-for-ounce, take more energy to break down than <a href="http://www.scientificamerican.com/article/science-reveals-why-calorie-co... rel="nofollow">cooked foods</a> (one reason some people embrace a <a href="http://health.usnews.com/best-diet/raw-food-diet" rel="nofollow">raw food diet</a>).</p><p>In addition to these factors, scientists are also exploring others that may impact the accuracy of the <a href="http://www.scientificamerican.com/article/science-reveals-why-calorie-co... rel="nofollow">almighty calorie</a>, such as gut bacteria, the immune system, and certain genetic variations.</p></body></html> <!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>While it’s a tricky business to calculate the calories in food, figuring out the other side of the equation may make busting a sweat on the <a href="http://greatist.com/move/reasons-treadmill-doesnt-suck" rel="nofollow">treadmill</a> or powering through a heavy <a href="http://greatist.com/fitness/ladies-lifting-weights-wont-make-you-bulky" rel="nofollow">weightlifting</a> session seem easy.</p><p>Measuring calorie expenditure, like measuring the calories in foods, is pretty convoluted. While there are a couple of methods that are pretty darn accurate for determining a person’s daily burn, these are very expensive and/or involve some specialized equipment—not very practical for the average person .</p><p>So">www.ncbi.nlm.nih.gov%2Fpubmed%2F21892558%22+rel%3D%22%22%3EEnergy+Expend... we have to turn to easier, albeit less accurate, ways to tally daily energy expenditure. The <a href="http://www.calculator.net/calorie-calculator.html" rel="nofollow">Mifflin St. Jeor</a> equation, which takes into account age, height, current weight, and sex, is the go-to for registered dietitians and <a href="http://greatist.com/fitness/best-health-fitness-apps" rel="nofollow">weight-loss apps</a> to estimate your caloric needs. The equation spits out a number that gives a rough estimate of a person’s resting daily energy expenditure (REE, or the <span >energy required to simply exist, couch-potato-style)</span>. This is multiplied by a <a href="http://35-210-203-f13.wiki.uml.edu/file/view/Lab+3_EER+and+BMI.pdf" rel="nofollow">physical activity factor</a> (such as multiplying by 1.2 for someone who does no physical activity and up to 1.9 for someone who has an intensely physical job) to calculate a rough guess of how many calories a person expends on a daily basis—but it’s only a guess.</p><p>Altogether, a person’s daily <a href="http://www.nal.usda.gov/fnic/DRI/DRI_Energy/107-264.pdf" rel="nofollow">energy expenditure</a> looks like this:</p><p><em>basal energy expenditure + physical activity + non-exercise activity thermogenesis + thermic effect of food = total daily energy expenditure</em></p><p>If that formula reads like Greek, don't worry. Let's walk through each of these components.</p></body></html> <!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>This is basically REE, but it's measured in a slightly <a href="https://www.acefitness.org/blog/616/bmr-versus-rmr" rel="">different way</a>. BEE is by far the largest part of your daily burn, accounting for<a href="http://www.fao.org/docrep/007/y5686e/y5686e04.htm" rel="nofollow"> 45 to 70 percent</a> of total daily energy expenditure (TDEE). It’s mostly determined by how much <a href="https://books.google.com/books?id=MVJPAQAAQBAJ&pg=PA20&lpg=PA20&... rel="nofollow">lean body mass</a> you have (your total weight minus fat mass), and age, sex, genetic variations, and certain conditions (such as thyroid problems) also <a href="http://www.nal.usda.gov/fnic/DRI/DRI_Energy/107-264.pdf" rel="nofollow">factor in</a>. And yes, your body does slow the burn when in “starvation mode,” which can be triggered by too few calories and/or too much exercise. It’s your body’s way of protecting itself by pumping the breaks on losing more muscle mass Metabolic Adaptation to Malnutrition. Carbonnel, F. Annales De Medecine Interne, 2000; 151:644-651..</p></body></html>">www.ncbi.nlm.nih.gov%2Fpubmed%2F2017606%22+rel%3D%22%22%3EThe+Impact+of+... <!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>The neat thing about NEAT is its ability to bump up your burn without the sweat factor. NEAT, which includes energy spent on <a href="http://greatist.com/fitness/unexpected-ways-cardio-exercise" rel="nofollow">daily activities</a> from fidgeting to cooking to Xbox-ing, can differ between individuals by up to 2,000 calories per day ">www.ncbi.nlm.nih.gov%2Fpubmed%2F16439708%22+rel%3D%22%22%3ENon-Exercise+.... Fidgeting alone can burn up to 350 calories a day, and some scientists have hypothesized that lack of NEAT has contributed to America’s obesity epidemic .</p></body></html>">www.ncbi.nlm.nih.gov%2Fpubmed%2F16439708%22+rel%3D%22%22%3ENon-Exercise+... Hereâs what most of us picture when we think âcalories outâ: purposeful physical exercise, like Spinning class or a pick-up soccer game. While this contributes to TDEE, it varies between individuals. For most people, itâs a small chunk of daily caloric burn, but for mega-endurance athletes, it can be a pretty big piece of the pie. <!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>Strangely, food itself can contribute about <a href="http://www.fao.org/docrep/007/y5686e/y5686e04.htm" rel="nofollow">10 percent</a> of total daily energy expenditure. The thermic effect of food (TEF) is the work expended by the digestive system to <a href="http://greatist.com/health/small-meals-weight-loss-myth-062513" rel="nofollow">digest food</a>. Fats require relatively little energy to digest, while proteins and complex carbohydrates require quite a bit more.</p><p>Despite lots of hype to the contrary, there’s no evidence that eating smaller, more frequent meals will bump up caloric burn or help with appetite control Evidence for Efficacy and Effectiveness of Changes in Eating Frequency for Body Weight Management. Kant, A. K. Advances in Nutrition, 2014; 5:822-828.">www.ncbi.nlm.nih.gov%2Fpubmed%2F21123467%22+rel%3D%22%22%3EThe+Effect+of.... Instead, it’s <a href="http://greatist.com/health/small-meals-weight-loss-myth-062513" rel="nofollow">how much and what</a> we eat that determines the energy expended by TEF.</p></body></html>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>Calorie counts are everywhere these days, from <a href="http://www.nytimes.com/2014/11/25/us/fda-to-announce-sweeping-calorie-ru... rel="">fast food menus</a> to fitness trackers. You might even be able to rattle off the calories in a cup of spinach. But what exactly is a calorie?</p><p>In short, it’s a measurement of energy; the “calories” seen on nutrition labels describes the <a href="http://www.scientificamerican.com/article/how-do-food-manufacturers/" rel="nofollow">amount of energy</a> needed to heat up a gram of water by one degree Celsius. But the energy in the cranberry <a href="http://greatist.com/eat/healthy-muffin-recipes" rel="nofollow">muffin</a> you just ate doesn’t go to heating up water; instead, it provides fuel for a number of processes in the body, including staying alive and breathing. So figuring out how many calories are in that muffin is a bit more complicated.</p></body></html>
To determine the total energy content of a food, scientists use a fancy-pants piece of scientific equipment known as a bomb calorimeter. Into this device goes our muffin, which gets completely incinerated. During that muffin-burning process, the bomb calorimeter measures the heat produced. This number represents the total amount of energyâor what is known as the âgross energyââof the muffin.
But gross energy isnât very helpful in indicating how much energy humans can actually get out of foods, because human digestion isnât as efficient as a bomb calorimeter. Our digestive systems produce waste products and canât completely break down all foods, which means that not all of the gross energy in food goes to fueling our bodies.
When youâre looking at the calorie count on muffinâs nutritional label, youâre not seeing the gross energy. What youâre seeing is the amount of energy thatâs up for grabs by your digestive system, or metabolizable energy (ME). Since this is tricky to measure, we have to rely on estimates, which have been approved by the FDA as accepted ways that food manufacturers can calculate the calories posted on food labels.
One way to estimate ME involves taking the gross energy and adjusting that number downward to account for waste and digestive inefficiency. Foods containing fats and simple sugars, (like doughnuts) are fairly easy for your body to digest, so their metabolizable energy is pretty darn close to their gross energy. However, other foods with complex carbs and fiber (think a whole-grain bran muffin) take a bit more digestive power to break down, hence their ME is much less than their gross energy.
The most common method used for calculating ME is known as the Atwater System. This method uses a series of factors derived from 19th century experiments to give an approximation of the energy per gram of protein, fat, carbohydrate, and alcohol. To calculate total calories in a muffin, food manufacturers count up the number of grams of fat, protein, carbohydrate, and alcohol; multiply each by its respective factor (nine calories per gram of fat, four calories per gram of protein, four calories per gram of carbohydrate, and seven calories per gram of alcohol); and add up the totals.
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>Though the original system remains in widespread use more scientific research ">www.ncbi.nlm.nih.gov%2Fpubmed%2F22760558%22+rel%3D%22%22%3EDiscrepancy+B... has been done since Atwater’s original experiments to come up with “specific factors” for particular food groups such as dairy products.</p><p>Scientists are learning that calories calculated from the Atwater factors are <a href="http://greatist.com/health/calorie-counts-misleading-research-022113" rel="nofollow">more accurate</a> for certain diets and certain foods than others. One study found that the Atwater general factors overestimated the energy content of a low-fat, high-fiber diet by 11 percent .</p><p>More">www.ncbi.nlm.nih.gov%2Fpubmed%2F18065582%22+rel%3D%22%22%3EAccuracy+of+t... recently, USDA researchers discovered that Atwater factors overestimate the calories in a serving of raw almonds. Food labels typically list a calorie count of 160 to 170 calories per ounce of the nut, but this study showed that our bodies only absorb about 129 calories .</p><p>But">www.ncbi.nlm.nih.gov%2Fpubmed%2F22760558%22+rel%3D%22%22%3EDiscrepancy+B... this may not apply to almond butter since less-processed foods give up their energy less readily. Whereas nut butter is already ground and therefore kind of “pre-digested,” our digestive systems have to work a lot harder to break down whole almonds. Same goes for cooked foods: Raw foods, ounce-for-ounce, take more energy to break down than <a href="http://www.scientificamerican.com/article/science-reveals-why-calorie-co... rel="nofollow">cooked foods</a> (one reason some people embrace a <a href="http://health.usnews.com/best-diet/raw-food-diet" rel="nofollow">raw food diet</a>).</p><p>In addition to these factors, scientists are also exploring others that may impact the accuracy of the <a href="http://www.scientificamerican.com/article/science-reveals-why-calorie-co... rel="nofollow">almighty calorie</a>, such as gut bacteria, the immune system, and certain genetic variations.</p></body></html>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>While it’s a tricky business to calculate the calories in food, figuring out the other side of the equation may make busting a sweat on the <a href="http://greatist.com/move/reasons-treadmill-doesnt-suck" rel="nofollow">treadmill</a> or powering through a heavy <a href="http://greatist.com/fitness/ladies-lifting-weights-wont-make-you-bulky" rel="nofollow">weightlifting</a> session seem easy.</p><p>Measuring calorie expenditure, like measuring the calories in foods, is pretty convoluted. While there are a couple of methods that are pretty darn accurate for determining a person’s daily burn, these are very expensive and/or involve some specialized equipment—not very practical for the average person .</p><p>So">www.ncbi.nlm.nih.gov%2Fpubmed%2F21892558%22+rel%3D%22%22%3EEnergy+Expend... we have to turn to easier, albeit less accurate, ways to tally daily energy expenditure. The <a href="http://www.calculator.net/calorie-calculator.html" rel="nofollow">Mifflin St. Jeor</a> equation, which takes into account age, height, current weight, and sex, is the go-to for registered dietitians and <a href="http://greatist.com/fitness/best-health-fitness-apps" rel="nofollow">weight-loss apps</a> to estimate your caloric needs. The equation spits out a number that gives a rough estimate of a person’s resting daily energy expenditure (REE, or the <span >energy required to simply exist, couch-potato-style)</span>. This is multiplied by a <a href="http://35-210-203-f13.wiki.uml.edu/file/view/Lab+3_EER+and+BMI.pdf" rel="nofollow">physical activity factor</a> (such as multiplying by 1.2 for someone who does no physical activity and up to 1.9 for someone who has an intensely physical job) to calculate a rough guess of how many calories a person expends on a daily basis—but it’s only a guess.</p><p>Altogether, a person’s daily <a href="http://www.nal.usda.gov/fnic/DRI/DRI_Energy/107-264.pdf" rel="nofollow">energy expenditure</a> looks like this:</p><p><em>basal energy expenditure + physical activity + non-exercise activity thermogenesis + thermic effect of food = total daily energy expenditure</em></p><p>If that formula reads like Greek, don't worry. Let's walk through each of these components.</p></body></html>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>This is basically REE, but it's measured in a slightly <a href="https://www.acefitness.org/blog/616/bmr-versus-rmr" rel="">different way</a>. BEE is by far the largest part of your daily burn, accounting for<a href="http://www.fao.org/docrep/007/y5686e/y5686e04.htm" rel="nofollow"> 45 to 70 percent</a> of total daily energy expenditure (TDEE). It’s mostly determined by how much <a href="https://books.google.com/books?id=MVJPAQAAQBAJ&pg=PA20&lpg=PA20&... rel="nofollow">lean body mass</a> you have (your total weight minus fat mass), and age, sex, genetic variations, and certain conditions (such as thyroid problems) also <a href="http://www.nal.usda.gov/fnic/DRI/DRI_Energy/107-264.pdf" rel="nofollow">factor in</a>. And yes, your body does slow the burn when in “starvation mode,” which can be triggered by too few calories and/or too much exercise. It’s your body’s way of protecting itself by pumping the breaks on losing more muscle mass Metabolic Adaptation to Malnutrition. Carbonnel, F. Annales De Medecine Interne, 2000; 151:644-651..</p></body></html>">www.ncbi.nlm.nih.gov%2Fpubmed%2F2017606%22+rel%3D%22%22%3EThe+Impact+of+...
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>The neat thing about NEAT is its ability to bump up your burn without the sweat factor. NEAT, which includes energy spent on <a href="http://greatist.com/fitness/unexpected-ways-cardio-exercise" rel="nofollow">daily activities</a> from fidgeting to cooking to Xbox-ing, can differ between individuals by up to 2,000 calories per day ">www.ncbi.nlm.nih.gov%2Fpubmed%2F16439708%22+rel%3D%22%22%3ENon-Exercise+.... Fidgeting alone can burn up to 350 calories a day, and some scientists have hypothesized that lack of NEAT has contributed to America’s obesity epidemic .</p></body></html>">www.ncbi.nlm.nih.gov%2Fpubmed%2F16439708%22+rel%3D%22%22%3ENon-Exercise+...
Hereâs what most of us picture when we think âcalories outâ: purposeful physical exercise, like Spinning class or a pick-up soccer game. While this contributes to TDEE, it varies between individuals. For most people, itâs a small chunk of daily caloric burn, but for mega-endurance athletes, it can be a pretty big piece of the pie.
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"><html><body><p>Strangely, food itself can contribute about <a href="http://www.fao.org/docrep/007/y5686e/y5686e04.htm" rel="nofollow">10 percent</a> of total daily energy expenditure. The thermic effect of food (TEF) is the work expended by the digestive system to <a href="http://greatist.com/health/small-meals-weight-loss-myth-062513" rel="nofollow">digest food</a>. Fats require relatively little energy to digest, while proteins and complex carbohydrates require quite a bit more.</p><p>Despite lots of hype to the contrary, there’s no evidence that eating smaller, more frequent meals will bump up caloric burn or help with appetite control Evidence for Efficacy and Effectiveness of Changes in Eating Frequency for Body Weight Management. Kant, A. K. Advances in Nutrition, 2014; 5:822-828.">www.ncbi.nlm.nih.gov%2Fpubmed%2F21123467%22+rel%3D%22%22%3EThe+Effect+of.... Instead, it’s <a href="http://greatist.com/health/small-meals-weight-loss-myth-062513" rel="nofollow">how much and what</a> we eat that determines the energy expended by TEF.</p></body></html>
In short, the âcalories in versus calories outâ equation works, however it's pretty much impossible for an individual to measure either with precision. So do what works for you.
Given the inaccuracies, counting calories may seem like a waste of time, but plugging your foods into a calorie-tracking app isnât completely pointless for everyone: Thereâs some evidence that writing down food intake can contribute to weight loss Self-Monitoring in Weight Loss: A Systematic Review of the Literature. Burke L.E., Wang J., and Sevick M.A. Journal of the American Dietetic Association, 2011 Jan;111(1):92-102. because food diaries help people pay attention to their choices and provide a sense of accountability. For the more numerically inclined, tracking calories, quality of foods, and weight changes will give a big picture of how meals and snacks translate into weight changes, even if calorie labels arenât foolproof.
And if you like crunching numbers but question the whole calorie-counting thing, there are several alternative tools, such as the NuVal and Orac scales, that can help you judge the healthfulness of foods without relying on a running tally of calories.
For others, for ignoring calories completely and instead focusing on consuming whole, nutritious foods may be better. In addition to providing tons of good-for-you nutrients, these kinds of foods typically take more work to digest. If youâre looking to lose weight, try playing with proportionsâbump up the fraction of unprocessed foods in your diet and see what happens.
Counting Calories Is Flawed. But Here's Why I Still Do It
Why You Can't Always Trust Calorie Counts
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|More Britney Civil Rights Violations||In addition to all of the civil rights violations I mentioned in my post below, Britney was treated with drugs that are not FDA approved as safe and effective for use in the treatment of alleged bipolar disorder. Either separately, or in combination. Britney is literally being used for drug experimentation without her informed consent, […]|
|FDA, lÃ¶semi ile savaÅmak iÃ§in yeni bir gen tedavisini onayladÄ±||GeÃ§tiÄimiz hafta Amerikan GÄ±da ve Ä°laÃ§ Dairesiânin Heyeti (FDA), Daireânin oybirliÄiyle, lÃ¶semi ile savaÅmak Ã¼zere hastanÄ±n kendi hÃ¼crelerini genetik olarak deÄiÅtirecek bir tedaviyi onaylayacaÄÄ±nÄ± bildirdi. FDA onayÄ± verirse, ilk kez bÃ¶ylesi bir tedavi, tÄ±pta âyaÅayan ilaÃ§â Ã§aÄÄ±nÄ±n baÅlangÄ±cÄ± olacak. BÃ¶ylece, doÄal baÄÄ±ÅÄ±klÄ±k sistemimizi kuvvetlendirip, Ã¶nceden yenilmez olan hastalÄ±klarÄ± baskÄ±lama yeteneÄini iyileÅtirmek iÃ§in teknolojiyi koÅturacaÄÄ±z. CTL019 diye bilinen bu lÃ¶semi tedavisi pazara ulaÅan ilk gen terapisi olsa da pek Ã§oÄu sÄ±rada bekliyor. SaldÄ±rgan bir tip beyin tÃ¼mÃ¶rÃ¼, miyeloma ve diÄer lÃ¶semi tÃ¼rleri iÃ§in tedaviler geliÅtiriliyor. Bu teknik kiÅiye Ã¶zel ilacÄ±n gerÃ§ek bir Ã¶rneÄi: her hasta iÃ§in kendi hÃ¼crelerinden yaratÄ±lacak tedavinin emsalsiz bir tÃ¼rÃ¼. HÃ¼creler tÄ±bbi personel tarafÄ±ndan alÄ±ndÄ±ktan sonra, dondurulup terapinin uygulayan Novartisâe gÃ¶nderiliyor. Ä°Ålendikten sonra da tekrar dondurulup tÄ±bbi merkeze geriye gÃ¶nderiliyor. Tedavi onaylanÄ±rsa FDA iÃ§in bir ilk olacak. ÅaÅÄ±rtÄ±cÄ± deney sonuÃ§larÄ± Ä±ÅÄ±ÄÄ±nda, tedavinin onaylanmasÄ±, aÃ§Ä±kÃ§asÄ±, Ã§ok da sÃ¼rpriz niteliÄinde.. |
|Will the Trump presidency mean the end of FDA drug regulation?||…|
|BioethicsTV: Pure Genius is Purely Corrupt|
by Craig Klugman, Ph.D.
In this weekâs episode (Season 1, Episode 7 -12/8), an FDA reviewer trades a case so that she can review a compassionate use request for a new drug at the hospital where her husband is the chief of staff. Her spouse was even was a participant in the proposal presentation to her for approval. Meanwhile, the owner of the hospital asks his chief of staff to be his doctor for his neurodegenerative diseaseâserving as the physician for his boss, in an area that is outside his specialty.…
|BIOETHICS TV 10/27 â Modern miracles, body hacking, and sex trafficking|
by Craig Klugman, Ph.D.
Pure Genius (Seasons 1, Episode 1)
This new TV show might be the ethicists worst nightmare. The show opens with Dr. Mulroney at a hearing where he admits to giving a patient an unapproved FDA drug to a patient who died. He is dismissed. The point of this opening scene is to present medicine as too conservative, too stodgy, and not willing to take risks for innovation.
The second presents a case takes in an Oakland, CA hospital where a 15-year-old girls is unresponsive in a âcomaâ for some unknown reason.…
|Do the EPA Exposure Studies Violate Do No Harm and Informed Consent?|
by Craig Klugman, Ph.D
A government agency recruits elderly and sick patients for an important research study. In a controlled environment, subjects are exposed to airborne pollutants at levels many times higher than found in the real world. Some pollutants are considered so dangerous that the FDA considers any exposure to be dangerous.
Such a scenario may sound like a historical case study of human subjects abuse, but such studies are actually the subject of an 18-month review by the EPA on ethical conduct of research.…
|Eric Egozi, MD, is Leading Clearwater, Florida Plastic Surgeon Provider of Sculptra Aesthetic, an Injectable Facial Filler Just Approved by the FDA for Cosmetic Use|| |
On July 28, 2009, the FDA approved Sculptra® Aesthetic, an injectable poly-l lactic acid dermal filler, for treating facial aging with results lasting up to two years--about twice as long as hyaluronic acid fillers. Sculptra is much more difficult to inject than Botox or other facial fillers, so finding an experienced provider is key. Plastic surgeon Eric Egozi, MD, has been treating patients with Sculptra since 2007 and has more experience with it than any other plastic surgeon in the Tampa Bay area.
(PRWeb October 20, 2009)
Read the full story at http://www.prweb.com/releases/2009/10/prweb3053344.htm
|Tens Handheld Electronic Pulse Massager Unit Review|| Tens Handheld Electronic Pulse Massager Unit Review|
Today I am reviewing a different type of product. This is an electronic pulse massager. It comes with the remote and 4 different sticky pads. The directions are very useful and straight forward. It has settings for sole, leg, waist etc so you know exactly where you should place it. The only 2 spots that you cannot put this massager is over your heart and your head.
To begin you put the sticky pads on your body. I did this on my feet as they were sore. I stuck them to the soles of my feet and used the sole mode on the massager. It then has a turn dial to turn up the pulses. I couldn't go past number 2 as it got uncomfortable. At 2 though it was comfortable. It pulses and my toes would twitch which was interesting. The session lasted 15 min. I did another just because but you shouldn't do more then 2.
My feet did feel less sore after and the next day.
My husband used this on his lower back and didn't think one pad was working. He turned it up and was uncomfortable so he put it back down to 2. He then said it felt great and worked just fine.
Because there are 2 separate ports for the sticky pads 2 people can use it 2 different ways.
Overall this is an interesting product. It is not a normal massager that you would think but makes an interesting twitchy feeling. My dad and mom use this for their shoulders and they both avoided surgery by using this product.
Santamedical electronic tens pulse massager features microcomputer controls therefore you can easily adjust massager with available six automatic programs and three diverse styles of modes. The device has dual channel system; hence it can easily work two areas at one time. Recommended by doctors, this is best handheld tens massager in the market. Buy with Confidence, Santamedical unit is FDA approved. Quality - Santamedical unit is designed with quality and durability in mind. Our factory is ISO-9001 certified. It conforms to international medical standards of excellence in manufacturing.
|Eco Friendly BPA Free Sports Water Bottle Review|| |
Eco Friendly BPA Free Sports Water Bottle Review
These water bottles are really cool because they not only come in fun bright colors but they roll up when empty! They also have a handy hook on the side which can be attached to your bag or belt! I am taking 2 of these on my honeymoon because we can hook them onto our bags during the day and roll them up for easy storage when we are done with them.
Everyone knows that drinking water is healthy and that's why you try to get your daily 8 glasses of H20. You carry a water bottle around or worse yet you buy water bottles every day! Stop wasting money on plastic bottles you lose all the time and feeling guilty about throwing your empty plastic bottles into the environment. Whether you're running, jogging, cycling, hiking, snowboarding, skiing, mountain climbing, camping or working out hard in the gym, the Mindbody Active bottle won't get in the way and you'll have peace of mind knowing that you're treating your body right! Our portable bottles are more compact and easier to transport than any other water bottle! When empty the Mindbody Active 20 oz bottle can be folded, rolled, or flattened to 1/4 its original size for convenient travel transportation. Simply refill and watch as this durable bottle stands straight up retaining its original shape.
- BPA Free
- Phthalate Free
- FDA Approved
- Eco Friendly
- Leak Free
- Dishwasher Safe
- Microwave Safe
- Freezer Safe
- 100% Food Grade SiliconDid You Know?
Most plastic water bottles are made with harmful chemicals such as BPA and Phthalate. Researchers have proven these toxic chemicals can seep into your water from your plastic bottle, causing long term health effects such as cancer. Equip yourself and your loved ones with a BPA / Phthalate FREE 100% food grade silicon water bottle. Stay hydrated with peace of mind knowing your water is chemical free.
Why Mind Body Active (MBA)?
MindBody Active's goal is to help you live an active, healthy and environmentally clean life.
All our products are environmentally safe and promote an active and balanced lifestyle.
|Does Alli Work?||Does alli work as a weight loss pill? The quick answer seems to be yes, but there is a downside, so read on.|
Alli is the over-the-counter name for orlistat which is also available in prescription form as Xenical. If you are going to ask for it you may like to know that it is pronounced like ally, not alley. It is essentially a fat blocker. It works by preventing the body from absorbing the fat from the foods that we eat, and it is the one freely available drug that has FDA backing for its claims to aid weight loss. You might think you could eat all the fatty foods you liked and then take alli to negate the effect but sadly that is not true. It should always be used in conjunction with a low fat diet plan under the supervision of a doctor.
The amount of weight loss achieved with alli is variable. In one study involving one-year clinical trials, between 35.5% and 54.8% of subjects attained a 5% or greater decrease in body mass, although we do not know how much of this mass was fat. Between 16.4% and 24.8% of the subjects achieved a 10% or more decrease in body mass. In combination with a calorie controlled diet, the effects could be expected to be greater. It was also shown to reduce the risk of developing type 2 diabetes. The participants regained an average of one third of the weight that they had lost after stopping alli, but this is typical of most dieters.
The main disadvantage of alli is the side effects which center around digestive and bowel problems. The higher the fat content in the diet, the greater these side effects are likely to be, as the undigested fat is expelled from the body. Flatulence, loose stools and bowel incontinence can result, especially in the early stages before the body is accustomed to the drug. The manufacturer's website warns, "You may feel an urgent need to go to the bathroom. Until you have a sense of any treatment effects, it's probably a smart idea to wear dark pants, and bring a change of clothes with you to work." You really need to want to lose weight to take alli!
However these side effects are reduced if you stick to the recommended low fat diet and as the manufacturers hint, the potentially embarrassing side effects can even be helpful in encouraging you to keep to your diet. Always remember that alli does not claim to work without consistent efforts toward weight loss from you. What they do claim is that it can improve your weight loss by up to 50%. That would mean a person who lost 10 pounds without taking alli would lose 15 pounds taking it. It boosts your weight loss and rewards your efforts with better results than you could get by yourself. Note though that individual results will vary and are not guaranteed.
Sadly there is no magic diet pill that will melt away your excess pounds while you sleep, but alli is a pill that has documented results. If you are determined to lose weight and have been struggling with diets without much effect, it may be a good time to discuss it with your doctor and find out does alli work for you.
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|5,000 Pounds of pine nuts recalled due to possible Salmonella|
U.S. Food and Drug Administration says that the Wegmans supermarket chain is recalling 5,000 pounds of pine nuts from Turkey due to possible salmonella contamination. The FDA said that the pine nuts are linked to at least 43 cases of salmonellosis in California, New York, New Jersey,Â Maryland, Pennsylvania and Virginia, citing information from the […]
The post 5,000 Pounds of pine nuts recalled due to possible Salmonella appeared first on Minor Topics.
|âBaddiesâ â Overview Of Unwanted Chemicals In Cosmetics||by Dr. Irene Reyzis “Baddies” â Overview Of Unwanted Chemicals In Cosmetics Can chemicals in cosmetics affect your health? You may be wondering, if a chemical is bad for your health, why would it be used in cosmetics? The FDA does not usually ban ingredients even if they are known […]|
|A Guns-Drawn Office Raid|
Folks, remember Joe McCarthy in the 1950s? Well tyranny is back, only worse. We are in the midst of an ugly struggle for power by the FDA and those who support giving the FDA more power over the nutritional supplement industry. They are today’s crop of bureaucratic tyrants. Whereas Joe McCarthy’s witch hunt was based […]
|A 20th Century Book Burning|
In his book,Â Racketeering in Medicine, the Suppression of Alternatives, James P. Carter, MD, professor at Tulane University, writes, “The FDA serves as the pharmaceutical industry’s watchdog, which can be called upon to attack and destroy a potential competitor under the guise of protecting the public.” To this end, the FDA will evenÂ burn booksÂ and intended to […]
|The Stevia Saga|
This is aÂ Tale of Two Sweeteners,Â full of sound and fury, signifying that the FDA has sold you and your kids to the drug companies again, and you are unwitting receptacles of a sweetener that has obvious toxicity. The Dark Side of Aspartame If you drink diet sodas or add Equal or NutraSweet to your coffee, […]
An obvious source of information for healthcare consumers is nutritional supplement labels. Believe it or not, until recently, itâs been illegal for manufacturers to print consumer-friendly information on their productsâ labels. The Food and Drug Administration (FDA) has suppressed virtually all scientific information on supplement labels that would explain how to use them to prevent […]
|Comment on Vaccines, mercury and you by Mairi Morrison||Merbromin is now banned in the USA, Germany & France, due to the mercury content - hardly a good example to support your claims, Luke, seems to me like you shot yourself in the foot there, mate.
Another "own goal" is your false claim that infant vaccines do not contain thimerosal - they do. These include the DTaP vaccine, DT vaccine, Hib (ACTHib, TriHIBit) and Meningococcal vaccine - see more at: http://healthimpactnews.com/2014/dr-oz-warns-about-mercury-in-flu-shots/#sthash.FkGepSF1.dpuf
Lastly, you appear to be ignorant of the FDA rule change, which allows vaccine-manufacturers to lie about the fact that their vaccines still contain thimerosal, The meningococcal vaccine given to children age two years and older contains the same amount of thimerosal (50 mcg.) as the multi-dose flu shots. - More at: http://healthimpactnews.com/2014/dr-oz-warns-about-mercury-in-flu-shots/#sthash.FkGepSF1.dpuf
The FDA rule change means that Thimerosal used in the manufacture process of a vaccine DOES NOT need to be listed - even although the actual amount of Thimerosal in the final vaccine can exceed the amount present in vaccines that must honestly list this on the label - ie when used as a preservative, post-manufacture.
Thimerosal contains almost 50% mercury. You remember Alice in Wonderland? The Mad Hatter? That's what happened to milliners (hat-makers) in the old days - they went nuts, due to the amount of mercury used in curing the felt pelts for the hats. Hence the phrase "as mad as a hatter" - which could accurately be used to describe yourself, as anyone who would recommend to others that willingly taking doses of the highly neuro-toxic element Mercury is good for them, has to either be mad, high, drunk, or deranged.
Maybe you've just had too much mercury, Luke?|
|FDA Announces New Draft Guidance on Use of Electronic Health Record Data in Clinical Investigations|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law On May 17, 2016, the United States Food and Drug Administration (FDA) published a draft guidance titled “Use of Electronic Health Record Data in Clinical Investigations” (Draft Guidance) which emphasizes interoperability and outlines other best practices for effectively using EHR data in FDA-regulated studies. The Draft Guidance is intended to assist sponsors, clinical investigators, contract research organizations (CROs), institutional review boards, and other interested parties on the use of EHR data in FDA-regulated clinical investigations....
|FDA Issues Warnings About Research Participant Protections and Inadequate Sterilization of Medical Equipment to Mayo Clinic Care Network Hospital|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law On April 12, 2016, the US Food and Drug Administration (FDA) issued warnings that targeted the allegedly substandard protection of research participants at a hospital in the Mayo Clinic Care Network. It also addressed shortcomings involving the sterilization of medical devices used to harvest fat during plastic surgery. Below are the enforcement actions taken by the FDA. Hospital Allegedly Fell Short on Protecting Human Research Participants....
|2015 Proved to Be a Good Year in Medicine as FDA Approvals of First-Of-A-Kind Drugs Continued to Escalate|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law It's been 19 years since anyone has seen the approval of more first-of-a-kind drugs by the US Food and Drug Administration (FDA). 2015 proved to be a year of satisfactory innovation for medicine. With the approval of 45 drugs formulated with never-before-sold ingredients, the FDA came close to surpassing its previous all-time record of 53 first-of-a-kind drug approvals in 1996. The increase in newly formulated drugs is a reflection of the industry's shift in focus to a greater availability of treatments for rare and hard-to-treat diseases....
|Amarin Pharma, Inc., Wins Injunction Against FDA's Off-Label Marketing Ban|| |
By Michael L. Smith, R.R.T., J.D., Board Certified by The Florida Bar in Health Law The US District Court for the Southern District of New York granted a preliminary injunction to Amarin Pharma, Inc. (Amarin), prohibiting the Food and Drug Administration (FDA) from enforcing its off-label marketing ban. The injunction means that Amarin can engage in truthful marketing of Vascepa even when the marketing is used to promote an off-label use of Vascepa. FDA Ban on Off-Labeling Drugs. Off-label use of drugs is the prescribing of a drug for a purpose other than what has been approved by the FDA....
|U.S. Food and Drug Administration Finalizes Rule on Codes that Will Track Medical Devices|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law On September 20, 2013, the US Food and Drug Administration (FDA) announced that companies will have to include unique device identification (UDI) codes on medical devices. These codes will provide a consistent way to identify medical devices, and therefore, should improve patient safety, according to the FDA. The codes allow regulators to track products, monitor them for safety and expedite recalls. The UDIs will be entered into a public database that the FDA will maintain. Click here to read the press release from the FDA ....
|Steroid Injections Compounded at Tennessee Pharmacy Recalled Due to Possible Contamination|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law The US Food and Drug Administration (FDA) sent out a warning to health care professionals that steroid injections compounded by Main Street Family Pharmacy, LLC, in Tennessee, may be contaminated. The announcement came on May 24, 2013. So far, seven patients have allegedly suffered adverse reactions from the medications. The FDA says it is working with the Centers for Disease Control and Prevention (CDC) and the Tennessee Board of Pharmacy to investigate. The steroid injections were allegedly sent to 13 states, including Florida. To read the press release from the FDA, click here ....
|Food and Drug Administration (FDA) Recalls Sterile Drugs from Florida Compounding Pharmacy|| |
By Lance O. Leider, J.D., The Health Law Firm There’s been yet another recall from a compounding pharmacy. On May 8, 2013, the US Food and Drug Administration (FDA) sent a warning to doctors and pharmacists to avoid drugs made by The Compounding Shop, based in St. Petersburg, Florida. The recall is due to potential safety concerns. Click here to read the press release from the FDA . This recall is part of a nationwide crackdown by the FDA and state agencies on compounding pharmacies, setting off a number of recalls across the country. These agencies are trying to prevent another widespread outbreak, like the fungal meningitis outbreak in the fall of 2012....
|Florida Compounding Pharmacy Recalls Eye Products|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law A Lake Mary, Florida, compounding pharmacy recently recalled products due to concerns from the Food and Drug Administration (FDA). The Balanced Solutions Compounding Pharmacy, LLC (Balanced Solutions), a division of Axium Healthcare Pharmacy Inc., announced a voluntary recall of all lots of its sterile unexpired ophthalmic products on April 17, 2013. Click here to read the press release from Balanced Solutions on the recall . This recall was issued as the FDA and state agencies step up regulation on compounding pharmacies across the country....
|Food and Drug Administration (FDA) Updates Safety Concerns on Metal-on-Metal Hip Implants After Two Wide-Spread Recalls|| |
By George F. Indest III, J.D., M.P.A., LL.M., Board Certified by The Florida Bar in Health Law and Carole C. Schriefer, R.N., J.D., The Health Law Firm On January 17, 2013, the Food and Drug Administration (FDA) issued an updated public health communication about hip replacement components that have both a metal ball and a metal socket, or metal-on-metal hip devices. This comes after two recent hip replacement recalls that are sparking thousands of lawsuits. Click here to read the FDA communication . In August 2010, Johnson and Johnson’s DePuy Orthopaedics implemented a DePuy ASR hip recall, withdrawing more than 93,000 hip implants from the market....
|fast weight lose and diet for diabetes|
First, you should consider the technical and mechanical aspects of choosing the right exercise regime and the right diet for yourself. In this writer's opinion, the best workout and meal-plan is the one that satisfies you, challenges you, and, more often than not, makes you glad that you are doing what you are doing. There are a few general guidelines that you should follow. In choosing a workout routine, try to do at least as much cardiovascular exercise as you do strength training. If you lift weights two times a week, go for a jog two days as well. When it comes to diet for diabetes, focus less on the type of food you are eating (it seems like the 'right food' changes weekly, anyway) and instead try to control the amount of food that you eat. This is a surprisingly difficult thing to do, but if you can cut down your meal size by just a small amount each day, after several (2-9) weeks you should be able to comfortably eat the FDA recommended caloric intake per day.
As a diabetic, you know that the challenges of life do not come with a 'satisfaction-guaranteed' sticker- there are some obstacles that take a lot of you, and there is rarely ever an expectation of complete success. But if you keep your eyes on the long-term goal of health success, you should be able to weather any setback that comes your way.
Any individual with diabetics interested in fast weight lose and keeping their body healthy should consider their task on multiple levels. Certainly, there is the technical and mechanical aspect of performing the correct exercises, eating the right foods, and training your body in the most beneficial and satisfying ways, but there is also the less considered aspect of mental preparation and sound spiritual framework.
There is a wide body of magazine and health journal literature that focuses on preparing an athlete or an individual for the rigors of a training regimen by seemingly trying to 'cure' them of the difficulties and the failures they will no doubt face, but this is not the right way to train. Any individual currently living with diabetes knows that there is more to life than simply succeeding and doing well. Like battling the disease itself, battling a workout routine and a new diet will be filled with achievements as well as failures and setbacks; the key is to continue moving forward. Ultimately, it is just your weight, but the success and self-confidence that you can earn through working out and eating right can be carried over to the rest of your life and into your fight against diabetes.
|Franck's Pharmacy Announces Compounding Prescriptions Recall, Shuts Down Sterile Compounding Service|| |
Beleaguered Franck's Pharmacy, Inc. located in Ocala, Florida, has issued a recall for its compounded prescriptions. The prescriptions impacted by this recall include all sterile human and veterinary compounded prescriptions distributed by Franck’s Pharmacy from November 21, 2011 to May 21, 2012. Franck's Pharmacy made the announcement on the company's website on May 24, 2012. To see the recall click here . Recall Based on FDA Findings of Fungal Growth in Pharmacy's Clean Room. The recall was apparently prompted by action by the US Food and Drug Administration (FDA)....
|Clinical Trial: When Research Goes Wrong|| |
Three patients died in an unapproved medical trial conducted between 2003 and 2004. Now, the executives of Snythes Inc., a medical-device company, are awaiting sentencing this week after pleading guilty to a misdemeanor as "responsible corporate officers," according to Business Week. The Synthes officials allegedly bypassed FDA protocol to have surgeons test bone cement in people with spine fractures. The product was not approved for that use, and three people died in the operating room in 2003 and 2004. The patients who died suffered a severe drop in blood pressure following the injections....
|Shareholder Notice: Update in Lawsuit Against Insulet Corporation (NASDAQ:PODD)|
A lawsuit is pending for investors in shares of Insulet Corporation (NASDAQ:PODD) over alleged securities laws biolations and NASDAQ:PODD investors should contact the Shareholders Foundation.
San Diego, CA -- (SBWIRE) -- 08/09/2017 -- A lawsuit is pending for certain purchasers of NASDAQ:PODD shares against Insulet Corporation over alleged Violations of Securities Laws.
Investors who purchased shares of Insulet Corporation (NASDAQ:PODD) in April 2013 or earlier and continue to hold any of those NASDAQ:PODD shares have certain options and should contact the Shareholders Foundation at firstname.lastname@example.org or call 858-779-1554.
On May 6, 2013, Insulet Corporation announced the successful launch of its new Eros system, touting positive customer feedback, the transition of all new customers to the system and a resulting growth in both United States and overseas markets.
On January 7, 2015, Insulet disclosed that it was appointing six new executives from outside the company into key leadership positions and that its fourth quarter 2014 revenue would be $5 to $8 million less than the company's recent guidance due to reduced demand for Eros product from Insulet's distributors.
On April 30, 2015, Insulet Corporation revealed that revenues were much lower than forecasted, due in part to a myriad of issues with the Eros system.
On May 5, 2015, a lawsuit was filed against Insulet Corporation over alleged securities laws violations. The plaintiff alleged that the defendants allegedly failed to disclose that Insulet Corporation was experiencing slower demand for its products, that Insulet Corporation was facing issues with its sales and marketing efforts, that that, as a result, Insulet Corporation experienced unevenness in its financial performance, and that, as a result of the foregoing, Defendants' positive statements about Insulet's business, operations, and prospects lacked a reasonable basis.
On June 5, 2015, the U.S. FDA issued a letter to Insulet Corporation regarding defective lots of Eros that had been manufactured and shipped between 2013 and 2014 resulting in the Company recalling over 40,000 boxes of the product.
On June 1, 2016 an amended complaint was filed and on August 1, 2016 the defendants filed their motion to dismiss the case. On March 17, 2017, the Court denied the defendants' motion to dismiss the securities class action complaint.
Those who purchased shares of Insulet Corporation have certain options and should contact the Shareholders Foundation.
For more information on this press release visit: http://www.sbwire.com/press-releases/shareholder-notice-update-in-lawsuit-against-insulet-corporation-nasdaqpodd-845559.htm
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|Fads and Faith: Belief vs. Fact in the Struggle for Health|
In 2014 the United States had 650 reported cases of measles, a disease made preventable by a vaccine introduced 30 years ago. The majority of these measles victims were children whose parents chose not to vaccinate them.Â Meanwhile at least 85,000 dietary supplements line the shelves of GNC and other âbig boxâ chains, as well as smaller health food stores. Even though the FDA cannot assureÂ the safety or effectiveness of any of these products before they're sold, they enjoy widespread popularity in the United States. This episode of Distillations explores what connects these two issues.
Our journey starts in Shanghai, where reporter Rebecca Kanthor investigates a strange fashion trend among pregnant womenâa special apron meant to protect its wearers from the harms of electromagnetic radiation.
Then we talk with Paul Offit, an infectious disease pediatrician at Childrenâs Hospital of Philadelphia and author of Bad Faith: When Religious Belief Undermines Modern Medicine, and Catherine Price, author of Vitamania: Our Obsessive Quest for Nutritional Perfection,about what drives these fads. Our guests suggest that faith, a desire for easy answers, and a lack of trust in medical science all come into play.
01:40 Pregnancy Aprons in Shanghai
11:33 InterviewÂ with Catherine Price and Paul Offit
Hosts: Michal Meyer and Bob Kenworthy
Guests: Catherine Price and Paul Offit
Reporter: Rebecca Kanthor
Producer & Editor: Mariel Carr
Music courtesy of the Audio Network.
Check outÂ DistillationsÂ magazine atÂ distillations.org, where you'll find articles, videos, and our podcast.
|Seminar: Software as a Medical Device|
Seminar: Software as a Medical Device:
Safety and security.
January 5, 9-11 am
Seminar room: Merkuur
Connected Health cluster presents a practical seminar to help health IT developers and startups plan and manage smoothly their products to comply with needed standards and rules.
9:00 What is a software as a medical device and what is required to get regulatory compliant products on the market - overview of medical device software safety, regulations in EU and US, standards and FDA guidance - Dr. Marion Lepmets, Co-Founder & CEO of SoftComply â 30 min presentation + 15 min Q&A
9:45 Privacy Engineering and Health Data: IT and IoT - Dr. Ian Oliver, Security Specialist at Bell Labs â 30 min presentation + 15 min Q&A
10:30 Discussion and 1-2-1 Q&A
Please register by January 3 the latest: email@example.com
Free for Science Park Tehnopol network and service clients and Connected Health cluster members. 30â¬ + vat for others.
|Do Drug Reps Have Free-Speech Rights to Share Shoddy Studies?|
Pharma has landed a double blow against the American government. The U.S. Court of Appeals in New York has ruled that a drug salesman was exercising his right to free speech by pitching a narcolepsy drug as effective against insomnia, chronic fatigue and other conditions the Food and Drug Administration had not approved. If the Supreme Court upholds this decision, companies will pay fewer multi-billion dollar fines and useless healthcare spending will increase.
Regulators argued that the pitch showed the salesman was illegally selling a misbranded drug. But the court said he had a free-speech right to give doctors truthful information so they could legally prescribe the medicine. The regulator violated that right, the judges ruled, by barring his off-label recommendations.
The decision applies only in three states, but the FDA is likely to appeal. That could put the case before the Supreme Court and make this victory for the pharmaceutical industry a national precedent. GlaxoSmithKline, for instance, shelled out $3 billion in July to settle three indictments, two of which were off-label marketing of antidepressants and other drugs. In the past four years Pfizer, Johnson & Johnson, Abbottand Eli Lilly have each paid, or are negotiating to pay, settlements over $1 billion.
Itâs not just missing these regular injections of cash that will cause the government pain. It will also increase medical spending. Thatâs because pharma reps will be allowed to discuss studies of drugs that the FDA has not vetted. Unfortunately, some studies are shoddy and clinical trials cherry-picked by sales staff. This encourages doctors to prescribe extremely costly drugs, which can have little benefit, to patients.
In the GSK settlement, for example, the company allegedly participated in preparing, publishing and promoting a journal article that misleadingly asserted its drug Paxil was effective in treating depression in minors. Other studies showed the drug didnât work in teens, with some demonstrating that antidepressants like Paxil may increase suicide risk.
The industry has engaged in such behavior because it is financially appealing. The ruling increases the temptation, which is likely to pile more costs onto Medicare and Medicaid, which spent $86 billion on branded pharmaceuticals in 2010. With Medicare already accounting for about 4 percent of GDP, thatâs bad news for the nationâs financial health.
Read more at Reuters Breakingviews
|Handy Tips: Green Living|
Martha Stewart queen of home and living, has inspired me to collate a list for all our elaundry lovers, how to go green, save energy and money!
Bring Back Cloth Napkins
On average, each American uses a staggering 2,200 paper napkins a year, none of which are recycled. Yes this is an American figure however we are just as guilty of using paper napkins to fix spills and have for your dinner guests than Americans. So in turn why not reduce waste (and deforestation) by choosing cloth instead? I know where you can find some great cloth napkins and even better enjoy customization with embroidery! You might even boost your mindful eating quotient: It's much easier to linger over dinner with the table set the old-fashioned way.
Try Reusable Towels
Paper towels cause waste yep 2012 doesn't get any easier waste and consumption are our two main offenders -- even if you stick to the recycled brands. Microfiber towels grip dirt and dust like a magnet and don't let go. After use, toss the towels into the laundry and reuse over and over. Mind the
There are a few simple guidelines to follow to make microwave use safer and energy efficient, including avoiding certain plastics when reheating obviously you already know this! Use the microwave infrequently, if at all. Microwave ovens do leak radiation, but at very low levels that the FDA and most scientists believe are harmless.
Eco Shopping Bag
Take a recycled pillowcase bag to the store or farmers' market and cut down on plastic usage! It will surprise you how little plastics will build up in your household!
|16 ridiculous 'facts' about animals you should really stop repeating||
Who hasn't shared an amazing science fact about sharks, cats, bats, ostriches, or other animals, only to feel embarrassed later on when you find out the information was wrong?
It's time to put an end to these myths, misconceptions, and inaccuracies about animals passed down through the ages.
To help the cause we've rounded up and corrected dozens of the more popular myths we keep hearing repeated.
Have any favorites we missed? Send them to firstname.lastname@example.org.
MYTH: There are bugs in your strawberry Frappuccino.
This one is no longer true.
Before April 2012, Starbucks' strawberry Frappucino contained a dye made from the ground-up bodies of thousands of tiny insects, called cochineal bugs (or Dactylopius coccus).
Farmers in South and Central America make a living harvesting — and smashing — the bugs that go into the dye. Their crushed bodies produce a deep red ink that is used as a natural food coloring, which was "called cochineal" red but is now called "carmine color."
Starbucks stopped using carmine color in their strawberry Frappucinos in 2012. But the dye is still used in thousands of other food products — from Nerds candies to grapefruit juice. Not to mention cosmetics, like lovely shades of red lipstick.
MYTH: Beaver butt secretions are in your vanilla ice cream.
You've probably heard that a secretion called castoreum, isolated from the anal gland of a beaver, is used in flavorings and perfumes.
But castoreum is so expensive, at up to $70 per pound of anal gland (the cost to humanely milk castoreum from a beaver is likely even higher), that it's unlikely to show up in anything you eat.
In 2011, the Vegetarian Resource Group wrote to five major companies that produce vanilla flavoring and asked if they use castoreum. The answer: According to the Federal Code of Regulations, they can't. (The FDA highly regulates what goes into vanilla flavoring and extracts.)
It's equally unlikely you'll find castoreum in mass-marketed goods, either.
MYTH: Dogs and cats are colorblind.
Dogs and cats have much better color vision than we thought.
Both dogs and cats can see in blue and green, and they also have more rods — the light-sensing cells in the eye — than humans do, so they can see better in low-light situations.
This myth probably comes about because each animal sees colors differently than humans.
Reds and pinks may appear more green to cats, while purple may look like another shade of blue. Dogs, meanwhile, have fewer cones — the color-sensing cells in the eye — so scientists estimated that their color vision is only about 1/7th as vibrant as ours.
See the rest of the story at Business Insider
|FDA daje zielone ÅwiatÅo dla niwolumabu||AmerykaÅska Agencja ds. BezpieczeÅstwa Å»ywnoÅci i LekÃ³w (FDA) zarejestrowaÅa niwolumab w terapii pacjentÃ³w z klasycznym chÅoniakiem Hodgkina (cHL) - informuje w komunikacie prasowym firma Bristol-Myers Squibb.|
|The FDA and 23andMe|
First, download your 23andMe raw results now if you have them. If you don’t know what’s going on, the FDA has finally started to move aggressively against the firm. Unfortunately this is not surprising, as this was foreshadowed years ago. And, 23andMe has been moving aggressively to emphasize its medical, as opposed to genealogical, services […]
|The VLCC Coolsculpt! #VLCCStyleStatements|
A woman goes through a lot in her life, be it pregnancy or hormonal changes with changing age, that make us put on weight. Due to the constant pressure of being on top of things at home and office, we are more than often left with no time for ourselves, especially during those years when you have a baby or small child at home. Sadly, exercise and hitting the gym is not a privilege a lot of us get and eventually the fat cells stay in our body and we develop bulging tummies and love-handles that don't look good at all. Becoming a mommy is one of the busiest jobs in the world as you are constantly running behind the kids to feed them, clean them, play with them and help them learn new stuff. Before Aryaa was born I would regularly go to the gym to be in shape, but after her birth, my days are spent in working and spending time with her and I am left with no time to go to the gym. I did join martial arts classes a few months back, but couldn't continue going to the class because of time constraints.
Now that I am heading to the US for a vacation, I want to lose some weight because no one comes back from the US without weight gain, and I cannot afford to add anymore to my already increased weight! Since I have to finish my work commitments before I head for my vacation, my schedules are going to be super busy and as always, I am not going to have time to go the gym. Hence a few days ago I started finding out other safe options that would work for me since there are so many these days, and came across this really cool concept by VLCC called the VLCC Coolsculpt. Coolsculpting is a non-surgical way to reduce excess fat from the body without harming or damaging other cells or tissues. Confused when I say non-surgical way to reduce fat? Believe me, it's not impossible, and I am going to tell you all about it.
Coolsculpting uses a patented ultra-low temperature spot cooling process called Cryolipolysis which targets the excess fat areas of the body and freezes the fat in those particular areas. There is a special type of white blood cells in our body called Macrophages which digest and consume these crystallized fat cells, and the debris of the same are slowly cleared through the lymphatic system which leads to a permanent reduction of the fat cells of up to 25% from the treated areas. What made me zero down on this concept was that in traditional weight-loss programs, the size of the fat cells reduce but their number doesn't change, while via Coolsculpting the number of cells itself reduce. For this treatment, a special combination gel and film is used so as to protect the skin from damage caused by low temperatures. Each part of the body is treated with a different applicator depending on the shape of the body part to be treated, so that the result is optimum.
This VLCC Coolsculpt treatment is FDA approved. One sitting of the treatment can start showing results within two weeks and within three months you will be back in shape. No change in the lifestyle, no crash diets, no worries of taking artificial supplements - getting back into shape becomes a breeze with the help of this treatment that also has no side effects. ð
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|update on me|
A couple weeks ago I had a pretty nasty cold it was also right after we found out the Elliott had MRSA. I took that week, two weeks ago, off work thinking if I rested up from the cold which was kicking my butt and did the right things it would be 'just' a cold. I also figured that would give me the time to find E a new home and get our house decontaminated from MRSA which was an undertaking, the washing of stuff at the Laundromat alone cost almost $50.
I went to the doctor that week for my lungs as well which was a normally scheduled visit. My lung function was down a bit but at that point it was still just a cold and we agreed to watch and wait. I started to feel better on Sunday and was more than a bit tired of âtaking it easyâ so I decided to be busy and productive, tell my body to get over it and all was pretty good; I was looking forward to returning to work on Monday. My body had other plans I woke up about midnight with severe lung pain on both sides, after some ibuprofen failed to work I woke Jared and asked for a vicodin that I have for lung pain then I decided to go to the ER as the vicodin wasnât working either.
The ER was a futile trip spent in pain during all the hours of waiting while listening to the drug addict next door yell about he was in fact sober and they should let go of him and let him get back to the missionâ¦fun times, Iâd never been so glad for my kindle. Everyone seemed to think either I was having chest pain or back pain, no one seemed to accept that I was having pain from my lungs radiating down part of my back and into my chestâ¦.try explaining that when you canât take a real breathe. I have to admit hours later when the doctor finally came in and told me it was a virus that just needed to run itâs course and I should just continue doing all my normal treatments I completely lost my cool and chewed him out telling him if I could breathe enough to do a breathing treatment I wouldnât be here in the first place. In the end I said Iâd follow up with my doctors and wanted to leave and apologized for being short. He said that he would give me something for the pain and send me home with instructions I could take two vicodin next time and then had the nurse give me so much dilaudid I was loopey the good thing was it stopped my coughing which also served to reduce the pain; I could tell as soon as it took effect as I could draw a breathe without pain.
The next day once I woke up I called my doctors who decided to start me on IVâs which arrived the next day. I was to do on inhaled antibiotic and IV zosyn which I have been on many times over the past about 5 years. The drugs in my lungs are pretty resistant to many antibiotics and zosyn seems to be the one stronghold that really works. I started my IV that night so it did one IV then and one during the night while I was sleeping and then I slept through while it was infusing my early morning one, 3 doses in total. Imagine my surprise when I woke covered in blotchy hives. Zosyn is a member of the cephalosporin family and it looks like Iâve developed a sensitivity to them. This was obviously a big blow to me since I had to stop the antibiotics and then they werenât really sure on what they wanted to do since it appears that most of the drugs the bugs in my lungs are not resistant to also just happen to be part of the cephalosporin family. It took a day or so and then I started levaquin which is a strong oral antibiotic, initially I protested because it doesnât normally work for me and the doctor had already passed over it in favor of IVs. I have what they call âintermediateâ to that drug meaning basically it works but not as well as it should. Since our options were limited my normal doctor confirmed that was the best course but at a higher dosase and in continuance with the twice as strong inhaled antibiotics I was still doing.
The good news is that this combo seems to be working. Honestly I believe it is the inhaled antibiotic doing a good portion of the work since it started improving before the levaquin but with the type of bugs we CFâers have in our lungs you never want to treat with only one antibiotic since that allows them to more easily build a resistance.
What one drug reaction wasnât enough? Ok number two has intensified over the past week or so on the oral antibiotics and I am not scheduled to finish until Friday. I have previously been told I have plantar fasciitis in my right foot now it has intensified greatly and the left foot has started in. The bottoms of both feet have a swollen red nodule present just past my heel that persists despite icing and ibuprofen popping. According to Dr. Google it seems I may have really aggravated the fasciitis or partially torn itâ¦fun. Levaquin has a black box warning from the FDA about tendonitis and tendon rupture but I am pretty certain it is responsible for this recent turn of events. Iâm going to give my foot doctor a call on Monday to see if he can get me in. Unfortunately the tendon on my left wrist and foot are also hurting, Iâve had a bad bought tendinitis in my wrist before so Iâm pulling out the wrist guards for sleeping to hopefully keep it from getting worse.
So letâs see, cold, MRSA scare, lung infection, hives, and now Iâm hobbling like an old womanâ¦.ah these are the times of CF.
The good thing is that even if I have to stop the levaquin my lungs donât feel in too bad of shape. I may be able to stop orals and start a second inhaled antibiotic, that will make for a lot of nebulizer times but if it lets me walk again and breathe easy it will be worth it. Better news is that the MRSA scare was just that, so far, a scare I have not tested positive for MRSA in my nose or my lungs *claps*. Also awesome news is that E is doing wonderfully as the only child in a first time foster family who are thrilled to have him are supporting reunification but also hoping to adopt some day.
|What is Aqualyx and How Does it Work?||Deoxycolic Acid is a molecule that naturally occurs in our bodies, helping us to break down and absorb fat in our diet. This is the active ingredient in Aqualyx, an injectable solution capable of dissolving fat in stubborn areas that seem to be resistant to exercise and diet.
It is also the same elementÂ found in Kybella, a similar fat dissolver, which is used here in the United States. In fact, Aqualyx is only used in the U.K. and Europe, as the FDA hasn’t approved it for use in the U.S.
So how do these fat melting injections work. This post gives a more scientific rundown of the process:
Aqualyx – Illuminate Skin Clinics | Illuminate Skin Clinics
The Aqualyx molecule attaches itself to the membrane of fat cells in the area of injection, and starts to dissolve the membrane surrounding the cell. This causes the fat cell to become unstable and to break open. The fatty acids contained within the cell are then eliminated by macrophages (part of the bodyâs immune system). The fat is ultimately eliminated from the body by the liver.
Read more here: Â Aqualyx – Illuminate Skin Clinics | Illuminate Skin Clinics
Even though it is considered a minimally invasive procedure, there is some pain and swelling involved. However, it is nothing like the recovery time of having liposuction.
The key is that the patient continues to massage the area several times a day for approximately five minutes a time, as this helps the fat to dissolve quicker. Mild swelling can last for up to two weeks, but most patients are able to return to work right away.
This cosmetic surgeon from London provides more details about the injectable solution, answering the question – what is Aqualyx and how does it work:
Aqualyx has been approved in many areas of the world as a safe way to dissolve smaller pockets of fat, such as under the chin but has also been used on other areas like the stomach, hips, and thighs. It usually takes at least two treatments to show good results, and sometimes up to eight return visits are required.
Because of this, the cost is always a question on everyone’s mind. Compared to an all-out surgical procedure, such as liposuction, the cost is more affordable and you don’t have to go under anesthesia to have it done.
Although, if you have to have the treatment done repeatedly, it can still get rather pricey. The next post gives an idea of what to expect with the cost:
Aqualyx Review – Can A Sugar-Based Substance Be Helpful As Weight Loss Shots?
The first concern we have is the Aqualyx price. According to our Research Editor, âThe actual cost of these fat-loss injections is $600 to $700 per treatment, which is unaffordable for many people.â
Read the original post here:Â Aqualyx Review – Can A Sugar-Based Substance Be Helpful As Weight Loss Shots?
So, if liposuction costs between $2,000 to $8,000 depending on the area you are having worked on, it is probably still more cost effective to do an injectable, especially if you consider the recovery time.
On the other hand,Â if you have to keep coming back numerous times for more injections, eventually you might want to weigh the pros and cons. Always consult with a reputable cosmetic surgeon about what is the best solution for you.
|michael_vassar3 on Recursive Self-Improvement||
Phil: Anthropic pressures should by default be expected to be spread uniformly through our evolutionary history accelerating the evolutionary and pre-evolutionary record of events leading to us rather than merely accelerating the last stretch.
Exponential inputs into computer chip manufacture seem to produce exponential returns with a doubling time significantly less than that for the inputs, implying increasing returns per unit input, at least if one measures in terms of feature number. Obviously returns are exponentially diminishing if one measures in time to finish some particular calculation. Returns will more interestingly be diminishing per unit labor in terms of hardware design effor per unit of depth to which a NP and exponential complexity class problems can be calculated, e.g. the number of moves ahead a chess program can look. OTOH, it bizarrely appears to be the case that over a large range of chess ranks, human players seem to gain effective chess skill measured by chess rank with roughly linear training while chess programs gain it via exponential speed-up.
Society seems to in aggregate get constant zero returns on efforts to cure cancer, though one can't rule out exponential returns starting from zero. OTOH, this seems consistent with the general inefficacy of medicine in aggregate as shown by the Rand study, which doesn't overturn the individual impacts, as shown by FDA testing, of many individual medical procedures. Life expectancy in the US has grown linearly while GDP per capita has grown exponentially, but among nations in the modern world life expectancy clearly has a different relationship to income, not linear, not logarithmic, more plausibly asymptotic moving towards something in the early 80s.
I'm glad that you consider the claim about turning object level knowledge metacognitive to be the most important and controvercial claim. This seems like a much more substantial and precise criticism of Eliezer's position than anything Robin has made so far. It would be very interesting to see you and Eliezer discuss evidence for or against sufficient negative feedback mechanisms, Eliezer's "just the right law of diminishing retunrs" existing.
|A Mysterious Anonymous Letter Was Allegedly Behind Targetâs Hampton Creek Recall|
The envelope of a letter sent to a retailer this summer, containing allegations about Hampton Creek's products. The return address names Josh Tetrick, Hampton Creek's CEO; the company says he did not write this letter.
An investigator hired by Hampton Creek, the Silicon Valley food startup famous for its eggless mayonnaise, says a mysterious entity appears to be trying to sabotage it.
An unsigned letter sent this summer to an unnamed major retailer claimed that Hampton Creek had contaminated and mislabeled products, according to the investigator. And the return address indicated that it was from CEO Josh Tetrick — even though Hampton Creek denies he wrote it.
The investigator told BuzzFeed News this was one of two known such anonymous letters — and the other was sent to Target, which issued a high-profile recall of Hampton Creek’s products as a result.
While it’s unclear whether the two letters were identical or sent by the same person, the identity of the sender or senders is “the million-dollar question,” said the investigator, who requested anonymity. “It’s clearly fraud.” He also said that Hampton Creek is “weighing their legal options.”
At the time of its recall in late June, Target publicly said that the allegations it had received were unconfirmed, but specific and serious enough to warrant action.
Those claims included allegations that pathogens like salmonella and listeria were found in Hampton Creek products and at one of the facilities where the company’s products are made; that some products were incorrectly labeled as non-genetically modified; and that the company failed to list honey as an ingredient in its sweet mustard salad dressing.
Bryan Bedder / Getty Images
This week, Hampton Creek said it’s working to get back on Target’s shelves after the Food and Drug Administration reviewed its products and told the company it found nothing of concern. Target had carried around 20 of Hampton Creek’s items, which include eggless mayonnaise, cookies, cookie dough, and salad dressing.
“More than a month ago, Target was led to believe that several of our products were mislabeled or unsafe,” Hampton Creek spokesperson Andrew Noyes said in a statement. “We’ve remained confident that our products were safe and properly labeled, and that when presented with the facts, the FDA would agree. As expected, they have. They informed us, after reviewing applicable evidence, that the matter is closed.”
A Target spokesperson did not immediately return a request for comment.
News of the Target recall was originally broken by Bloomberg. The investigator said that in addition to being mailed in an envelope with a return label that falsely named Tetrick, the letter also indicated that a copy was sent to Bloomberg.
This is the latest twist in a tumultuous summer for Hampton Creek. Last month, Bloomberg reported that at least five members have left the startup’s board of directors, leaving only Tetrick.
But on Tuesday, Hampton Creek also got the effective green light from the FDA to use a proprietary ingredient — a mung bean protein isolate — in a forthcoming product, Just Scramble, an egg substitute that scrambles like an egg.
Herzliya Medical Center, the leading private hospital in Israel is honored to introduce the newly renovated, state of the art and advanced Catheterization center. The best team of medical experts await to care, assist and provide for you, in your time of need.
Catheterization â the procedure
Catheterization is a diagnostic procedure that aids in detecting and negating sclerotic processes in blood and cardiac vessels, while eliminating existing blockage. A tiny catheter is inserted and contrast material is injected.
The physician, medical staff and x-ray technicians are able to observe and monitor continuous x-ray, actual imaging, allowing for the detection of blood vessel blockage. once obstruction is determined the relevant treatment plan is implemented.
The Catheterization process allows for actual diagnostic and relevant immediate treatment.
Above all, the priorities of the doctors and the entire medical staff are the health and well-being of the patient and promoting and improving life-quality.
A personalized treatment plan is applied, based on medical history and personal information (age, gender) for each individual patient, together with diagnostic, technical applications.
During the procedure the medical team applies physiological measurements, "FFR" â Fractional Flow Reserve management, which monitoring arterial blood flow.
In comparison to other hospitals at Herzliya Medical Center, Catheterization are performed on a regular basis and are aimed on personalizing our unique treatment plan.
The most common conservative treatments for lowering risk factors are medications, to regular healthy cholesterol and blood pressure levels, as well as, a healthier diet and exercise strategy.
Therapeutic heart catheterization
If there is significant narrowing of the arteries observed, it may be found necessary to insert a balloon and a stent that secrete the most up to date medications, helping to preserve normal blood flow.
Diagnosis â surgical intervention
There are cases that reveal the need for by-pass surgery, due to significant blockage of the blood vessels. In this situation, depending on urgency, the patient is transferred to the heart institute and will be treated by one of the leading cardiac surgeons in the country, of his own choice.
The importance of choosing the correct Catheterization theatre
Catheterization is a safe conventional procedure that has been performed for decades on countless patients.
Herzliya medical center has recently acquired a state of the art "continuous monitoring x-ray imagine deviceâ that allows for actual on-line display of the patientsâ blood vessels. These on-line x-rays views, that are displayed on large screens in the cauterization theatre at all times, accompanied by a small amount of contrast material that is injected, allowing for the doctor and medical staff to view on a constant basis, blood flow in large areas of the body simultaneously and to perform the necessary treatment with optimum technique and precision.
This newly designed theatre, together with cutting-edge technology is the sole Catheterization center in Israel that has sufficiently reduced the radiation intensively by 70%.
The three main instruments used during the Catheterization procedure:
Catheterization - a common procedure and the importance of the specific doctor who performs the process
It is true that this is a common procedure and years of experience is crucial to make the difference, especially in regard to invasive procedures. Here at HMC, our doctors the most experienced expertise medical professional are here for you. The medical team and x-ray technicians are able to observe and monitor continuous x-ray imaging at all times, allowing for the detection of blood vessel blockage. once obstruction is determined, the relevant treatment plan is implemented.
As a patient in our private hospital you are entitled to determine the doctor of your choice. We are obligated and honor your decisions and the doctor named will accompany you through all stages of your treatment plan.
We commit that all of our doctors will have senior status, with years of experience, guaranteeing you "peace of mind".
Safety and quality
The HMC Catheterization theatre is unique in Israel, recently designed as a most modern center with maximum safety measures employed. The center is hermetically sealed to guarantee the utmost sterility while the patient receives high quality treatment and privacy.
Following Catheterization procedure
Following the Catheterization procedure the patient is transferred to the admittance ward, where he receives VIP service, as it is our priority and policy to extend excellent care.
|Endo Pills - 11||InformaÃ§Ã£o cientifica de aÃ§Ã£o rÃ¡pida|
Ano 3 NÂ° 11
Curso de EspecializaÃ§Ã£o em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
Prof.: Luiz CÃ©sar Povoa (A47)
Ricardo Martins Rocha Meirelles (A37)
Editores: Rosa Rita Santos Martins (A33) e Isabela Bussade (A6)
Editores Associados: Walmir Coutinho (A21), Edna Pottes (A34) e Claudia Pieper
ComposiÃ§Ã£o GrÃ¡fica: Wallace Margoniner
Iniciamos o terceiro ano do Endopills o que nos deixa muito orgulhosos. Para os novos que chegam, a nossa proposta Ã© fazer uma publicaÃ§Ã£o produzida pelos alunos para os alunos com informaÃ§Ãµes mÃ©dicas atualizadas e resumidas sobre trabalhos a serem publicados ou recÃ©m publicados alÃ©m da discussÃ£o de caso clÃnico e opiniÃ£o de especialistas convidados para discutirem assuntos âpalpitantesâ.GraÃ§as ao trabalho meticuloso, dedicado e competente da Dra Rosa Rita foi possÃvel chegarmos atÃ© aqui. Conduzindo como exÃmia maestra, junto aos professores Dr. Luiz CÃ©sar, Dr.Ricardo e os editores Dr. Walmir,Dra Edna e Dra Claudia, a seleÃ§Ã£o, correÃ§Ã£o e ediÃ§Ã£o dos textos trabalhados pelos alunos, Dr Rosa foi ,Ã© e sempre serÃ¡ fundamental neste projeto inovador. Considerando a admiraÃ§Ã£o que temos pro ela, temos juntos um desafio e espero contar com todos: manter a qualidade do EndoPills e como fruto colher mais conhecimento e sabedoria para exercermos cada vez melhor a endocrinologia.
I. CASO CLÃNICO
Mulher de 59 anos admitida no hospital local com histÃ³ria de crescimento excessivo de pÃªlos na regiÃ£o da face, braÃ§os e parede abdominal associada a calvÃcie com padrÃ£o androgÃªnico.A paciente estava em amenorrÃ©ia hÃ¡ 4 anos.
Sua histÃ³ria patolÃ³gica pregressa incluÃa diabetes tipo 2 , hipertensÃ£o arterial , tireoidectomia e sÃndrome de ovÃ¡rios micropolicÃsticos.
A avaliaÃ§Ã£o clÃnica inicial revelou nÃveis elevados de testosterona (8,9nmol/L, ref <2,5), Ãndice de testosterona livre (31,8, ref 0-7) e androstenediona (13,7nmol/L, ref <6,8).SHBG e DHEA estavam normais. Os exames de imagem da supra renal e ovÃ¡rios, TC e RM , estavam normais.Dosagem de esterÃ³ides na urina de 24 horas foi normal.
Teste com baixa doses de dexametasona revelou supressÃ£o do cortisol, mas apenas 20% e 40% de supressÃ£o de testosterona e androstenediona.A resposta de 17OH progesterona ao estimulo de ACTH foi normal com pico de androstenediona(>200) na veia adrenal esquerda.
1. Considerando esta amostra venosa vocÃª repetiria os exames de imagem?
2. VocÃª indicaria administraÃ§Ã£o de GnRH como prÃ³xima etapa no diagnÃ³stico?
3. Ã possÃvel tratar-se de malignidade?
DROGAS QUE DIMINUEM O COLESTEROL PROTEGEM CONTRA NEUROPATIA DIABÃTICA:
Um estudo epidemiolÃ³gico durante 8 anos na AustrÃ¡lia mostrou que as estatinas e os fibratos diminuem significantemente o risco do desenvolvimento de neuropatia perifÃ©rica sensorial diabÃ©tica.
A mÃ©dia de idade dos participantes no inÃcio do estudo foi de 64 anos, com diabetes diagnosticado hÃ¡ 4 anos sendo 48,8% homens e 30,9% destes apresentavam neuropatia.
A idade, duraÃ§Ã£o do diabetes, obesidade, glicemia de jejum, hipertensÃ£o sistÃ³lica, taxa de albuminÃºria urinÃ¡ria e raÃ§a foram fatores independentes no risco para neuropatia diabÃ©tica, enquanto os fibratos foram associados com reduÃ§Ã£o de 70% da prevalÃªncia de neuropatia perifÃ©rica.
Parece que os benefÃcios desses medicamentos sÃ£o efeitos de classe das drogas. Enquanto vÃ¡rios mecanismos jÃ¡ foram propostos, o mecanismo de aÃ§Ã£o da neuropatia permanece desconhecido. A grande teoria em relaÃ§Ã£o as estatinas esta relacionada com a reduÃ§Ã£o da inflamaÃ§Ã£o e estresse oxidativo.
Segundo o organizador do estudo, pessoas com diabetes devem usar essas drogas para proteÃ§Ã£o cardiovascular e para proteÃ§Ã£o de neuropatia. Apesar da escolha entre utilizar fibratos ou estatina nÃ£o ser fÃ¡cil, as estatinas em geral sÃ£o as drogas de primeira linha devido a elevada evidencia dos benefÃcios de prevenÃ§Ã£o cardiovascular. Lipid âlowering drugs protect against peripheral diabetic neuropathy.In Diabetes Today http://www.diabetes.org
Fabiano Marcel Serfaty (R2)
SALIVA â UM MARCADOR PARA O DIABETES TIPO 2
A saliva pode ser um marcador tanto para atividade de doenÃ§a periodontal como para hiperglicemia em diabetes tipo 2 descompensado, de acordo com uma nova pesquisa.
Carol W. Bassim, MD, pesquisador do Instituto Nacional de SaÃºde, em Bethesda, Maryland, Estados Unidos, notou que a saliva tem muito potencial como um marcador para doenÃ§a em periodontite e diabetes tipo 2.
"NÃ³s estamos vendo que a saliva pode ser um meio para verificar doenÃ§a periodontal e diabetes, mais do que o controle sÃ©rico", disse Dr. Bassim. "NÃ³s sabemos que a inflamaÃ§Ã£o e a infecÃ§Ã£o em doenÃ§a periodontal Ã© associada com o mau controle do diabetes tipo 2".
Investigadores estudaram prospectivamente indivÃduos que apresentavam periodontite severa ou doenÃ§a periodontal moderada. Todos tinham diabetes tipo 2 descontrolada. Especificamente, eles mediram procalcitonina salivar e correlacioram com o controle glicÃªmico no diabetes.
"NÃ³s sabemos que se vocÃª fica sÃ©ptico, por um momento, e tem inflamaÃ§Ã£o ou infecÃ§Ã£o sistÃªmica severa, o nÃvel de procalcitonina aumenta significativamente" disse Dr. Bassim.
Dr. Bassim e colegas coletaram amostras da saliva total nÃ£o estimulada atravÃ©s de expectoraÃ§Ã£o de 22 pacientes com periodontite e diabetes tipo 2 descontrolado; sua HbA1C excedia 7.0. Eles tambÃ©m realizaram um exame periodontal completo e coletaram sangue de cada indivÃduo.
A Pro CT salivar correlaciona se com sangramento gengival que indica doenÃ§a periodontal ativa. Em adiÃ§Ã£o, a Pro CT salivar foi correlacionada com a HbAlC, nas medidas basais e em trÃªs meses na visita de acompanhamento, nÃ£o se correlacionando diretamente com a HbAlC. Mais ainda, nÃveis sÃ©ricos de Pro CT nÃ£o se correlacionaram nem com os indicadores periodontais, nem com o controle glicÃªmico. NÃveis sÃ©ricos de Pro CT estavam diminuÃdos comparados aos da saliva: 92 vs. 246 pg/ml. âQuantidades salivares parecem importar mais do que as sÃ©ricas", observou Dr. Bassim.
Pesquisas futuras podem levar a um potencial biomarcador salivar para periodontite e diabetes tipo 2 mal controlado, de acordo com Dr. Bassim.
"NÃ£o hÃ¡ teste fÃ¡cil e rÃ¡pido para periodontite", disse Dr. Bassim. "Seria maravilhoso ter um biomarcador como a saliva neste sentido. Para os endocrinologistas, seria um meio rÃ¡pido e fÃ¡cil de observar os valores de HbA1C em uma aplicaÃ§Ã£o clÃnica e acompanhar estes valores." Procalcitonin: a salivary biomarker for periodontal disease activity and hyperglycemia in uncontrolled type II diabetes. Abstract P2-231 89th Meeting of Endocrine Society.http://www.diabetesincontro.com/results
Mariana Aparecida Machado Teixeira (C2)
DIABETES GESTACIONAL LIGADO AO CÃNCER
Mulheres que tiveram diabetes gestacional podem ter um risco maior de desenvolver cÃ¢ncer de pÃ¢ncreas, de acordo com pesquisadores americanos e israelitas, os primeiros a correlacionar as duas doenÃ§as.
Estudos prÃ©vios mostraram que pessoas com diabetes mellitus tipo 2 tem risco aumentado de cÃ¢ncer de pÃ¢ncreas, mas os novos resultados mostram uma ligaÃ§Ã£o com uma forma menos comum de diabetes causada pela liberaÃ§Ã£o de determinados hormÃ´nios e ganho de peso durante a gravidez.
CÃ¢ncer de pÃ¢ncreas Ã© particularmente letal devido ao diagnÃ³stico tardio e apenas 5 % das pessoas com a doenÃ§a sobrevive por 5 anos. Mais de 200 000 novos casos sÃ£o diagnosticados anualmente no mundo. Mary Perrin, uma pesquisadora da New York University's School of Medicine, disse que os dados novos precisam ser confirmados em estudos futuros, mas sÃ£o importantes porque o diabetes gestacional parece aumentar a taxa de risco para obesidade.
Em dÃ©cadas recentes, o diabetes tomou se mais comum nos Estados Unidos e em outros lugares, em parte devido ao crescimento das taxas de obesidade. Ã estimado que 20,8 milhÃµes de americanos tenham diabetes, principalmente o tipo 2. Alguns estudos tÃªm mostrado que o diabetes pode ser o sintoma inicial do cÃ¢ncer de pÃ¢ncreas.
Neste estudo, os pesquisadores analisaram os prontuÃ¡rios de 40000 mulheres que deram a luz entre 1964 e 1976 em JerusalÃ©m. Devido aos registros detalhados feitos em Israel, os pesquisadores puderam encontrar essas mulheres e avaliar quantas desenvolveram cÃ¢ncer de pÃ¢ncreas numa fase tardia da vida. O estudo mostrou que mulheres diagnosticadas com diabetes gestacional em uma ou mais gestaÃ§Ã£o, tinham risco 5 vezes maior de desenvolver cÃ¢ncer de pÃ¢ncreas.
Os achados representam um nÃvel estatÃstico significativo do risco e estudos futuros para correlacionar as duas doenÃ§as, disse Perrin. Ela acrescentou que o risco absoluto foi muito baixo.
"Realmente Ã© necessÃ¡rio ser confirmado em outros estudos, mas nÃ£o deve alarmar quem teve diabetes gestacional de que elas sÃ£o destinadas a ter cÃ¢ncer de pÃ¢ncreas", disse ela.
Gestacional diabetes linked to cÃ¢ncer. In Diabetes in control.com http:www.diabetesincontrol.com
Katiuscia de Carli Loureiro (C2)
ÃCIDO ZOLEDRÃNICO ANUAL FUNCIONA?
O Ã¡cido zoledrÃ´nico Ã© um bisfosfonato de terceira geraÃ§Ã£o, o mais potente disponÃvel no mercado. Os estudos prÃ© clinÃcos de toxicologia demonstraram um perfil farmacolÃ³gico similar ao dos outros bisfosfonatos. A formulaÃ§Ã£o aprovada recentemente pelo FDA e ANVISA, para tratamento da osteoporose, contÃ©m 5 mg de Ã¡cido zoledrÃ´nico e 100 mg de manitol e citrato de sÃ³dio como excipiente e deve ser administrada em infusÃ£o venosa durante 15 minutos. A droga atua na via do mevalonato inibindo a enzima farnesyl difosfato sintase, reduzindo a atividade osteoclÃ¡stica e promovendo a sua apoptose sem comprometer a formaÃ§Ã£o Ã³ssea ou a mineralizaÃ§Ã£o Ã³ssea. A via venosa tem sido proposta em decorrÃªncia da observaÃ§Ã£o de intolerÃ¢ncia esofÃ¡gica e baixa adesÃ£o a longo prazo dos bisfosfonatos orais.
Estudos clÃnicos demonstraram que os bisfosfonatos produzem um rÃ¡pido efeito anti reabsortivo aumentando a BMD da coluna lombar e do fÃªmur proximal apÃ³s 1 ano e resultados preliminares demonstram reduÃ§Ã£o do risco de fraturas vertebrais e nÃ£o vertebrais em pacientes de alto risco. Os marcadores de reabsorÃ§Ã£o Ã³ssea permanecem suprimidos durante 12 meses apÃ³s o uso da droga. Os eventos adversos mais comuns sÃ£o sintomas "flu like" (febre, mialgia, coriza) e nÃ¡useas, que podem melhorar com o uso preventivo de paracetamol. InsuficiÃªncia renal e necrose tubular renal tÃªm sido relatadas apÃ³s uso de Ã¡cido zoledrÃ´nico e, portanto a droga nÃ£o deve ser usada em pacientes com clearance de creatinina menor que 30 mi/min. Devemos estar atentos par o risco de hipocalcemia principalmente em pacientes com fatores de risco, como a deficiÃªncia de vitamina D ou sÃndromes de mÃ¡ absorÃ§Ã£o. A osteonecrose da mandÃbula tem sido relatada com maior freqÃ¼Ãªncia apÃ³s o uso dos bisfosfonatos injetÃ¡veis e a histÃ³ria de cirurgia dental recente ou extraÃ§Ã£o dentÃ¡ria, infecÃ§Ã£o ou trauma sÃ£o contra indicaÃ§Ãµes ao uso do Ã¡cido zoledrÃ´nico.
Estudos clÃnicos de longo prazo e com maior nÃºmero de pacientes sÃ£o necessÃ¡rios, ao nosso ver, para confirmar a eficÃ¡cia e seguranÃ§a no tratamento da osteoporose.
Luiz Henrique de GregÃ³rio
RESPOSTA AO CASO CLÃNICO:
Os exames de imagem foram repetidos e mantiveram-se sem alteraÃ§Ãµes.
A paciente foi encaminhada a um serviÃ§o de referencia para investigaÃ§Ã£o onde foi administrado anÃ¡logo de GnRH( Buserilin por 4 semanas) que reduziram de forma significativa os nÃveis de androgÃªnios tendo sido feito diagnostico de hiperandrogenismo ovariano e a mesma encaminhada para cirurgia.
O histopatolÃ³gico de mostrou hiperplasia estromal difusa sem evidencia de malignidade.
A funÃ§Ã£o ovariana pÃ³s menopausa estÃ¡ associada com reduÃ§Ã£o de folÃcluos produtores de estradiol e cÃ©lulas granulosas com persistÃªncia de cÃ©lulas do estroma medular.O diagnÃ³stico diferencial se faz com tumor de cÃ©lulas produtoras de androgÃªnios e hiperplasia estromal. A paciente tinha histÃ³ria previa de PCO e ainda nÃ£o Ã© claro atÃ© que ponto estes achos histopatolÃ³gicos possam representar a evoluÃ§Ã£o a longo prazo do PCO, uma proliferaÃ§Ã£o celular caracterÃstica do perÃodo de peri pÃ³s menopausa, ou uma combinaÃ§Ã£o de ambos.
|Endo Pills - 10||InformaÃ§Ã£o cientifica de aÃ§Ã£o rÃ¡pida|
Ano 2 NÂ° 10
Curso de EspecializaÃ§Ã£o em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
Prof.: Luiz CÃ©sar Povoa
Ricardo Martins Rocha Meirelles
Editores: Rosa Rita Santos Martins e Isabela Bussade
Editores Associados: Walmir Coutinho, Edna Pottes e Claudia Pieper
ComposiÃ§Ã£o GrÃ¡fica: Wallace Margoniner
Chegamos ao final do segundo ano do Endopills. Neste perÃodo tivemos sempre em mente o objetivo do Dr. LuÃs CÃ©sar Povoa: um folhetim feito pelos alunos para os alunos com o objetivo de fornecer informaÃ§Ãµes sobre trabalhos a serem publicados ou recÃ©m-publicados. Com o tempo fizemos algumas modificaÃ§Ãµes, como a introduÃ§Ã£o de um caso clÃnico, artigos de revisÃ£o e atualizaÃ§Ãµes. Com este nÃºmero encerro minha colaboraÃ§Ã£o com o Endopills, com a certeza de que nada contribui mais para o crescimento de uma idÃ©ia do que a sua renovaÃ§Ã£o, assim a partir do prÃ³ximo nÃºmero a ediÃ§Ã£o estarÃ¡ sob a responsabilidade da Dra. Isabela Bussade. AgradeÃ§o a todos os alunos que nestes dois anos colaboraram com o sucesso deste trabalho.
Rosa Rita dos Santos Martins
I. CASO CLÃNICO
Uma mulher de 45 anos com histÃ³ria de falÃªncia ovariana prematura (POF) desde os 35 anos e hipotireoidismo diagnosticado aos 40 anos faz terapia de reposiÃ§Ã£o hormonal diÃ¡ria com 2mg de estradiol e 2,5 mg de medroxiprogesterona. Tem cariÃ³tipo normal e Ultra-som transvaginal tambÃ©m normal. Sua densidade mineral Ã³ssea Ã© adequada. Na histÃ³ria familiar duas irmÃ£s gÃªmeas dizigÃ³ticas, uma delas tambÃ©m com diagnÃ³stico de POF e uma terceira irmÃ£ com 30 anos em tratamento para infertilidade e um irmÃ£o com dificuldades de comportamento, sem especificar quais.
Pergunta-se: Com essa histÃ³ria familiar qual conduta vocÃª recomendaria?
a) suspender a medicaÃ§Ã£o e realizar a prova de LH-RH.
b) repetir o cariÃ³tipo.
c) pesquisar, por tÃ©cnica de biologia molecular, mutaÃ§Ãµes do gene FMR1.
A resposta e discussÃ£o estÃ£o no final do Endopills.
NOVOS FATORES DE RISCO PARA CÃNCER DE MAMA:
A maioria das candidatas Ã prevenÃ§Ã£o do cÃ¢ncer de mama nÃ£o aceita usar o tamoxifeno por perceberem uma relaÃ§Ã£o custo-benefÃcio desfavorÃ¡vel. Atualmente os risco potencias para este cÃ¢ncer sÃ£o: histÃ³ria familiar, idade, atipia celular em biÃ³psia de nÃ³dulos benignos e fatores reprodutivos. Seria importante avaliar aquelas em que o risco Ã© realmente elevado para o risco de cÃ¢ncer de mama. A densidade mamogrÃ¡fica, fator de risco mais importante, nÃ£o Ã© rotineiramente empregado. Os nÃveis plasmÃ¡ticos de estrogÃªnio e androgÃªnio, densidade Ã³ssea, ganho de peso, idade da menopausa e histÃ³ria de fratura sÃ£o tambÃ©m potencialmente importantes, mas nÃ£o tÃªm sido usados em um modelo compreensivo de prediÃ§Ã£o de risco, devido Ã falta de validaÃ§Ã£o em estudos prospectivos. Um grupo colaborativo de PrevenÃ§Ã£o do CÃ¢ncer de Mama se reuniu para examinar criticamente e, por anÃ¡lise multivariada, os fatores de risco que poderiam ser selecionados usando o material clÃnico jÃ¡ existente para indicar quais mulheres se beneficiariam do uso preventivo do tamoxifeno. Santem, R. et al. Critical assessment of new factors for breast cancer: considerations for development of an improved risk prediction model. Endocrine-Related Cancer, 14(2) 167-187, 2007.
Vicente Lopes da Silva JÃºnior (R1)
TRATAMENTO DE INFERTILIDADE ANOVULATÃRIA EM PACIENTES COM SOP:
Citrato de clomifeno (CC) Ã© uma droga chave prescrita na infertilidade anovulatÃ³ria, porÃ©m estudos recentes indicam que a metformina tambÃ©m pode induzir ovulaÃ§Ã£o em pacientes com SOP. Stefano Palomba e cols da Universidade de Magna Graecia, na ItÃ¡lia, compararam a eficÃ¡cia da metformina com o clÃ¡ssico tratamento com CC. Foram incluÃdas no estudo pacientes com SOP e infertilidade anovulatÃ³ria, pareadas para idade e IMC. NÃ£o houve diferenÃ§a estatÃstica no sucesso da induÃ§Ã£o da ovulaÃ§Ã£o entre metformina e CC (55,4% vs 59,8%), no nÃºmero de gestaÃ§Ãµes por ciclo ovulatÃ³rio (10,8% vs. 11,2%) e no nÃºmero de abortos (19,5% vs 26,3%). A taxa cumulativa de gestaÃ§Ãµes (62,9% vs 48,6%) tambÃ©m nÃ£o variou significativamente. Entretanto, houve diferenÃ§a nas respostas clÃnicas. O tempo mÃ©dio para a primeira gravidez com o uso de metformina foi de sete meses e de cinco meses nas pacientes em uso de CC. A taxa de gravidez por ciclo ovulatÃ³rio foi constante para metformina; enquanto que mais de 70% das gestaÃ§Ãµes ocorreram durante os primeiros trÃªs ciclos do tratamento com CC. O estudo demonstrou que ambas, metformina e CC, sÃ£o tratamentos eficazes para infertilidade em pacientes com SOP. Estudos mais longos sÃ£o necessÃ¡rios para determinar se a metformina pode ter um resultado clÃnico melhor, embora seja reconhecida a aÃ§Ã£o mais rÃ¡pida do CC. Palomba S et al. Clomiphene Versus Metformin for Ovulation Induction in Polycystic Ovary Syndrome: Barbieri J Clin Endocrinol Metab.2007; 92: 3399-3401.
Aline Pereira Pedrosa (R1)
O PAPEL DA P27 NO DESENVOLVIMENTO OVARIANO E NA INFERTILIDADE:
Em humanos os mecanismos moleculares envolvidos no recrutamento e ativaÃ§Ã£o do folÃculo ovariano que controlam a reproduÃ§Ã£o feminina, menopausa e doenÃ§as como falÃªncia ovariana prematura (POF), sÃ£o pouco compreendidos. Estudos prÃ©vios sugerem que o inibidor 1B quinase ciclina dependente poderia retardar o crescimento do ovÃ³cito e o desenvolvimento folicular. Singareddy Rajareddy, Kui Liu e cols tÃªm estudado o desenvolvimento ovariano controlado pela p27 em camundongos atravÃ©s da hipÃ³tese de que a p27 suprimiria o recrutamento e a ativaÃ§Ã£o folicular e promoveria a morte folicular. Os pesquisadores descobriram que camundongos com a p27 ausente (p27 -/-) tinham a ativaÃ§Ã£o de folÃculos pÃ³s-natais acelerada e o dobro de folÃculos recrutados em relaÃ§Ã£o aos camundongos p27+/+. A ausÃªncia de p27 nos ovÃ¡rios causou ativaÃ§Ã£o prematura do âpoolâ de folÃculos primordiais e impediu a morte folicular maciÃ§a que normalmente ocorre antes da maturaÃ§Ã£o sexual. AtivaÃ§Ã£o excessiva do âpoolâ folicular em camundongos p27-/- deixou estes ovÃ¡rios amplamente exauridos de folÃculos no inÃcio da vida adulta, causando POF. Os autores estudaram exaustivamente os mecanismos moleculares envolvidos no controle do desenvolvimento folicular por mecanismos diversos nas diferentes etapas do desenvolvimento ovariano e concluÃram que o gene p27 Ã© importante na determinaÃ§Ã£o do desenvolvimento ovariano dos mamÃferos. Desta forma, o estudo fornece uma idÃ©ia sobre o papel das mutaÃ§Ãµes genÃ©ticas que causam infertilidade e defeitos na folÃculogÃªnese. Rajareddy S, Reddy P, Du C, et al. p27kip1 (Cdkn1b) controls ovarian development by supressing follicle endowment and activation, and promoting follicle atresia in mice. Mol Endocrinol. 21(9):2189-2202.
Carolina Preissler (C1) e Caroline Wust do Nascimento Gaya (C1)
OBESIDADE INFANTIL INDICA ALTO RISCO DE FALTA ESCOLAR:
Em estudo pioneiro de como o peso corporal pode afetar a assiduidade escolar, pesquisadores da Universidade da PensilvÃ¢nia apontaram o sobrepeso infantil como um grande fator de risco de ausÃªncia escolar em relaÃ§Ã£o aos alunos com peso corporal normal. O estudo envolveu mais de 1000 estudantes de 4Âª, 5Âª e 6Âª sÃ©ries de escolas da FiladÃ©lfia e determinou que o Ãndice de massa corporal (IMC) Ã© um fator determinante significativo do nÃ£o comparecimento escolar, assim como idade, etnia, nÃvel socioeconÃ´mico e sexo, considerados formalmente como os quatro principais preditores. Verificou-se ainda que alunos com sobrepeso faltam em mÃ©dia 20% mais que os demais com peso normal. Segundo os autores o que os mantÃ©m longe da escola, mais do que as questÃµes de saÃºde sÃ£o o estigma e a intimidaÃ§Ã£o que essas crianÃ§as sofrem. Novos trabalhos devem explorar esse aspecto danoso que acompanha o sobrepeso. As taxas de obesidade na infÃ¢ncia triplicaram nos EUA nos Ãºltimos 25 anos. AlÃ©m dos 4 indicadores tradicionalmente descritos, verificou-se que a combinaÃ§Ã£o de sexo masculino e pior nÃvel socioeconÃ´mico aumentaram consideravelmente a ausÃªncia escolar, contudo, o IMC se tornou o melhor indicador de falta de assiduidade do que os 4 indicadores jÃ¡ descritos. Essa pesquisa foi apoiada pelo National Institute of Health, e seus achados se encontram disponÃveis na ediÃ§Ã£o de agosto do jornal Obesity e tambÃ©m no endereÃ§o eletrÃ´nico http://www.docguide.com .
Carlos Eduardo Santos (R1)
75% DOS DIABÃTICOS TÃM DEFICIÃNCIA DE B1 LEVANDO A PROBLEMAS VASCULARES:
Uma deficiÃªncia de tiamina (vitamina B1) pode ser a chave dos problemas vasculares em pacientes diabÃ©ticos tanto do tipo 1 quanto do tipo 2 da doenÃ§a. A incidÃªncia do diabetes vÃªm aumentando e um dos problemas dessa patologia Ã© sua associaÃ§Ã£o com complicaÃ§Ãµes micro vasculares com dano ao rim, a retina e aos nervos perifÃ©ricos e complicaÃ§Ãµes macro vasculares, tais como a doenÃ§a cardÃaca. Em um artigo publicado na revista Diabetologia, foi citado que a concentraÃ§Ã£o de tiamina no plasma do sangue estava 76% diminuÃda no tipo I diabÃ©tico e 75% no tipo 2. Estudos passados tinham considerado a atividade normal desta enzima e supunham nÃveis normais de tiamina quando de fato a atividade da enzima era normal devido Ã s quantidades aumentadas de duas proteÃnas THTR-1 e RFC-1 que ajudam a transportar a tiamina em glÃ³bulos vermelhos. Os nÃveis aumentados destas proteÃnas era uma resposta direta pela deficiÃªncia de tiamina no corpo. Os autores concluÃram que a baixa concentraÃ§Ã£o de timina Ã© prevalente em pacientes com diabetes tipo 1 e 2, associado a um clearence aumentado da tiamina. Thornalley, J. et al. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia, Volume 50 (10): 2164-2170, 2007
Nathalia Fernandes dos Santos (C1 )
III. ARTIGOS DE REVISÃO
PREVALÃNCIA DE DIABETES CRESCE 5% ANUALMENTE DESDE 1990:
Um novo estudo do Centro para controle e prevenÃ§Ã£o de doenÃ§as (CDC) mostra que a prevalÃªncia da diabetes cresce 5% anualmente desde 1990, e que esta tendÃªncia de incidÃªncia coincide com os dados de prevalÃªncia, de acordo com os registros apresentados na 67a SessÃ£o CientÃfica Anual da AssociaÃ§Ã£o Americana de Diabetes. Segundo a Dra. Linda S. Geiss, M A, chefe do serviÃ§o de vigilÃ¢ncia de diabetes (Diabetes Program, Center of Disease Control and Prevention), este aumento estÃ¡ intimamente relacionado com o crescimento da obesidade e se os sistemas de saÃºdem quiserem resistir ao fardo crescente do diabetes, precisam aprimorar esforÃ§os preventivos. O diabetes pode levar a complicaÃ§Ãµes fatais ou severamente debilitantes, como doenÃ§as cardÃacas, cegueira, doenÃ§a renal e amputaÃ§Ãµes. O diabetes tipo 2, que responde por 90 a 95 % de todos os casos diagnosticados de diabetes, envolve resistÃªncia insulÃnica - a incapacidade do organismo de usar adequadamente a sua prÃ³pria insulina e costumava ocorrer principalmente em adultos, acima do peso e com 40 anos ou mais, entretanto como crianÃ§as e adolescentes vem se tornando cada vez mias inativos e com peso acima do normal este quadro tem ocorrido em pessoas mais jovens. O estudo usou os dados de 1963 a 2005 de um levantamento de saÃºde nacional, para obter taxas de prevalÃªncia e incidÃªncia para idade e seus desvios-padrÃ£o. Foram identificados trÃªs perÃodos distintos na taxa de diabetes existente na populaÃ§Ã£o em um determinado tempo: 1963 a 1975, entre 1975 e 1990 e de 1990 a 2005. Neste Ãºltimo perÃodo a incidÃªncia de novos casos de diabetes aumentou de 4 a 7,7 por 1000 (5,1% anualmente). Os autores dÃ£o vÃ¡rias hipÃ³teses para explicar as diferenÃ§as nas incidÃªncias, entre elas a observaÃ§Ã£o da contribuiÃ§Ã£o da obesidade crescente para a ascensÃ£o do diabetes iniciada em 1990. Todos os dados desse trabalho podem ser acessados pelo site www.diabetes.org.
Mariana Aparecida Machado Teixeira (C 1)
Inicialmente pensada como uma forma rara de hipertensÃ£o, atualmente o hiperaldosteronismo primÃ¡rio Ã© uma causa bem definida de elevaÃ§Ã£o da pressÃ£o arterial, correspondendo a 5-13% dos pacientes hipertensos. O tratamento visa Ã reduÃ§Ã£o da morbimortalidade associada com hipertensÃ£o e dano cardiovascular. Originalmente, o hiperaldosteronismo nÃ£o era suspeitado, a menos que o paciente apresentasse hipertensÃ£o e hipopotassemia espontÃ¢nea. Atualmente, sabemos que a maioria dos pacientes nÃ£o apresenta essa hipopotassemia. A identificaÃ§Ã£o dos casos estÃ¡ baseada na dosagem de aldosterona e da atividade da renina plasmÃ¡tica. Um teste positivo deve ser confirmado com teste de supressÃ£o com sobrecarga oral de sÃ³dio para avaliar secreÃ§Ã£o autÃ´noma. A etapa final do diagnÃ³stico consiste em diferenciar entre os sete subtipos do hiperaldosteronismo primÃ¡rio, jÃ¡ que o tratamento varia de acordo com cada subtipo. O adenoma produtor de aldosterona (APA) e o hiperaldosteronismo bilateral idiopÃ¡tico sÃ£o os subtipos mais comuns. A adrenalectomia unilateral em pacientes com APA ou hiperplasia adrenal unilateral resulta em normalizaÃ§Ã£o da hipocalemia; nas formas bilaterais de hiperaldosteronismo primÃ¡rio a adrenalectomia unilateral raramente corrige a hipertensÃ£o e os pacientes devem ser tratados com antagonistas do receptor mineralocorticÃ³ide. Primary aldosteronism: renaissance of a syndrome. Clinical Endocrinology 66(5): 607-618, May 2007.
Rachel Gazzola Giovanella (C2)
RESUMO DO RELATÃRIO CIENTÃFICO SOBRE OS DESAFIOS DA REGULAMENTAÃÃO DA NANOTECNOLOGIA PELO FDA (25/07/20007).
A Nanotecnologia permite aos cientistas trabalharem com produtos e substÃ¢ncias tÃ£o pequenas que sÃ£o medidas em nanoescala, com o tamanho equivalente a bilionÃ©sima parte do metro. Por exemplo, a espessura de uma folha de papel e do cabelo humano equivalem, respectivamente, a 100.000 e 80.000 nanÃ´metros. Esta nova e promissora tecnologia vÃªm despertando grande interesse no mundo cientÃfico e industrial. Em 1990, aproximadamente 1000 publicaÃ§Ãµes cientÃficas foram identificadas, ao passo que em 2002 o nÃºmero de publicaÃ§Ãµes nessa Ã¡rea subiu para 22.000. Esse crescimento exponencial foi resultado de grandes descobertas e investimentos da qual vem resultando numa intensa e contÃnua modificaÃ§Ã£o dos produtos que deverÃ£o ser regulamentados pelo FDA. Desta forma, a partir de julho deste ano, o FDA, atravÃ©s da entÃ£o denominada âForÃ§a Tarefa em Nanotecnologiaâ, liderada pelo Dr. Von Eschenbach, passou a apresentar como objetivo direcionar e regularizar cientificamente o desenvolvimento desta nova tecnologia, liberando assim um relatÃ³rio de recomendaÃ§Ãµes sobre os benefÃcios e riscos da tecnologia em nanoescala. Este grupo tem como responsabilidade formar e manter um programa de desenvolvimento e pesquisa para desvendar o grande potencial da nanotecnologia, facilitando a transferÃªncia desta nova tecnologia para os produtores de modo a promover o crescimento da economia, empregos e outros benefÃcios pÃºblicos, alÃ©m de desenvolver recursos educacionais para suportar a infra-estrutura e as ferramentas necessÃ¡rias para o avanÃ§o dessas pesquisas. As substÃ¢ncias em nanoescala geralmente tÃªm propriedades quÃmicas, fÃsicas e biolÃ³gicas diferentes que modificam suas caracterÃsticas eletro-magnÃ©ticas, interferindo significativamente nas atividades quÃmico-biolÃ³gicas, o que lhe conferem superioridade de aÃ§Ã£o. Estudos em laboratÃ³rios determinam que a superfÃcie de Ã¡rea por unidade de volume (massa) e a carga elÃ©trica (+/-) sÃ£o os principais determinantes das interaÃ§Ãµes biolÃ³gicas . Assim, quaisquer modificaÃ§Ãµes no tamanho ou mudanÃ§a na carga elÃ©trica de uma determinada substÃ¢ncia podem determinar grandes diferenÃ§as de interaÃ§Ã£o. Por exemplo, vesÃculas lipÃdicas, carregadas positivamente, tÃªm a capacidade de induzir edema cerebral, ao contrÃ¡rio daquelas neutras ou negativamente carregadas. ModificaÃ§Ãµes da superfÃcie de materiais como surfactantes e polÃmeros biocompatÃveis (PEG) tÃªm sua toxicidade reduzida in vitro e alterada a sua meia-vida e deposiÃ§Ã£o tecidual in vivo. Desta forma, as interaÃ§Ãµes biolÃ³gicas sÃ£o influenciadas particularmente pela composiÃ§Ã£o fÃsico-quÃmica de substÃ¢ncias em nanoescala, bem como pela superfÃcie de Ã¡rea independentemente da sua massa. Organizar e desenvolver estudos usando a farmacocinÃ©tica, fisiologia e caracterÃsticas como tipo, tamanho, carga elÃ©trica e superfÃcie das partÃculas em nanoescala serÃ¡ particularmente Ãºtil para a compreensÃ£o geral das suas interaÃ§Ãµes biolÃ³gicas. Por isso, o FDA terÃ¡ que treinar e capacitar membros que deverÃ£o ter vastos conhecimentos na Ã¡rea de farmacologia, toxicologia, biologia, fÃsica, quÃmica e medicina para regulamentar as decisÃµes a serem aprovadas por esse Ã³rgÃ£o na Ã¡rea de nanotecnologia. Uma das grandes dificuldades para a regulamentaÃ§Ã£o das nanosubstÃ¢ncias se encontra no fato dos testes in vitro serem incapazes de determinar real seguranÃ§a, uma vez que avaliam um Ãºnico ou poucos tipos celulares. A detecÃ§Ã£o e estudo dos materiais em nanoescala em certos produtos necessitam de equipamento altamente sofisticados, caros e de mÃ£o de obra extremamente especializada, que parecem estar pouco disponÃveis atÃ© o momento. Eles vem sendo desenvolvidos e estudados nÃ£o sÃ³ na Ã¡rea de farmacologia como tambÃ©m nas Ã¡reas de materiais mÃ©dicos, indÃºstria alimentÃcia e cosmÃ©tica. Desta forma, o FDA e as 22 outras agÃªncias federais que fazem parte da NNI (National Nanotechnology Initiative) nÃ£o estÃ£o medindo esforÃ§os para a realizaÃ§Ã£o de pesquisas e programas de desenvolvimento para o estabelecimento de coordenadas para o uso eficaz e seguro dessa promissora forma de tecnologia, que parece ser indispensÃ¡vel para a criaÃ§Ã£o de novas abordagens diagnÃ³sticas e terapÃªuticas na Ã¡rea de biomedicina assim como tambÃ©m nas Ã¡reas cosmÃ©ticas e da indÃºstria alimentÃcia. Veja o relatÃ³rio completo no site www.fda.gov/nanotechnology/taskforce/report2007.pdf.
CÃ¡tia Ferreira de AraÃºjo
RESPOSTA DO CASO CLÃNICO: (c)
A histÃ³ria familiar da paciente sugere a presenÃ§a nessas mulheres da prÃ©-mutaÃ§Ã£o ou da mutaÃ§Ã£o do SÃtio FrÃ¡gil do Cromossomo X, que ocorre em 3.3% nas formas esporÃ¡dicas de POF e em 12% a 16% dos casos familiares. A prÃ©-mutaÃ§Ã£o Ã© definida como a presenÃ§a de 56 a 199 repetiÃ§Ãµes dos nucleotÃdeos CGG na regiÃ£o nÃ£o traduzida 5' do gene FMR1 (Fragile X Mental Retardation Syndrome), mapeado na regiÃ£o Xq27.3. Mais de 200 repetiÃ§Ãµes resultam na sÃndrome completa do SÃtio FrÃ¡gil de X nos filhos do sexo masculino. Esta sÃndrome cursa com retardo mental, comportamento autismo like, macroorquidismo e um fÃ¡cies caracterÃstico no sexo masculino. As mulheres portadoras podem ser clinicamente normais e do mesmo modo que as portadoras da prÃ©-mutaÃ§Ã£o apresentar menopausa precoce. O diagnÃ³stico Ã© feito pela pesquisa por Biologia Molecular do nÃºmero de repetiÃ§Ãµes CGG descritas acima. A histÃ³ria de um irmÃ£o com dificuldades de comportamento torna obrigatÃ³rio o aconselhamento genÃ©tico nessa famÃlia, principalmente na irmÃ£ em tratamento para infertilidade. Case studies from The Endocrine Society's Clinical Endocrinology.
Cristiane da Rocha Azevedo (C1)
|Endo Pills - 7||InformaÃ§Ã£o cientifica de aÃ§Ã£o rÃ¡pida|
Ano 2 NÂ°7
Curso de EspecializaÃ§Ã£o em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
Prof.: Luiz CÃ©sar Povoa (A45)
Ricardo Martins Rocha Meirelles (A35)
Editor: Rosa Rita Santos Martins (A31)
Editores Associados: Walmir Coutinho (A19)
Edna Pottes (A32)
ComposiÃ§Ã£o GrÃ¡fica: Wallace Margoniner
No EndoPills deste mÃªs nossa trajetÃ³ria de estudo vai desde a revisÃ£o de uma condiÃ§Ã£o clÃnica como a SÃndrome de Mauriac a trabalhos de pesquisa bÃ¡sica e clÃnica em osteoporose, incluindo um trabalho sobre osteoporose em homens na ArÃ¡bia Saudita, passando pela posiÃ§Ã£o de mÃ©dicos americanos sobre os hormÃ´nios bioidÃªnticos, discussÃ£o do real papel das isoflavonas no osso, pela diminuiÃ§Ã£o do nÃvel da testosterona nos homens na era atual, um novo tratamento para os mÃ³dulos tÃ³xicos e prÃ©-tÃ³xicos da tireÃ³ide e trÃªs trabalhos sobre pesquisas em obesidade.
Dra. Edna Pottes Pinto
RELAÃÃO DA OBESIDADE COM O CÃNCER VIA ESTROGÃNIO
As pesquisas tÃªm consistentemente demonstrado que a obesidade aumenta o risco de cÃ¢ncer. Mulheres na pÃ³s-menopausa, assim como roedores apÃ³s ooforectomia, freqÃ¼entemente se tornam obesas, sugerindo a importÃ¢ncia dos estrogÃªnios na manutenÃ§Ã£o da composiÃ§Ã£o corporal e na homeostase lipÃdica. Um grupo de pesquisadores de vÃ¡rias instituiÃ§Ãµes, liderado por Shoshana Yakar, Ph.D., da Mount Sinai School of Medicine, investigou a relaÃ§Ã£o entre sexo, obesidade e cÃ¢ncer â especificamente como o status estrogÃªnico nas mulheres obesas afeta o crescimento de tumores. O grupo injetou em ratos, modelo C57BL/6, linhagens celulares tumorais de pulmÃ£o e de colon por via subcutÃ¢nea pesquisando o aumento da velocidade de crescimento das cÃ©lulas tumorais em ratos obesos versus ratos controle. Os pesquisadores compararam entÃ£o os parÃ¢metros metabÃ³licos e o crescimento tumoral em ratas fÃªmeas ooforectomizadas e obesas intactas. As fÃªmeas obesas ooforectomizadas desenvolveram resistÃªncia insulÃnica e intolerÃ¢ncia a glicose em nÃveis similares aos machos obesos. A adiposidade corporal aumentou nas fÃªmeas ooforectomizadas independente da dieta administrada, e o crescimento tumoral se relacionou positivamente com a adiposidade corporal. Os pesquisadores afirmam que seus dados apontam para um crescimento tumoral mais rÃ¡pido em ratos obesos e que nas ratas, a ooforectomia aumenta a susceptibilidade Ã obesidade, resistÃªncia insulÃnica e crescimento tumoral, sugerindo que os estrogÃªnios endÃ³genos, junto com a dieta, afetam a adiposidade, a sensibilidade insulÃnica e o crescimento tumoral nas mesmas. O mecanismo que medeia o crescimento tumoral associado Ã obesidade Ã© incerto, e os autores planejam investigar possÃveis participaÃ§Ãµes do processo de sinalizaÃ§Ã£o insulina/IGF e ligado a adipocina. Os resultados foram publicados no artigo: Yakar, S. et al., Increased Tumor Growth in Mice with Diet-Induced Obesity: Impact of Ovarian Hormones. Endocrinology, Dec 2006; 147: 5826 - 5834.
Camila Mont-Serrat (C2)
DESVENDANDO OS MISTÃRIOS DA GORDURA: A IMPORTÃNCIA DA SUA LOCALIZAÃÃO E DOS GENES REGULADORES
Dentre os muitos mistÃ©rios sobre o tecido adiposo estÃ£o as dificuldades de se compreender como sua localizaÃ§Ã£o no corpo pode ser tanto benÃ©fica ou malÃ©fica para saÃºde, como sua interaÃ§Ã£o com a insulina pode predispor a obesidade e finalmente como influencia na sobrevida. O padrÃ£o de distribuiÃ§Ã£o de gordura e a relaÃ§Ã£o cintura/quadril sÃ£o programados de modo diferente nos vÃ¡rios grupos Ã©tnicos e tambÃ©m entre indivÃduos de uma mesma populaÃ§Ã£o, sugerindo algum padrÃ£o de hereditariedade. Pesquisas tÃªm sugerido que a gordura intra-abdominal ou visceral (GV) estocada centralmente, como no abdome, Ã© mais prejudicial que a gordura subcutÃ¢nea (SC) estocada perifericamente. Dr. Kahn citou nesta sua apresentaÃ§Ã£o a pesquisa que investiga as diferenÃ§as estruturais e funcionais entre o tecido adiposo branco nos seus dois depÃ³sitos principais no corpo e que a GV intra-abdominal, que se acumula com a idade, ligada Ã resistÃªncia insulÃnica e Ã sÃndrome metabÃ³lica, intrinsecamente, apresenta maior taxa lipolÃtica e produz e secreta relativamente menores taxas de leptina. O reverso permanece verdadeiro para o tecido celular SC. As GV e SC diferem nÃ£o somente em funÃ§Ã£o, mas talvez tambÃ©m nos vÃ¡rios tipos de cÃ©lulas com padrÃµes especÃficos de desenvolvimento e resposta ao receptor de insulina. O adipÃ³cito branco desenvolve-se tanto em precursor comum de cÃ©lula marrom quanto em cÃ©lula branca. O precursor comum de cÃ©lula branca posteriormente se diferencia em um dos dois tipos de cÃ©lula gordurosa branca-gordura visceral ou gordura subcutÃ¢nea. Ele descreveu a pesquisa de seu serviÃ§o onde analisaram a expressÃ£o gÃªnica da gordura intra-abdominal de roedores e a gordura SC ao redor, focando mais a expressÃ£o de genes de desenvolvimento do que o metabolismo. A analise inicial revelou que existem 6.174 genes diferentes entre os dois tipos de gordura e a anÃ¡lise posterior da expressÃ£o por âPCR em Tempo Realâ encontrou 198 padrÃµes de genes de desenvolvimento (homeobox - Hox) e destes, 12 que diferiam nos depÃ³sitos de GV e SC. Estes incluÃam genes cruciais do desenvolvimento como Tbox-15, Shox2, Sfrp2 e vÃ¡rios outros genes Hox. Em experimento posterior, o grupo mostrou que a expressÃ£o celular desses genes era diferenciada nos dois tipos de gordura, provando que ela era autÃ´noma nos dois tecidos. AlÃ©m disso, os autores observaram tambÃ©m que a expressÃ£o em fÃªmeas foi, em muitos casos, mais alta que em machos. Sabemos que Ã© muito importante entendermos porque algumas pessoas se tornam mais centralmente e outras perifericamente obesas e porque obesidade central pode predispor a sÃndrome metabÃ³lica. Este conhecimento poderÃ¡ um dia tornar possÃvel reprogramar o desenvolvimento do adipÃ³cito e atacar o problema global e nacional da obesidade. O Dr. Kahn discutiu ainda se a razÃ£o da gordura visceral ser tÃ£o ruim era nÃ£o somente pelo alto poder lipolÃtico, mas tambÃ©m pela liberaÃ§Ã£o de Ã¡cidos graxos livres que drenam imediatamente para o fÃgado onde eles podem regular o metabolismo. Inversamente, a gordura subcutÃ¢nea drena perifericamente e tÃªm menor expressÃ£o de fatores com efeitos deletÃ©rios. Suas conclusÃµes podem ser lidas no trabalho: Kahn, R. Getting to the Bottom of FatÂ´s Mysteries: the importance of genes and location. ENDOCRINENEWS (February, 2007): 17-18 ou acessado pelo site http://videocast.nih.gov./PastEvents.asp, clicar em Clinical Center Grand Rounds, na data January 10, 2007.
Ana LÃºcia Marinho Vinagre (C2)
COMO OS MACRÃFAGOS REGULAM A OBESIDADE NOS HUMANOS
A obesidade Ã© uma doenÃ§a inflamatÃ³ria crÃ´nica com hipertrofia de adipÃ³citos e formaÃ§Ã£o de novas cÃ©lulas no tecido adiposo. As cÃ©lulas nÃ£o inflamatÃ³rias do tecido adiposo seriam as responsÃ¡veis pela origem da inflamaÃ§Ã£o. Pesquisas em Paris e Frankfurt levantaram a hipÃ³tese da infiltraÃ§Ã£o de macrÃ³fagos afetarem a expansÃ£o da gordura com aÃ§Ã£o parÃ¡crina na diferenciaÃ§Ã£o do adipÃ³cito. Experimentos em ratos sugerem que macrÃ³fagos do tecido adiposo sÃ£o originados dos monÃ³citos circulantes no sangue. Neste estudo os prÃ©-adipÃ³citos foram condicionados em macrÃ³fagos isolados do sangue de pacientes com sobrepeso. Foi demonstrado baixo acÃºmulo de lipÃdios e reduÃ§Ã£o da expressÃ£o de marcadores âadipogÃªnicosâ e âlipogÃªnicosâ. Por causa do estÃmulo inflamatÃ³rio marcante houve uma mudanÃ§a do fenÃ³tipo dos macrÃ³fagos ativados por lipopolissacarÃdeos. O condicionamento de macrÃ³fagos estimulou a sinalizaÃ§Ã£o TF-kbeta (a chave da transcriÃ§Ã£o reguladora da inflamaÃ§Ã£o), aumentou a expressÃ£o do seu gene, realizou a prÃ³-inflamaÃ§Ã£o com citocinas e induziu a proliferaÃ§Ã£o dos prÃ©-adipÃ³citos. Os autores observaram tambÃ©m que se mantiveram os aumentos da expressÃ£o do gen ciclina D1 e da fibronectina da matriz. Estes e outros dados observados pelos autores demonstraram que fatores secretados pelos macrÃ³fagos inibem a formaÃ§Ã£o de adipÃ³citos maduros e possivelmente limitam a expansÃ£o de tecido adiposo em humanos. Ainda precisa ser entendido se o efeito proliferativo dos macrÃ³fagos ativados Ã© um fator chave dirigindo a resistÃªncia Ã perda de peso ou Ã freqÃ¼ente manutenÃ§Ã£o do peso em sujeitos obesos. A metodologia, os resultados e a discussÃ£o deste trabalho devem ser dos conhecimentos de todos os mÃ©dicos que se interessam por pesquisas em obesidade e podem ser buscados on line (com acesso livre ao trabalho) ou na referÃªncia: Lacasa, D. et al. Macrophage-Secreted Factors Impair Human Adipogenesis: Involvement of Proinflammatory State In Preadipocytes. Endocrinology (2007) Vol. 148, No. 2 868-877.
Carolina de Abreu GonÃ§alves MergulhÃ£o (C2)
NÃVEIS DE IGF-1 NA MEIA-IDADE E A FUNÃÃO COGNITIVA TARDIA
O Fator de Crescimento Insulina-sÃmile 1 (IGF-1) tem sido estudado por seu possÃvel papel protetor nas doenÃ§as degenerativas. Pesquisadores liderados por OlÃvia I. Okereke M.D., S.M., na Brigham and Womenâs Hospital em Boston, examinaram a relaÃ§Ã£o dos nÃveis plasmÃ¡ticos do IGF-1 na meia-idade com a cogniÃ§Ã£o na vida tardia. Usando amostras de sangue obtidas em 1982-1984 (idade mÃ©dia de 57 anos) do Physiciansâ Health Study II, o grupo mediu o IGF-1 livre em 376 homens e IGF-1 total e IGFBP-3 em 460. ComeÃ§ando em 2001, eles aplicaram a Entrevista TelefÃ´nica de Status Cognitivo (TICS) e testes de memÃ³ria verbal e fluÃªncia. Usando o score do TICS e da memÃ³ria verbal, e um score global da performance mÃ©dia, eles entÃ£o estimaram as principais diferenÃ§as ajustadas para as multivariÃ¡veis na performance cognitiva atravÃ©s dos nÃveis do IGF-1 livre e da relaÃ§Ã£o IGF-1/IGPBP-3. Os pesquisadores nÃ£o observaram nenhuma diferenÃ§a significativa entre o score de TICS e os nÃveis de IGF-1. Para a memÃ³ria verbal, cada aumento de SD no IGF-1 livre esteve significativamente associado com uma diferenÃ§a ajustada de 0,08U. Os resultados obtidos utilizando a razÃ£o IGF-1/IGFBP-3 nÃ£o foram estatisticamente significativos. O trabalho completo pode ser acessado em: OlÃvia, I. et al. Midlife Plasma Insulin-Like Growth Factor I And Cognitive Function In Older Men. J of Clinical Endocrin & Metab (2006), vol. 91, (11) 4306-4312.
Camila Mont-Serrat (C2)
COMO Ror2 PROMOVE A DIFERENCIAÃÃO DE OSTEOBLASTOS
Os osteoblastos derivam de cÃ©lulas tronco mesenquimais. A transiÃ§Ã£o da cÃ©lula tronco atÃ© o osteoblasto maduro Ã© controlada pelos fatores de transcriÃ§Ã£o Runx2 e osterix, assim como por diversos hormÃ´nios, fatores de crescimento e citocinas. O Ror2 Ã© um receptor tipo tirosina quinase conhecido por seu papel na morfogÃªnese, particularmente do esqueleto derivado de cartilagem. Sua expressÃ£o aumenta durante a diferenciaÃ§Ã£o das cÃ©lulas pluripotenciais em osteoblastos e se reduz quando estes progridem para osteÃ³citos, mostrando um papel na osteoblastogÃªnese. Para testar esta possibilidade cientistas do Wyeth Research in Collegeville estudaram os efeitos da expressÃ£o e regulaÃ§Ã£o do Ror2 na linhagem osteoblÃ¡stica. Eles mostraram que a expressÃ£o deste fator em cÃ©lulas mesenquimais atravÃ©s de infecÃ§Ã£o por adenovÃrus levou a formaÃ§Ã£o de matriz extracelular mineralizada. O Ror2 estimulou a osteoblastogÃªnese atravÃ©s da inibiÃ§Ã£o de fatores adipogÃªnicos e induÃ§Ã£o do fator de transcriÃ§Ã£o osterix. O mesmo efeito foi demonstrado em cÃ©lulas MC3T3-E1 (osteoblasto-like). Neste artigo os autores concluem que o Ror2 inicia o recrutamento de cÃ©lulas tronco mesenquimais para diferenciaÃ§Ã£o na linhagem osteoblÃ¡stica e promove a diferenciaÃ§Ã£o nas fases precoces e tardias da osteoblastogÃªnese. O trabalho completo e a discussÃ£o dos resultados pode ser lido no artigo. Lyu Y, Bhat RA, Seestaller-Wehr LM, et al. The orphn receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation. Mol Endocrinol (2007): 21:376-387.
Leandro Kasuki Jomori de Pinho (R2)
OSTEOPOROSE NOS HOMENS DA ARÃBIA SAUDITA: UM ESTUDO-PILOTO
De acordo com a OMS, 55% das pessoas acima de 50 anos nos EUA apresentam osteoporose. Estudos indicam uma incidÃªncia de osteoporose na pÃ³s-menopausa de 30 a 40%, e de osteopenia de mais de 60%. Na ArÃ¡bia Saudita, a prevalÃªncia de mulheres com osteoporose na pÃ³s-menopausa foi subestimada por muito tempo, mas com relatos recentes de ser maior que a do Ocidente. A situaÃ§Ã£o parece ser similar quando se estuda a prevalÃªncia da osteoporose na populaÃ§Ã£o masculina da ArÃ¡bia Saudita, jÃ¡ que pouca atenÃ§Ã£o tem sido dada ao assunto. Neste trabalho os autores avaliaram a prevalÃªncia da osteoporose nos homens com idade acima de 50 anos da ArÃ¡bia Saudita. Para isso estudaram 115 homens (61,8 Â± 0,75 anos) , que nÃ£o apresentavam osteoporose secundÃ¡ria e tinham IMC de 24,7Â± 0,35. Todos tiveram a DMO da coluna lombar e colo de fÃªmur medidos pelo DXA. Um escore âTâ â¤ -2,5 DP foi o critÃ©rio para osteoporose, e entre -1 e -2,5 DP para osteopenia. A prevalÃªncia de osteoporose foi de 37,4% e de osteopenia de 33,9%. A comparaÃ§Ã£o destes resultados com outros dados da literatura e a discussÃ£o dos resultados podem ser lidos no trabalho: Sadat-Ali, M & AlElq, A. Osteoporosis among male Saudi Arabs: a pilot study. Ann Saudi Med (2006):26(6): 450-454
Vanessa de AragÃ£o SÃ¡dio (C2)
AMERICANOS MOSTRAM MISTÃRIOSA QUEDA DOS NÃVEIS DE TESTOSTERONA
A queda nos nÃveis de testosterona pode causar numerosas condiÃ§Ãµes adversas para saÃºde como obesidade abdominal, diabetes, dislipidemia, perda Ã³ssea e muscular, disfunÃ§Ã£o erÃ©til e depressÃ£o do humor. Esse declÃnio da testosterona Ã© considerado normal em homens com idade avanÃ§ada, entretanto um estudo recente na populaÃ§Ã£o dos Estados Unidos revelou uma queda inexplicÃ¡vel nos nÃveis de testosterona, idade independente, em homens a partir dos 17 anos. A hipÃ³tese deste estudo transversal discute a possibilidade do estado de saÃºde fÃsica e funÃ§Ãµes endÃ³crinas do homem serem fatores causais. O estudo foi realizado com um coorte prospectivo avaliando a saÃºde e funÃ§Ãµes endÃ³crinas com seleÃ§Ã£o randomizada dos homens de idade entre 49 a 79 anos. As pesquisas demonstraram evidÃªncias do decrÃ©scimo secular nos nÃveis de testosterona, com interferÃªncia na contagem de espermatozÃ³ides e fertilidade. Este artigo pode se lido em: Travison T.C. et al. A population-level decline in serum testosterone levels in American men. J. Clin. Endocrinol. Metab. (2007): 92(1): 196 - 202.
Carolina de Abreu GonÃ§alves MergulhÃ£o (C2)
HORMÃNIOS BIOIDÃNTICOS â A POSIÃÃO DA SOCIEDADE AMERICANA DE ENDOCRINOLOGIA
Os hormÃ´nios bio-idÃªnticos sÃ£o definidos como compostos que possuem exatamente a mesma estrutura quÃmica e molecular dos hormÃ´nios produzidos naturalmente no corpo humano. Embora qualquer hormÃ´nio possa ser produzido para ser bio-idÃªntico o termo Ã© geralmente usado para descrever formulaÃ§Ãµes contendo estrogÃªnio, progesterona e androgÃªnios. A reposiÃ§Ã£o hormonal Ã© comum e um tratamento efetivo para sintomas associados Ã menopausa pode trazer efeitos colaterais potencialmente sÃ©rios. Pessoas fora da comunidade mÃ©dica sem nenhum conhecimento cientÃfico tÃªm afirmado que os chamados hormÃ´nios bio-idÃªnticos, particularmente o estrogÃªnio e a progesterona sÃ£o uma terapia segura e mais efetiva quando comparada Ã s terapias tradicionais, e indicando-as sem nenhuma informaÃ§Ã£o ou seguranÃ§a dos mesmos para os pacientes, pois tais hormÃ´nios nÃ£o estÃ£o sujeitos a averiguaÃ§Ãµes pelo FDA (FederaÃ§Ã£o de Drogas e Alimentos dos EUA) no que diz respeito Ã dose ou pureza. Os hormÃ´nios usados na terapia de reposiÃ§Ã£o hormonal sÃ£o comercialmente disponÃveis e suas estruturas quÃmicas e moleculares sÃ£o muito semelhantes, mas nÃ£o exatamente uma rÃ©plica daqueles hormÃ´nios produzidos pelo corpo humano. A dosagem de cada hormÃ´nio usado tem sido constante dentre as mulheres que receberam tratamento hormonal. Nenhuma evidÃªncia mÃ©dico-cientÃfica existe para dar suporte a idÃ©ia de que os efeitos adversos e/ou benefÃcio encontrados resultaram da estrutura molecular dos hormÃ´nios sintetizados, nem houve nenhuma evidÃªncia cientÃfica para mostrar que uma diferenÃ§a ou dose personalizada de hormÃ´nio teria um resultado diferente na doenÃ§a, caso a dosagem e pureza fossem iguais. Portanto, seria esperado que todo o estrogÃªnio contido na TRH bioidÃªntica ou tradicional levasse essencialmente aos mesmos riscos e benefÃcios. Considerando-se a fonte ou estrutura dos hormÃ´nios administrados terapeuticamente todos os regimes de TRH mesmo aqueles em tratamento âpersonalizadosâ devem ser cuidadosamente controlados. A posiÃ§Ã£o da Sociedade Americana de Ginecologia e ObstetrÃcia, da Academia Americana de MÃ©dicos da FamÃlia, da Sociedade Americana de Endocrinologia e da AssociaÃ§Ã£o MÃ©dica Americana podem ser lidas na apresentaÃ§Ã£o da dra. Loretta Doan em âEndocrineNewsâ (January 2007: Bioidentical Hormones. The Endocrine SocietyÂ´s Position).
Maria da SaÃºde de Oliveira (C2)
ISOFLAVONAS DE SOJA NA DIETA NÃO AJUDAM OS OSSOS
Apesar da reposiÃ§Ã£o estrogÃªnica reduzir a reabsorÃ§Ã£o Ã³ssea, a preocupaÃ§Ã£o com seus efeitos colaterais negativos levou a uma procura por tratamentos alternativos, dentre eles a isoflavona de soja. Para identificar a dose necessÃ¡ria para aumentar a massa Ã³ssea pesquisadores da Purdue University conduziram um estudo utilizando espectrometria de massa e marcadores de reabsorÃ§Ã£o Ã³ssea no intuito de detectar baixas relaÃ§Ãµes cÃ¡lcio41/cÃ¡lcio urinÃ¡rio. O novo mÃ©todo permite medir o impacto do tratamento anti-reabsortivo no intervalo de dias a semanas, ao invÃ©s de seis meses a anos. Em estudo duplo-cego, randomizado, os pesquisadores administraram 41cÃ¡lcio intravenoso em 13 mulheres pÃ³s-menopausa. ApÃ³s um perÃodo de 200 dias, as participantes do estudo receberam por 50 dias, 43 gramas de proteÃna de soja que continham 0 mg, 97,5 mg ou 135,5 mg de isoflavona. A cada 10 dias amostras de urina de 24 horas foram coletadas para medida da relaÃ§Ã£o 41cÃ¡lcio/cÃ¡lcio. Os pesquisadores observaram que nenhuma dose de isoflavona influenciou a reabsorÃ§Ã£o Ã³ssea ou a absorÃ§Ã£o de cÃ¡lcio. Os marcadores sÃ©ricos e urinÃ¡rios de formaÃ§Ã£o e reabsorÃ§Ã£o Ã³sseos permaneceram inalterados, apesar do reconhecimento por parte dos pesquisadores de que o estudo nÃ£o tem poder estatÃstico para mostrar diferenÃ§as nestes marcadores. AlÃ©m disso, o estudo incluiu mulheres com mais de quatro anos pÃ³s-menopausa, jÃ¡ passada a fase de perda Ã³ssea rÃ¡pida. A conclusÃ£o dos pesquisadores Ã© de que seu estudo tem resultados semelhantes ao de outros estudos em humanos e animais, que mostram que a isoflavona de soja nÃ£o afeta a perda Ã³ssea, apesar de outros estudos terem mostrado o contrÃ¡rio. A discussÃ£o sobre essas divergÃªncias pode ser lida no trabalho Cheong JMK et al. Soy isoflavones do not affect bone resorption in postmenopausal women: A dose response study using a novel approach with 41Ca. J Clin Endocrinol Metab (2007). N. 92:2577-2582
Leandro Kasuki Jomori de Pinho (R2)
NOVOS MÃTODOS TERAPÃUTICOS
ABLAÃÃO PERCUTÃNEA POR LASER NO TRATAMENTO DE BÃCIO NODULAR TÃXICO E PRÃ-TÃXICO
NÃ³dulos tireoidianos hiperfuncionantes constituem cerca de 4% dos nÃ³dulos tireoidianos. Podem ser solitÃ¡rios ou, mais comumente, fazer parte de um bÃ³cio multinodular (BMN). Sintomas geralmente se manifestam quando os nÃ³dulos sÃ£o suficientemente grandes para serem capazes de produzir quantidade de hormÃ´nio tireoidiano que diminui o nÃvel de TSH. A importÃ¢ncia dos sintomas depende da idade do paciente e da presenÃ§a de doenÃ§as subjacentes, principalmente cardiovasculares. A ablaÃ§Ã£o percutÃ¢nea por laser (APL) tem sido usada de modo experimental e clinico em ablaÃ§Ã£o de tecido tumoral. Entretanto, sua utilizaÃ§Ã£o nos nÃ³dulos tireoidianos Ã© recente. Alguns estudos tÃªm demonstrado que a APL pode ser capaz de diminuir o tamanho dos nÃ³dulos tireoidianos nos pacientes que apresentam contra-indicaÃ§Ã£o cirÃºrgica ou que recusam este procedimento. Os autores deste trabalho citam algumas possÃveis vantagens da APL em comparaÃ§Ã£o com os tratamentos mais clÃ¡ssicos como: na terapia com o radioiodo, o tratamento com drogas antitireoidianas tem que ser descontinuado por certo perÃodo; na intervenÃ§Ã£o cirÃºrgica hÃ¡ o uso de anestesia geral e o custo do procedimento; a injeÃ§Ã£o percutÃ¢nea de etanol nos nÃ³dulos sÃ³lidos nÃ£o destrÃ³i o tecido tireoidiano de maneira regular e homogÃªnea e pode levar a problemas relacionados Ã difusÃ£o do etanol nos tecidos circundantes. Os autores trataram 18 pacientes (10 mulheres e 8 homens, de 31 a 80 anos) que apresentavam um Ãºnico nÃ³dulo tireoidiano hiperfuncionante ou um BMN com Ã¡reas claramente hiperfuncionantes na cintigrafia com tecnÃ©cio 99m; o tamanho mÃ¡ximo dos nÃ³dulos variou de 24,2 a 48,6 mm (volume de 4,7 a 39,2 ml). O tratamento foi descontinuado quando o ultra-som mostrou destruiÃ§Ã£o quase completa do nÃ³dulo, que ocorreu apÃ³s uma a cinco semanas (mediana, trÃªs semanas). O grupo controle constou de 64 pacientes (36 mulheres e 28 homens, 37 a 71 anos) com BMN ou uninodular tÃ³xico ou prÃ©-tÃ³xico (TSH menor que 0,20 ÂµUI/ml em pelo menos duas ocasiÃµes), admitidos consecutivamente durante o mesmo ano. Estes pacientes foram submetidos a acompanhamento durante seis meses para detectar a possibilidade de normalizaÃ§Ã£o espontÃ¢nea do TSH, e tambÃ©m nestes pacientes foi iniciado metimazol quando necessÃ¡rio. O nÃºmero total de sessÃµes de APL variou de um a cinco, o nÃºmero usado foi baseado no tamanho da Ã¡rea de lesÃ£o induzida pelo laser percebida pelo controle ultra-sonogrÃ¡fico, realizado uma semana apÃ³s cada sessÃ£o. Vinte e quatro horas apÃ³s cada sessÃ£o de APL houve aumento leve e transitÃ³rio dos nÃveis de T4 e T3 livres â de 5,2% a 18,1% (p< 0,001) nos pacientes nÃ£o tratados com metimazol e de 4% a 8,3% nos pacientes tratados com metimazol; entretanto nunca atingiram valores de hipertireoidismo. AlÃ©m disso, a tireoglobulina apresentou aumento importante apÃ³s 24 horas â 115% a 390% (p< 0,001). O TSH aumentou em todos os casos e atingiu valores normais em todos os pacientes com nÃ³dulo Ãºnico e em cinco pacientes (50%) com BMN em trÃªs meses. Em dois pacientes, o TSH permaneceu temporariamente normal ou baixo apesar de valores baixos de T4 livre. NÃ£o houve aumento significativo dos anticorpos anti-TPO ou anti-tireoglobulina. O ultra-som realizado na primeira semana pÃ³s-tratamento demonstrou na Ã¡rea tratada, como relatado anteriormente, trÃªs regiÃµes diferentes: fina regiÃ£o central anecÃ³ica, correspondendo Ã cavitaÃ§Ã£o, uma camada hiperecÃ³ica circundante e uma camada externa hipoecÃ³ica devido Ã necrose. O volume nodular nÃ£o apresentou alteraÃ§Ã£o. No exame realizado no terceiro mÃªs apÃ³s a APL, todos estes aspectos estavam menos definidos e o volume nodular diminuiu 15% a 43% (p< 0,001). Em um ano, a diminuiÃ§Ã£o do volume foi de 24% a 72% (p< 0,001) e os nÃ³dulos se mostraram menos nÃtidos, com Ã¡reas nÃ£o homogÃªneas. No grupo controle, nenhum paciente apresentou normalizaÃ§Ã£o do TSH ou diminuiÃ§Ã£o do volume nodular. Dados especÃficos da tÃ©cnica aplicada, efeitos colaterais, intercorrÃªncias clÃnicas e a discussÃ£o dos resultados estÃ£o descritos no trabalho: BÃ¡rbaro, D. et al. Endocrine Practice (2007). Vol 13 (1): 30-36.
Roberta Portugal Henriques (R2)
SÃNDROME DE MAURIAC EM UM MENINO DE 3 ANOS
A SÃndrome de Mauriac apresenta como pontos cardinais hepatomegalia, dÃ©ficit de crescimento e fÃ¡cies cushingÃ³ide associado a diabetes mellitus (DM) tipo 1 mal controlado durante a infÃ¢ncia e adolescÃªncia. Com o advento dos anÃ¡logos de insulina e insulinizaÃ§Ã£o intensiva a incidÃªncia deste quadro tem diminuÃdo. Neste trabalho foi descrito o paciente mais jovem jÃ¡ publicado com SÃndrome de Mauriac, 3 anos de idade, com DM tipo 1, abdome protuberante, hepatomegalia e elevaÃ§Ã£o de enzimas hepÃ¡ticas. Todos esses dados se normalizaram com a melhora no controle glicÃªmico. Seu diagnÃ³stico de diabetes tipo 1 havia sido realizado com 14 meses de idade, com hemoglobina glicosilada de 11,3%; a insulinizaÃ§Ã£o nÃ£o foi adequada e o controle irregular o levou a apresentar trÃªs episÃ³dios de cetoacidose diabÃ©tica em 2 anos, com uma variaÃ§Ã£o de HgA1C de 13 a 17%, com elevaÃ§Ã£o moderada de transaminases hepÃ¡ticas sem hepatomegalia. EvidÃªncias de descaso e negligÃªncia fizeram necessÃ¡rio o envolvimento do ServiÃ§o de ProteÃ§Ã£o Ã CrianÃ§a. Evoluiu com hepatomegalia, desaceleraÃ§Ã£o do crescimento linear, no exame fÃsico. Durante o diagnÃ³stico de sÃndrome de Mauriac apresentava fÃ¡cies de lua cheia, rotunda e com abdome distendido, glicosÃºria sem proteinÃºria; colesterol 225 mg/dl, triglicerÃdeos 208 mg/dl, Hg A1C 14,2%, TGO 51 U/L, TGP 146U/L, albumina 4 g/dl, TAP 11, 6 segundos, PTT 18,4 segundos, IGF-1 < 10 ng/mL e IGFBP3 0,8mg/L (0,9-4,1), hemograma, funÃ§Ã£o renal, cortisol livre urinÃ¡rio e hormÃ´nios tireoidianos normais, testes para hepatite auto-imune, doenÃ§a celÃaca, doenÃ§as do trato biliar e toxicidade medicamentosa foram negativos, US abdominal mostrou grande hepatomegalia, atraso de idade Ã³ssea; apÃ³s duas semanas de controle glicÃªmico estrito hospitalar houve reduÃ§Ã£o do tamanho do fÃgado e apÃ³s cinco meses sua Hg A1C caiu para 9,9%, sua necessidade de insulina diÃ¡ria caiu de 1,0 para 0,75 U/Kg, houve aumento da velocidade de crescimento, nova dosagem de IGF-1 foi de 30 ng/ml e a IGFBP-3 foi 1,3 mg/L; normalizaÃ§Ã£o do tamanho do fÃgado e das provas funcionais. Os achados do paciente batem com a descriÃ§Ã£o clÃ¡ssica de SÃndrome de Mauriac, incluindo a desaceleraÃ§Ã£o do crescimento, traÃ§os cushingÃ³ides, abdome protuberante e hepatomegalia associada ao controle glicÃªmico ruim de longa data. DiscussÃ£o dos mecanismos envolvidos no dÃ©ficit de crescimento, nos sinais clÃnicos e mecanismos fisiopatolÃ³gicos envolvidos podem ser lidos no trabalho: Shefali Mahesh, MD et al. Mauriac Syndrome in a 3 Year Old boy. Endocrine Practice (2007), 13 (1): 63-66
Beatriz Ohana Marques Coelho de Carvalho (C2)
|Endo Pills - 5||InformaÃ§Ã£o cientifica de aÃ§Ã£o rÃ¡pida|
Ano 2 NÂ°5
Curso de EspecializaÃ§Ã£o em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
Prof.: Luiz Cesar Povoa (A45)
Ricardo Martins Rocha Meirelles (A35)
Editor: Rosa Rita Santos Martins (A31)
Editores Associados: Walmir Coutinho (A19)
Edna Pottes (A32)
ComposiÃ§Ã£o GrÃ¡fica: Wallace Margoniner
O ENDOPILLS Ã© mais um instrumento que criamos para aprimorar a Ã¡rea acadÃªmica. Ã um folheto, simples, cada vez mais eletrÃ´nico, baixando o custo, mas sobretudo trazendo resumos de artigos de ponta e atÃ© mesmo com matÃ©ria jÃ¡ aceitos e ainda nÃ£o publicados. Mais do que isto, este folheto seria feito pelos alunos, iniciando-se a prÃ¡tica de ler e escrever sobre artigos cientÃficos. Comecei, cresceu, Dra. Rosa o amadureceu, Ã© nossa idÃ©ia que com a coordenaÃ§Ã£o da equipe acadÃªmica, mais e mais alunos participarÃ£o.
O Endopills nasceu sadio e jÃ¡ tenta engatinhar sozinho. Ã mais um sonho que se torna realidade.
Luiz Cesar Povoa
IMPACTO DO PARATORMÃNIO NOS OSSOS:
O tratamento de mulheres osteoporÃ³ticas com paratormÃ´nio (PTH) aumenta os marcadores bioquÃmicos de turnover Ã³sseo, a densidade mineral Ã³ssea do eixo axial e reduz o risco de fraturas. Entretanto, pouco se sabe acerca dos nÃveis basais dos marcadores de turnover Ã³sseo e de sua resposta inicial na densitometria em mulheres pÃ³s-menopausa. Para esclarecimento destas questÃµes pesquisadores, liderados por Douglas C. Bauer, mÃ©dico, na Universidade da CalifÃ³rnia em San Francisco, realizaram um estudo randomizado, controlado com placebo, do uso de PTH em 238 mulheres pÃ³s-menopausa com densidade mineral Ã³ssea (DMO) diminuÃda no quadril ou coluna. Eles dosaram os marcadores de turnover Ã³sseo em amostras de sangue colhidas em jejum, antes da terapia e apÃ³s um e 3 meses. ApÃ³s um ano, eles analisaram a DMO na coluna e quadril. Eles encontraram relaÃ§Ã£o inconsistente entre o turnover basal e as modificaÃ§Ãµes na DMO apÃ³s um ano. Maiores aumentos no turnover em 1 e 3 meses, especialmente do marcador de formaÃ§Ã£o Ã³ssea prÃ³-colÃ¡geno tipo I N propeptÃdeo, estavam associados com maiores ganhos na DMO. AnÃ¡lises da DMO volumÃ©trica na coluna e quadril mostraram associaÃ§Ã£o ainda mais positiva do aumento a curto prazo do turnover com ganhos na DMO em 1 ano. Os pesquisadores concluÃram que, entre mulheres osteoporÃ³ticas pÃ³s-menopausa, maiores modificaÃ§Ãµes a curto prazo no turnover utilizando a terapia com PTH estÃ£o associadas com maiores incrementos na DMO do quadril e coluna apÃ³s um ano. Os resultados e discussÃ£o dos mesmos podem ser lidos no artigo: Bauer DC, Garnero P, Bilezikian JP, et al., for the PTH and Alandronate (PaTH) Research Group. Short term changes in bone turnover markers and bone mineral density response to parathyroid hormone in postmenopausal womem with osteoporosis, J Clin Endocrinol Metab (Apr 2006); 91: 1370-1375.
Leandro Kasuki Jomori de Pinho (R2)
REGULAÃÃO DA RESISTÃNCIA AO TAMOXIFENO:
Tamoxifeno, um modulador seletivo do receptor de estrogÃªnio (RE), reduz significativamente a recorrÃªncia de tumores de mama com RE alfa-positivos, se ligando ao domÃnio ativador de funÃ§Ã£o-2 (AF-2) do RE. Entretanto, resistÃªncia adquirida ao tamoxifeno tem se tornado um sÃ©rio problema terapÃªutico. Neoplasias de mama resistentes ao antiestrogÃªnico normalmente apresentam expressÃ£o aumentada dos membros da famÃlia de fatores de crescimento epidÃ©rmico, EGFR e ErbB2, porÃ©m os mecanismos envolvidos nÃ£o foram comprovados. Por isso, uma equipe de pesquisadores examinou as vias de sinalizaÃ§Ã£o envolvidas na regulaÃ§Ã£o da resistÃªncia ao tamoxifeno nas cÃ©lulas que expressam mais o ErbB. A equipe, liderada por Kaladhar B. descobriu que a expressÃ£o aumentada do EGFR ou do AKT-2 ativado em cÃ©lulas MCF-7 causa a fosforilaÃ§Ã£o da Ser167 no domÃnio AF-1 do RE alfa, aumento da interaÃ§Ã£o RE: AIB1 na presenÃ§a do tamoxifeno, e resistÃªncia ao tamoxifeno. Pelo contrÃ¡rio, a transferÃªncia de um ativador imediato da proteÃna quinase mitogÃªnica ativada (MAPK/Erk1&2) para as cÃ©lulas MCF-7, leva a fosforilaÃ§Ã£o da Ser118 no domÃnio AF-1 do RE alfa, inibindo a interaÃ§Ã£o RE:AIB1 na presenÃ§a do tamoxifeno, com manutenÃ§Ã£o da sensibilidade ao fÃ¡rmaco. A inibiÃ§Ã£o do AKT pelo siRNA bloqueou a fosforilaÃ§Ã£o da Ser167 no receptor de estrogÃªnio e restaurou a sensibilidade ao tamoxifeno. Entretanto, a sensibilidade Ã© mÃ¡xima quando ambas AKT e MAPK eram inibidas. Os pesquisadores concluÃram que diferentes sÃtios de fosforilaÃ§Ã£o do domÃnio AF-1 no RE alfa regulam a aÃ§Ã£o agonista e antagonista do tamoxifeno nas cÃ©lulas do cÃ¢ncer de mama humano. Trabalho completo pode ser lido no artigo: Glaros S. et al. Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifeno. Mol Endocrinol (May, 2006); 20:996-1008.
Leandro Kasuki Jomori de Pinho (R2)
EXPRESSÃO DA P450C17 EM FETOS E ADULTOS COM SÃNDROME DE OVÃRIOS POLICÃSTICOS:
A super expressÃ£o do andrÃ³geno intersticial Ã© um aspecto chave na SOP e estudos tÃªm sugerido que pode ser causado por hiperandrogenismo fetal. Pesquisadores detectaram RNAm da enzima esteroidogÃªnica P450c17 - a qual catalisa a conversÃ£o de pregnenolona e progesterona em seus produtos andrÃ³genos â em ovÃ¡rios fetais humanos entre 14,9 e 21,5 semanas de gestaÃ§Ã£o. Este Ã© o momento que os ovÃ¡rios fetais comeÃ§am a secretar espontaneamente dehidroepiandrosterona e androstenediona. Uma equipe de pesquisa chefiada por Gregory F. Erickson pesquisou a expressÃ£o espaÃ§o-temporal da proteÃna P450c17 no ovÃ¡rio fetal humano. Os pesquisadores estudaram os ovÃ¡rios de 48 controles (fetos nÃ£o-anencÃ©falicos) e 18 fetos anencÃ©falicos entre 17 e 42 semanas de gestaÃ§Ã£o. A proteÃna P450c17 foi altamente expressa nas cÃ©lulas intersticiais primÃ¡rias durante o segundo trimestre nos ovÃ¡rios controle. Relativamente poucas cÃ©lulas expressaram P450c17 entre 25 e 32 semanas, mas apÃ³s este perÃodo a enzima foi fortemente expressa nas cÃ©lulas da teca. CÃ©lulas da teca positivas para P450c17 cresceram em abundÃ¢ncia durante o terceiro trimestre, desenvolvendo folÃculos prÃ©-antrais e expressÃ£o forte foi vista nas cÃ©lulas intersticiais do hilo. As anÃ¡lises dos ovÃ¡rios dos fetos anencÃ©falos revelaram um padrÃ£o similar nas trÃªs cÃ©lulas intersticiais, sugerindo que hormÃ´nios pituitÃ¡rios nÃ£o estÃ£o envolvidos na expressÃ£o do P450c17 no ovÃ¡rio fetal humano. Em conclusÃ£o, a equipe identificou trÃªs classes de cÃ©lulas com expressÃ£o da enzima, cada uma com um diferente padrÃ£o de expressÃ£o do P450c17 e, presumivelmente, diferentes funÃ§Ãµes fisiolÃ³gicas. O trabalho completo pode ser lido no artigo: Cole B, Hensinger, K., Maciel, GAR et al. J Clin Endocrinol Metab (Sep 2006), 91:3654-3661.
Paloma Hess (C2)
QUALIDADE DE VIDA MAIS BAIXA EM PACIENTES COM MACROADENOMA HIPOFISÃRIO NÃO-FUNCIONANTE (MHNF):
Os pacientes tratados com sucesso com MHNF tendem a ter pior qualidade de vida, especialmente se apresentam mÃºltiplas deficiÃªncias hipofisÃ¡rias, apesar de estratÃ©gias de reposiÃ§Ã£o hormonal adequadas, de acordo com estudo do JCE&M. No primeiro estudo de qualidade de vida relacionado a esta especÃfica forma de macroadenoma, Olaf M. Dekkers e colegas compararam 99 pacientes adultos em remissÃ£o apÃ³s cirurgia transesfenoidal e radioterapia com 125 controles. Os participantes responderam a quatro questionÃ¡rios validados relacionados Ã saÃºde. Na avaliaÃ§Ã£o, 83% dos pacientes apresentavam deficiÃªncia de GH, 82% de LH/FSH, 63% de ACTH e 62% de TSH. Hipopituitarismo estava presente em 93 de 99 pacientes, panhipopituitarismo da hipÃ³fise anterior em 48% e diabetes insipidus em 9%. Defeitos do campo visual estavam presentes em 41% dos casos. Em cada questionÃ¡rio, os pacientes com MHNF relataram significativo prejuÃzo na qualidade de vida, incluindo maiores fadiga mental e fÃsica e menor motivaÃ§Ã£o e atividade. Eles tambÃ©m relataram energia e reaÃ§Ã£o emocional afetiva reduzidas, e limitaÃ§Ãµes no Ã¢mbito social devido a problemas fÃsicos e emocionais. A discussÃ£o dos resultados pode ser lida no artigo: Quality of life is decreased after treatment for non-functioning pituitary macroadenoma. J Clin Endocrinol Metab (Sep 2006), 91: 3364-3369.
Paloma Hess (C2)
BAIXO PESO AO NASCIMENTO E RESPOSTA ADRENOCORTICAL AO STRESS:
Em animais, o ambiente adverso prÃ©-natal pode causar alteraÃ§Ãµes permanentes na atividade do eixo hipotalÃ¢mico - hipofisÃ¡rio - adrenal â o qual Ã© o mediador da resposta ao stress atravÃ©s da secreÃ§Ã£o dos hormÃ´nios glicocorticÃ³ides. Para investigar se isso tambÃ©m pode ocorrem em humanos, um grupo de pesquisadores estudou se bebÃªs a termo menores, porÃ©m saudÃ¡veis, estariam mais propensos a apresentar resposta glicocorticÃ³ide aumentada ao stress psicolÃ³gico na infÃ¢ncia. O estudo foi liderado por Alexander Jones. Os pesquisadores mediram a resposta do cortisol salivar ao stress psicolÃ³gico em 68 meninos e 72 meninas, com idade entre 7-9 anos e os seguiram desde 12 semanas de gestaÃ§Ã£o. Em meninos, o peso ao nascimento foi inversamente relacionado Ã resposta do cortisol salivar ao stress, mas nÃ£o com os nÃveis do cortisol pela manhÃ£, enquanto nas meninas, o pico de cortisol pela manhÃ£ foi inversamente relacionado ao peso ao nascimento. Essas associaÃ§Ãµes foram independentes da idade gestacional e de outros potenciais fatores de interferÃªncia, e sugerem que determinados processos na vida fetal, resultando em recÃ©m-nascidos menores, apresentam um efeito permanente na resposta adrenocortical ao stress em meninos e na atividade adrenocortical basal em meninas. Maiores informaÃ§Ãµes sobre o trabalho podem ser lidas no artigo: Jones A., Godfrey KM., Wood P. et al. J Clin Endocrinol Metab (May 2006), 91:1868-1871.
Camila Mont Serrate (C2)
BLOQUEIO ANDROGÃNICO DIMINUI A SENSIBILIDADE INSULÃNICA:
Agonistas gonadotropÃnicos aumentam a massa gorda em homens com cÃ¢ncer de prÃ³stata, mas pouco se sabe sobre os efeitos desse tratamento na sensibilidade insulÃnica. Um grupo de pesquisadores do Hospital Geral de Massachusetts em Boston, chefiado por Matthew R. Smith, M.D, Ph.D., pesquisou os efeitos a curto prazo do tratamento com os agonistas das gonadotrofinas na sensibilidade insulÃnica em um estudo prospectivo em 12 semanas. O grupo estudou 25 homens nÃ£o diabÃ©ticos com cÃ¢ncer de prÃ³stata sem evidÃªncia radiolÃ³gica de metÃ¡stases. Os homens foram tratados com leuprolide depot e bicalutamida. O teste oral de tolerÃ¢ncia Ã glicose e a anÃ¡lise da composiÃ§Ã£o corporal por Absortiometria com Raios-X de dupla energia foram feitos antes do tratamento e apÃ³s 12 semanas. Os pesquisadores constataram que a percentagem de massa gorda, os nÃveis de insulina plasmÃ¡tica pÃ³s-prandial e a HbA1C mÃ©dia aumentaram significativamente do basal para a 12Âª semana. Inversamente, o Ãndice de sensibilidade insulÃnica e a sensibilidade insulÃnica pela anÃ¡lise do modelo homeostÃ¡tico diminuÃram. Essas observaÃ§Ãµes sugerem que os agonistas das gonadotrofinas aumentaram fortemente o risco de diabetes mellitus e doenÃ§a cardiovascular em homens idosos. Os resultados e discussÃ£o dos mesmos foram publicados no artigo: Smith MR, Lee, H., Nathan D.M. Insulin sensitivity during combined androgen blockade for prostate cÃ¢ncer. J Clin Endocrinol Metab (Apr. 2006); 91:1305-1308.
Ana LÃºcia Marinho Vinagre C2)
DROGA ESTABILIZA LESÃO RENAL EM ROEDORES:
Diabetes Mellitus (DM) Ã© a principal causa de insuficiÃªncia renal nos Estados Unidos. Apesar do bloqueador do receptor de mineralocorticÃ³ide (RM) ter um benefÃcio na proteinÃºria nos pacientes com diabetes tipo 2, um estudo recente mostrou piora da funÃ§Ã£o endotelial. Devido ao risco potencial de hipercalemia em pacientes diabÃ©ticos, o FDA (Food and Drug Administration) contra-indica o seu uso nesses casos. Entretanto, os antagonistas dos RM nÃ£o tem sido estudados em pacientes que nÃ£o estavam usando inibidor da enzima de conversÃ£o da angiotensina nem no diabetes tipo 1. Cientistas do Hospital de Mulheres de Brigham, em Boston, liderados por Gail K. Adler, M.D., Ph.D., investigaram se o bloqueadores do RM tem efeitos benÃ©ficos ou malÃ©ficos na nefropatia diabÃ©tica. A equipe utilizou uma linhagem de camundongos tratados previamente com estreptozocina como modelo para DM tipo1, e ratos bd/bd como modelo para DM tipo 2. Ambos os grupos foram divididos em dois subgrupos para receber esplerenone, como BRM, e controles. Os camundongos e os ratos diabÃ©ticos desenvolveram albuminÃºria e evidÃªncia histopatolÃ³gica de doenÃ§a renal, bem como aumento dos nÃveis corticais de mineralocorticÃ³ide e de seus mRNAs, fator de crescimento transformador do mRNA, e osteopontina mRNA. Exceto por nÃveis elevados de mineralocorticÃ³ides, o tratamento com esplerenone reduziu significativamente essas alteraÃ§Ãµes em ambas as espÃ©cies de roedores e em ambos os tipos de DM. Os efeitos benÃ©ficos nÃ£o foram atribuÃdos as alteraÃ§Ãµes na pressÃ£o arterial ou glicemia. Os investigadores sugerem que a ativaÃ§Ã£o dos RM Ã© fator crucial na patogÃªnese precoce da doenÃ§a renal tanto na DM tipo1 como no DM tipo 2. Os resultados foram publicados no artigo: Cuo C, Martinez-Vasques D, Mendes GP et al. Minerolcorticoid receptor antagonis reduces renal injury in rodent models of type 1 e 2 diabetes mellitus. Endocrinol (Nov 2006), 147:5363-5373.
Joana R. Dantas Pereira (R2)
TIREOIDITE AUTOIMUNE APÃS O ACIDENTE DE CHERNOBYL:
A exposiÃ§Ã£o ao iodo radioativo, especialmente I 131, apÃ³s o acidente nuclear de Chernobyl, Ã© reconhecido como fator de risco para o aumento dos casos de cÃ¢ncer de tireÃ³ide na populaÃ§Ã£o regional, entretanto evidÃªncias do aumento de tireoidite autoimune (TAI) nÃ£o tem sido conclusivas. Um grupo de pesquisadores dos Estados Unidos e UcrÃ¢nia investigaram a relaÃ§Ã£o entre TAI e a exposiÃ§Ã£o ao iodo 131 como fator de risco determinante. Pelo fato da tireoidite autoimune ser uma doenÃ§a comum que aumenta a prevalÃªncia de acordo com a idade, foi aventada a hipÃ³tese de quanto maior o tempo de exposiÃ§Ã£o ao iodo 131 maior a carga acumulada da radiaÃ§Ã£o nessa populaÃ§Ã£o. Os pesquisadores coletaram dados de uma coorte de indivÃduos contaminados no local do acidente, moradores em uma regiÃ£o com deficiÃªncia de iodo na UcrÃ¢nia. Os indivÃduos tinham menos de 18 anos na Ã©poca do acidente nuclear em 26 de Abril de 1986 e tiveram a radiaÃ§Ã£o da tireÃ³ide mensurada logo apÃ³s o acidente. Os pesquisadores sugeriram que nÃ£o havia associaÃ§Ã£o significativa entre a dose de I 131 estimada e incidÃªncia de tireoidite autoimune, entretanto a prevalÃªncia de anticorpos antiperoridase (ATPO) tinha uma relaÃ§Ã£o modesta, mas significativa, com discreta elevaÃ§Ã£o de ATPO em indivÃduos eutiroidianos. Os autores concluÃram que a identificaÃ§Ã£o de dose-resposta em relaÃ§Ã£o ao aumento da prevalÃªncia de ATPO poderÃ¡ possibilitar mudanÃ§as clÃnicas importantes a qualquer momento, requerendo melhor acompanhamento e anÃ¡lise prospectiva da coorte. Os resultados e sua discussÃ£o podem ser lidos no artigo: Tronko MD, Brenner AV, Olijnyk VA, et al. Autoimmune thyroiditis and exposure to iodin 131 in the Ukrainian cohort study of thyroid cancer and other thyroid diseases following the Chornobyl accident. Results from the first screening cycle (1998-200). J Clin Endocrinol Metab (Nov 2006), 20:2898-2908.
Carolina MergulhÃ£o (C2)
TRATAMENTOS ÃTICOS QUANDO OS RECURSOS SÃO RESTRITOS:
No campo da Endocrinologia, o conceito de âpossibilidades mÃ©dicasâ trazem a mente tecnologias de reproduÃ§Ã£o assistida, melhora da funÃ§Ã£o sexual, testes genÃ©ticos preditivos, ganho estatura para crianÃ§as com baixa estatura idiopÃ¡tica (BEI), retardar/otimizar processo de envelhecimento. Em seu artigo publicado na revista Endocrine News (outubro de 2006) Katrina A Bramset, Ph D, discute que freqÃ¼entemente relacionado com essas âpossibilidades mÃ©dicasâ estÃ£o argumentos sobre os objetivos da medicina, necessidades mÃ©dicas, tratamento, melhora da qualidade de vida, custo, verba, e direito.
Usando BEI (baixa estatura idiopÃ¡tica), como exemplo, ela discute que nÃ£o hÃ¡ consenso verdadeiro no diagnÃ³stico de BEI, mas vÃ¡rios critÃ©rios sÃ£o geralmente aceitos. Estes incluem uma estatura de mais de dois desvios padrÃµes (DP) abaixo da mÃ©dia, a ausÃªncia de doenÃ§a identificada, peso normal para idade gestacional, proporÃ§Ãµes corporais normais, ingesta calÃ³rica adequada, ausÃªncia de doenÃ§a psiquiÃ¡trica, e pico de hormÃ´nio do crescimento em resposta ao teste de estimulaÃ§Ã£o padrÃ£o maior do que 10 ng/ml.
Uma diretriz recente do Food and Drug Admnistration aprovou o tratamento para crianÃ§as com estatura de mais de 2,25 DP abaixo da mÃ©dia (totalizando aproximadamente 410.000 crianÃ§as americanas). O custo estimado com a terapia Ã© de $ 20,000 por ano ou mais de $ 42,305 por centÃmetro no aumento de estatura final (dependendo do peso da crianÃ§a, dose, e custo da droga).
Junto do diagnÃ³stico e custo relacionado, existe uma significativa controvÃ©rsia sobre categorizar BEI como uma âdesordem clÃnicaâ que deve ser tratada como qualquer outro problema mÃ©dico, ou como uma âconseqÃ¼Ãªnciaâ que deve ter pronta tentativa no aumento de estatura.
DiscussÃµes Ã©ticas emergem de uma questÃ£o fundamental complexa quanto a importÃ¢ncia da estatura final. Alguns autores denominam o tratamento de BEI como âendocrinologia cosmÃ©ticaâ e discutem que baixa estatura deveria ser considerada como uma condiÃ§Ã£o social e tratada por meios baratos, nÃ£o-invasivos, como terapia cognitivo comportamental.
A Dra. Katrina discute como se avalia a melhora da qualidade de vida? HÃ¡ um nÃºmero mÃnimo de centÃmetros ganhos (um limiar) que tenha impacto âsignificativoâ na qualidade de vida? HÃ¡ ganho em qualidade de vida proporcional com os enormes custos do tratamento? Se pessoas mais altas sÃ£o realmente mais bem pagas do que pessoas mais baixas, este argumento pode apoiar a suplementaÃ§Ã£o com hormÃ´nio do crescimento em uma tentativa de reduzir o risco dessa desigualdade. Entretanto, tal apoio deverÃ¡ levar em consideraÃ§Ã£o outras necessidades mÃ©dicas da infÃ¢ncia.
Em uma sociedade competitiva, a batalha de explorar possibilidades de conhecimento e crescimento Ã© atraente para pais e crianÃ§as, mas qualquer ganho relacionado a medicamentos deve ser cuidadosamente pesado contra encargos financeiros e nÃ£o financeiros da terapia, incluindo as aplicaÃ§Ãµes de injeÃ§Ã£o e efeitos colaterais a curto e longo prazo. Ã importante citar que a terapia com GH nÃ£o garante crescimento adicional, e a crianÃ§a pode experimentar problemas psicolÃ³gicos se nÃ£o alcanÃ§ar a estatura alvo. Pais, tambÃ©m, podem experimentar decepÃ§Ã£o emocional e financeira se os resultados nÃ£o alcanÃ§arem suas expectativas.
O campo da endocrinologia apresenta uma gama de âpossibilidades mÃ©dicasâ, muitas das quais muito caras. Do ponto de vista Ã©tico, o desafio Ã© analisar o custo e o beneficio dessas terapias e identificar quais pacientes tÃªm real probabilidade clÃnica de experimentar os benefÃcios. Muitos tÃªm contra-indicaÃ§Ãµes como histÃ³ria de cÃ¢ncer ou fibrose cÃstica; outros tÃªm condiÃ§Ãµes crÃ´nicas com significante potencial de complicaÃ§Ãµes a longo prazo como Diabetes.
A Dra Katrina termina seu artigo concluindo que em face aos recursos financeiros limitados, o uso terapÃªutico do GH em crianÃ§as com BEI nÃ£o deve estar entre as prioridades de tratamento em Endocrinologia, dado que BEI nÃ£o apresenta risco de vida e sua morbidade Ã© geralmente superada por outras condiÃ§Ãµes da infÃ¢ncia.
Michelle Bravo (C2)
|Endo Pills - 3||InformaÃ§Ã£o cientifica de aÃ§Ã£o rÃ¡pida|
Ano 1 NÂ°3
Curso de EspecializaÃ§Ã£o em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
Prof.: Luiz Cesar Povoa (A45)
Ricardo Martins Rocha Meirelles (A35)
Editor: Rosa Rita Santos Martins (A31)
Editores Associados: Walmir Coutinho (A19)
Edna Pottes (A32)
ComposiÃ§Ã£o GrÃ¡fica: Wallace Margoniner
O Projeto Genoma foi criado em 1990 atravÃ©s de dois grupos: um pÃºblico envolvendo cientistas dos Estados Unidos, Inglaterra, FranÃ§a, Alemanha, CanadÃ¡ e JapÃ£o com a direÃ§Ã£o do Dr. Francis Collins e uma empresa particular, a CELERA Genomics, sob a direÃ§Ã£o do Dr. Graig Venter. O objetivo de ambos: desenhar o genoma humano. Ambos usaram DNA de voluntÃ¡rios anÃ´nimos baseados no fato de que os genes codificantes de proteÃnas sÃ£o os mesmos nos humanos. Em 2001, em conjunto, apresentaram o primeiro rascunho do genoma humano e a descriÃ§Ã£o dos genes codificantes foi considerada concluÃda em 2004. Estes resultados, entretanto, nÃ£o incluÃram a maior parte dos polimorfismos nem os genes codificantes das molÃ©culas funcionais do RNA.
No Endo Pills deste mÃªs apresentamos exemplos da aplicaÃ§Ã£o dos objetivos do Projeto Genoma na PrÃ¡tica MÃ©dica: desenvolvimento de mÃ©todos diagnÃ³sticos em doenÃ§as de etiologia genÃ©tica, otimizaÃ§Ã£o das medidas terapÃªuticas para essas doenÃ§as e doenÃ§as infecciosas e prevenÃ§Ã£o de doenÃ§as multifatoriais, como diabetes e hipertensÃ£o arterial.
Rosa Rita Santos Martins
1. GENÃMICA E MEDICINA PERSONALIZADA
O genoma humano, com seus 35 mil genes pode se considerado o manual de instruÃ§Ãµes do organismo. A GenÃ´mica estuda a estrutura individual de cada gene, alÃ©m de suas interaÃ§Ãµes com outros genes e com o meio. Esta ciÃªncia seria revolucionÃ¡ria, segundo o autor, pois promoveria a prÃ¡tica da âmedicina personalizadaâ, ajudando na prevenÃ§Ã£o, diagnÃ³stico e tratamento de doenÃ§as.
A medicina personalizada tenta responder a perguntas como: porque algumas pessoas desenvolvem cÃ¢ncer e outras nÃ£o; porque o cÃ¢ncer Ã© mais agressivo em determinada pessoa; porque determinada droga, ou dose, funciona para alguns e nÃ£o para outros? Seu alvo Ã© conseguir os melhores resultados terapÃªuticos para o perfil genÃ©tico especÃfico de cada paciente, podendo auxiliar inclusive familiares, mÃ©dicos e na evoluÃ§Ã£o de outros testes diagnÃ³sticos nÃ£o genÃ´micos.
A combinaÃ§Ã£o da Farmacologia com a GenÃ´mica originou a FarmacogenÃ´mica, que Ã© uma ciÃªncia que permite aos cientistas predizer a probabilidade de uma droga responder baseado no perfil gÃªnico de uma pessoa. Segundo o Dr. Larry Lenko, do FDA, hÃ¡ trÃªs maneiras principais de se aplicar a FarmacogenÃ´mica:
â¢ A primeira Ã© a de ajudar a predizer a dose apropriada de uma determinada droga. Os genes regulam o metabolismo dos medicamentos. DiferenÃ§as na seqÃ¼Ãªncia de um gene podem causar diferenÃ§as na atividade enzimÃ¡tica, resultando em diferentes apresentaÃ§Ãµes dessas enzimas em cada indivÃduo.
â¢ A segunda Ã© a de criar terapias especÃficas para cada doenÃ§a, por alguns chamada de GenÃ´mica Tumoral. Testes genÃ´micos tÃªm ajudado na identificaÃ§Ã£o de tumores que respondem melhor a um tratamento especÃfico. Lenko cita drogas Gleevec (Imatinib) para leucemia mielÃ³ide crÃ´nica, Tarceva (Erlotinib) para cÃ¢ncer de pulmÃ£o e Herceptina (Transtuzumab) para cÃ¢ncer de mama como exemplos. As duas primeiras interagem com enzimas inibitÃ³rias tirosinoquinases, que ao serem inibidas previnem o crescimento celular tumoral. A Ãºltima age em tumores que produzem grandes quantidades da proteÃna HER2, produzida pelo gene HER2, que quando estimulado em excesso aumenta a taxa de crescimento celular.
â¢ A terceira forma de uso Ã© a de selecionar o tratamento de pacientes com HIV de acordo com a resistÃªncia viral para as medicaÃ§Ãµes disponÃveis. O kit TRUGENE HIV-1 de genotipagem Ã© um exemplo de detecÃ§Ã£o de variaÃ§Ãµes gÃªnicas que causam resistÃªncia a alguns anti-retrovirais.
Esse tipo de pesquisa poderÃ¡ tornar mais efetivo o tratamento para vÃ¡rias doenÃ§as, tais como para a doenÃ§a cardÃaca, diabetes, depressÃ£o, asma, etc... alÃ©m da resposta a quimioterÃ¡picos e antibiÃ³ticos. InformaÃ§Ãµes sobre esse tema podem ser acessados pelo site: http://www.fda.gov/fdac/features/2005/605_genomics.html
Dra. Nadja Zennig (C2) e Dra. Thalita Bittar Carneiro de Oliveira (C2)
2. EQUIPAMENTOS MÃDICOS E A âGENÃMICAâ: NOVOS PARADIGMAS NA ÃREA DE SAÃDE:
Neste artigo, publicado âon lineâ na pÃ¡gina da organizaÃ§Ã£o americana FDA (Food and Drug Administration), sÃ£o comentados novos equipamentos mÃ©dicos que fazem a anÃ¡lise genÃ©tica de certas doenÃ§as.
ApÃ³s a conclusÃ£o do projeto genoma humano e o desenvolvimento de tecnologias de anÃ¡lise genÃ©tica e molecular, como o âMICROARRAYâ, laboratÃ³rios comeÃ§aram a desenvolver equipamentos que possibilitariam em questÃ£o de poucos dias, a anÃ¡lise do DNA Ã partir de amostra de sangue total ou saliva e com isso.
O âMICROARRAYâ (ou âgene chipâ) consiste numa fina plataforma de vidro ou plÃ¡stico contendo milhares de segmentos gÃªnicos como um microchip. Estes genes na verdade sÃ£o âprobesâ (sondas DNA), consistem em pequenas seqÃ¼Ãªncias conhecidas de DNA capazes de se combinar com o DNA da amostra do paciente e causar uma reaÃ§Ã£o. Esta reaÃ§Ã£o pode ser mensurada e, desta forma, Ã© possÃvel analisar ao mesmo tempo milhares de genes (ou seqÃ¼Ãªncias conhecidas), avaliando mutaÃ§Ãµes, susceptibilidade a doenÃ§as e resposta a medicamentos.
Esta tÃ©cnica possibilita tambÃ©m avaliar qual gene estÃ¡ ativo e qual estÃ¡ inativo. Este tipo de tecnologia Ã© chamada GENÃMICA e possui variaÃ§Ãµes de acordo com o objetivo, como por exemplo, a FARMACOGENÃMICA (quais fÃ¡rmacos funcionam melhor em quais pacientes), METABOLÃMICA (estudo dos fluidos corporais para determinaÃ§Ã£o de alteraÃ§Ãµes no metabolismo) e PROTEÃMICA (estudo de proteÃnas num organismo ou tecido).
Exemplos de tecnologias que jÃ¡ estÃ£o em desenvolvimento sÃ£o o TAG-IT CYSTIC FIBROSIS KIT, que detecta as variaÃ§Ãµes genÃ©ticas mais comuns nos EUA causadoras de Fibrose CÃstica, ajudando no diagnÃ³stico das crianÃ§as acometidas e tambÃ©m identificando carreadores adultos do gene. Outros tipos de teste em estudo sÃ£o o TRUGENE HIV-1 que determina se o paciente Ã© portador de uma cepa de HIV resistente Ã certas drogas, guiando o tratamento. O AMPLI-CHIP CYTOCROME P450 GENOTYPING TEST detecta variaÃ§Ãµes num gene que determina a taxa de metabolismo e excreÃ§Ã£o de certos fÃ¡rmacos, possibilitando o ajuste da dose individual, e o UGT1A1 MOLECULAR ASSAY, que Ã© semelhante ao Ampli-chip, porÃ©m especÃfico para uma droga utilizada no tratamento do CÃ¢ncer de CÃ³lon, com isso avalia a possibilidade de resposta do tumor e minimiza os riscos de efeito colateral.
Estes exemplos demonstram o potencial de uso destas novas tecnologias que, no entanto, nÃ£o sÃ£o livres de falha. Uma das principais limitaÃ§Ãµes Ã© a falta de padronizaÃ§Ã£o nos resultados (tanto na nomenclatura quanto na identificaÃ§Ã£o dos genes utilizados nas diferentes plataformas de microarray), o que pode vir a causar erros em potencial. Especialistas dizem que ainda Ã© necessÃ¡rio padronizar, criar ferramentas de controle de qualidade, formato e interpretaÃ§Ã£o de resultados para que estas ferramentas possam ser usadas na prÃ¡tica clÃnica.
Outras informaÃ§Ãµes podem ser obtidas nos sites www.fda.gov?cder/genomics; www.personalizedmedicinecoalition.org; www.cdc.gov/genomics.
Thalita Bittar Carneiro de Oliveira (C2) e Juliana Gabriel Ribeiro de Andrade (C2)
3. VARIANTE DE GENE PODE PREDIZER DIABETES
Pesquisadores da Universidade Southwestern Medical Center, no Texas, identificaram uma variante gÃªnica que poderÃ¡ servir como preditora de DM tipo II. Segundo o Dr. Scott Grundy, diretor da Unidade de NutriÃ§Ã£o Humana dessa Universidade, a variante do gene ENPPI foi 13% mais freqÃ¼ente em pessoas com DM2 e naqueles em grande risco de desenvolvÃª-la. O gene ENPPI codifica uma proteÃna que bloqueia a aÃ§Ã£o da insulina e sua variaÃ§Ã£o aumenta ainda mais essa inibiÃ§Ã£o, contribuindo para a resistÃªncia insulÃnica. Nas trÃªs populaÃ§Ãµes estudadas, uma de nativos de Chennai, na Ãndia, outra de imigrantes indianos habitantes em Dallas e a ultima de norte-americanos caucasianos de Dallas, divididas em dois grupos formados por nÃ£o-diabÃ©ticos com alto risco e diabÃ©ticos, a variante do gene esteve presente em 25% do grupo nÃ£o-diabÃ©tico e 34% dos diabÃ©ticos na primeira populaÃ§Ã£o, em 33 e 45% naqueles imigrantes da segunda populaÃ§Ã£o e 26 e 39%, nos caucasianos nÃ£o-diabÃ©ticos e diabÃ©ticos americanos, respectivamente. O estudo demonstrou que a variante desse gene nas trÃªs populaÃ§Ãµes foi capaz de predizer o diabetes. Diabetes News â American Diabetes Association. In Diabetes Today. Gene Variant May Predict Diabetes, 04-JUL-2006. Originally Published: (20060101).
Dra. Nadja Zennig (C2)
4. ANÃLISE DA EXPRESSÃO GÃNICA DE TUMORES ADRENOCORTICAIS HUMANOS PELA ANÃLISE CDNA POR MICROARRAYS.
A anÃ¡lise comparativa cDNA por microarrays para o estudo da expressÃ£o gÃªnica dos tumores adrenocorticais benignos e malignos permitiu a identificaÃ§Ã£o de novos genes supressores tumorais e proto-oncogenes que ajudaram a delinear a tumorigÃªnese corticoadrenal, atÃ© o momento pouco conhecida. A anÃ¡lise do RNA de 10 amostras de tecido tumoral de adenocarcinoma adrenal (ACC) e 10 adenomas adrenocorticais benignos, pareados com 10 exemplares de tecido adrenocortical normal revelou vÃ¡rios genes com diferentes expressÃµes entre: ACC e tecido normal (42 genes), adenoma cortical e tecido normal (11 genes) e ACC e adenoma cortical (21 genes), respectivamente. Como confirmado pela tÃ©cnica âPCR em tempo realâ, o gene IGF2 estava significantemente estimulado no adenocarcinoma adrenal enquanto outros dois genes (o da cromatogranina B e o responsÃ¡vel pela resposta precoce ao fator de crescimento 1) se encontraram bloqueados nesses tumores malignos. AtÃ© o momento, as pesquisas com cDNA ajudaram a elucidar alguns aspectos moleculares associados a tumorigÃªnese adrenal. Para a identificaÃ§Ã£o da expressÃ£o de cada gene, mais anÃ¡lises serÃ£o necessÃ¡rias, os resultados obtidos atÃ© hoje ainda nÃ£o permitem elucidar as diversas etapas associadas a tumorigÃªnese destes neoplasias. (Slater, E.P et al. Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. European Journal of Endocrinology, 154(4): 587-598, 2006).
Dra. Nadja Zennig (C2)
5. CÃLULAS TRONCO: FALTA CONSENSO, SOBRA ESPERANÃA.
Segundo o Professor AntÃ´nio Carlos Paes de Carvalho, da UFRJ, a definiÃ§Ã£o clÃ¡ssica de cÃ©lula tronco Ã©: âuma cÃ©lula nÃ£o especializada com grande potencial de auto-renovaÃ§Ã£o, capaz de originar diferentes tipos celulares no organismoâ, que podem ser obtidas do feto e do adulto. As cÃ©lulas embrionÃ¡rias sÃ£o capazes de gerar qualquer um dos tipos celulares presentes nos tecidos do organismo, mas sua utilizaÃ§Ã£o do ponto de vista clÃnico ainda estÃ¡ bastante distante, porque precisarmos ter um controle sobre a sua proliferaÃ§Ã£o e diferenciaÃ§Ã£o.
O projeto Ghente - Estudos sociais, Ã©ticos e jurÃdicos sobre o acesso e uso de genomas na saÃºde, da FIOCRUZ promoveu recentemente um fÃ³rum para esclarecimento das possibilidades atuais de aplicaÃ§Ã£o das cÃ©lulas tronco, dos limites da tÃ©cnica e do uso seguro das terapias gÃªnicas.
As principais conclusÃµes foram:
â¢ Os procedimentos ainda estÃ£o em fase de pesquisa e levarÃ£o pelo menos dois anos para sua aplicaÃ§Ã£o (apesar de jÃ¡ haver resultados positivos, como a injeÃ§Ã£o de cÃ©lulas-tronco no coraÃ§Ã£o â Hospital PrÃ³-cardÃaco, que reduziu a isquemia de 15 % para 4,5%.
â¢ A Lei de BiosseguranÃ§a vigente no paÃs contÃ©m grandes falhas no que diz respeito Ã cÃ©lula-tronco embrionÃ¡ria, necessitando que ainda haja regulamentaÃ§Ã£o da ReproduÃ§Ã£o Assistida. Por outro lado, a ANVISA estÃ¡ criando um cadastro nacional para controle e rastreamento dos embriÃµes criados em clÃnicas de fertilizaÃ§Ã£o in vitro. Existe, contudo, uma aÃ§Ã£o no Supremo Tribunal Federal contra o artigo desta Lei que regulamentaria o uso dos embriÃµes inviÃ¡veis em pesquisas.
â¢ Para que se possa regulamentar todos os aspectos atravÃ©s de leis, que realmente sÃ£o categÃ³ricas, e nÃ£o atravÃ©s de portarias, passÃveis Ã relatividade, ainda hÃ¡ que se debater de forma muito difundida com toda a sociedade para que os termos da lei realmente sejam democrÃ¡ticos.
O Dr. AntÃ´nio Carlos divulgou o Brasil Cord â banco pÃºblico de cÃ©lulas de cordÃ£o umbilical, integrado a uma rede mundial coordenada pela OMS. As doaÃ§Ãµes sÃ£o de fundamental importÃ¢ncia, pois jÃ¡ ajudaram mais de 4 mil pessoas. As doaÃ§Ãµes podem ser feitas direto por um parente tambÃ©m pra este banco, o que evitaria que bancos particulares induzissem os pais do recÃ©m-nato a gastos desnecessÃ¡rios. AlÃ©m do uso terapÃªutico, estas cÃ©lulas tambÃ©m sÃ£o uma alternativa ao uso dos embriÃµes nas pesquisas. Mais informaÃ§Ãµes: Projeto Ghente: www.ghente.org (Bruno Rodrigues e ClaÃºdia Lopes). RADIS, jul 2006
Thalita Bittar Carneiro de Oliveira(C2)
6. GLOSSÃRIO âOMICSâ: SELEÃÃO DE TERMOS E CONCEITOS IMPORTANTES
â¢ AminoÃ¡cido: uma das 20 diferentes formas estruturais que se combinam para formar proteÃnas. A estrutura e a funÃ§Ã£o da proteÃna sÃ£o determinadas pela seqÃ¼Ãªncia de aminoÃ¡cidos presentes.
â¢ Base: uma das molÃ©culas â adenina, guanina, citosina, timina, ou uracila, que formam partes da estrutura molecular do DNA ou RNA. A seqÃ¼Ãªncia de bases moleculares do DNA determina a estrutura de proteÃnas codificadas por aquele DNA.
â¢ CÃ©lula: unidade bÃ¡sica de um ser vivo.
â¢ Cromossomo: estrutura intracelular que contÃ©m material genÃ©tico para formaÃ§Ã£o do gene. Cada cromossomo pode apresentar dezenas ou centenas de genes prÃ³prios. Cada espÃ©cie tem seu nÃºmero especÃfico de pares cromossÃ´micos, no homem sÃ£o 23 pares no interior do nÃºcleo e uma molÃ©cula de DNA nas mitocÃ´ndrias.
â¢ DNA: Ã a abreviaÃ§Ã£o de Ã¡cido desoxirribonuclÃ©ico, estrutura molecular dentro do nÃºcleo de uma cÃ©lula que carrega informaÃ§Ãµes genÃ©ticas para formaÃ§Ã£o do ser vivo.
â¢ Enzima: proteÃna que age como catalisador na iniciaÃ§Ã£o ou aceleraÃ§Ã£o de uma reaÃ§Ã£o quÃmica dentro da cÃ©lula.
â¢ Espectrometria de massa: mÃ©todo que utiliza um instrumento sofisticado que identifica substÃ¢ncias quÃmicas atravÃ©s do peso molecular.
â¢ ExpressÃ£o gÃªnica: processo pelos quais as proteÃnas sÃ£o constituÃdas no organismo atravÃ©s de instruÃ§Ãµes codificadas pelo DNA.
â¢ FarmacogenÃ´mica: associaÃ§Ã£o do estudo das drogas (farmacologia) com o estudo de todos os genes (genÃ´mica) com o objetivo de determinar como variaÃ§Ãµes do genoma humano afetam a resposta individual aos medicamentos.
â¢ FenÃ³tipo: caracterÃsticas e traÃ§os fÃsicos de uma pessoa ou um organismo, como por exemplo, cor dos cabelos, peso, ou a presenÃ§a ou ausÃªncia de uma doenÃ§a.
â¢ Gene: unidade bÃ¡sica de hereditariedade passada dos pais para os filhos, seqÃ¼Ãªncias de DNA, que instruÃ§Ãµes para formaÃ§Ã£o de proteÃnas ou outros componentes do ser vivo.
â¢ Genoma: grupo completo de DNA que contÃ©m toda informaÃ§Ã£o genÃ©tica do indivÃduo ou organismo.
â¢ GenÃ´mica: estudo de todos os genes de um organismo vivo assim como suas funÃ§Ãµes e atividades e a interaÃ§Ã£o entre eles e entre eles e o ambiente.
â¢ GenÃ³tipo: informaÃ§Ã£o genÃ©tica de um indivÃduo ou organismo.
â¢ Marcadores biolÃ³gicos: indicadores de doenÃ§a ou risco de uma doenÃ§a, por exemplo: colesterol sÃ©rico Ã© um marcador biolÃ³gico de risco de doenÃ§a cardÃaca.
â¢ Metabolismo: todo processo fÃsico e quÃmico do organismo necessÃ¡rio para vida.
â¢ MetabÃ³lito: qualquer molÃ©cula ou substÃ¢ncia produzida a partir do metabolismo.
â¢ MetabÃ³lito de Baixo Peso Molecular: metabÃ³lito de peso leve que pode apresentar indÃcios importantes sobre a saÃºde de uma pessoa, incluem aminoÃ¡cidos, aÃ§Ãºcares, carboidratos, e lipÃdios
â¢ MetabÃ³lito PrimÃ¡rio: metabÃ³lito essencial para o crescimento normal e desenvolvimento em um ser vivo. Os cientistas acreditam que existem no corpo humano em torno de 3000 metabÃ³litos primÃ¡rios.
â¢ MetabÃ³lito SecundÃ¡rio: metabÃ³lito nÃ£o essencial para o crescimento e desenvolvimento em um ser vivo, mas podem combater infecÃ§Ãµes ou outras formas de stress.
â¢ Microarray: ferramenta que estuda como o genes, em geral, interagem entre si e sua expressÃ£o nos tecidos alvos.
â¢ MolÃ©cula: Ã a combinaÃ§Ã£o de dois ou mais semelhantes ou diferentes Ã¡tomos.
â¢ MutaÃ§Ã£o: mudanÃ§a na seqÃ¼Ãªncia do DNA que pode levar a sÃntese de uma proteÃna alterada ou inativa ou perda da capacidade do gene de produzir proteÃna.
â¢ NucleotÃdeo: estrutura de Ã¡cidos nuclÃ©icos; consiste uma das cinco bases nitrogenadas: adenina, guanina, citosina, timina ou uracila.
â¢ Polimorfismos: variaÃ§Ã£o de bases que nÃ£o incorrem em manifestaÃ§Ã£o clÃnica, sÃ£o observados numa freqÃ¼Ãªncia igual ou acima de 1% e transmitidos com heranÃ§a autossÃ´mico dominante.
â¢ Projeto Genoma Humano: pesquisa internacional extensiva empenhada em determinar a seqÃ¼Ãªncia pelo qual o DNA humano Ã© organizado.
â¢ ProteÃna: uma molÃ©cula que consiste em uma cadeia formada pela uniÃ£o de vÃ¡rios aminoÃ¡cidos.
â¢ ProteÃ´mica: campo de estudo que avalia todas as proteÃnas em um ser vivo, determinando sua formaÃ§Ã£o, funÃ§Ã£o e como elas interagem entre si.
â¢ SeqÃ¼enciamento de DNA: uma tÃ©cnica laboratorial usada para determinar a ordem exata dos pares de bases em um segmento do DNA.
â¢ SNPs (single nucleotide polyorphism): sÃtios na seqÃ¼Ãªncia do DNA do genoma humano que diferem os indivÃduos. Estas variaÃ§Ãµes podem ser usadas para rastrear heranÃ§a familiar.
â¢ Sonda de DNA: segmento de uma molÃ©cula do DNA usado em experimentos laboratoriais para detectar a presenÃ§a ou perda de um gen.
Aline Barbosa Moraes (C2)
ARTIGOS PUBLICADOS ENDOCRINOLOGIA
7. HIPOTIREOIDISMO: O DEBATE CONTINUA...
O artigo debate sobre o tratamento com hormÃ´nios tireoidianos para pacientes com clÃnica sugestiva e laboratÃ³rio normal voltou Ã tona recentemente. No inÃcio de 2006 a Sociedade de Endocrinologia recebeu uma petiÃ§Ã£o contendo mais de 2000 assinaturas de pacientes que encaminharam uma reclamaÃ§Ã£o formal contra os clÃnicos que âsuper estimavamâ os resultados de laboratÃ³rio âsub tratandoâ ou nÃ£o tratando os sintomas, apesar do sofrimento dos pacientes. Um editorial do presidente da associaÃ§Ã£o britÃ¢nica de tireÃ³ide (BTA), Tony Weetman, dizendo que os clÃnicos possuem ferramentas laboratoriais robustas para direcionar o tratamento do hipotireoidismo, foi a causa das manifestaÃ§Ãµes.
O debate nÃ£o foi sobre o hipotireoidismo sub clÃnico e sim sobre o tratamento de pacientes com sintomas inespecÃficos cujos resultados laboratoriais encontram-se dentro dos limites considerados ânormaisâ. A BTA nÃ£o recomenda tratamento nestes casos. Mesmo assim, em 2000 a BBC News noticiou que alguns clÃnicos continuam prescrevendo hormÃ´nios tireoidianos para pacientes sintomÃ¡ticos e com exames normais, a despeito desta recomendaÃ§Ã£o.
O artigo termina lembrando tambÃ©m que o tratamento de sintomas inespecÃficos com hormÃ´nios tireoidianos nÃ£o sÃ³ submete o paciente aos riscos de um excesso destes hormÃ´nios como tambÃ©m desvia a atenÃ§Ã£o do mÃ©dico para o diagnÃ³stico correto da afecÃ§Ã£o que atinge o paciente, que pode ser inclusive mais grave.
Juliana Gabriel Ribeiro de Andrade (C2)
8. TERAPIA COM TESTOSTERONA EM HOMENS ADULTOS COM SÃNDROMES DE DEFICIÃNCIA ANDROGÃNICA: UM GUIA CLÃNICO PRÃTICO DA ENDOCRINE SOCIETY
O Hipogonadismo em homens Ã© uma sÃndrome clÃnica que resulta da deficiÃªncia do testÃculo em produzir nÃveis fisiolÃ³gicos de testosterona e nÃºmero normal de espermatozÃ³ides pela deficiÃªncia de um ou mais nÃveis do eixo hipotÃ¡lamo-hipÃ³fise-gonadal. A Endocrine Society promoveu grupo para produzir as diretrizes de diagnÃ³stico e tratamento da DeficiÃªncia androgÃªnica (DA), que foi composto por membros do sub-comitÃª de guidelines clÃnicos, outros cinco especialistas, um metodologista e um escritor profissional. Foi utilizada revisÃ£o sistemÃ¡tica para uso das recomendaÃ§Ãµes-chave.
Recomendou-se fazer o diagnÃ³sticos de DA somente em homens com sintomas e sinais consistentes e nÃvel sÃ©rico baixo de testosterona inequÃvoco. Preferiu-se a dosagem matinal da testosterona total por um mÃ©todo seguro como teste de diagnÃ³stico inicial, com confirmaÃ§Ã£o atravÃ©s da repetiÃ§Ã£o do mesmo e, em alguns pacientes, pela dosagem do nÃvel de testosterona livre ou bioativa.
Foi recomendado terapia com testosterona para homem sintomÃ¡ticos com DA, que tem nÃveis baixos de testosterona, para induzir e manter caracterÃsticas sexuais secundÃ¡rias e aumentar sua funÃ§Ã£o sexual, sensaÃ§Ã£o de bem estar, densidade mineral Ã³ssea, massa e forÃ§a muscular. Recomendou-se nÃ£o utilizar terapia com testosterona em pacientes com cÃ¢ncer de mama ou de prÃ³stata, nÃ³dulo ou endurecimento prostÃ¡tica palpÃ¡vel, PSA maior ou igual a 3ng/ml, eritrocitose (hematÃ³crito > 50%), hiperviscosidade, apnÃ©ia obstrutiva do sono nÃ£o tratada, sintomas graves do trato urinÃ¡rio com IPPS (Internacional Prostate Symptom Score) maior que 19, ou insuficiÃªncia cardÃaca classe III ou IV. Quando a terapia com testosterona Ã© constituÃda, sugere-se monitorar o nÃvel de testosterona, mantendo-os no meio normal de variaÃ§Ã£o do mÃ©todo, com uso de qualquer formulaÃ§Ã£o aprovada baseado na preferÃªncia do paciente, consideraÃ§Ã£o da farmacocinÃ©tica do medicamento e Ã´nus do tratamento.(A descriÃ§Ã£o completa dos sinais e sintomas, dos dados de histÃ³ria do paciente e mÃ©todos de dosagem de testosterona podem ser obtidos no artigo: Matsumoto, MD & Vigersky, R.V. (2006), J Clin Endocrinol Metab 91: 1995-2010).
Karyne Lima (C2)
9. PREDITORES DE DIABETES NO PÃS-PARTO EM MULHERES COM DIABETES GESTACIONAL
O Diabetes Mellitus Gestacional (DMG) Ã© definido como a intolerÃ¢ncia Ã glicose diagnosticada durante a gestaÃ§Ã£o e estÃ¡ presente em 4% das mulheres grÃ¡vidas. O DMG aumenta substancialmente o risco de desenvolvimento de diabetes no pÃ³s-parto e identifica uma populaÃ§Ã£o de alto risco para desenvolvimento de Diabetes mellitus (DM) tipo 1 e 2.
O objetivo desse estudo foi o de estratificar o risco no pÃ³s-parto de diabetes em mulheres que apresentaram DMG. Foram recrutadas 302 mulheres com DMG, no perÃodo entre 1989 e 1999, que foram submetidas ao teste oral de tolerÃ¢ncia Ã glicose no nono mÃªs e no segundo, quinto, oitavo e dÃ©cimo primeiro ano apÃ³s a gestaÃ§Ã£o.
No oitavo ano de acompanhamento jÃ¡ havia uma incidÃªncia de 52,7% de DM, ou seja, 130 casos. Os fatores de risco positivos e estatisticamente significativos para o desenvolvimento de DM foram: anti-GAD e anti-IA2 positivos (p< 0,0001), necessidade de insulina durante a gestaÃ§Ã£o (p<0,0001), IMC >30kg/m2 (Ãndice de massa corporal) (p = 0,04) e mais do que duas gestaÃ§Ãµes com DMG. NÃºmero de gestaÃ§Ãµes, proteÃna C reativa, histÃ³ria familiar de DM, idade da gestante, duraÃ§Ã£o da gestaÃ§Ã£o e o peso de nascimento da crianÃ§a nÃ£o afetaram o risco na anÃ¡lise multivariada.
Conclui-se, entÃ£o, com esse trabalho que Ã© necessÃ¡rio o acompanhamento e a intervenÃ§Ã£o em mulheres com histÃ³ria de DMG que apresentam anticorpos positivos ou que necessitaram de insulina durante a gestaÃ§Ã£o ou que sÃ£o obesas. (LÃ¶bner K et al. Predictors of Pospartum Diabetes in Women with Gestacional Diabetes Mellitus: Diabetes, vol 55, 792-797, March 2006)
Luciana Lopes de Souza (C2)
10. ESTUDO DE CASO: INDUÃÃO DE FERTILIDADE EM HOMEM
Caso ClÃnico: homem de 40 anos, encaminhado para avaliaÃ§Ã£o de hipogonadismo e infertilidade. Nos Ãºltimos 2 anos notou diminuiÃ§Ã£o progressiva da libido, do volume ejaculatÃ³rio e do tamanho testicular. Costuma beber 3 a 4 taÃ§as de vinho por semana, nÃ£o usa nenhum remÃ©dio e nÃ£o tem histÃ³ria patolÃ³gica pregressa digna de nota. Na histÃ³ria familiar, seu pai teve cirrose hepÃ¡tica, provavelmente induzida por Ã¡lcool. Ao exame fÃsico, apresentava sinais vitais normais e IMC de 24, nÃ³dulos de Bouchard bilateralmente e nenhuma evidÃªncia de bÃ³cio. Caracteres sexuais secundÃ¡rios eram normais e nÃ£o havia ginecomastia. FÃgado palpÃ¡vel a 2cm do RCD mas sem estigmas de disfunÃ§Ã£o hepatocelular. O volume testicular era de 10ml bilateralmente.
AvaliaÃ§Ã£o laboratorial inicial mostrava uma Testosterona total de 36ng/dL (1.3nmol/L), LH de 1,5 IU/L e FSH de 1,0 IU/L. O espermograma demonstrava azoospermia e volume de 0,5mL. T4 total era de 6,6mcg/dL (VR: 4,5-10,9), prolactina de 4,2ng/mL (VR: 2-18). TGP 88 (VR: 7-30) e TGO 70 (VR: 9-25). Glicemia de jejum era 105mg/dL.
QuestÃµes: 1. Quais testes adicionais seriam necessÃ¡rios para elucidaÃ§Ã£o diagnÃ³stica?
2. Como tratar o paciente?
1. Paciente com hipogonadismo hipogonadotrÃ³fico apesar de ter outras funÃ§Ãµes hipofisÃ¡rias e RNM normais. A chave para o diagnÃ³stico neste paciente Ã© a hepatomegalia, artropatia e aumento de transaminases que levantam a possibilidade de HEMOCROMATOSE HEREDITÃRIA. O consumo relativamente pequeno de Ã¡lcool e uma relaÃ§Ã£o TGO/TGP abaixo de 1 diminuem a chance de uma hepatite alcoÃ³lica.
A hemocromatose Ã© uma doenÃ§a autossÃ´mica recessiva caracterizada por depÃ³sito excessivo de ferro no organismo, incluindo a hipÃ³fise. O hipogonadismo hipogonadotrÃ³fico Ã© a anormalidade mais freqÃ¼ente nesta condiÃ§Ã£o. O hipogonadismo primÃ¡rio por depÃ³sito testicular de ferro tambÃ©m ocorre mas Ã© muito menos freqÃ¼ente.
Os testes adicionais para a confirmaÃ§Ã£o diagnÃ³stica seriam uma saturaÃ§Ã£o de transferrina e ferritina aumentadas. O tratamento deve ser primeiramente voltado para a condiÃ§Ã£o de base, que Ã© a flebotomia terapÃªutica. A reversÃ£o do hipogonadismo apÃ³s depleÃ§Ã£o de ferro foi descrita em alguns casos, mas Ã© exceÃ§Ã£o, principalmente pela idade do paciente, que tambÃ©m torna a induÃ§Ã£o de espermatogÃªnese questionÃ¡vel. O tratamento escolhido no caso deste paciente foi apenas Ã reposiÃ§Ã£o de testosterona para recuperaÃ§Ã£o da libido e potÃªncia.
Juliana Gabriel Ribeiro de Andrade (C2)
|Pills to cure acne|
|Get Rid of Cold Sores Fact or Fantasy||The Herpes family of viruses has plagued mankind throughout the ages. Eight different viruses, and all sorts of mutated forms of them, make up the herpes virus family. The two most common ones that come to mind are herpes simplex 1 (cold sores) and herpes simplex 2 (genital herpes). Modern medicine claims that there is no cure for herpes. But, does a natural cure for herpes exist?|
Many holistic medical practices claim that herpes can be cured naturally through the use of certain herbs and vitamins. No one is, however, able to completely prove these claims
One reason for this is that the FDA does not control herbal or vitamin supplements. The government does not recognize any of these substances as having the ability to prevent, treat, or cure any medical condition, whatsoever. The other reason is that natural remedies have no financial advantage for anyone. They can not be patented or limited in any way, so nobody wants to invest a lot of money in the necessary research to determine if these agents are truly effective.
The internet is, however, loaded with sites claiming to have the cure for herpes. Many claim to have a natural cure for herpes and can show a long list of customer testimonials on the effectiveness of their product. All of these sites are set up to promote their own unique, proprietary blend of herbs and vitamins. Some are in tablet form. Others are in the form of a salve to be applied directly to the affected skin. All claim to prevent future outbreaks if used regularly.
There's the catch. "If used regularly". That doesn't sound like a cure. Herpes can be treated in a number of different ways. Doctors will prescribe antivirals that are designed to keep the virus in a weakened state and help eliminate outbreaks. These medications must be taken regularly to be effective. Other medications are available that will treat the symptoms of herpes outbreaks at the site. These medications are tested and approved by the FDA for the treatment of herpes. None claim to cure the disease.
Another problem with claims of having a natural cure for herpes is the method used to test whether a person is infected. Viruses are so small that they can only be seen using a very expensive piece of equipment known as an electron microscope. These devices are very rare due to their price. Doctors, therefore, have adopted the practice of testing a person's blood for viral infections by looking for the antibodies associated with the virus, rather than the virus itself. The problem here is that antibodies are part of the body's natural immune system.
If a body has ever had a virus, the antibodies will be present in some small quantity in the blood forever. This makes it impossible to truly tell if a person still has the virus or has been cured.
A natural cure for herpes may very well exist. Nobody can truly say conclusively in today's modern medical world. Until someone can prove a cure, natural or otherwise, it is best to continue regular treatment for herpes and prevent future outbreaks. Medicines and natural compounds can be used for this. Just never assume that you are cured and take precautions against the possible spread of herpes. This is the safest course.
Lance Thorington's articles have been published on numerous places online including web sites, ezines, blogs and email lists. Is there a natural cure for herpes? There is! Read more at http://www.remediesforherpes.com
get rid of cold sores: get rid of cold sores
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Article Source: www.articlesnatch.com
|Don't worry, your Moscow Mule copper mug isn't going to kill you||
A minor panic broke out when Iowa banned restaurants and bars from using copper mugs due to safety concerns.
The FDA guidelines say that copper shouldn't come to contact with foods that have a pH below 6.0. The pH of Moscow Mules is well below 6.0, but the copper mugs that are usually served with the drink are lined with tin or stainless steel.
So they're safe to drink from. Enjoy your Moscow Mule with a peace of mind! Read more...More about Food, Health, Beverage, Alcohol, and Drink
|Do a Pubmed search after talking to your doctor||When evidence says no, but your doctor says yes For all the truly wondrous developments of modern medicineâimaging technologies that enable precision surgery, routine organ transplants, care that transforms premature infants into perfectly healthy kids, and remarkable chemotherapy treatments, to name a fewâit is distressingly ordinary for patients to get treatments that research has shown are ineffective or even dangerous. Sometimes doctors simply haven't kept up with the science. Other times doctors know the state of play perfectly well but continue to deliver these treatments because it's profitableâor even because they're popular and patients demand them. Some procedures are implemented based on studies that did not prove whether they really worked in the first place. Others were initially supported by evidence but then were contradicted by better evidence, and yet these procedures have remained the standards of care for years, or decades.
That isn't likely to change any time soon. The 21st Century Cures Actâa rare bipartisan bill, pushed by more than 1,400 lobbyists and signed into law in Decemberâlowers evidentiary standards for new uses of drugs and for marketing and approval of some medical devices. Furthermore, last month President Donald Trump scolded the FDA for what he characterized as withholding drugs from dying patients. He promised to slash regulations "big league. ... It could even be up to 80 percent" of current FDA regulations, he said. To that end, one of the president's top candidates to head the FDA, tech investor Jim O'Neill, has openly advocated for drugs to be approved before they're shown to work. "Let people start using them at their own risk," O'Neill has argued. |
|FDA Approved Hair Loss Treatment||It's a bone of contention about what exactly carries a FDA Approval when it comes to Hair Loss Treatment or any other FDA Approved product for that matter.|
I have it on good authority that FDA Approval is more a matter of Economics than whether a drug actually works or not.
Makes you wonder doesn't it?
Even so, if a product carries FDA Approval it is more than likely to be a better option than something that doesn't if logic has anything to do with it.
And, when it comes to FDA Approval and Hair Loss Treatments it's also interesting to note that only two (2) drugs actually have the documented Approval.
Funilly enough the two drugs that have FDA Approval are also the base for some of the products that are currently on the market.
Interestingly enough the product that you will find a link to at the base of this article is One of those that have one of the two drugs approved by the FDA as it's base.
There are also lots of products that purport to assist with Hair Loss but they really aren't worth considering because they don't have one of the two FDA Approved drugs.
In case you actually want to know what those two drugs are their names are Minoxidil and finasteride.
Minoxidil is in the product that we recommend - Provillus which you can access by going to the website address at the bottom of the article.
The truth of the matter is simply this if you are one of the Millions of people World wide who have a thinning hair or hair loss problem then you have to rely on something to help you fix your problem.
And, let's face it the FDA Approval still carries more weight than something with no approval at all. It only stands to reason doesn't it?
So, here's your chance to get that FDA Approval and hair loss treatment in one hit!
FDA Approval, for what it is worth is better than Nothing.
|Salon Madam: Tanam Bulu Mata di Trans TV|
Salon Madam: Tanam Bulu Mata adalah sebuah judul sinetron lepas yang menghiasi slot Bioskop Indonesia Siang di Trans TV pada Sabtu, 14 Maret 2015 pukul 12.00-14.00 WIB. Menghadirkan Ryn ChiBi dan Cleo eks-JKT48. Bagi yang tidak terbiasa menonton Bioskop Indonesia Siang Trans TV mungkin cerita seperti ini susah ditebak. Apalagi ini beda banget dengan FTV SCTV yang biasanya tentang romansa muda-mudi.
Menonton film televisi ini sangat seru dan menarik. Pesona cantik member Chibi itu membuat semuanya betah nonton FTV ini.
Di akhir cerita kita mendapatkan pesan moral yang bisa kita petik untuk kehidupan kita.
Nomor Pendaftaran : 6209/PSV-NAS/DVD/LSF/III/2015 Kamis, 12 Maret 2015 Jam 13:04:41 Pengukuran Video Kamis, 12 Maret 2015 Jam 13:22:48 Berita Acara Penyensoran : NO. 1295/DVD/2015 Kamis, 12 Maret 2015 Jam 14:12:14 Lulus Sensor Nomor : 2025/DVD/13/PH.NAS/03.2020/2015 Judul Rekaman Video : SALON MADAM, TANAM BULU MATA Negara Asal : INDONESIA Diluluskan Untuk : 13 TAHUN KE ATAS Batas Waktu Berlaku : 12 MARET 2020 MPP/MPI/Kosong : MENIT/ 89 MENIT/ MENIT T y p e : DVD B a h a s a : INDONESIA Teks Terjemahan : --- Jenis : DRAMA Pemilik Film : PT. KINOKO HALLOGEMA KREASINDO JAKARTA, 13 MARET 2015
|State Regulators Warn Halloween Colored Contacts Could Permanently Damage Your Eyes|| CHICAGO â With the Halloween season upon us, the Illinois Department of Financial and Professional Regulation (IDFPR) is reminding the public that purchasing colored contact lenses from anyone other than a licensed eye care professional or pharmacist is dangerous. In recent years, illegally-purchased colored contacts have flooded the retail market during Halloween and are most often found at malls, beauty supply stores and via online websites. These lenses are often made overseas in non-FDA approved facilities with tinting materials that may be toxic to the eye. Without a proper examination and fitting, colored contacts can cause damage to the eye, including blindness.|
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|Klonopin(Clonazepam) Questions||Question: I am on 1 mg. of Klonopin, twice a day. I tried to find an alternative anxiety med with less side effects, and discovered Grandaxin (tofisopam), a benzo derivative that does not cause sedation, memory loss or dependence. http://en.wikipedia.org/wiki/Grandaxin The only problem is, this med is not available in the U.S., so I can't seem to find any info on switching to it from benzo's. I have found a reputable dose equivalent chart online [http://www.non-benzodiazepines.org.uk/benzodiazepine-names.html ], but is it safe to switch directly from a benzo like Klonopin to a benzo derivative like Grandaxin, as long as the doses are equivalent? Grandaxin does not act on GABA, like benzo's, and I know you are supposed to taper off of benzo's to avoid withdrawal symptoms. Will I go into withdrawal, or will the Grandaxin simply work like the Klonopin without the nasty side effects, like I hope it will, if I switch? Or, would it be better to taper off the Klonopin onto the Grandaxin, since it is safe to combine them? Thank you.|
Answer: So here's the thing...there is a reason grandaxin is not FDA approved in the USA. You have put a lot of research and effort into finding an alternative to the clonazepam(klonopin). You say you are having side effects from the klonopin. But it sounds like the klonopin has been controlling your anxiety. If you were my patient, I would explore with you the side effects and how your typical day goes. Do you have worse anxiety in the morning, evening, or night? Do you have side effects shortly after taking the klonopin? Do you have other symptoms such as difficulty focusing, insomnia, poor appetite, no motivation? Maybe you have more than just simple anxiety or maybe it is just anxiety. I would change your klonopin dosing to 0.5mg three times a day. I would discuss with you adding on another medication that will help your symptoms and while we give the new medication time to work, I would slowly taper you off the klonopin. You need to cross taper if you truly want to come off the klonopin. I don't recommend a complete switch. And, it is very dangerous to stop the klonopin abruptly. You can have terrible withdrawal such as panic and seizures. There is a very specific equivalency chart of how much klonopin equals how much valium and so on. 1mg of klonopin does not equal 1mg of valium or xanax or ativan. There are many options. It is all about me listening to exactly what symptoms you are having at what times of day in what kinds of situations. That's how we(me and you) would pick a medication for you. If you feel like your prescriber is not helpful in this way, time for a new prescriber. I happen to use klonopin quite a bit. It is a medication to be used short term while you explore what's at the root of your anxiety. Sometimes, I prescribe klonopin at the same time I do intensive cognitive therapy and then ween off the klonopin and the person is able to adequately control their anxiety with new coping skills and behavioral techniques. It's time to put all that energy into evaluating yourself. Stop looking for a magic pill. Your "magic pill" is your mind, you are in control of your thoughts and feelings and behaviors. Buddha says: "All that we are is the result of what we have thought." Good luck!
|Too Much Adderall?||Question: What would the maximum dose for Adderall Extended Release be for an adult male? I am very concerned that my brother in law was given a RX for far more than he needed.|
Answer: Well, many prescriber's go above the FDA recommended dose of Adderall XR 20mg daily. The XR should only be taken once a day. This is not a medication that adults should take long-term. In my practice, I avoid prescribing this medication. I just have not seen long-term success with it and too many people abuse the medication. I know this sounds quite negative, but it's my opinion, it's a dangerous medication if not prescribed and taken appropriately. Your brother-in-law should get a second opinion.
|Details Teams with CFDA for Designer Duffel Bag Auction||Details Magazine partners up with CFDA once again to release a collection of weekenderÂ bags based on the basic army duffel. Twenty designers including Todd Snyder, Marc Jacobs, Isaora, Tommy Hilfiger, Billy Reid and more contributed bags for the auction. Each bag will be sold on eBay auction style with proceeds going to the CFDA […]|
|CFDA Pocket Squares + Details Magazine Auction||Details Magazine, teams up with the CFDA, commissioning ten award-winning designers to create a series of limited edition pocket squares in time for holiday. Designers include Band of Outsiders, Billy Reid, John Varvatos, Marc Jacobs, Michael Bastian, Rag & Bone, Richard Chai, Robert Geller, Thom Browne, and Tommy Hilfiger. Each designer will develop 11 pocket […]|
|Isopropyl Alcohol Wipes||Some pre-moistened wipes compound formulations are multiple-ammonium compounds, beverage-quaternary ammonium compounds, gas supported, and gas whitener based. Most people prefer alcohol germicidal wipes as a pre-moistened tissue. |
Alcohol wipes come in simple to open, convenient packaging. Alcohol wipes are fantastic antiseptic source for skin preparation prior to injections. The content of these alcohol wipes is 70 percent isopropyl alcohol. Disposable wipes and most Dynarex medical supplies are sold by the box or case.
The healthcare facilities are facing a lot of challenges nowadays. Preventing infection transmission is the major challenge. To prevent infections from healthcare, make sure you clean and disinfect surfaces properly. Playing a vital role in infection transmission, is the environment, as everything that moves between patients (equipment, hands, etc.), may be a transmission method. More people want pre-moistened germicidal wipes more than ever because they are cleaning and disinfecting environmental surfaces and non-critical patient-care equipment. Germicides are agents that make microorganisms inactive. Terms with the suffix "cidal" or "cide" refers to the killing action.
The working ingredient of alcohol-quaternary ammonium wipes is quaternary ammonium chloride. Alcohol could be an ingredient on the label, and the alcohol percentage can be located in safety data sheets.
Why are alcohol-quaternary ammonium formulations a good choice?
Alcohol-quaternary formulations are not corrosive to metals. Alcohol wipe is used to clean, remove grease or fat, and as an antiseptic.
Reducing the contamination risk for wounds and injection sites can be achieved by removing the bacteria around the site, which can be done by degreasing the surrounding skin. Alcohol wipes are quicker than soap and water for skin cleansing and are more efficient than plain water in this way.
People often wonder, "Does the FDA approve your alcohol wipes ?" The answer is definitely "yes". FDA regulates the manufacturing process of all commercial alcohol wipes intended for skin contact or for sanitizing purposes.
Alcohol wipes, although not specifically endorsed by the FDA, are mentioned as necessary for sanitation in many FDA-related studies.
Antiseptics, such as alcohol, kill bacteria and viruses. It is an imperfect antiseptic, so it won't sterilize instruments. In order to prep thermometers, instruments or skin for IVs, blood draws or IM injections, it's a near-solution.
It's safe to apply alcohol wipes to intact skin. Mucous membranes are damaged when the product is applied on them; it shouldn't be used on these.
The alcohol found here is different from what is found in beer or wine. If someone drinks it, it could cause sickness or even death. Do not ingest or allow others to ingest alcohol wipes.
|25 Legal Drugs More Dangerous Than Marijuana|
How long will politicians live in fear of marijuana and throw billions of dollars into eradicating it and jailing thousands of people for possessing it? The overwhelming majority of its users do not develop addictions. It is practically impossible to overdose on. It even has health benefits, like slowing tumor growth and easing glaucoma. And it’s safer than the 25 legal drugs, substances, and even household products we’ve laid out here. By the end, you’ll be ready to say with us: legalize it!
Over The Counter
The phrase “drugs and alcohol” is redundant. People who drink alcohol can impair their faculties, develop a tolerance for it, and become addicted. That’s a drug, and a very dangerous one at that. Brain damage, cancer, and death (37,000 of them in the U.S. each year) are just some of those dangers to alcohol consumers, not to mention the nearly one-third of violent crimes perpetrated in the U.S. each year that are alcohol-related.
Yes, through some fluke in the legal system, cigarettes remain legal while weed is banned. As cigarette smoking claims more than 5 million lives around the world annually, one might rightly wonder why that is the case. Even in a direct comparison, marijuana is demonstrably safer. A 20-year study found smoking as often as a joint a day for seven years does not harm the lungs.
The active ingredient in Tylenol and the most commonly used painkiller in America, acetaminophen has caused many cases of liver failure, mainly by overdose but also through users taking the recommended dosage. In fact, in about 10% of deaths due to ingestion levels are found to be at or below the daily maximum recommended dosage.
The American worker’s favorite substance is dangerous in high enough doses. Since 2005, reports of caffeine overdoses have risen from 1,128 to 16,055 in 2008 and 13,114 in 2009. The dangers short of death include weaker bones, higher blood pressure and flat-out addiction. But then again, many of us already knew that, didn’t we?
These are the gas station drugs, the ones with names like “Bliss” that are still legal in many states by posing as supplements or vitamins. President Obama has gone so far as to issue a warning about these drugs.
K2 or “Spice” is also a synthetic drug, but it bears special mention on its own because it’s synthetic weed. It happens to be more dangerous than natural pot and as with other synthetic recreational drugs it's effects are not well known. Intense hallucinations, seizures, and rapid heartbeat are the negative effects one can expect when smoking the man-made cannabis. The Synthetic Drug Abuse Prevention Act of 2012 was brought in law in the US to control this substance.
Used as a diet pill, bitter orange contains a chemical called synephrine. Synephrine is very similar to ephedra, which is banned in the U.S. because it increases the risk of heart attack and stroke. Bitter orange has been linked to a number of deaths and is not recommended by the Mayo Clinic.
Health and fitness website Livestrong.com says the common side effects of this over-the-counter male enhancement supplement “border on dangerous.” They include blurred vision and dizziness (which could also come with smoking marijuana), but also arm, back and/or jaw pain and chest tightness.
Teens have no trouble getting their hands on dextromethorphan, or DMX, the chemical found in cough medicine tablets, gels, and syrups. Though drinking too much syrup causes vomiting before overdose is possible, DMX can be extracted and sold, creating a healthy market for a very dangerous drug that can cause everything from seizures to brain damage and even death.
Legal in more than half the states in the U.S., salvia is a herb with leaves that users smoke to reach a “high.” Um, that sounds familiar. Many health professionals have drawn comparisons between salvia’s addictive qualities with PCP and cocaine and some users with histories of mental illness have reported relapses while smoking salvia. In other words, it’s a more addicting and more paranoia-causing form of weed.
This friendly party gas for filling up balloons is a dangerous drug when used as an inhalant, and it’s totally legal and easy to come by. There are few official statistics on helium huffing deaths, but there have been noted cases of death from air embolism upon inhaling helium.
The upsides of huffing paint are apparently euphoria and some pretty cool hallucinations. But it’s not worth the downside: vomiting, skyrocketing heart rate, pneumonia, liver damage, cardiac arrest … we could go on. A particularly conscientious store might card for its purchase, but other than that, paint is about as easy to come by as paper towels.
How many other school supplies can be compared in regards to danger with to cocaine? Glue sniffing kills people, especially young people, all over the world. Its use remains popular as a cheap high in poor areas because it’s easy to get, but it is far more dangerous than smoking marijuana.
A 2007 study that appeared in medical journal The Lancet rated this wake-up drug more harmful than cannabis in both physical harm and level of possible dependence and as having the same risk of social harm. It’s the main chemical in medications like Adderall, the popular ADHD drug.
Also marketed under the name Dolophine, methadone is a prescription drug used for pain relief and helping heroin addicts detox. Unfortunately, methadone also caused 4,462 deaths in 2005. A year later it was dubbed the leading drug killer in several states. In 2009 it caused 15,597 deaths. The drug is known to cause often fatal cases of respiratory depression and fatal overdose in kids who take it accidentally.
The high-profile deaths of people like Heath Ledger and the painter Thomas Kinkade due to overdose involving Valium are shocking reminders of the dangers of this Class IV drug. On its own it is very prone to causing dependency and is often taken as a “secondary” drug to maximize the effect of illegal drugs.
The legal use of ketamine is as an anesthetic in medical operations. However, drug abusers use it to experience that same feeling of floating, and it is easily obtained online. Paralysis, psychological dependency, hallucinations, and overdose are all risks of ketamine.
This painkiller has been found so dangerous in recent years it has now been pulled from the market in Canada, where addiction is rampant. It had been causing 300 deaths a year in just Ontario. With a nearly identical chemical makeup as heroin, many wonder why one is illegal and the other legal.
Xanax is prescribed to combat anxiety, but one might think jaundice (liver damage) and seizures would increase worry rather than decrease it. Other dangerous side effects include hallucination and suicidal thoughts. It is highly addictive and was recently named one of the most dangerous drugs being abused in the state of Florida.
This drug that is the key ingredient in Vicodin is the second-most abused drug in America. From 2000 to 2009, while the FDA muddled over putting harsher restrictions on hydrocodone, the number of ER visits due to its use skyrocketed from 19,221 to 86,258.
Researchers from San Diego recently found that in 2010, “excess deaths” related to the use of sleeping pills like Ambien and Restoril totaled up to 500,000 in the U.S. They also found even light users who take less than two pills a month have a risk of death three times higher than non-users.
A just-released U.K. study found these anxiety and insomnia drugs killed roughly five times as many British people as marijuana in 2011. These “downers” hook people faster than tranquilizers and can damage the liver and cause blood problems with regular use.
Viagra is a hugely popular drug, but it’s also killed hundreds of people, making it far more dangerous than weed. One study in 2000 found 522 Viagra-related deaths, most of them in people under 65. Because it lowers blood pressure, it can also be very dangerous for people already on medication to lower blood pressure (e.g. older people who need Viagra).
This one could go in either category. The stuff known as “laughing gas” is only legally available to doctors, but small canisters of nitrous oxide called Whip-Its (of which Demi Moore is clearly aware) are sold to anyone off the street. When inhaled, “hippie crack” can be addictive, cause nerve damage, and even kill.
If you have to die to quit smoking, it’s not really worth it. In its five years on the market, this Pfizer product has been responsible for hundreds of suicides in both the U.S. and Britain. More than 2,400 people have sought legal representation for possible action against the drug megacorp and many are calling for a ban.
|FDA Clears First Respirators for Use in Public Health Medical Emergencies||The U.S. Food and Drug Administration (FDA) today cleared for marketing the first respirators that can help reduce the user's exposure to airborne germs during a public health medical emergency, such as an influenza pandemic. |
These two filtering facepiece respirators, manufactured by St. Paul, Minn.-based 3M Company (and called the 3M Respirator 8612F and 8670F), will be available to the general public without a prescription.
The devices are also certified as N95 filtering facepiece respirators by the National Institute for Occupational Safety and Health (NIOSH). NIOSH certifies respirators for use in occupational settings in accordance with an appropriate respiratory protection program.
An N95 filtering facepiece respirator is a type of face mask that fits tightly over the nose and mouth. It is made of fibrous material that is designed to filter out at least 95 percent of very small airborne particles. The filter and a proper fit determine the effectiveness of the product.
"While the exact nature and concentration of the biological agent or germ may not be known in a public health medical emergency, we believe that minimizing exposure will help reduce risk," said Daniel Schultz, M.D., director, FDA's Center for Devices and Radiological Health. "These respirators are only one part of a combination of approaches that can be used to help reduce the spread of infection between individuals during such events."
Many companies make N95 respirators for workplaces, including health care settings. However, the 3M respirators are the first devices to receive FDA clearance for use by the public during public health medical emergencies to reduce exposure to airborne germs.
Under Occupational Safety and Health Administration and other occupational health regulations, respirators used in the workplace must be individually selected for each worker and tested to ensure a proper fit. This kind of fit testing is not generally employed outside the workplace now and would probably not be feasible during a public health medical emergency.
FDA is requiring those who want to market respirators for use during public health medical emergencies to assure that they are certified by NIOSH to provide adequate filtration without hampering people's ability to breathe. In addition, companies must conduct fit assessment testing, conduct biocompatibility testing to reduce the chance for allergic skin reaction, and provide instructions that will enable wearers to achieve a protective fit and use the devices properly.
3M evaluated fit characteristics in healthy adults to determine that a user could achieve a protective fit following the instructions on the label. They measured how many airborne test particles were able to get inside the respirator through small leaks between the edges of the respirator and the wearer's face. While individual results varied, all participants tested achieved some reduction in exposure to airborne test particles.
The 3M respirators are sized for adults and may not form a proper fit on children. Anything that comes between the respirator and the face, such as facial hair, may interfere with its fit. Persons with pre-existing heart or lung disease or other health conditions may have difficulty breathing through a respirator. The devices are for single use. Wearers should not wash, disinfect, reuse or share their respirator with others. The respirators should be discarded after use.
FDA will soon issue a guidance document outlining its regulatory approach to this new type of device.
Inhaling particles is just one route of exposure to disease-causing organisms. Others include touching contaminated surfaces and coming into close contact with those who have infectious diseases. A total approach to personal protection includes hand hygiene, cough etiquette and other protection practices such as avoiding crowded settings.
|Raf Simons Becomes First Designer Since Calvin Klein to Win Both Womenswear and Menswear at CFDA Awards|
|Rock N Roll Manifesto 251||FDA approved, Grade A prime, non-GMO, organic rock and fucking roll.|
|IPAB revocation of Allerganâs Combigan patent: Viewing it through the lens of American patent doctrines|
Recently Anubha had blogged about the IPAB decision revoking Allerganâs patent for Combigan. Combigan refers to a combination eye-drop product used for treating glaucoma comprising combination of Brimonidine tartarate and Timolol maleate. Media reports termed this decision as the latest in a series of intellectual property setbacks suffered by Western drugmakers. These skewed reports also portray this revocation decision as one of many tactics by India to remove an inconvenient patent out of the way to introduce affordable generic versions. What these reports failed to highlight was that several claims of patents covering Combigan were invalidated as being obvious even in major jurisdictions like US and EU. Also it wasnât as though the Indian patent was invalidated by applying one of those sections (eg. Section 3) which is unique to Indian patent law. An analysis of US CAFC decisions and IPAB decision for Combigan is presented below. Longish post, but hope to make it worth your while.
Combigan US patents: Background
The patents in question are 4 OB listed patents related to Combigan viz: the â463 patent, the â258 patent, the â976 patent and theâ149 patent. The claims of '463, â258, and '976 patents with the exception of claim 4 of â149 patent were generally treated as a single group.
Claim 1 of â463 patent was considered representative and it states: 1. A composition comprising about 0.2% timolol by weight and about 0.5% brimonidine by weight as the sole active agents, in a single composition.
Sandoz sought to market a generic version of Combigan thus triggering litigation under Hatch Waxman framework. The district court rejected allegations that claim 1 of â463 patent was invalid as obvious over prior art. On appeal, the Fed circuit reversed the district court's finding that the claims of the '463 patent were non-obvious.The CAFC decision can be found here
Prior art: what was known at the time of invention?
Both timolol and brimonidine were commercially available drugs in their claimed concentrations used for ophthalmic conditions at the time of the invention. At the time of the invention, it was known that the serial administration of brimonidine and timolol reduced intraocular pressure greater than either timolol or brimonidine alone. Moreover, DeSantis (US 5502052), the primary prior art reference, expressly provided a motivation to formulate fixed combinations of alpha2-agonists and beta blockers, including timolol, in order to increase patient compliance.
District court findings:Summary
Federal circuit: Do secondary considerations outweigh motivation to combine?
The CAFC addressed each of the findings of district court as follows:
Thus the CAFC opined that unexpected results and prior art teaching away were NOT sufficient to outweigh the other evidence of obviousness with respect to these formulation claims.
Claim 4 of â149 patent: A different conclusion?
As mentioned above, claim 4 of â149 patent was analyzed separately by Federal Circuit. Claim 4 of the â149 patent is directed to reducing the daily number of doses of brimonidine without loss of efficacy by administering fixed combination and reads as follows:
4. A method of reducing the number of daily topical ophthalmic doses of brimonidine administered topically to an eye of a person in need thereof for the treatment of glaucoma or ocular hypertension from 3 to 2 times a day without loss of efficacy, wherein the concentration of brimonidine is 0.2% by weight, said method comprising administering said 0.2% brimonidine by weight and 0.5% timolol by weight in a single composition
While the federal circuit held that the formulation of 0.2%wt brimonidine and 0.5%wt timolol was obvious, it came to a different conclusion with respect to claim 4 of the '149 patent. The CAFC reasoned that although the prior art shows concomitant administration of brimonidine and timolol, it does not establish that switching from 3 times a day to 2 times a day does not result in loss of efficacy. Hence it concluded that claim 4 was NOT obvious in light of prior art.
Avoiding loss of efficacy an inherent result of the formulation?: Judge Dykâs dissent
Dissenting from the majorityâs opinion holding that claim 4 of the â149 patent is not invalid as obvious Judge Dyk observed that avoiding loss of efficacy is an inherent result of the claimed method. Since the formulation was held obvious, inherent result /property of the formulation is also obvious. Judge Dyk reasoned a newly-discovered result or property of an existing (or obvious) method of use is not patentable.
The majority differed and observed that the prior art evidence does not conclusively establish that dose reduction âfrom 3 to 2 times a day without loss of efficacyâ limitation is an inherent property or a necessary result of the administration.
The IPAB concluded âWe too are of the opinion like the Federal Court that there was a reasonable expectation of success in view of the DeSantis. Therefore for the above reason, we find that the invention is obvious."
With regard to non-compliance of Section 8, the IPAB noted that the applicant had failed to inform the Controller regarding refusal of corresponding EU patent and various stages of prosecution in the US counterpart patents (non-final rejections etc.). Curiously, Allergan tried to argue that Therasense like inequitable conduct standards should be set for Section 8. In Therasense, Inc. vs. Becton, Dickinson and Co (Fed. Cir. 2011) an en banc decision, the Federal Circuit held that inequitable conduct must be shown with clear and convincing evidence and that there was intent to withhold or misrepresent information and that the information was material. However, the IPAB reasoned that our law does not make any qualification regarding the failure to disclose nor does it say that the failure to furnish the S.8 details must be deliberate and willful. The IPAB opined that even if it was to assume Therasense like standards for the present case but for that the fact that the EP office action and/or US office action were kept away from the Controller, the patent may not have been granted. The IPAB decision itself can be found here and Anubhaâs post on the same can be accessed here.
What was different in the Indian decision?
In India, Combigan was protected by only one patent viz IN219504. Since method of treatment claims are precluded from patentability in India, claim 4 of â149 wasnât patented. Since the claims of IN219504 were invalidated by IPAB, it paved way for generic entry (read Ajanta pharma).
On the other hand in US, as discussed earlier Combigan was protected by several patents (patent thicket). Even though Sandoz succeeded in establishing that claims of â463 patent were invalid as obvious, the Fed circuit ruled that claim 4 of 149 as not obvious. Thus market entry for generics (Sandoz) in US is barred until expiry of â149 patent i.e. April 19, 2022.
|Starbucks stops using tainted milk in China|
According to Bloomberg.com, Starbucks and its 300 plus cafes in China have stopped using milk by Mengniu Dairy CO. Mengniu, together with the other top milk producers in China, Inner Mongolia Yili Industrial Group Co. and Bright Dairy & Food Co., were part of the scandal where China found the toxic chemical melamine in the liquid milk and yogurt products they produce.
"Though we believe based on assurances from the supplier that the milk we received from Mengniu is not included in the contaminated lot, due to the serious nature of this warning, Starbucks has voluntarily pulled all Mengniu milk offerings until further notice," Starbucks said.
Melamine, used to make plastic and tan leather, is now being linked to the kidney failures in babies and leading to at least four deaths. Melamine, which is high in nitrogen, can be used to mask diluted milk because it makes protein levels appear higher than they really are, allowing producers to cut costs by watering down their products. [Read the full article]
Having stayed in China for a year back in 2006 and drinking milk almost everyday, I find it disturbing to know that my system must have been affected somehow by melamine. I seem okay and not affected by it but I think I'd like to have my system checked just to be sure. It's a little weird how they have the brand YiLi here in the Philippines and I was looking at it at the supermarket and I told the lady beside me that this is really good and she should get it since it's on sale. I wonder if as early as 2 weeks ago they already knew something was wrong with their milk. The expiration date is January 2009 so it couldn't be that hmm...
It's just crazy how their FDA didn't have much stricter standards when it comes to their milk, which is a $19 billion industry, and possibly even other food or drinks.
I wonder how Starbucks' sales have been the past few day and what alternatives they've been using for milk in their coffee. Soy maybe? If I were still staying in China and this happens to me, I'd be drinking my coffee black, which is something I rarely do. I haven't tried using soy as an alternative or I could be happy with using creamers that are imported just as long as I know it's safe.
This comes at a very bad time especially after China spent a lot during the Olympics where they were trying to tell the world that "We are now open, come visit us!" Only time will tell whether they can bounce back from this and still continue their image that started in the Olympics.
Photo by: SMCP
|"Asparagus For Cancer"|
"Asparagus For Cancer"
Subject: Asparagus DO NOT FAIL TO READ THIS AND SEND TO YOUR FAMILY &FRIENDS When I was in the USN, I was stationed in Key West, FL. I worked at the clinic at Naval Air Station on Big Coppitt Key just a few miles north of Key West. The hospital at Key West was for out- patients only, for retired armed forces personnel that lived in the area. If you needed to be hospitalized you were sent to Homestead AFB Florida. I had the day off and just went inside the hospital (Corpman barracks were next to hospital). There was a retired Navy man that worked in the lab and he was very interesting gentleman to talk with. He was a retired biochemist from the USN. He asked me what was going on that day,and I said I had the day off. I wish I was working, as the crew on, today was taking a sailor to Homestead as he had a very bad kidney infection. Now this elderly gent told me the man should have eaten more asparagus, and he wouldn't have that problem. I asked why? I'll never forget him saying, do you eat asparagus? and I said yes, I love them. He replied you notice how your urine stinks after eating asparagus? I said well I never thought it was what I ate but yes it does have a pungent odor. He said, It is because it is detoxifying your body of harmful chemicals!!! This was back in 1986 when I was stationed there and to read this email again I had to share this story...Eat more asparagus, my friends.
Asparagus -- Who knew?
My Mom had been taking the full-stalk canned style asparagus, pureed it and took 4 tablespoons in the morning and 4 tablespoons later in the day. She did this for over a month. She is on chemo pills for Stage 3 lung cancer in the pleural area and her cancer cell count went from 386 down to 125 as of this past week. Her oncologist said she will not need to see him for 3 months.
Several years ago I met a man seeking asparagus for a friend who had cancer. He gave me a copy of an article, entitled "Asparagus For Cancer" printed in the Cancer News Journal, December 1979. I will share it here, just as it was shared with me: I am a biochemist, and have specialized in the relation of diet to health for over 50 years. Several years ago, I learned of the discovery of Richard R. Vensal, D.D.S. that asparagus might cure cancer. Since then, I have worked with him on his project. We have accumulated a number of favorable case histories. Here are a few examples:
Case No. 1, A man with an almost hopeless case of Hodgkin's disease (cancer of the lymph glands) who was completely incapacitated. Within 1 year of starting the asparagus therapy, his doctors were unable to detect any signs of cancer, and he was back on a schedule of strenuous exercise
Case No. 2, A successful businessman, 68 years old, suffered from cancer of the bladder for 16 years. After years of medical treatments, including radiation without improvement, he began taking asparagus. Within 3 months, examinations revealed that his bladder tumor had disappeared and that his kidneys were normal.
Case No. 3, On March 5th 1971, a man who had lung cancer was put on the operating table where they found lung cancer so widely spread that it was inoperable. The surgeon sewed him up and declared his case hopeless. On April 5th he heard about the Asparagus therapy and immediately started taking it. By August, x-ray pictures revealed that all signs of the cancer had disappeared. He is now back at his regular business routine.
Case No. 4, A woman had been troubled for a number of years with skin cancer. She developed different skin cancers which were diagnosed by the acting specialist as advanced. Within 3 months after beginning asparagus therapy, the skin specialist said her skin looked fine with no more skin lesions. This woman reported that the asparagus therapy also cured her kidney disease, which had started in 1949. She had over 10 operations for kidney stones, and was receiving government disability payments for an inoperable, terminal, kidney condition. She attributes the cure of this kidney trouble entirely to the asparagus treatment.
I was not surprised at this result as `The elements of materia medica', edited in 1854 by a Professor at the University of Pennsylvania, stated that asparagus was used as a popular remedy for kidney stones. He even referred to experiments, in 1739, on the power of asparagus in dissolving stones. Note the dates! ---We would have other case histories but the medical establishment has interfered with our obtaining some of the records. I am therefore appealing to readers to spread this good news and help us to gather a large number of case histories that will overwhelm the medical skeptics about this unbelievably simple and natural remedy.
For the treatment, asparagus should be cooked before using. Fresh or canned asparagus can be used. I have corresponded with the two leading canners of asparagus, Giant and Stokely, and I am satisfied that these brands contain no pesticides or preservatives. Place the cooked asparagus in a blender and liquefy to make a puree. Store in the refrigerator. Give the patient 4 full tablespoons twice daily, morning and evening. Patients usually show some improvement in 2-4 weeks. It can be diluted with water and used as a cold or hot drink. This suggested dosage is based on present experience, but certainly larger amounts can do no harm and may be needed in some cases.
As a biochemist I am convinced of the old saying that `what cures can prevent.' Based on this theory, my wife and I have been using asparagus puree as a beverage with our meals. We take 2 tablespoons diluted in water to suit our taste with breakfast and with dinner. I take mine hot and my wife prefers hers cold. For years we have made it a practice to have blood surveys taken as part of our regular checkups. The last blood survey, taken by a medical doctor who specializes in the nutritional approach to health, showed substantial improvements in all categories over the last one, and we can attribute these improvements to nothing but the asparagus drink. As a biochemist, I have made an extensive study of all aspects of cancer, and all of the proposed cures. As a result, I am convinced that asparagus fits in better with the latest theories about cancer.
Asparagus contains a good supply of protein called histones, which are believed to be active in controlling cell growth. For that reason, I believe asparagus can be said to contain a substance that I call cell growth normalizer. That accounts for its action on cancer and in acting as a general body tonic. In any event, regardless of theory, asparagus used as we suggest, is a harmless substance. The FDA cannot prevent you from using it and it may do you much good. It has been reported by the US National Cancer Institute, that asparagus is the highest tested food containing glutathione, which is considered one of the body's most potent anticarcinogens and antioxidants.
Just a side note... In case you are wondering why this has not been made public, there is no profit in curing cancer.
Please send this article to everyone in your Address Book. The most unselfish act one can ever do is paying forward all the kindness one has received.
Alex W Fraser
|Chemical Resistant Plastics||All of the plastics discussed in this blog have remarkable chemical resistance; PVDF and Ultem have resistance up to pH 11. These plastics are therefore often used in corrosive or acidic environments, offering solutions to problems that other materials cannot. Some popular plastics with extreme chemical resistance are: Ketron PEEK Techtron HPV PPS Ultem PEI 1000 Symalit PVDF 100 Ketron PEEK PEEK- Polyetheretherketone. PEEK has a unique combination of high mechanical properties and temperature resistance. It has an extremely high maximum service temperature (250â°C continuously and up to 310â°C for short periods of time) as well as being flame-resistant and thermally stable. PEEK has excellent retention of strength and stiffness, creep resistance over a wide temperature range and excellent wear and frictional behaviour. PEEK is often used to replace PTFE when higher mechanical load bearing capacity, or when superior wear resistance is needed. Also widely used as a replacement for metal components. Applications of PEEK include pump components, valve seats, bearings, pistons, rollers, gears, high temperature insulators, components exposed to boiling water or steam. PEEK is used in aerospace, automotive and chemical processing industries. PEEK is also used for medical applications. Techtron HPV PPS PPS- Polyphenylene Sulfide Techtron was developed to close the gap both in performance and price between the standard thermoplastic materials (e.g. PA, POM, PET) and the high-end advanced engineering plastics (e.g. PBI, PI, PAI, PEEK). Techtron has a high maximum service temperature, as it can operate at 220â°C continuously. Techtron has a high retention of strength and stiffness, creep resistance over a wide temperature range, excellent wear behaviour and good electrical insulating and dielectric properties. It also has good UV-resistance and is physiologically inert (suitable for food contact). Techtron is used in industrial equipment such as industrial drying and food processing ovens, bearings, rollers, chemical process equipment, pump, valve and compressor components and electrical insulating systems. It is also used in manifolds, distributor valves, medical equipment components and steam cleaning equipment inserts. Ultem PEI 1000 PEI- Polyether Imide. Ultem is amber coloured and translucent. Ultem has high strength, stiffness and heat resistance (performs continuously to 170â°C), making it ideal for high strength / high heat applications. Ultem has excellent abrasion resistance, excellent ageing stability and UV resistant. High dielectric and piezoelectric values. Ultem is FDA compliant. Thanks to its good hydrolysis resistance, ULTEM PEI 1000 is capable of withstanding repeated autoclaving cycles (good for surgical probes). Applications of Ultem include manifolds (offer resistance to hot chemical solutions), insulators and clamps (high voltage and flame resistance). Symalit PVDF 100 PVDF- Polyvinylidene Fluoride. PVDF has good mechanical, thermal and electrical properties and shows good resistance to high-energy radiation (considerably better than other fluoropolymers). PVDF has excellent abrasion resistance, excellent ageing stability and UV resistant. PVDF also has high dielectric and piezoelectric values. PVDF is suitable for the manufacture of components for the petro-chemical, chemical, metallurgical, food, paper, textile, pharmaceutical and nuclear industries.|
|Iowa Farm Resumes Selling Eggs After Recall||The smaller of the two major egg farms involved in the FDA recall over the summer has resumed shipping eggs. The larger farm may|
|FDA Requires Testosterone Medication Manufacturers to Add Expanded Blood Clot Risk to Warning Labels, Baron and Budd Reports|| |
Required Change Reflects Reports of Additional Clotting Not Related to Condition Covered by Current Warnings
(PRWeb July 17, 2014)
Read the full story at http://www.prweb.com/releases/2014/07/prweb12016998.htm
|FDA Sends Warning Letter to Transvaginal Mesh Manufacturer American Medical Systems, National Law Firm Baron and Budd Reports|| |
Letter Cited Several Issues Found After Inspection of Companyâs Minnesota Plant
(PRWeb June 11, 2014)
Read the full story at http://www.prweb.com/releases/2014/06/prweb11932645.htm
|Smartphone microscope and app for testing your sperm|
YO is an FDA-cleared sperm quality analyzer for your smartphone. It consists of a detachable mini microscope and light that clips to your mobile phone. You "acquire" a sperm sample, drop it into the YO Clip, and the app records a video of your sperm in action and analyzes the activity. Available in January, you can pre-order two tests for $50. I bet the app has social media integration so if you have strong swimmers, you can proudly share the proof with your friends.
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|House Holds mHealth Hearings, FDA Promises Final Guidance Forthcoming||Three days of hearings by a House of Representatives committee concluded yesterday with a pledge from an FDA official to finalize long-awaited guidance on the regulation of mobile medical applications “in coming weeks“; at the latest by the end of the FDA’s fiscal year (i.e., September 30th). The hearings, convened jointly by several subcommittees of […]|
|The FDA, Social Media & Consumer Genomics: A Lot Not to âLikeâ||Last week, the FDA published on its website a warning letter to AMARC Enterprises, Inc., a marketer of a dietaryÂ supplement known as Poly-MVA. (Here is the company’s description of the supplement.) While the letter is not addressed to a high-profile company or product, given that the FDA’s action will likely have broader significance beyond just […]|
|23andMe Seeks FDA Clearance (Podcast)||Last week, personal genetics company 23andMe announced that it had formally delivered the first round of documentation to the U.S. Food and Drug Administration (FDA) in an attempt to receive 510(k) clearance for its consumer product. 23andMe declared itself âfirst in the [ direct-to-consumer (DTC) genetic testing] industry to announce it is working towards FDA […]|
|Tobacco Investors Just Learned That Trump Isnât the Salvation of Every Odious Industry|
The tendency to lean on political beliefs is one of the most powerful forces in investing and financial media, and one of the most dangerous. Thereâs a general sense that Republicans are good for business (lower taxes, fewer regulations, an overall permisiveness) and therefore good for the stock market. And thereâs a sense that Democrats are bad for business (higher taxes, more regs, a skepticism toward industryâs prerogatives) and therefore bad for the stock market. The lived experienced of the markets over the past 25 yearsâbooming under Clinton and Obama, tanking under Bushâshould give the lie to this feeling. But it endures. And it has become particularly powerful under Trump, who regards the stock market as a kind of real-time approval gauge.
But doing so is precarious. And it can be continually confounding at the macro level and at the level of sectors and individual companies. Thatâs a lesson that investors who held stocks in tobacco companiesâin particular the biggest one, Altria (formerly Philip Morris)âlearned Friday.
Tobacco companies are in a strange position right now. Smoking is on the decline in the U.S., in part because of government efforts to discourage it via higher taxation, regulation, outright bans, and President Obamaâs use of the bully pulpit and the executive pen. Only about 15.1 percent of Americans smoked in 2016, down from about 21 percent in 2005, according to the Centers for Disease Control and Prevention. And yet the profits of tobacco companies, paradoxically, are booming, in part because sales overseas are growing and in part because tobacco companies have the ability to raise prices. (Thatâs one of the advantages of making a product that is addictive.) Altriaâs profit margins on tobacco products are remarkably high. Between 2001 and 2016, as the chart on Page 11 of Altriaâs annual report shows, Altriaâs stock nearly tripled, while the S&P 500 merely doubled.
Altriaâs stock, like many others, continued to soar after Trumpâs electionâup about 10 percent in the first half of the year. Itâs not hard to see why. Aside from benefiting from the general pro-business agenda of Trumpâcutting corporate taxes, reducing the capital gains tax, and so onâAltria would seem to have far less to fear from a Trump administration than from an Obama or Clinton administration. While he doesnât drink or smoke, Trump isnât a particularly healthy person: He doesnât work out or exercise or maintain a healthy diet. His administration has backed measures that would cut health care spending by hundreds of billions of dollars, some of which is now spent on smoking cessation. The Trump administration is full of lobbyists and corporate types eager to do the bidding of companies. The likelihood of the first family engaging in aggressive anti-smoking campaigns is laughable. Altria kicked in $500,000 to fund the Trump inauguration.
And the person Trump named to be the head of the Food and Drug Administration, which regulates tobacco, doesnât have a history of anti-smoking activism. Scott Gottlieb is a physician, biotech investor, and former resident fellow at the American Enterprise Institute who also served in the Bush administration. Whatâs more, Gottlieb has been strongly in favor of deregulating pharmaceuticals and medical devices, as part of an effort to bring innovations to market more quickly and reduce costs.
And yet Friday morning, with little apparent warning, Gottlieb announced a new comprehensive plan to regulate nicotine. In an aggressive speech that spoke about cigarettes and nicotine in harsh terms, Gottlieb said âwe need to envision a world where cigarettes lose their addictive potential through reduced nicotine levels.â For this reason, Gottlieb said, âIâm directing our Center for Tobacco Products to develop a comprehensive nicotine regulatory plan premised on the need to confront and alter cigarette addiction.â With a âbalanced regulatory approach,â he noted, âwe may be able to reach a day when the most harmful products are no longer capable of addicting our kids.â
This clearly came as a surprise to the companies and to their investors. Stocks reacted violently. In about 30 minutes, Altriaâs stock fell 15 percent, sawing nearly $21 billion in market capitalization off the company. By later in the afternoon, the stock had stabilized, though it was still off by about 10 percent, or about $14 billion.
Clearly, investors and the tobacco companies believed that the Trump FDA would take a more hands-off approach to regulating tobacco. After all, weâve seen sharp pullbacks from regulation of toxic emissions and substances at the Environmental Protection Agency and a general desire to rip up consumer protections. But just because thereâs a general air of deregulation, and just because people now in positions of responsibility are hostile to scientific consensus (hello, EPA and Interior), doesnât mean that all important executive-branch appointees do so.
Thatâs the mistake tobacco investors made. Gottlieb, after all, is a physician, and a cancer survivor to boot. The science and medicine surrounding tobacco is long since settled, and the consensus is broad. The product has been regulated, without much controversy, for several decades. Everybody involved in health care really hates tobacco, an addictive product that has a host of really bad, expensive, and predictable effects on peopleâs health. âAs a physician who cared for hospitalized cancer patients, and as a cancer survivor myself, I saw first-hand the impact of tobacco,â Gottlieb said in a speech Friday. âAnd I know all too well that itâs cigarettes that are the primary cause of tobacco-related disease and death. Whatâs now clear is that FDA is at a unique moment in history, with profound new tools to address this devastating impact.â
Not all of Trumpâs appointees will be pro-corporate stooges at all times. And investing as if they are can be remarkably expensive.
|Federal Circuit upholds Millenniumâs Patent on VelcadeÂ®||MILLENNIUM PHARMACEUTICALS, INC. v. SANDOZ INC - (Fed. Cir. July 17, 2017) (NEWMAN, Mayer, OâMalley) - This case arose out of an ANDA litigation between Millennium and a number of generic-drug companies who sought FDA approval of the generic...|
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|Drugs@FDA Download File (new structure)||Data files updated through August 9, 2017.|
|Drugs@FDA Data Files||Data files updated through August 9, 2017.|
|FDA Drug Safety Communication: Risk of oral clefts in children born to mothers taking Topamax (topiramate)||[03-04-2011] The U.S. Food and Drug Administration (FDA) is informing the public of new data that show that there is an increased risk for the development of cleft lip and/or cleft palate (oral clefts) in infants born to women treated with Topamax (topiramate) during pregnancy.|
|FDA Drug Safety Communication: New warnings against use of terbutaline to treat preterm labor||[02-17-2011] The U.S. Food and Drug Administration (FDA) is warning the public that injectable terbutaline should not be used in pregnant women for prevention or prolonged treatment (beyond 48-72 hours) of preterm labor in either the hospital or outpatient setting because of the potential for serious maternal heart problems and death.|
|FDA Drug Safety Communication: Liver injury warning to be removed from Letairis (ambrisentan) tablets||The U.S. Food and Drug Administration (FDA) is removing the warning related to liver injury from the boxed warning of the Letairis (ambrisentan) tablet label.|
|FDA Drug Safety Communication: Special storage and handling requirements must be followed for Pradaxa (dabigatran etexilate mesylate) capsules||[03-29-2011] The U.S. Food and Drug Administration (FDA) is alerting the public to important storage and handling requirements for Pradaxa (dabigatran etexilate mesylate) capsules.|
|FDA Drug Safety Communication: Connection problems involving certain needleless pre-filled glass syringes containing adenosine and amiodarone||[05-06-2011] The U.S. Food and Drug Administration (FDA) is alerting the healthcare community about syringe connection problems when certain needleless glass syringes containing the cardiac drugs adenosine and amiodarone are used with particular types of intravenous (IV) access systems.|
|FDA Drug Safety Communication: No increase in risk of cancer with certain blood pressure drugs--Angiotensin Receptor Blockers (ARBs)||[06-02-2011] The U.S. Food and Drug Administration (FDA) has completed a review of the potential risk of cancer associated with the class of medications known as angiotensin receptor blockers (ARBs). FDA has concluded that treatment with an ARB medication does not increase a patientâs risk of developing cancer.|
|FDA Drug Safety Communication: 5-alpha reductase inhibitors (5-ARIs) may increase the risk of a more serious form of prostate cancer||[6-9-2011] The U.S. Food and Drug Administration (FDA) is informing healthcare professionals that the Warnings and Precautions section of the labels for the 5-alpha reductase inhibitor (5-ARI) class of drugs has been revised to include new safety information about the increased risk of being diagnosed with a more serious form of prostate cancer (high-grade prostate cancer).|
|FDA Drug Safety Communication: Addition of another concentration of liquid acetaminophen marketed for infants||none|
|FDA Drug Safety Communication: Selective serotonin reuptake inhibitor (SSRI) antidepressant use during pregnancy and reports of a rare heart and lung condition in newborn babies||[12-14-2011] The U.S. Food and Drug Administration (FDA) is updating the public on the use of selective serotonin reuptake inhibitor (SSRI) antidepressants by women during pregnancy and the potential risk of a rare heart and lung condition known as persistent pulmonary hypertension of the newborn (PPHN).|
|FDA Drug Safety Communication: Modified Risk Evaluation and Mitigation Strategies (REMS) for Nplate (romiplostim) and Promacta (eltrombopag)||none|
|FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFα) blockers now include warnings about infection with Legionella and Listeria bacteria||[9-07-2011] The U.S. Food and Drug Administration (FDA) is informing healthcare professionals that the Boxed Warning for the entire class of Tumor Necrosis Factor-alpha (TNFÎ±) blockers has been updated to include the risk of infection from two bacterial pathogens, Legionella and Listeria.|
|FDA Drug Safety Communication: Serious allergic reactions reported with the use of Saphris (asenapine maleate)||[09-01-2011] The U.S. Food and Drug Administration (FDA) is warning the public that serious allergic reactions have been reported with the use of the antipsychotic medication Saphris (asenapine maleate).|
|FDA Drug Safety Communication:Use of long-term, high-dose Diflucan (fluconazole) during pregnancy may be associated with birth defects in infants||[8-03-2011] The U.S. Food and Drug Administration (FDA) is informing the public that chronic, high doses (400-800 mg/day) of the antifungal drug Diflucan (fluconazole) may be associated with a rare and distinct set of birth defects in infants whose mothers were treated with the drug during the first trimester of pregnancy.|
|FDA Drug Safety Communication: Reminder to healthcare providers and patients to enroll in the Avandia-Rosiglitazone Medicines Access Program||[11-04-2011] The U.S. Food and Drug Administration (FDA) is reminding healthcare providers and patients about the need to enroll in the Avandia-Rosiglitazone Medicines Access Program by November 17, 2011 in order to continue prescribing and receiving rosiglitazone-containing medicines (Avandia, Avandamet, and Avandaryl).|
|FDA Drug Safety Communication: Review update of Multaq (dronedarone) and increased risk of death and serious cardiovascular adverse events||[12-19-2011] The U.S. Food and Drug Administration (FDA) has completed a safety review of the heart drug Multaq (dronedarone). This review showed that Multaq increased the risk of serious cardiovascular events, including death, when used by patients in permanent atrial fibrillation (AF).|
|Addiction and Mental Health Expert Ben Brafman Weighs in on FDA Painkiller Approval|| |
The Food and Drug Administration (FDA) recently approved Zohydro to treat chronic pain, an opiate that some experts fear may be highly addictive.
(PRWeb November 01, 2013)
Read the full story at http://www.prweb.com/releases/2013/11/prweb11294211.htm
|Comment on Legislature debates tobacco tax hike by Michelle La Pointe||Come on people it is time to start telling the truth instead of telling people its an health issue, it is a way to raise revenue to fund schools and state gov. If gov. was so concerned with smokers health why didn't they use the millions of dollars obtained from law suits from the tabacco companies years ago? Hey why not raise the cigarette tax $5 dollars a pack and smokers could pay down the deficit and give politicians more wiggle room for reckless spending? The gov. and FDA is allowing GMOs in the food we eat,last I heard insecticides and herbacides aren't good for human consumption, and over time will cause health problems for all who consume foods with GMOs.If gov. is so concerned with everyones health, why are they not addressing the health risks of GMOs?|
|Comment on E-cigarettes not recommended without FDA approval by Frankie Guinle||Wow, 180 websites would be a lot of work. We struggled in the past with 20 that was too many. At one time we realised it wasnt going to work and just let them go. We didn't sell them or anything but we just didnt work on them anymore and focused solely on one website. That was the turning point for us.|
|Comment on E-cigarettes not recommended without FDA approval by Karoline Pulkrabek||It's really a cool and helpful piece of info. I'm glad that you shared this helpful information with us. Please keep us up to date like this. Thanks for sharing.|
|Comment on California : Cigarette sales drop following new tax implementation by charlie||Last Friday the FDA announced they will delay the ecig deeming rules for 5 years. At the same time they announce the intention to use their existing authority to nearly eliminate nicotine from cigarettes and encourage smokers to get their nic fix from less harmful and less expensive sources--like ecigarettes. When smoking parents switch to vaping it's a big economic benefit to families. There should be no interference with this.|
|FDA Defends Its Decision of Lawsuit Against Cigarette Companies||To rebut the contention of five of the nationâs largest cigarette manufacturing giants by way of a lawsuit, the U.S. Food and Drug Administration has sought court orders blocking any delay in implementing the new regulations that require graphic warning labels on cigarette packages to take effect from September 2012. The plea of economic harm […]|
|FDA Officially Bans Texas' Attempted Import Of Execution Drugs||Almost two years after Texas tried to import an execution drug from overseas, the U.S. Food and Drug Administration ruled Thursday that the drug canât be admitted into the United States.|
|Could the FDA Sanction Texas for Buying Lethal Drugs from India?||From Texas Standard: Back in July, Texas and Arizona were caught illegally importing a lethal injection drug compound as the product was passing through an airport in Houston. The federal Food and Drug Administration, responsible for food and drug regulation in the United States, has said in the past that importing the drug is illegal. The Texas Department of Criminal Justice told the Dallas Morning News that the department had a license from the Drug Enforcement Administration saying the state could import the drug.|
|Buzz on Pringles Recall â Potential Threat in Health||There is another recall alert spreading on the news today as the FDA advised Proctor & Gamble to recall their latest Pringles being manufactured and distributed to stores.Â There is a potential threat to the consumer’s health and the threat may be a big issue. Salmonella was found in one of the machines that manufacture […]|
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Dutasteride is not approved by the FDA for hair loss. Â Documentation about such sheds is not available except in the hands of the doctors who prescribe it in what is called an “off label” circumstance. I am sure that it behaves like Finasteride, which suggests that the shed should reverse in 2-3 months. This patient […]
The post I took Dutasteride and have had a massive hair shed in the first 2 weeks appeared first on Hair Loss Information.
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Seizures can be a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug can also raise blood pressure and pulse rate, and shouldn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.
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To keep up with essentially the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click the subscribe link near the top of the page for email notification when new articles are published. Please leave a comment for any article.
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This blog will tell you about some of the health risks associated with sulfites and reasons why Harmony Houseâs freeze dried fruit stays fresh, nutritious, delicious, and shelf stable for years without any sulfur dioxide (or other preservative or additive of any kind).
What is Sulfur Dioxide?
Sulfites, also known as sulfiting agents, are inorganic salts that are commonly used as preservatives by food and beverage producers. Sulfur dioxide is a compound that many dried fruit sellers add to their products to delay spoiling and to prevent them from turning brown on the shelf.
What are the Health Risks Associated with Sulfites?
The US Food and Drug Administration (FDA) classifies sulfites as Generally Recognized as Safe (GRAS). But a small number of people are very sensitive to sulfiting agents. For those who are sensitive or hypersensitive to sulfites, eating even a tiny amount of sulfur dioxide can trigger symptoms that range from uncomfortable to dangerous. When exposed to sulfites, sensitive individuals have been known to suffer a wide range of symptoms including itching, flushing, hives, facial swelling, low blood pressure, gastrointestinal pain, diarrhea, wheezing, asthma attacks, and, in the most rare and worst cases, life-threatening anaphylaxis. Symptoms of sulfite sensitivity usually begin within half an hour after eating food that contains sulfur dioxide.
Who is at Risk?
Children and adults of all ages are prone to sensitivity to sulfites, and sensitivity can arise later in life, even if there has been no history of a reaction at any point earlier. People who have asthma have a higher risk of reaction to sulfur dioxide than those who donât, however, some non-asthmatics are also at risk. The FDA estimates that one out of a hundred people is sulfite sensitive, and most of them have asthma. Many studies have found 3â10% of people with asthma are sensitive to sulfites, particularly among people with chronic asthma. A number of studies have suggested that 5â10% of all chronic asthmatics are hypersensitive to sulfites. Researchers are not 100% certain of the underlying causes that lead to sulfite sensitivity, though they are certain that it is best for asthmatics and those who have had symptoms of sensitivity to sulfur dioxide to avoid the preservative. All Harmony House dried fruit is completely free from sulfur dioxide, and therefore completely safe for anyoneâincluding those who have asthma or sensitivity to sulfiting agents.
How are Sulfites Regulated by the FDA?
In the 1980s several individuals developed asthma after eating fresh vegetables and fruit that were treated with sulfites. After the cases of asthma were traced back to sulfites, the FDA banned the use of sulfites on fresh fruits and vegetables in 1986. Sulfiting agents, however, have always been legal for use as a preservative in processed food productsâthough the FDA requires that food manufacturers must list sulfites on the label as an ingredient if their product contains more than 10 parts per million.
How Can I Known if Dried Fruit is Safe to Eat if I am Sensitive to Sulfites?
Always carefully read the labels of any dried fruit before you eat it. If it is from Harmony House, then you know it is safe because we do not use any kind of sulfites in our products.
How Freeze Dried Fruits Stay Fresh Without Sulfites
Chemical preservatives are only one way of keeping dried fruit fresh. Instead of treating our fruit with chemicals, we freeze dry our premium fruit through a safe, chemical-free process that extracts all of the water. Fresh fruit contains up to 90% water. The microorganisms (including bacteria, mold, and fungus) that cause food to discolor and go bad need water to live. Freeze dried food lasts on the shelf for years because the freeze drying process removes all of that water! Here is how it works: The food is placed into a vacuum chamber. The temperature is lowered well below freezing and the pressure is lowered. The frozen water turns directly from a solid (ice) into a gas (steam) without ever turning back into a liquid. The steam is immediately extracted from the chamber. Freeze drying preserves nutrition and flavor and keeps fruit from from going bad for years if stored properly. And you will get almost the same nutrition, flavor, and energy that you would out of fresh!
100% Sulfur Dioxide-Free Freeze Dried Fruit
All of our freeze dried fruit is preserved without sulfur dioxide or any other type of preservatives. You can rest assured that all of our dried fruits are safe for anyone who is sulfite-sensitive. If you have had reactions to any sulfating agent in the past or worry about the possibility that you or someone in your family might have an allergy to sulfur dioxide, you can confidently use any Harmony House freeze dried fruits as snacks or in cooking and baking. A list of our sulfur dioxide-free freeze dried fruits includes:
You can rest assured that we at Harmony House do not use preservatives or additives (including sugar and salt) in ANY of these dried fruits. Our freeze dried fruit is guaranteed to be 100% all natural.
Sulfite Sensitivity from the Cleveland Clinic
Sulfites from the University of Nebraska-Lincolnâs Institute of Agriculture and Natural Resources Food Allergy Research and Resource Program
Sulfites: Separating Fact from Fiction from the University of Floridaâs Institute of Food and Agricultural Sciences
|FDA Advisory Committee Votes Against Approval of Eteplirsen; Coalition Duchenne Comments|| |
Coalition Duchenne Founder and Executive Director Catherine Jayasuriya Reflects on the Recent FDA Advisory Committee Meeting on Eteplirsen
(PRWeb April 29, 2016)
Read the full story at http://www.prweb.com/releases/2016/04/prweb13380374.htm
|Coalition Duchenne Advocates for FDA Approval of Eteplirsen|| |
Coalition Duchenne is attending the April 25 U.S. Food and Drug Administration advisory committee hearing on the efficacy of the Sarepta Therapeuticâs novel Duchenne drug eteplirsen.
(PRWeb April 24, 2016)
Read the full story at http://www.prweb.com/releases/2016/04/prweb13365975.htm
|US FDA attracts former adversaries|
The US Food & Drug Administration has recruited one of its own long-standing critics, hiring Peter Lurie from the watchdog Public Citizen as a policy adviser. That suggests a more enlightened approach from the regulator under Margaret Hamburg, the new commissioner named by President Barack Obama.But what is good for goverment is bad for independent scrutiny. Earlier this year, the agency hired Sidney Wolfe, another vocal critic from Public Citizen, which must now be reeling from the departures. Who will be left to provide commentary and outside analysis?
It all tastes less of poacher turned gamekeeper than of gamekeeper poaches critics.
|Vioraâs Receives CFDA Approval for Reactionâ¢, Multi-RF Technology Bi-Polar Device in China|| |
Certification Allows Chinese Physicians Access to Reaction, a Leading Aesthetic Solution Provider for Skin Tightening, Body & Facial Contouring and Cellulite Reduction Treatments
(PRWeb May 28, 2015)
Read the full story at http://www.prweb.com/releases/2015/05/prweb12749728.htm
|Vioraâs V-20 Multi-Technology Platform Receives FDA Approval|| |
New Medical Aesthetic System Driven by Innovative and Advanced PCRâ¢ & COREâ¢ Technology
(PRWeb December 02, 2014)
Read the full story at http://www.prweb.com/releases/2014/12/prweb12365050.htm
|Vioraâs V30 Multi-Technology Platform Receives FDA & CE Certifications|| |
Innovative Laser, IPL and RF Technology Device Is Now Cleared for Marketing Worldwide
(PRWeb May 08, 2014)
Read the full story at http://www.prweb.com/releases/2014/05/prweb11836049.htm
|New Certifications Received in APAC Market for V-touch, Vioraâs Fractional RF Device|| |
V-touchâ¢ receives Taiwanese FDA, Thai FDA and South Korean MFDS Clearance for Fractional RF treatments.
(PRWeb April 08, 2014)
Read the full story at http://www.prweb.com/releases/2014/04/prweb11742007.htm
|New Pets Column Now Live||I'm happy to report that I am now writing a monthly column about Pets for Prevention magazine. An editor at the magazine contacted me after reading this article I wrote about my dog Bonny plus several animal-related posts on this blog -- she suggested I combine my love of animal stories with my decade of experience as a veterinary technician to write a regular series for Prevention (which I thought was a fabulous idea).|
My first column just hit stands in their June issue (now available in grocery stores everywhere) -- it's called "Feeding Disorders," and it was inspired by this post about pet obesity, which I wrote when the FDA approved a crazy new diet drug for dogs (interestingly, that is one of my most widely read posts, perhaps in part because of the amazing photograph I posted with it).
Stay tuned for more columns, which I'll post here each month as they run. And feel free to email me any tips or suggestions for future columns.
|A Sad Day: FDA Approves First Dog Obesity Drug||The FDA just announced that they've just approved the first-ever obesity drug for dogs, which really makes me cringe. Why? Because dogs don't have eating disorders -- their owners have feeding disorders.|
This summer, I adopted a new dog after she ran in front of my car on an interstate. She was starved, so I took her home and fed her. And fed her. And fed her. She weighed 20 pounds and could eat a heaping cup of food in 28 seconds (yes, I timed her). But that was fine, because she needed all the extra calories she could get. Then, about three months later, during a good wrestling match, I realized I couldn't feel her ribs anymore. Suddenly, she'd gone from being emaciated to being pudgy. So I did exactly what everyone else with a pudgy dog should do: I started feeding her less. Instead of getting a heaping cup at each meal, she got 2/3 of a cup. Three weeks later, she wasn't pudgy anymore. That's the amazing thing about dogs and weight: Humans control their calorie intake, and there's nothing dogs can do about it. If your dog needs to lose weight, you feed it less food.
It's true that there's an epidemic of canine (and feline) obesity right now, just like there's an epidemic of human obesity. Which is no coincidence: People don't exercise, which means their dogs don't exercise. When people eat, they feed their dogs scraps, so the dogs gain weight right along with their owners. And don't even get me started on the ingredients in dog food.
But there are other less obvious problems: Owners often have no idea how much they should feed their dogs, and if they follow the guidelines on most dog food bags, they're probably going to have obese dogs, because pet food companies encourage overfeeding. I had a 125 pound dog who lived to be 16 and was never an ounce over or under weight. If I'd followed the guidelines for his food, he'd have eaten 2 1/2 times what I actually fed him, and surely become obese. My very healthy 17 year old dog Bonny eats 1/4 the recommended amount, always has.
During my years as a veterinary technician, I saw many dogs die or become paralyzed from obesity. Today, when I see an obese dog on the street, I want to walk up to its owner and say, You love your dog, right? Then why are you killing it?
If it's come down to this, and people are unable to control themselves when it comes to feeding their dogs, I'd rather see dogs medicated than dead. But I hope vets who prescribe this stuff paste a sticker on every bottle that says, Dogs don't need obesity drugs. They need owners who will feed them the right amount, cut back when necessary, and make sure they get exercise. (Perhaps the FDA should consider a self-control drug for humans with dog feeding disorders.)
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|Adult Body Painting - What's the Fuss About?|
Did you ever want to be a cowboy? Maybe a rain forests? What about trading your skin in to become a seductive tigress ready to pounce on fresh meat? Well, whatever your adult fantasy may be, adult body painting may be the temporary and fun solution.
Though this art form has been around for centuries, many people haven't tuned-in to this creative outlet. Some people claim that body painting is actually the oldest art form (Considering that people were painting their bodies pre-anno domini. Just think of early century Egyptians). And, with adult body painting companies and artist all around the globe, one would probably have little difficulty finding an artist close by.
Adult body painting is an art that uniquely transforms your everyday skin into a beautiful picturesque scene or life form. How? Glad you asked. By using safe, FDA approved make-up, oils, and other various paints and applying it directly to your skin. Any part of your skin. Oh yes, that's right, any part. Body painting artists are extremely professional and willing to cover any part of your body that you so desire, from head to toe. Or, if you can't make your mind up on which body part to paint, you can have your entire body brushed with a plethora of colors that completely disguises the real you underneath. Unless, of course, you really are Smokey the Bear. Which can be done. By method of airbrushing, painting, and drawing, your body can soon be entirely transformed into your fantasy.
|How Gluten Causes Alopecia Areata||Do you recognize this circular hair loss pattern? It is called alopecia areata. According to the National Alopecia Areata Foundation, “no FDA approved treatment or cure exists yet.” No cure, eh? It is amazing how many times I hear this “no cure” declaration when I KNOW people who have been cured of the condition in ...|
|HeartIT Receives FDA 510(k) Clearance for Wider Clinical Indications||August 17, 2016 – Heart Imaging Technologies,LLC (HeartIT) today announced that the United States Food and Drug Administration (FDA) has issued a new 510(k) clearance for HeartIT’s products, FDA 510(k) Number K152949. The new clearance states that HeartIT’s software products “can be configured with different combinations of clinical applications which are intended to assist the physician in diagnosis or treatment Continue Reading|
|FDA Approved Temodar|| |
The U.S Food and Drug Administration's approval of Temodar as a treatment for people newly diagnosed with glioblastoma recognizes the importance of hope. These reports signify movement in the treatment of one of the most aggressive brain tumors.
(PRWeb March 16, 2005)
Read the full story at http://www.prweb.com/releases/2005/03/prweb219054.htm
|[Sponsored] ClearSK Laser SHR Hair-Free||I always have issues with keeping my under arm hair-free, but that's impossible with just shaver. Especially that is an action that you have to do everyday. Waxing is out of question since it does hurt (I guessed). The other alternative is to go for Laser SHR and ClearSK has the solution to solve the hair issue that we have been all worried about.|
Their Laser SHR Hair-Free is their latest treatment for ladies who have no time to spend on shaving or scare of pain.
Lasers and light sources use the principle of selective photothermolysis to eliminate hair and its potential regrowth without damaging the surrounding skin. During ClearSK Laser SHR treatment, light passes through the skin and is absorbed by the melanin in the hair shaft. This absorption raises the temperature of the hair follicle and thermally destroys the cells responsible for regrowth.
Clinically-tested by US FDA for safety and efficacy, this treatment is suitable for all hair types (from thick to fine) and skin tone (light to dark). Highly comfortable for bikini line and Brazilian hair removal too.
So i was offered a session of Laser SHR Hair-Free treatment at Novena Medical Centre. And was ushered into the treatment room once I've reached as I reached on the dot for my appointment. *haha*
Pardon for the blur photo, but it was taken right after the treatment. Not really hair-free but most of the hair were gone and basically can't even see the tiny heads like I do see after shaving ( either that I really suck at shaving).The 1st trial treatment is 20 minutes at the price of $68 each. They have outlets at Scotts Medical Center, Novena Medical Center, Velocity, Orchard, Tampines, Jurong East. They have an outlet at the different parts of this sunny island to cater to their customers.
After treatment, I applied moisturizer as I felt a little dryness over that area. And after a month, I do see even after a session of Laser SHR Hair-free treatment, the hair growth is minimal! This is amazing. Their recommended sessions to see optimal results is a minimum of 6 weeks and once per month. For hairier people, they recommend up to 10 sessions.
Hair reduction is observed after 4-6 sessions. Hair is evidently finer. For those with less serious case, the treatment causes permanent damage to the hair follicle and hence the results will be permanent.
SHR Hair Free treatment targets the deeply seated hair follicles and permanently damages them as opposed to shaving, waxing, hair removal creams which only serve to remove the hair shaft. Unless you have gone through hormonal imbalances caused by pregnancy, menopause, intake of hormone pills, most people enjoy permanent hair reduction/removal.
You can visit their website for more information: http://www.clearsk.com
|Center For Womenâs Care & Reproductive Surgery Launches FDA Trial of Olympus Narrow Band Imaging to Detect Endometriosis; New Technique May Improve Diagnostic Ability|| |
"About four-fifths of endometriosis patients do not display symptoms,â said Tom Lyons, MD, a pioneer in gynecologic laparoscopy and co-author of WHAT TO DO WHEN THE DOCTOR SAYS ITâS ENDOMETRIOSIS (Fair Winds Press).
(PRWeb June 30, 2011)
Read the full story at http://www.prweb.com/releases/2011/6/prweb8608436.htm
|Center For Women's Care Offers Fibroid Treatment New To Atlanta, FDA Says Proven Noninvasive Ultrasound Treatment Offers Significant Advantages|| |
The latest medical technique to treat fibroid tumors, exablation, also known as MR-guided focused ultrasound (MRgFUS), "offers significant advantages over existing treatments for uterine fibroids," says the FDA. The incision-free fibroid tumor treatment that destroys tumors with high-energy sound waves is now available in Atlanta. Unlike Uterine Artery Embolization (UAE) or Uterine Fibroid Embolization (UFE), the FDA says the treatment is "not contra-indicated in women who may be seeking pregnancy in the future."
(PRWeb April 15, 2008)
Read the full story at http://www.prweb.com/releases/2008/04/prweb852654.htm
|Clinical Trial On Dysfunctional Uterine Bleeding (DUB) Now Conducted by Thomas L. Lyons, MD, GYN Surgeon|| |
The Center for Women's Care & Reproductive Surgery, headed by laparoscopic pioneer Thomas L. Lyons, MD, is conducting a placebo controlled FDA clinical trial on a drug used to control dysfunctional uterine bleeding (DUB). Women who experience heavy menstrual bleeding on two to five days of their cycle, and who have to alter their normal social and work activities due to heavy bleeding may be qualified for the study. Women must be generally healthy, and between the ages of 18 and 49, have regular menstrual cycles with heavy bleeding and not have any other bleeding disorder.
(PRWeb July 24, 2007)
Read the full story at http://www.prweb.com/releases/2007/07/prweb541552.htm
|1/10/04 HURRICANE & the making of "Lost in New Mexico"||The naturally talented David Paytiamo (left, who played Lonnie), filmmaker/director Jason Rosette (center, who also played FDA Agent Carl Wisconsin), and the improvisationally gifted Dale Waseta...|
Check out the Blog for LOST IN NEW MEXICO (The Movie) for complete info & updates!
|Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products|| |
Efficient and cost-effective, the Reed Tech LDR solution enables biologics and vaccine manufacturers to prepare required periodic distribution reports and successfully meet new regulatory challenges
(PRWeb April 17, 2015)
Read the full story at http://www.prweb.com/releases/2015/04/prweb12662585.htm
|Off Base Percentage World Series Predictions|
Here we are. It's the middle of October, and baseball has now finally widdled itself down to its final two teams. As all the experts predicted, the Royals and the Giants will square off on Tuesday to kick off the 111th World Series. What? No one predicted this World Series matchup? OK, maybe they didn't. But, now that we are here, who is really upset about this matchup? That's right. Nobody.
In advance of the Fall Classic, the Czar of Off Base Percentage, MJ Lloyd, and myself are going to kick around the old question ball and see if we can come to a consensus on who will be standing victorious at the end of the World Series. We put on pants for this shindig, so you would know that we mean business. Well, MJ is wearing pants. I'm wearing Spongebob Squarepants pajama pants. But for this exercise, they count as pants.
Let's cut to the chase, MJ. Ned Yost. Micro-managing genius, or insanely lucky? Side thought: How much does the ghost of Dale Earnhardt have to do with the Royals insane winning streak in these playoffs?
It's funny that Ned Yost was your first question because that was going to be my first question. But more of an over/under on when he calls for the first bunt of the World Series and I imagine it comes during media day. "Eric, you've been hot but as soon as somebody asks you a question with a runner on, you square up that mic and put it down the right exit hallway."
I don't think he's been lucky or good. He realized he needs his starter for five or six innings and if they have a lead, they win. I'll give him credit for using some of those guys for multiple innings but, oh god, Dayton Moore did a fine job giving him a bullpen that can win a championship.
And maybe the ghost of Earnhardt has played a role with the Royals. It's a nice story. Maybe Ned is hearing whispers of "go faster" when he sends everybody running on the bases. That would explain why Dyson gunned it so hard (20.1 mph) he slid past second into left field.
While I'm sure I know the answer long suffering Royals fans would give, I'll ask you. Is the Royals winning the World Series worth another 10 years of Ned Yost and Dayton Moore? Flags fly forever and sac bunts only drive you crazy for 162 games a year.
Worth it? To the outsider, probably not. But for fans, a World Series hangover can last for a long time. Of course, Ned Yost's wacky and zany land of small ball antics will only be endearing for as long as it is working. And I believe that the expiration date for this product is coming up pretty soon. But, to be fair to Yost, Joe Torre was considered a terrible manager before he got hired to manage the dynasty that was the late 90's Yankees. So, for Yost, who knows. Maybe he has finally found his place in KC. But, at this stage, I'm banking on the smoke and mirrors wearing off sometime around March of 2015.
Whatever crossroads both Yost and Moore went to in order to hook up with Robert Johnson and his genie of dark magic, they need to share it's location. I'm not saying that it is a good idea to sell your soul to the Devil, I'm just saying that maybe its not as bad of an idea as I originally thought.
Jarrod Dyson's hair? Fun and quirky oddity of this year's playoffs, or an undeniable cry for help?
Fun and quirky for sure. You've never had some strange choices in hair? When I was in my early 20's, my spikey hair color changed every two weeks and I had designs in my facial hair that would impress Jeff Hardy.
Dyson has one big job for this Royals team. Run fast. So, he chose to shave "Zoom" into the side of his head. If they win the World Series, Dyson's agent better get Mazda on the phone.
Speaking of agents getting on the phone, if the Giants win, what else would Buster Posey have to do to be the face of MLB? Seems like he should be a bigger star.
I had a rat tail at one point, and in recent years I've been rocking the mullet with a receding hair line. So, yes, I have enjoyed strange hair style choices. Maybe I should take it easy on Dyson.
Posey on the other hand, could probably use a bottle of my newly created and recently patented (but still not FDA approved) elixir, Be Less Boring. Posey is a wonderful player, and an excellent catcher. But, my goodness, is he boring. Without being a flashy star like some of the other big names in the game, he needs to do something. Maybe start compiling a rap sheet, or buy drinks for the entire bar after a series win a la Eric Hosmer.
Say you are walking down a dark alley in some seedy neighborhood in a scary city in America, who would you rather not run into in this situation: Hunter Pence, Michael Morse or Eric Hosmer? Why Hosmer, you ask. Have you heard him yell things?
Can I choose Pablo Sandoval if he wasn't smiling? If I ran into him in a dark alley of a shady neighborhood, I'd assume he was a bodyguard for the local mob leader. Plus he knows Kung-Fu, or so I've heard.
And if I was trying to get into a club, I wouldn't want to run into Madison Bumgarner. He doesn't give free passes this time of year.
Are you impressed by my boy MadBum yet?
Yes, I am. And not just because his snot rockets are monitored, charted and tracked (I hear his velocity on boogers is up from last year. Worth keeping an eye on). He's just good at everything on the mound. He also has great hair and wonderful facial hair. But I'm still not upset that I left him off of the ballot for the Walter Johnson Award.
Everyone made a big deal about the Royals being last in the known world in hitting dingers in 2014. However, the Giants hit exactly zero dingers until game five of the NLCS in this year's playoffs. With all of the media fawning over what is happening with regards to the Royals, is it possible that the media is missing out on a team that is out-Royalsing the Royals?
Could be. Eric Hosmer and Mike Moustakas were highly regarded prospects. So, maybe their monster shots in extra innings were just more exciting than Michael Morse and Travis Ishikawa? The Giants at least hit 132 homers during the regular season. The Royals finished dead last and didn't break 100. That makes the recent power surge a talking point for anybody trying to make a deadline. Speaking of which...
Let's start making some predictions. There's always an unlikely hero in the World Series. I know David Eckstein actually won a WS MVP but I want to call this the Eckstein anyway. That makes my pick David Eckstein. Wait, I mean Alcides Escobar. Who you got?
I'm putting my collection of George Washington's on Alex Gordon. It'll be the perfect ending to this KC masterpiece when the team's longest tenured, and former hotshot prospect, carries this band of crazy midwesterners to their first title in 29 years.
I assume that since you are picking Escober to take home the Eckstein that you are also picking the Royals to win the series. Is that correct?
You would think, right? I love that Royals bullpen and them in six sounds awfully tempting. But if I've learned anything since 2010, it's that Lindsay Lohan is never going to get her shit together. Also, the Giants win the World Series in even numbered years. I'll take the Giants in seven with Madison Bumgarner winning three games and the actual WS MVP.
Your final prediction?
Royals in six. Cut, print, on to the next scene. Their bullpen has made each game a five-inning affair, or it has been able to keep the opposition down for five innings of free baseball. They also have history on their side. The only other time that two Wild Card teams met in the World Series, the American League team won. This matters because, who really cares about sample size? Either way, it is going to be a really fun series that I am sure will cause 30-year old men in Kansas City and San Francisco to lose at least a solid inch of hair from their hairline.
Best of luck to the Gigantes and the Monarchs. To the fans: Stock up on antacids. All the antacids.
|FDA Finally Issues Some Biosimilar Guidance Documents||
The US Food and Drug Administration finally released portions of the long-awaited guidance documents that will help to implement the development and approval of biosimilar molecules under the Biologic...
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|Regulatory Affairs Update; FDA 483 and Warning Letters Trends for 2012||
Those of you who manufacture products approved by the US Food and Drug Administration (FDA) are well aware of the importance of complying with Current Good Manufacturing Practices (cGMP) during FDA ma...
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|Bioidentical Hormones and The Wiley Protocol Testimonies||Bioidentical Hormones: Its Dose Dependency and Duty for Hormone Receptor Reaction|
There's this little FDA approved drug named estrazorb and it's a small kechup sachet filled with soy oil and estradiol. It comes in 4.3mgs. and you are meant to have it twice a day. That is's 8.6 mgs, the basic dose on the Wiley Protocol. Okay. It never goes past that except for 2 days. We are within the range of FDA but nobody notices it. Even with an FDA merchandise you can't expect to get benefits from right away. Without peaks and valleys, without differential drops and high amounts, you can't reset receptor response and it's not how much you take, its how much receive.
So, without those receptors falling into line and making this work in a normal way as it might in a normal young woman. You are not having hormone re-establishment. You barely have replacement. I attempt to make them understand that bioidentical hormones are dose reliant in their effects. This much does one thing, this much does another thing. So, they understand that without that peak on day 12, you have got steady proliferation in any static dose of anything.
Estrogen converts it on the twelfth day. It's a negative feedback loop. Hormones are efficient same as endocrinology both on positive and negative results and with no high level on the twelfth day, not only will it put a stop to estrogen but also it will not permit the progesterone receptor to accept progesterone in the second half batch.
I'm not sure it is very clear in the literature. Isn't it just common-sense that after you eventually studied molecular biology that both progesterone and estrogen creates its own *** by making another receptor for the progesterone. And that is just negative cycle. Negative feedback loop to turn itself off. *** on arrest or just expansion stopping on day twelve is not enough.
He will have to disengage from the procedure. So you turn off the receptor energy amd then deactivated. Then you turn off the estrogen. All of these ladies who've been robbed, who have lost their uris, the gynecologist who prescribes static dose hormones, and then get to perform surgery later.
That is where ladies take a pause in this nation. Infrequently they are stuck on them, even in such an inexpensive manner. They're known as iatrogenic but am not so sure of the rationale why. They're stuck. They are not of the same field in endocrinology. The endocrinologist wont be in a position to cure menopause. Endocrinologists are put in drugs to address diabetology and thyroid and infertility. They're dealing with hormones.
They have incorrect interpretation of men having andropause and women having menopause as having none whatsoever. So they are not being treated. They just have faith in what these doctors say because these doctors are also knowledgeable in medicine. They assume they could modify some things but they cannot.
Dr. Fred Bloem Question and Answer
Medical practicians have come across a discovery that is pliable for the enhancement of finding and healing the patients. Then they take that knowledge and use it to those in want.
My name is Dana Gillian together with Dr. Fred Bloem, a physician with an expertness in the area of family and internal medicine. He thinks in a holistic medical practice involving bio-identical hormone replacement therapy, weight decrease therapy, nutrition, vitality healing and some raw food instruction. He practices in Olney, Maryland. So, you attended the two days back on earth seminar. What is the important information you've extracted from that symposium?
Dr. Fred Bloem:
There are 2 essential things. One was seeing T.S. Wiley prior to coming to Santa Barbara. I came to hear about her through Susan Somers' book Ageless and her own "Sex, Lies and Menopause." But, meeting her was really impressive. Seeing her made it possible, I had learned about her through another physician that I spoke with before making the conclusion to come to Santa Barbara. So, I knew that she was very intelligent. I was not disappointed when I came to Santa Barbara. She has a wealth of knowledge on the topic of internal secretions and related physiology. That is why I am glad to have listened to her.
Another thing that was very central to me was validation. Convening with the other physicians from all over North America who generously contribute their views and testimonies.
With your own experience, what is the most essential positive answer given to women who undertook the Wiley Protocol?
Dr. Fred Bloem:
The very important aid is the aid on their common issues. Some of these include hot flashes, insomnia sweating during nighttime. Another, one is less feasible but the ability to regain their femininity.
Is there any distinct story of your patient who undertook the Wiley Protocol?
Dr. Fred Bloem:
Yes, I would be happy to share with you an example of a patient who's been very successful on the Wiley Protocol. She was 45 years old when she came to me last year. She consulted me for a weight loss treatment. But as I met with her, I discovered that she was actually born without a left ovary and she only had a little right ovary. And because of that she never got to experience having menstrual periods, the only time she did have was once when she was given Premarin and birth control pills.
She shared with me that for a long time she was angry because she was not able to have kids. She disliked her body type. Her chest was a bit slight. All her life she's been misery and so I recommended the Wiley Protocol and recounted to her some of my patients' experience. She had the process since last June and she felt positive effects in just one month. She shared with me that she had more vitality. She shared that her body felt weird and felt that the hormones altered the shape of her body. She noted that her breasts became fuller within the first month and she also felt that the heaviness and this is actually a way how she identified her feelings of depression that feeling of heaviness vanished.
She also said that her rest pattern bettered and totally feels contented. And one of the things that she shared with me also which I found was very interesting was that she never felt womanly. She always felt more butch. She was joyful to tell me that Wiley Protocol made her feel like a actual woman again. I thought that was very interesting. Most of my patients really feel the distinct switch when they begin the Wiley Protocol. The Wiley Protocol has been an significant facet of my medical practice.
I really consider myself really lucky that I have been introduced to this protocol indirectly through my patients by their sharing Susan Somers book Ageless with me. It really makes a lot of sense to me. I have been recommending bioidentical hormones replacement therapy for more than six years and have had in mind as to how much is the proper dose of Estradiol and Progestrone for my patients and whether to use Estradiol or Biased and just how long should I be giving it in sessions.Should I organize it with a ***4:47? I was really bewildered about things like that and I really didn't have a good understanding of the lab follow up in terms of what the right dosages of Estradiol and Progesterone should be for women at any particular time in the cycle. And so getting acquainted with the Wiley Protocol is really significant for me.
We replace Estradiol and Progesterone and we observed a pattern that we see in healthy young women and so we know that Estradiol, sometimes it should be low in the cycle and sometimes it should be high on day twelve. Progesterone throughout the follicular stage and gradually build up through the luteal stage, highest level is at 21 and it goes down. And I found that that is really the optimal way for women, young and old, to place their internal secretions and it does not matter whether they're you know perimenopausal or post-menopausal or whether they're younger. In my years of medical work, I found that some young women also encounter problems with regards to menstrual period. And that is an indication that their Estradiol and Progesterone secretion is not harmonious.
Dr. Mitchel Fleisher Sees Dramatic Results in Auto-Immune Illnessees With Wiley Protocol
My interest in it is having the ability to combine this very accurate rhythmic bioidentical hormone therapy with constitutional homoeopathy which is you've got the bio-energetic kick, specific bio-energetic kick on a mind, body, spirit plane together with biochemical, bio-hormonal kick and bringing in both in the balance ideally to realize perfect health and well being. And I'm actually anticipating interfacing with other doctors who're using this protocol and standardizing it so we actually, actually know what we're doing and having the ability to have a definitive protocol to work by that everybody's using at the same level and gather enough research ad clinical info that we can present it to the medical profession and to the govt. and say hey, this is the way to go.
This is the way to be in a position to deal with lots of protracted sicknesses we have not been in a position to master. I have heard stories of some of my co-workers in Texas and other states who've been treating patients with dreadful autoimmune illness diseases, rheumatoid arthritis, lupus, multiple sclerosis that they put them on the Wiley Protocol and they saw amazing results. I help patients with illnests with the use of the Wiley Protocol and I'm excited to mix it with homeopathic nutritive that may be good for all.
A Testimony on Wiley Protocol by Julie and Ola Johnson
The common problems that are being complained by most women are the hot flashes, sleeplessness, head blurriness, different aches and the feeling of not being alive. I did have the mind fog. I had insomnia. I didn't experience hot flashes but there were so many other problems I had and after staring the process, I felt that I was back once more.
PYou know, I felt reconnected to everything and everybody and I had balance again.|I felt I had regained all that I have lost and felt the balance.} And when you are of this age, you know you are 50s, you are sixties, you've got a lot of issues to handle in your family immediate and otherwise. And I wasn't coping well you know and then when I kept balance again, I was able to actually get a grip of everything and I got my life back basically.
When she had not had the process yet she used to have all kinds of the issues and signs during menopause and could not absorb well because of the mind blurriness and most of all a little grouchy. After going thru the Wiley Protocol, she somewhat turned back to her ld self again and our sex life hasn't ever been better. She regained her old self again and our regular lives went on to be better and we appear to be always in high spirits. So, I'm totally happy with her being on the protocol, naturally.
If you do not resolve anything and will not take the hormones then you get ill. You die. When you go have hormones, you experience a better feeling. You have a great reaction. In some rare instance, you feel ecstatic. And when you do feel better, it's a sign that it is good for you. So, I suspect the fear thing is very over blown by maybe the media, maybe by other people that have no idea but you have to have the experience. You need to try it. You've got to do your own research and then go by how you're feeling and you look. You don't end up running out of step drugs in your system or arthritis drugs or sleeping pills. There is just a sense of hollowness within once the hormones are imbalanced. So, when you replace them, you know you basically get your life back.
The Wiley Protocol
Year after year A4M, the world's greatest anti aging establishment organize global seminars. So we took out cameras on the show hall grounds to offer you an idea about what are the latest in the anti aging marketplace.
The Wiley Protocol is a multi-phasic rhythmic dosing schedule for bioidentical hormones to be provided to women in a bio-mimetic way to mimic biology. Nobody has tried doing this before. WE started the transdermal estrogen and progesterone in a manner that it cpies the usual sequence of a young female in her twenties. Then we give explanation for the quantity of dose to be given with the aid of serum blood levels on the twelfth day and 21 to make sure if she turns out to be the 20 year old she was before. It is very profound because young women still have no trace of various sicknesses. So, when we put women back, we actually restore their hormone. We don't just treat the signs and we know that those young women are healthier in every way.
The delivery system is simple. We use 3ml syringes color coded, purple for progesterone, green for estrogen, and the women that way don't pick up the inaccurate syringe in the middle of the night when they're putting on their hormones and take the wrong thing. One of the reasons why the federal authorities wants to eradicate the bioidentical hormones is that they are constituted and made in so many manner. We have governed the means, the substance, the tagging and dose measure so they can be used for research. You can visit our website www.thewileyprotocol.com. In there you will see all the information you need including the practicing physicians.
|How Menopause Symptoms and Sleep Benefit From The Wiley Protocol As Proven By Experts||The Hormone Receptor Reaction Obligation and Dose Dependency of Bioidentical Hormones|
There's this little FDA authorized drug named estrazorb and it's a little kechup sachet full of soy oil and estradiol. It comes in 4.3mgs. and you are meant to have it twice a day. That's's 8.6 mgs, the basic dose on the Wiley Protocol. Fine. It must not exceed within 2 days. We are inside the range of FDA but nobody notices it. Even FDA products, you cannot treat somebody and get any effects immediately. Without tops and valleys, without differential drops and high doses, you can't reset receptor response and it isn't how much you take, its how much receive.
If receptors don't fall in its right places and not having the ability to work in the usual demeanour like it should have been in younger women. You do not have hormone restoration. You hardly have replacement. I try and make them see that bioidentical hormones depend on dose's result. This much does one thing, this much does another thing. So, they know that without that top on day 12, you have steady proliferation in any static dose of anything.
Estrogen turns it so far on day twelve. It is a damaging result circle. Hormones are effective same as endocrinology both on positive and negative results and with no high level on the twelfth day, not merely will it put a stop to estrogen but also it won't allow the progesterone receptor to accept progesterone in the second half batch.
I do not know it is very clear in the literature. Isn't it just common sense that after you ultimately studied molecular biology that both progesterone and estrogen makes its own *** by making another receptor for the progesterone. And that's just negative cycle. Negative feedback loop to turn itself off. It is in steady motion or stop the expansion on the 12th day.
He will have to disengage from the procedure. So you switch off the receptor energy amd then deactivated. Have all of the receptors turned off. So for those girls undergoing the treatment,that already is the validation to make it function better.
Here's where girls are stuck in this country. They're stuck taking something that basically makes them worse. They're called iatrogenic but am not so sure of the explanation why. They are steady. They are not endocrinologists. The endocrinologist won't treat menopause for women or andropause for men. Endocrinologists are put in medication to deal with diabetology and thyroid and infertility. They are dealing with hormones.
They perceive folks in andropause and menopause not to have any. So, they don't treat them. They just fall thru the cracks because endocrinology could step in here and there may be menopause medicine. They think they could change some things but they cannot.
Dr. Fred Bloem Question and Answer
Medical practicians have come across a breakthrough that is pliable for the enhancement of determining and healing the patients. Then they take that cognition and give it to those in need.
Hello, I'm Dana Gillian and I'm speaking today with Dr. Fred Bloem, a physician with a background in family and internal medicine. He thinks that bio- identical hormone replacement therapy, wait reduction therapy, nutrition, energy curing and other raw food lesson constitutes to the holistic medical practice. He operates in Olney, Maryland. So, you attended the two days back on earth seminar. What is the important info you've drawn from that symposium?
Dr. Fred Bloem:
Well, really 2 things. One was seeing T.S. Wiley prior to coming to Santa Barbara. I had only learnt about her through Susan Somers's book Ageless and through her book "Sex, Lies and Menopause." But, meeting her was really impressive. Seeing her was a validation because I had spoken with another physician before thinking of coming to Santa Barbara. That's how I came to know of her intelligence. I was not unfulfilled when I came to Santa Barbara. She has a huge storage of info regarding internal secretions and physiology. That is why I am happy to have listened to her.
Another thing that was very central to me was validation. The chance to meet other physicians from all across North America who shared their insights and success stories.
With your own practice, what is the most essential positive answer given to women who undertook the Wiley Protocol?
Dr. Fred Bloem:
The very important help is the aid on their everyday issues. Examples are easing of hot flashes, night sweat problems, sleeping problems with memory palpitations in several instances. Another, one is less tangible but the ability to regain their femininity.
Can you share any particular experiences of patients that have experienced dramatic results or any especially unforgettable patients you have had from the Wiley Protocol?
Dr. Fred Bloem:
Yes, I would be willing to share with you an example of a patient who's been very successful on the Wiley Protocol. She was forty five years old when she came to me last year. She came to me for weight reduction therapy. But as I met with her, I discovered that she was in reality born without a left ovary and she only had a little right ovary. So, for that reason, she never got a menstruation and in reality the first time that she did get a menstruation was when she was 18 years old and she was granted Premarin and birth control tablets.
She told me that she was unrewarded for the longest time for not able to have babies. She didn't like her body type. She had smaller breasts. All her life she's been woeful and so I recommended the Wiley Protocol and recited to her some of my patients' experience. She had the process since last June and she felt positive results in just one month. She shared with me that she had more vitality. She told me that somehow she felt that the internal secretions have modified her body. She noticed that her breasts became plumper within the first month and she also felt that the heaviness and this is in reality a way how she described her feelings of clinical depression that feeling of heaviness evaporated.
Also, she felt that her slumber was much improved and just felt very comfortable overall. And among the things that she shared with me also which I found was very interesting was that she never felt womanly. She had that feeling that she was more similar to a man. She was really charged to share with me that she was just observing now what it was like to be a female since beginning the Wiley Protocol. That was just so extraordinary. I have patients like that, not precisely like her but patients who experience a tremendous transformation when they start the Wiley Protocol. The Wiley Protocol has become a very significant part of my practice.
I really see myself really lucky that I have been introduced to this protocol indirectly through my patients by their sharing Susan Somers book Ageless with me. It really makes plenty of sense to me. I have been offering Bio-identical hormone replacement therapy to my patients for about six or seven years starting with statically dosed bioidentical hormones replacement and from the very start, I always wondered what is the right dosage of Estradiol and Progesterone for my patients and should I use Estradiol or Biased and for how long should I use it in the cycle.Should I synchronize it with a ***4:47? I was really baffled about things like that and I really didn't have a good understanding of the laboratory follow up in terms of what the right doses of Estradiol and Progesterone should be for women at any particular time in the cycle. And so getting acquainted with the Wiley Protocol is really remarkable for me.
We substituted Estradiol and Progesterone and observed a sequence seen in healthy youthful women and now we discovered that Estradiol should be low in dosage and must be high on the twelfth day. And Progesterone is low during the follicular stage and it slowly rises during the luteal stage, peaks only at 21 and then goes down. I discovered that it is the most possible means for women to put their internal secretions whether they are young or old. In my years of medical profession, I discovered that some young women also encounter troubles with regards to menstrual period. And that is an indication that their Estradiol and Progesterone secretion is not well-balanced.
The Outstanding Effects of Wiley Protocol in Different Illnessees by Dr. Mitchel Fleisher
My interest in it is having the ability to combine this very accurate rhythmic bioidentical hormone care with constitutional homoeopathy which is you've got the bio-energetic stimulation, particular bio-energetic stimulation on a mind, body, spirit plane together with biochemical, bio-hormonal stimulation and bringing in both in the balance ideally to gain perfect health and well being. And I am really anticipating interfacing with other physicians who're using this protocol and standardizing it so we really, really know what we are doing and having the ability to have a conclusive protocol to work by that everyone's using at the same level and gather enough research ad clinical info that we can present it to the medical profession and to the govt and say hey, this is the way to go.
This would be the best demeanour in working with other illnesses that we haven't mastered yet. I have heard anecdotes of some of my co-workers in Texas and other states who've been treating patients with dreadful autoimmune disease sicknesses, rheumatoid arthritis, lupus, multiple sclerosis that they placed them on the Wiley Protocol and they found dramatic results. I help patients with illnests with the utilization of the Wiley Protocol and I am excited to combine it with homeopathic nutritional that would be good for all.
Julie and Ola Johnson's Testimony on the Wiley Protocol
The one that folk debate the most naturally would be their hot flashes and then it goes into sleep issues, mind fog, aches, pains, you know just feeling discombobulated; I think and for me before the protocol, I actually felt like a ghost. I did have the mind fog. I had insomnia. I didn't experience hot flashes but there were so many other issues I had and after staring the procedure, I felt that I was back.
PYou know, I felt reconnected to everything and everyone and I had balance again.|I felt I had found all that I have lost and felt the balance.} When you reach a certain age like your 50's to sixties, there are numerous issues that you do encounter in your family and so on . And I didn't cope up with all of the pressure but when I regained balance I felt like i was ready to face and deal nearly anything and I felt happy.
When she had not had the procedure yet she used to have all kinds of the problems and signs during menopause and couldn't absorb well thanks to the mind blurriness and most of all a tiny grumpy. After the Wiley Protocol, it was like the old lady again, physically and emotionally and our sex life improved tremendously. She, of course, had a period again which kept everything I suppose working as a young girl and our life seemed to be much smoother and happier. So I'm satisfied too she had the procedure.
If you don't do anything, if you don't take any hormones, you get sick. You die. You take hormones, you're feeling good. You have a good reaction. In some rare example, you feel euphoric. And when you do feel better, it is a sign that it is good for you. What causes the fear is the media hype and the talks from others who haven't yet experienced it. You have to experience it. You have to look at it and base the result on how you feel good within and out. You don't finish up running out of step drugs in your system or arthritis drugs or sleeping pills. There is just a feeling of hollowness inside once the hormones are imbalanced. So when you replenish them it gives a replenished feeling, of being alive again.
The Wiley Protocol
The A4M, the world's largest anti-aging organisation hosts dozens of global conferences every year. So, we took out cameras on the exhibit hall floor to show you what's new in the anti-aging marketplace.
The Wiley Protocol is a multi-phasic rhythmic dosing agenda for bioidentical hormones to be given to women in a bio-mimetic way to mimic biology. Nobody has tried doing this before. We brought in transdermal estrogen and progesterone in a way that mimics the normal cycle a young woman had at twenty. Then, we justify the dosing by using serum blood levels on days twelve and twenty one to see if she is in indeed the 20 year old reference range. It is very significant because young women still have no trace of various illnesses. So when we have them undergo the process, it's like bringing back their hormones. We don't just treat the symptoms and we know that those young women are healthier in every way.
The way of distribution is very plain. We use 3ml syringes color coded, purple for progesterone, green for estrogen, and the women that way don't pick up the inaccurate syringe in the middle of the night when they're putting on their hormones and take the wrong thing. Among the ways the federal government intends to get rid of bioidentical hormones is because they're recommended in so many ways, made so many ways. We have regulated the means, the substance, the marking and dosage measure so they can be used for research. You can read about us and our products in our internet site, www.thewileyprotocol.com. In there you will see all the data you require including the practicing doctors.
|Bio-Identical Hormone Replacement And Environmental Endocrinology||I don't know if you were at the first planetarium seminar, but I remember standing in front of all these doctors, and I did not know where to begin. So I asked them what their hormone replacement ideas were by going round the room. How they did it and why they did it that way. I do not think that's's okay. In fact, I suspect that is the reason why bio-identical hormones are having problems with the FDA because they do not approve of you simply handing it out like that in the guise of care. And if i'm not mistaken, the girl with self imitative recounted the easier standard of care would kill you. Why can't women have similar hormones through the skin as they'd have produced them? I believe we had a better plan. I usually show it in the seminar, sleeping controls eating, how you eat, what you eat. The number of trips round the sun depends on whether it was three or four months of high insulin and your food supply, and when you get only 1 summer trip round the sun, you will age four times as fast. You do not have the raw materials, and you understand all that when you realize that as your hormones run out, easy entropy winds you down. You cannot tinker in the powder, I mean. By putting the big pieces together first, the quality of life goes through the roof when people get seriously better."|
- By T.S. Wiley, The Woman Behind The Wiley Protocol
|LISTen: An LISNews.org Program -- Episode #263|
This week we have an essay on information ethics, use the word "lethal" more times than usual in this program, and present a news miscellany that seems biased towards libraries news out of the United Kingdom.
Download here (MP3) (Ogg Vorbis) (Free Lossless Audio Codec) (Speex), or subscribe to the podcast (MP3) to have episodes delivered to your media player. We suggest subscribing by way of a service like gpodder.net. Throw a paperback at us via this Amazon picklist.
This work is licensed under the Creative Commons Attribution-ShareAlike 3.0 United States License. To view a copy of this license, visit http://creativecommons.org/licenses/by-sa/3.0/us/.
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|FDA Postpones Food Labeling Deadline||Last month, the U.S. Food and Drug Administration (âFDAâ) pushed back the deadline for food companies to adopt changes to nutritional labels for packaged foods. Industry stakeholders welcomed the extension amidst concerns over their ability to meet the compliance deadline of July 26, 2018.Â The FDA has not yet set a new deadline for label...… Continue Reading|
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QualiTest Group, a global leader in quality assurance and software testing services announced today that it has been selected by an international healthcare corporation for a critical remediation project.
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|The 2010s revisited|
I wrote this blog entry over a year ago as a fictional retrospective on the 2010s from 50 years out and what it meant for LGBT equality. It occurred to me recently that much of what is written there has come pass, so I thought I'd look back at that checklist. Granted everything in the 2013 or prior category had already happened, but the rest was speculative.
2014 - In 2014 the Supreme Court did hear the case, and their decision lead to the 4th circuit's decision that lead to courts here in NC decided that marriage equality was constitutionally required as of October 10th, 2014. So I feel right about that one.
2015 - The employment non-discrimination executive order came in 2014, ahead of my schedule. So I was wrong on that one, in a good way. Legislation would go much farther and could cover other issues beyond employment, so there's still work to be done like passing the Equality Act that was introduced in Congress last week.
2016 - The Supreme Court brought marriage equality to everywhere but 13 counties in Alabama that are still holding out this year rather than next.
2017 - The transgender military ban coming down was my prediction. The military is actually making moves in this direction. It's not finalized yet to my knowledge, but it seems to be on track.
2018 - I thought this was when the scout leadership ban would be lifted, but it turns out that was yesterday instead. I also thought this is when the gay & bi blood donation ban would end. The FDA actually recently changed it from a lifetime to ban, to a ban that only requires 1 year of abstinence before any time you want to donate. In many ways that's essentially still a lifetime ban, but it shows that advocacy can make a difference.
2019 - 50th anniversary of the Stonewall Riots. Luckily that one is set in stone, pun fully intended.
There is progress to make on these issues and so many more, but as of yesterday every item on this checklist I wrote up last year has a full or partial check beside it. And that's worth celebrating. Activism has no finish line. But we can celebrate when we finish one chapter and start one anew.
|GST to prolong pain for pharma sector finds HDFC securities|| HDFC Securities' latest report on the outlook of the pharma industry paints a difficult picture for the sector owing to GST related concerns. The report identifies that GST may not essentially act as the wonder pill for the Indian pharmaceutical industry. |
The fourth quarter FY17 performance of the sector was impacted by a sudden drop in US sales, and the first quarter for FY18 is expected to be adversely impacted by de-stocking related concerns arising from GST.
In fact the brokerage house points out a probable drop in profitability owing to lower sales of exclusive products and compensation for lost tax credits offered to dealers by pharma majors post GST-implementation.
"The operating performance is likely to have bottomed out in 4QFY17 and companies like LPC (Lupin), CDH (Cadila), GNP (Glenmark) and ARBP (Aurobindo) are now receiving a higher number of product approvals, leading to stronger base businessesin the US," highlighted the report.
Of the 12 pharma stocks the report analyzed only Cadila Healthcare and Glenmark were rated with a positive outlook.
Glenmark is expected to improve sales for gZetia this quarter from a tepid fourth quarter in FY17. Overall top-line to grow ~22% YoY, despite ~5% decline in domestic business. Analysts have projected that EBITDA margins could elevate by 23% owing to gZetia sales. Furthermore, the pharma major with a Rs 192 billion market capitalization has been rated a buy at a target price of Rs. 1035. The CMP per share is Rs. 681.
The stock on the BSE grew marginally a 2.05 point or 0.30% hike to 682.85.
Cadila Healthcare too gained a buy rating. Nearly 18 FDA approvals are awaited in 1QFY18, and the growing US business is likely to compensate for domestic business disruption. Although updates on the generic Lialda, and approvals for transdermals are keenly awaited, the business is expected to grow nearly 7% YoY.
Cadila has a market capitalization of Rs530 billion and the target price of 600 at a CMP (Current Market Price) in the range of 517 per share makes this a worthy buy. The stock was discussed on social sites after news of Pankaj Patel stepping down as MD for son Sharvil Patel to take take over started doing the rounds. The scrip traded in the green by a margin of 1.80 points or 0.35% to 518.60 on the BSE on 13 July.
Considering the domestic market disruption, HDFC projected Lupin to grow on a high base. It is likely to post a nearly 4% decline in top-line with an EBITDA margin in the range of nearly 23%. The numbers are declining on account of increase R&D spends and decreasin contribution of gGlumetza and gFortamet. The company still has visible significant product launches visible for US markets in FY18. With a CMP of 1141, the Rs 513 billion market-capitalized company has been assigned a target price of 1800.
Granules India' revenue is expected to grow to a modest 5% YoY, with business expected to pick-up in the second half of the year. EBITDA margin is poised to reach 20.3%, a slight YoY improvement. Analysts at HDFC highlighted the stock, with a market capitalization of Rs. 32 billion to reach a target price of 195. The current market price of the stock is 141.
The HDFC analysts also suggested a Buy rating for Alkem Laboratories, Divis Lab, Alembic Pharma, Aurobindo, and Torrent Pharma.
Here are the other forecasts from the brokerage house
|5 Foods that are Natural Aphrodisiacs|
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|FDA announces major tactical shift in nationâs war on smoking||The nationâs long war on one of its leading preventable killers has taken a surprising tactical turn, as the head of the federal Food and Drug Administration has declared that tobacco companies will face new regulations aimed at slashing nicotine in cigarettes. FDA Commissioner Scott Gottlieb argues that cutting the noxious and addictive nicotine will […]|
|Deciding upon Speedy Products Of spray tan||
After you move inside these cave-like spraying booths and cover your entire body inside the chemical, your bronze is technically not as you could have inhaled DHA FDA accepted. Sun-tanning could cause defense mechanisms elimination â not forgetting burns, early aging, cataracts, and skin cancer. Everybody on the age of half a year should wear sunscreen by having an SPF of 15 or more each day, based on health professionals in order to avoid these outcomes. The problem comes from utilization of st Tropez fake tan Remover (DHA) in tanning options, which interacts with dead tissues about the skinis area to evoke color change.|
"Many dermatologists recognize that the spray-on tans in a jar, which basically cause color of the epidermis' outside level â the stratum corneum â are not dangerous and effective," says Dr. David J. Leffell. But many individuals don't use spray tans appropriately. Free radicals are a part of our organic metabolic rate but high quantities have now been associated with cell damage. It is far more cost-effective to choose the darkest color of tanning cream and implement it more sparingly so that you can obtain the same outcomes as a light color of the identical item. Keep in mind as once a month by visiting the salon as little that shade received from the visit to the salon may be managed.
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Dim clothing stops the rub -off from being obvious. Friends don't support allow you to get with that total experience who rests two rows in the front in economics into sleep. The skin may end-up too red, also dim or too light. Black colour normally makes your teeth appear brighter as it creates a far more remarkable contrast between the skin as well as your teeth. But as long as you're busy preventing damaging UV rays, the sprays you're inhaling or slathering in your skin might be just as damaging.
Capaci mentioned action's very best course will be to avoid utilizing thicker, deeper blankets, discoloration all together by spray-tanning earlier while in the day-so you're able to shower before sleeping and putting a towel between you along with the bedding. Once that is performed, we narrow down the list for the 10 finest self-tanners available today. You'll receive more of an even light. I really don't feel I could actually work with anything except I truly thought it had been the very best in its category" The makeup artist, 25-year veteran Lazz Rodriguez, said the candidate just sat down using a serious, natural bronze. Some of these goods also utilize erythrulose which operates identically to DHA, but advances.
Bear in mind that spray tans last approximately per week, 10 nights at the most. Inside the early '50s, Coppertone used up that using the sunless tanner for customers only a decade later and began promoting the primary commercially profitable sunscreen â. Tans in a sun and package bathing and it have struggled out ever since. You might want to test several products to view which works best with color and your own skin; in this case, it is about learning from your errors.
This bronzer offers a hint of rose to a "only tanned" search. There exists a better strategy to get that gold light. Allow bronzer dry completely before carrying something over it to avoid any possible discoloration, some bronzers washout of textiles. You realize cooking inside the sun not just ages the skin but may also donate to your skin cancer risk hugely. Home-tanner will âgrabâ on parts that are specially dry and appearance unpleasant, therefore get these locations softened before planning. Before implementing â Exam the self-tanner on a hidden part of your body (like the interior knee) before slathering it on all over.
We know you never exam, although we constantly alert you that you need to, but trust us on this one. Focus on skin that is clean â Provide 20 minutes if you've only bathed to make sure that your skin is wholly dried to yourself. For those who have on product or if your skin isn't dirty, you may get irregular spots that will not be soft to correct. You need shade on the top of the fingers, but you do not want palms and your cuticles to check just like you've been playing in wood stain. Our customers rinsed both prime and base of arms, simply rubbed their hands around the soap bar, and applied a brush gently on their cuticles. By before placing something on paint your nails, fix your hair, and enable at the least an hour go. And don't sit on any bright blankets or furniture (only lay on a dim-colored towel).
Reapplying will also offer you a better notion of how dim you're able to get. There are certainly a few reviews on below that have complaints about that item that I am likely to tackle below (mostly writing why they're silly claims). DHA acts with all the dead skin tissues relaxing on the top level of skin to temporarily darken its color when slathered on. by crushing up denture-cleaning drugs in a little bit of water the only thing she is discovered that works is just a strong cleaning with a substance created. I really don't learn about something how big a mattress she confessed although which may go from apparel.
In a attempt to solve his difficulty, Winters said he's begun teaching pupils to wear loose fitting pajamas to soak up the tanning color and has turned to polyurethane foam mattresses with washable addresses. It seemed totally dim and orangey (and that I got the lightest one) for around two days until it started to fade. And we also want one to know that we do not actually sell any of these products (though we will provide you with links to respected sites that). Here's steer clear of becoming a tangerine- wreck and get a flattering, bronze glow. Exfoliate using a body scrub which has sugar, which sloughs off the most effective coating of skin.
Select a self-tanning lotion for moderate color -tanning an aerosol spray for your darkest tone, or solution to get a dim tone. Receive your back by getting product while in a three's middle -foot piece of plastic wrap and rubbing across your back as you might having a towel. Or spray aerosol in to move and the air engrossed replicate and backwards. Find feet, joints, legs, your arms, and knuckles. When it is also dim in one single area utilize a lightening product including orange, toothpaste, strawberries, etc.
It has been served by the press finally admiring the item; and celebrities , fashion makers and buyers all hankering after that âbespoke color' that's not at all phony, or us cool â but cool and genuine. Intriguing guidelines, surprised Lancomes bronzer did not make the list. Likewise, taking assistance from here might save a little income too in the long run and can get you through them somewhat faster!
Nevertheless, continual, large doses of artificial Î²-carotene supplements have been connected with improved pace of lung cancer among people who smoke. The color impact ends slowly more than 3 to 10 times and is temporary. Both DHA and erythrulose happen to be known to trigger contact dermatitis. These are used with UV exposure in conjunction. At the moment, there is no scientific information open to help these claims.
It is derived in the foothills of the Himalaya, from the root of the Indian Coleus. Like makeup, the products film or spot someone's skin-only until they are washed down. Many remedies are available, and some have restricted light or work water weight. If employed under apparel, or where material and skin ends match, most will generate some lighting but visible rub-down. Color will proceed to darken the more the product can be used, although a small upsurge in shade is normally observable after the first use. Challenges of inhaling or eating DHA are not acknowledged.
Your friends enable you to along from time to time and so they do not usually allow you to search your absolute best. Friends and family don't make you look thinner. Your friends don't cause you to look that you simply have abs for that matter, or like an unique living lives. Nearly all skin cancers may be tracked back again to sun exposure. A particularly ambitious kind of skin cancer, melanoma, can kill you. Try to find remedies with antioxidants, vitamins and agents. While still within the shower, exfoliate your skin with soda by rubbing a handful in arenas across the aspects of concern. Right after, cut on the loose skin with shaving lotion and a blade.
Having a thick, fragrance- cream that is free, whilst the skin remains damp, moisturize after the bath to avoid skin irritation after shedding. A deeper go through the FDA's guidelines, however, suggests that their legality is dubious. Nevertheless, the FDA recommendations just affect "external" publicity, which doesn't are places or the lips that surround the eyes and eyebrowsâor your lungs. Nevertheless, most of the people, including tanning salon workers, are not aware the pitfalls connected with DHA (more on that in a little). DHA is really a glucose that transforms them brown and acts with your skin cells that are lifeless.
Plus it presents a specific threat when used in spray-tan items that would be inhaled. It must be used half an hour before you reapplied every two to three hours if you are in the sunshine and get outside. A 2010 small-scale review found that in case you aren't lathering you may be doubling your chance the most deadly kind of skin cancer, of developing melanoma. Just one single terrible sunburn can dramatically improve of developing skin cancer down the road a person's danger. When used correctly, DHA is known as not dangerous. The FDA suggests persons protect nose, their lips since the hazards from inhaling DHA are unfamiliar.
Till confronted with a special occasion others reside using their pallor,. Pay attention to regions which can be susceptible to excessive dryness like your bones (elbows, ankles and hips). Make sure to clean your hands thoroughly after-use (self-tans can stain your clothing and certainly will also appear in your palms, resulting in blotchiness), or in addition to this, use latex gloves when implementing the product. A relatively inexpensive solution from the regional pharmacy could possibly be just like great as these supplied in upper-scale retail outlets and specialty shops. A patch test (again, internally of the arms) while you're inside the store can be quite a good indication of anticipated benefits. Goods come in a range of color depths, with regards to awareness of the active ingredient's amount.
Neutrogena offers a really normal -looking type of affordable goods that are hypoallergenic and will not block pores. Its mousse fake tan is specially gentle in contrast to a lot of other brands, and leaves skin looking flat â a really positive thing if you're prone to outbreaks and/or have an oily appearance.
These products include components like oils that may ensure it is tough for the principal substance in self tanning spray for your skin to bind. We made a âchecklistâ of safety tips you ought to follow in the event you visit a salon to truly get your spray tan before we move ahead. Along with other visitors want to understand the tanning salons that are very best to go to to obtain spray tanning! DON'T get waxed after your spray tan and before you bathe.
Please exfoliate BEFORE your spray tan. Your spray color isn't currently washing-off, it is just bronzer. Your spray tan can last 4-8 times. Shaving as you can and the most effective exercise would be to keep the maximum amount of time taken between your spray color session.
So long as possible producing your airbrush tan go longer moisturizing will keep the dead skin tissues on your body,. From a tiny airbrush tanning salon to a worldwide purveyor of paraben -free spray-tanning & bodycare essentials, South SeasÂ® has grown since 2001. I would like spray tan to become called a super safe factor that helps people baking within perhaps a bed or the sunlight and obtaining skin cancer.
Your spray color is dim or as lighting while you wish. So on a wonderful brown color that always looks like a natural color, your skin takes after spray tanning. Golden brown, not red is temporarily made the skin by the air in spray tanning. Also fair skinned men who usually turn red in place of while tanning can take advantage of a bronze color by getting a spray color.
While you'll discover by reading on, there are specific measures you may take (before and after your spray tanning program) to ensure your tan lasts so long as possible. While beginning your cellular spray tanning business as many likes as you are able to you should attempt to obtain. Marketing your portable spray tanning enterprise the right way on social-media is vital for this to develop.
Remember that people get spray tans to create themselves feelgood. Get a skin treatment together with your spray color. "the main reason support or I am worried may be the deposit of the agents in to the lungs can really accomplish systemic absorption - that's, engaging in the body."
Keep in mind it requires about four hours for your treatment for absorb into the skin and provide you that natural and healthy glow and that the colour you are seeing is simply the spray tanning bronzer. At home airbrush tanning systems and aerosol mists are also available. As the quantities inhaled would have to be noticeably higher-than a typical buyer or even apply tan tech could be subjected to, quotation required press coverage on the situation has resulted in increased customer persistence pertaining to the degree of DHA as well as other ingredients within their spray-tanning items, as well as a shift toward more normally-derived spray color answers.
A spray color at Complete Tan is $23, and you will get adjustable and coupons -spray tan reductions. For Salon Owners â understand our spray-tanning gear and how the revenue of your salon can drastically improve straight away. The explanation for this is that left wax deposit will prohibit our Infinity Sunshine spray tanning solution's absorption.
It's also important to note is the fact that you'll not want to polish once you brown because you will actually wax off the spray tan. Your spray tanning painters are qualified and keep up inside the market with new improvements and every one of the styles. You've witnessed how spray-tanning products focus on your skin layer if you witnessed a sliced apple change to brown. That's one reason our the top of range spray tanning option includes a temporary color.
Please make an effort to see our website even as we present a number of the many depth details about sunless tanning. As Claremont expands we shall carry in a fresh Tantress to make certain we are able to offer outstanding cellular spray tanning services. Cellular tanning could be the final in convenience.
Regardless of the situation, tanning assistance that is mobile getting a stunning that glowing color as easy as possible and will be here to make your life. The planning method takes a short while once we have to make sure you have decided for the airbrush tan. It is differing and incredibly exclusive than tanning somebody. Types and several celebrities desire spray tanning to simply about anything else to acquire the colour they need. When you are done obtain in acar, all with that tanning remedy allover the body and you have to put back on your own garments.
This may cause your spray color to appear streaky and blotchy. It's proposed that you just have any body or facial waxing performed before your spray tan. We recommend then working-out, rinsing off the bronzer and then having a complete bathtub - simply which means you do not must take two baths back-to-back.
We will discuss customizing a sunless color to your specific requirements. For that most component screen cream will reduce spray color remedy from gathering in unwanted locations but we have presented some tips to help remove spray tan solution from these unwanted areas of the human body, just in case this happens to you personally.
With a demanding expulsion treatment before the color (the night before is okay), you will possess the color used on a refreshing layer of primarily living skin cells enabling you to obtain the best spray tan possible. All that effort preparing the skin evening on the days prior to tan could possibly be pointless should youn't have a few significant measures about the morning of one's airbrush color.
Please contact the tanning salon for more information. That I only relax sometimes, and spray tanning is so mainstream today and think about first. Spray tans usually last 5 to 7 days. Magnificent Bronze specializes in supplying a 99-percent-normal airbrush color option that is comprised of a brown sugar software. Mystic tan revolutionized the spray color, providing excellent, flawless, natural benefits each time.
So it is a very important thing you can find organic -seeking alternatives such as spray tanning to provide a safer choice once we desire to search sun-kissed to us. They add shine or can perhaps spray on the 6-pack for you! The most effective form of marketing to your portable spray tanning enterprise is wordofmouth.
A great marketing to operate to get a portable spray tan organization is get yourself a free bronze after investing in five. Be there to answer questions folks may have and introduce appropriate information in their mind about spray tanning. In order to efficiently advertise your mobile spray-tanning organization, about who your potential customers are you have to think,.
Focuses primarily on retaining skin intense and easy with waxing and tanning solutions provided by professionally trained experts who implement all spray tans yourself. a skin-treatment is doubled being by their airbrush tanning by mixing anti- aging antioxidant ingredients to the formulation. Spray-tanning attempts to tarnish gravityis reputation even more. To prevent the drop tan knee search forever, if you get out do not dry your-face first and function your way down (this is actually the most common article-bathtub practice) but must be done the alternative when spray tanning.
Be sure to not make use of a normal cream before spray tanning since it generates a barrier once we mentioned previously, but additionally the aroma could throw off your PH equilibrium which can negatively affect your color. Rey Panettieri has commented, "The reason I am worried may be the agents into the lungs' deposition might definitely aid or aid systemic absorption - that is, getting into the body.
We offer extraordinary UV spray that is free tanning providers, offering you obtain the exact bronze you wish. Whether you're self- finding a spray tan or tanning at home, the professionals at Hollywood Tans lately contributed their top-ten commandments for summer with us. Click through to see a few of our favorites â and you should be on your way to looking such as the ultimate beach bunny!
Contact your favorite tanning salon to have rates. Had my spray color that is complete with I & Tara love it! Once a fake tanning spray has set in to a product, Capaci said it is hard to deal with. In-salon choices include either spray color that is individual or a private spray booth by a technician. You must realize a couple of things to acquire ultimate benefits prior to going off to get a spray color,. You'll be happy together with the benefits but before you will get another spray color you need to wait for the past someone to fade. When you have an expert home spray tan machine, your Tanologist will have you stand-in selected jobs, thus she can apply on every inch of one's body.
This will leave an even tan to you. Once we came across the product I & my cousin had been looking into affordable spray tan products to work with. Like you wore that bra when you tanned it might truly look. Aside from having a slimming result, an airbrush tan can help hide skin conditions, varicose brown lines and veins. Pretend it or in addition to this, let's enable you to fake it with a cellular spray tan in the solitude of one's property.
I can not think about a quicker and more individual knowledge than an in the home spray tan in Nyc! Exfoliating may improve and increase your tanning results. All makeup must also be removed before your spray tan period and do not forget to take your jewelry off!
the best natural tanned color is offered by your proprietary sunless alternative. We are very distinct to the system as the system somebody uses may influence your airbrush tan is utilized we utilize,. Kristy will still handle by request merely portable spray tans provided that the request is long beforehand.
After your airbrush tan, the Tantress can dry you for some moments. You will need to submit a consumer permission form which will be traditional with any tanning company if you're a fresh consumer. We are not unable to adjust the total amount of spray and also the spray dimension to help blend the Vitiligo.
âWhat's so special regarding the tan will be the diamond particles reveal light flashes, so it makes glowing for redcarpet and photography instances and skin look additional luminous - it really is paparazzi permitted! And since we now realize that cooking in the sunlight all-day is not truly good for our skin, plenty of individuals are looking at spray-tanning to acquire that beautiful bronze glow. The outcomes you can get from tanning sprays are generally great.
Quickly the bat, understand that the price tag on spray tanning differs to spot from location. On the basis of the means self tanners work, it's important to slough just as much useless and dried skin that you can off before applying any self tanner or tanning spray. VeraSpa has a new encounter in spray-tanning that's more moisturizing claustrophobic than conventional stands, and personalized personalized to make sure you get yourself a shade that seems pure on you.
Eyelash extensions are ok to own on and do not affect your spray tan, however because of the way lash extensions are applied, it's recommended they be applied before your spray tan visit.
|Velasquez-Manoff on Autoimmune Disease, Parasites, and Complexity||Moises Velasquez-Manoff, author of An Epidemic of Absence, talks with EconTalk host Russ Roberts about his book--a discussion of why allergies and autoimmune diseases have been on the rise in the developed world for the last half-century. Velasquez-Manoff explores a recent hypothesis in the epidemiological literature theorizing the increase is a response to the overly hygienic environment in rich countries and the absence of various microbes and parasites. Velasquez-Manoff also considers whether reintroducing parasites into our bodies can have therapeutic effects, a possibility currently under examination through FDA trials. The conversation continues a theme of EconTalk--the challenge of understanding causation in a complex world.|
|Groups Sue FDA to Take Formaldehyde Out of Salons|
The Food and Drug Administration has failed to act on dangerous hair straighteners that contain unsafe levels of formaldehyde and pose a significant health hazard to consumers and salon workers, the Environmental Working Group and Womenâs Voices for the Earth … Continue reading
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|Researchers Accidentally Discover That Iron Nanoparticles Can Help Destroy Cancer Cells||La cÃ¢t mai multe astfel de accidente! De menÈionat cÄ descoperirea s-a fÄcut pe cobai, testele clinice pe oameni nu au Ã®nceput Ã®ncÄ, dar medicamentul este deja aprobat de FDA pentru tratarea anemiei, ceea ce va face mai scurt drumul cÄtre un eventual tratament pentru oameni. Stanford researchers accidentally discovered that iron nanoparticles invented for […]|
|Researchers Accidentally Discover That Iron Nanoparticles Can Help Destroy Cancer Cells||La cÃ¢t mai multe astfel de accidente! De menÈionat cÄ descoperirea s-a fÄcut pe cobai, testele clinice pe oameni nu au Ã®nceput Ã®ncÄ, dar medicamentul este deja aprobat de FDA pentru tratarea anemiei, ceea ce va face mai scurt drumul cÄtre un eventual tratament pentru oameni. Stanford researchers accidentally discovered that iron nanoparticles invented for […]|
|Researchers Accidentally Discover That Iron Nanoparticles Can Help Destroy Cancer Cells||La cÃ¢t mai multe astfel de accidente! De menÈionat cÄ descoperirea s-a fÄcut pe cobai, testele clinice pe oameni nu au Ã®nceput Ã®ncÄ, dar medicamentul este deja aprobat de FDA pentru tratarea anemiei, ceea ce va face mai scurt drumul cÄtre un eventual tratament pentru oameni. Stanford researchers accidentally discovered that iron nanoparticles invented for […]|
|Researchers Accidentally Discover That Iron Nanoparticles Can Help Destroy Cancer Cells||La cÃ¢t mai multe astfel de accidente! De menÈionat cÄ descoperirea s-a fÄcut pe cobai, testele clinice pe oameni nu au Ã®nceput Ã®ncÄ, dar medicamentul este deja aprobat de FDA pentru tratarea anemiei, ceea ce va face mai scurt drumul cÄtre un eventual tratament pentru oameni. Stanford researchers accidentally discovered that iron nanoparticles invented for […]|
|Researchers Accidentally Discover That Iron Nanoparticles Can Help Destroy Cancer Cells||La cÃ¢t mai multe astfel de accidente! De menÈionat cÄ descoperirea s-a fÄcut pe cobai, testele clinice pe oameni nu au Ã®nceput Ã®ncÄ, dar medicamentul este deja aprobat de FDA pentru tratarea anemiei, ceea ce va face mai scurt drumul cÄtre un eventual tratament pentru oameni. Stanford researchers accidentally discovered that iron nanoparticles invented for […]|
|An opportunity to safely dispose of outdated or unused prescriptions|
I just learned that Saturday, October 29th, is National Prescription Drug Take Back Day. The DEA is working with state and local law enforcement agencies to offer drop off sites for unwanted and unneeded prescriptions. The DEA has a drop off locator on their website for people who'd like to find a collection site. Right now we've only got a couple in Evansville, -- the Armory and the State Police post off Hwy 41 -- but they say to keep checking because they're continually adding new sites. I also noticed, when I searched using the library's zip code, that drop off sites in Henderson showed up as well.
This got me wondering about how to safely dispose of unneeded prescriptions the other 364 days a year. According to the FDA website on the subject, apparently flushing down the toilet is still a number one way; although, only if the prescription bottle says you may dispose of it that way. They go on to detail other ways to safely dispose of prescriptions, but since I don't generate cat litter or coffee grounds, it would be easier for me to just gather up any old prescriptions and drop them off Saturday.
|Local Seafood â Always In Season!|
Did you know that 80% of all seafood served in restaurants across America is imported? And out of that, only 2% of it is FDA inspected. Itâs often taken for granted that the seafood you order in Outer Banks restaurants is locally sourced, but unfortunately sometimes that just isnât the case. According to Outer Banks […]
|ALOKD4-ITM Waterproof Bags - Double Zip - 4 bag Multipack||
aLOKSAK bags are resealable element-proof storage bags featuring a hermetic seal. That means absolutley no water, air, dust or humidity permeates the closure. The transparent bags are flexible, puncture resistant and designed for a wide range of applications ans environments. Loksak says: This set of four aLOKSAK Waterproof Bags from Loksak contains one of each of the following size bags: 3.7 x 7", 4 x 7", 6 x 9", and 8 x 11". The bags are waterproof and airtight protecting your electronics, documents and other items that need shelter from the elements. A double-zipper closure creates a hermetic seal, which prevents any air, dust, or micro-organisms from leaving or entering the bag once it is sealed. The recyclable and reusable aLOKSAK bags are made from FDA and NSA-approved medical grade polyethylene that is safe for both food and biohazard storage. You can make and receive calls, and use touchscreens from phones or tablets within the bag. They are certified waterproof up to 200', and remain effective from -40Â° to 140Â°F.
|Comment on Engineers turn everyday objects into FM radio stations â singing posters and talking shirts by #android #biometric #devices #elasticsearch #fda #fmradio #healthcare #iphone8 #kibana #nonazis #privacy - domain crannies||[…] @uwengineering â college engineers transforming posters and tshirts into iot communication nodes […]|
|Mercury Fillings: Not Efficient|
Update: Recently, the FDA concluded that mercury filling have safety issues, see this news story. Sweden, Denmark and Norway have banned them. Germany and Austria have discouraged use. Yet, in the United States, dental amalgams, the âsilverâ fillings that have been commonly used in dental practices for decades, are still used frequently as an inexpensive and popular treatment for cavities. ...
|Dad Of The Year||From the Wall Street Journal, "Tech-Savvy Families Use Home-Built Diabetes Device":|
Third-grader Andrew Calabrese carries his backpack everywhere he goes at his San Diego-area school. His backpack isnât just filled with books, it is carrying his robotic pancreas.Unfortunately, the FDA isn't particularly supportive of such grass-roots endeavors.
|FTC and FDA to POM Wonderful â Not so wonderful & false claims||Do you have heart disease? Cancer? Erectile dysfunction? Drink a magic elixir and you too shall be cured! Those claims are no different from the traveling snake oil vendor of old days. Now, don’t get me wrong. I like pomegranates and pomegranate juice. I have 3 pomegranate trees and I love the fruit. I am|
A new state just joined the most fascinating birth control experiment in America.
People seeking out oral birth control in Colorado will now be able purchase the medication at a pharmacy without making a doctor's appointment first.
The law that loosens the restriction was passed in 2016 and went into effect in August â making the Centennial State the third to streamline the process of acquiring birth control pills, along with California and Oregon.
The medication still has to be prescribed â but that can be done by a pharmacist. The process involves a consultation, a questionnaire, and a blood pressure check, according to the Associated Press.
Permitting pharmacies to sell oral birth control over the counter has become a bipartisan cause in recent years â though the parties disagree on how to make it work.
Many drug companies are wary to undergo the FDA's approval process, which can be "lengthy and expensive" and includes the risk of incurring a political backlash, according to a 2015 Guttmacher Institute report.
Guttmacher, a reproductive health policy advocacy group, praised California and Oregon's partial approach, while noting that it's "unclear how pharmacists will be able to bill insurance companies for the costs of associated counseling and screening services."
Also in 2015, Senators Cory Gardner (R-Colorado) and Kelly Ayotte (R-New Hampshire) proposed a measure that would reward drug companies that filed applications to sell their oral contraceptives over the counter. Â
The plan, while supported by a half-dozen other GOP senators, was opposed by both the American Congress of Obstetricians and Gynecologists and Planned Parenthood on the grounds that such a measure would force potential patients to "pay twice for their birth control," if insurers no longer covered the medication as a result.
A separate plan, proposed by Democratic Senator Patty Murray in 2015, would have required insurers to cover oral contraceptives purchased over the counter.
Neither Gardner and Ayotte's bill nor Murray's bill passed.
This isn't the first time Colorado has experimented with reforming the birth control delivery process.
In 2009, the state began offering free long-acting intra-uterine devices (IUDs) to residents. Teen pregnancies fell by over 40% over the same period.
For now, those who advocate lowering barriers to access have a new laboratory where they can study the potential benefits.
"People could be coming in to buy shampoo or vitamins, and they can have that conversation with a pharmacist," pharmacist Kelsey Schwander told the Denver Post earlier this year in the run-up to the measure's implementation.
For Coloradans who fear the expense of a doctor's visit, it could be a conversation worth having. Â
|FDA proposes rules to make animal food safer||Amid incidents of pets dying from dog treats, the Food and Drug Administration is proposing long-awaited rules to make pet food and animal feed safer.|
|4 Insights From Top Tobacco Minds|
CSP nicotine meeting examines new FDA direction, local ordinances
|FDA Calls for Lower Nicotine Levels|
New strategy emphasizes addictive elements of tobacco, revisits e-cigarette deadlines
|FDA Seeks the âRight Balanceâ With New Tobacco Plan||Agency aims to reduce nicotine levels while shifting smokers toward e-cigarettes
|FDA Goes After Cigarette Nicotine Levels||Eases application requirements for e-cigs|
|Don't hold your breath if you're waiting for the new nutrition labels||The new nutrition labels would have updated serving sizes and identified added sugars, but the FDA has put an indefinite hold on them.|
|Testosterone Therapy Treatment Lawyer Help: Resource4thePeople Attorneys Now Available to File Lawsuits over Allegations of Heart Attacks and Strokes|| |
National network of attorneys follows up on substantial number of consumer inquiries into no-cost consultations in connection with FDA announcement of review of testosterone treatments.
(PRWeb March 24, 2014)
Read the full story at http://www.prweb.com/releases/2014/03/prweb11690313.htm
|Bard IVC Filter Failure Allegations Warning: Resource4thePeople Outlines Problems Being Investigated|| |
National network of attorneys offers complimentary consultations over several concerns raised in FDA IVC health advisory about allegations of migrations, perforation, filter fracture and other problems linked by FDA to life-threatening health problems.
(PRWeb March 01, 2014)
Read the full story at http://www.prweb.com/releases/2014/02/prweb11616917.htm
|Tylenol Liver Damage Allegations Update: Resource4thePeople Reacts to FDA Announcement Recommending Lower Acetaminophen Doses|| |
National network of attorneys continues to provide complimentary consultations to consumers inquiring about legal options to seek compensation over allegations that Tylenol and other acetaminophens may cause liver damage.
(PRWeb February 26, 2014)
Read the full story at http://www.prweb.com/releases/2014/02/prweb11612339.htm
|Lipitor Diabetes Allegation Attorneys: Resource4thePeople Is Tracking Australian Commissionâs Filing of Charges over Lipitor Sales Practices|| |
National network of attorneys will continue consumer updates of allegations raised in Australia and maintain offer of complimentary consultations in connection with concerns announced by FDA that Lipitor and other statins increase the risk of developing diabetes.
(PRWeb February 19, 2014)
Read the full story at http://www.prweb.com/releases/2014/02/prweb11592236.htm
|Yes, U.S. Scientists Edited an Embryoâs Genes, but Super-Babies Are a Ways Away|
MIT Technology Review reported Thursday that a team of researchers from Portland, Oregon were the first team of U.S.-based scientists to successfully create a genetically modified human embryo. The researchers, led by Shoukhrat Mitalipov of Oregon Health and Science University, changed the DNA ofâin MIT Technology Reviewâs wordsââmany tensâ of genetically-diseased embryos by injecting the host egg with CRISPR, a DNA-based gene editing tool first discovered in bacteria, at the time of fertilization. CRISPR-Cas9, as the full editing system is called, allows scientists to change genes accurately and efficiently. As has happened with research elsewhere, the CRISPR-edited embryos werenât implantedâthey were kept sustained for only a couple of days.
In addition to being the first American team to complete this feat, the researchers also improved upon the work of the three Chinese research teams that beat them to editing embryos with CRISPR: Mitalipovâs team increased the proportion of embryonic cells that received the intended genetic changes, addressing an issue called âmosaicism,â which is when an embryo is comprised of cells with different genetic makeups. Increasing that proportion is essential to CRISPR work in eliminating inherited diseases, to ensure that the CRISPR therapy has the intended result. The Oregon team also reduced the number of genetic errors introduced by CRISPR, reducing the likelihood that a patient would develop cancer elsewhere in the body.
Separate from the scientific advancements, itâs a big deal that this work happened in a country with such intense politicization of embryo research. But the climate around these issues has changed recently: The U.S National Academy of Sciences has repeatedly endorsed basic research related to embryo editing, doing so again this February.
But there are a great number of obstacles between the current research and the future of genetically editing all children to be 12-foot-tall Einsteins.
Possibly chief among these obstacles is that a CRISPR intervention would have to be completed at or just after fertilization to yield a super child. The authors of the upcoming paper (which is apparently scheduled to be published, though itâs unclear where) used the donated sperm of men carrying inherited disease mutations to create embryos with those mutations with the goal of then editing out the genetic diseases. This required the authors to know the disease carried by the sperm, and to be able to correct for that disease at the time of fertilization. Since human eggs can be fertilized by sperm half an hour after sex, CRISPR editing would likely require IVF, which is increasingly common but still out of reach for many families.
Furthermore, Stanford University law professor Hank Greely tweeted that the âkey pointâ was that no team had yet implanted a CRISPR-edited embryo in a uterus for development. Until this research is done with real embryos that are allowed to reach maturity, and not research embryos, we are still far away from CRISPR being used widely.
And no matter the amount of academic interest in the topic, further research and clinical trials wonât take place unless funding is given. Right now, all federal agencies in the U.S., including the National Institute of Health, are prohibited from funding research that edits genes in embryos. Science magazine reports this is âbecause of a congressional prohibition on using taxpayer funds for research that destroys human embryos.â This means that funding for embryo editing must (and will) come from private sources, inherently reducing the degree to which the government can supervise and direct this kind of research.
Thereâs also the issue of price. Several commercial CRISPR-based gene therapies have gone to market abroad in the last couple years. Theyâre intended for already-born humans, not embryos. None of them have yet made it to the U.S, but one company that may be the first, Spark Therapeutics of Philadelphia, estimates that its treatment will cost roughly $500,000. to treat a genetic eye condition in one eye if it finally gets FDA approval. Sparkâs treatment isnât even the most expensive. A 2012 drug called Glybera cost $1.4 million in Germany for genetic treatment of an ultra-rare disease called lipoprotein lipase deficiency.
So, while this research is an important building block for the future, it doesnât mean the future is already here.
|USA: implant rogÃ³wki na prezbiopiÄ||FDA zatwierdziÅa implant rogÃ³wki, ktÃ³ry posÅuÅ¼y pacjentom cierpiÄ
cym na prezbiopiÄ (starczowzrocznoÅÄ).|
|the celebration of max's life||first, i can't even begin to describe how amazingly beautiful and touching the celebration of max's life was. i'm going to try and share as many details as i can.|
the celebration took place on a grassy patch in del mar, that overlooks the beach. it's a place where the mikulaks spent a lot of time and holds many fun memories as a family. there were chairs set up in a center area, with many tables around the perimeter. in the front was a podium and two enlarged photos of max.
this table held photos of max, throughout his seven years, and pages for guests to create for max's scrapbook (in place of a guestbook).
this was the main table, with two beautiful orange bouquets of flowers, the angel in the sky photo, and bagels and water for guests.
and the mikulak family didn't miss any details. every vase at the celebration was filled with legos (in the place of stones, jewels, etc.).
the mikulaks had numerous lego tables set up for the kids. the kids quietly played with the legos throughout the ceremony, just the way max would have wanted it. after the ceremony, the children were able take home any lego creations that they made. even the big kids had fun with the legos.
a table, with all of max's favorite things. it was so beautiful how they had the blanket, with the words love isn't love until you give it away. max gave us all so much love. and his spirit and goodness continues to live on in all of those he touched.
andy, with three other incredible people (and the other three founders of the magic water project foundation).
- dr. giselle scholler. max's doctor (from vermont). she is a pediatric oncologist that has lead research work for the new and promising drug, nifurtimox. max was a participant in this FDA trial, which dr. scholler leads.
- pat lacey. pat, has a four year old, battling relapsed neuroblastoma (diagnosed at age 7 months). he keeps a wonderful blog on will's progress. and pat is such a fabulous writer.
- margot hutchison. i actually met max and his family through the hutchisons. kiele and their son, sam, went to the same elementary school. their son, sam, is also battling relapsed neuroblastoma.
kevin, melissa's brother, who they referred to as the ring master, started off the celebration and was such a great speaker.
i love this photo! andy and melissa smiling, while listening to melissa's brother share a story about max. hannah holding papa's hand. and one of hannah's closest friends, hersheeta, with her arm around hannah. earlier, i saw hannah playing with hersheeta's ponytail. it was so sweet.
bree, max's cousin's wife, read the book, where the wild things are.
randee, melissa's sister, also spoke fabulous words about max's life. randee has also been instrumental in making the sale of the angel in the sky print happen.
ms. weitz, max's kindergarten teacher, spoke and shared some wonderful stories of max. during her time, a train went by. this is part of why max loved this location so much. you could play at the park and see the trains all from the same location.
max's first and second grade teacher, mrs. sturt. i've had the pleasure of meeting mrs. sturt and seeing her in action, with max. she is such an incredible soul and her speech was beyond words, sharing her love for max and some incredible stories of her time with him.
then hannah's brownie troop sang this most beautiful version of you are my sunshine.
you are my sunshine,
my special sunshine.
you make me happy,
when skies are grey.
how much i love you.
please don't take my sunshine away.
the other night, max,
as i lay sleeping,
i dreamed i saw your smiling face.
when i awoke, max,
i knew i'd miss it,
but now you're in a better place.
you are our sunshine,
our special sunshine.
you make us happy,
when skies are grey.
you'll never know, max,
how much we'll miss you.
please don't take our sunshine away.
hannah, with the support of another one of her closest friend's, jenna, read a book, max. her parents were so proud of her.
den leader, steve, and his wolf den 734, were up to speak next and they had a special thing prepared, which andy was unaware of. at the last meeting, with the hopes that max would be able to attend, steve had planned that the cub scouts would make model airplanes. unfortunately, max was not able to make this meeting because he was too sick. steve spoke some wonderful stories about max and then, the boys did a missing man formation with their planes.
melissa's brother-in-law, mike, also spoke some beautiful words and prayers.
we weren't sure it was going to happen because of the clouds, but they cleared enough that they were able to fly....two vintage WWII aircraft. it was so awesome and special. kevin, the ring master, had said that he knew max was going to right there with the planes and that if we saw him, to give him a wave.